JP2017507139A5 - - Google Patents
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- JP2017507139A5 JP2017507139A5 JP2016552595A JP2016552595A JP2017507139A5 JP 2017507139 A5 JP2017507139 A5 JP 2017507139A5 JP 2016552595 A JP2016552595 A JP 2016552595A JP 2016552595 A JP2016552595 A JP 2016552595A JP 2017507139 A5 JP2017507139 A5 JP 2017507139A5
- Authority
- JP
- Japan
- Prior art keywords
- maintenance doses
- antagonist
- laba
- ics
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 22
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 18
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 18
- 238000012423 maintenance Methods 0.000 claims 18
- 239000005557 antagonist Substances 0.000 claims 13
- 229940125369 inhaled corticosteroids Drugs 0.000 claims 12
- PZSMUPGANZGPBF-UHFFFAOYSA-N 4-[5-(dithiolan-3-yl)pentanoylamino]butanoic acid Chemical compound OC(=O)CCCNC(=O)CCCCC1CCSS1 PZSMUPGANZGPBF-UHFFFAOYSA-N 0.000 claims 11
- 229940125389 long-acting beta agonist Drugs 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 208000006673 asthma Diseases 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 3
- 238000002648 combination therapy Methods 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000037874 Asthma exacerbation Diseases 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020036331A JP6893265B2 (ja) | 2014-02-21 | 2020-03-04 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943019P | 2014-02-21 | 2014-02-21 | |
| US61/943,019 | 2014-02-21 | ||
| EP14306413 | 2014-09-15 | ||
| EP14306413.7 | 2014-09-15 | ||
| US201462077669P | 2014-11-10 | 2014-11-10 | |
| US62/077,669 | 2014-11-10 | ||
| PCT/US2015/016852 WO2015127229A1 (en) | 2014-02-21 | 2015-02-20 | Methods for treating or preventing asthma by administering an il-4r antagonist |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020036331A Division JP6893265B2 (ja) | 2014-02-21 | 2020-03-04 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507139A JP2017507139A (ja) | 2017-03-16 |
| JP2017507139A5 true JP2017507139A5 (cg-RX-API-DMAC7.html) | 2018-03-22 |
| JP6673840B2 JP6673840B2 (ja) | 2020-03-25 |
Family
ID=51570453
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552595A Active JP6673840B2 (ja) | 2014-02-21 | 2015-02-20 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2023139455A Active JP7636487B2 (ja) | 2014-02-21 | 2023-08-30 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2025020415A Pending JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023139455A Active JP7636487B2 (ja) | 2014-02-21 | 2023-08-30 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2025020415A Pending JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10137193B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3973987B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6673840B2 (cg-RX-API-DMAC7.html) |
| KR (4) | KR20230167770A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106232140A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2015218808B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2940295A1 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2977332T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE065844T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL315136A (cg-RX-API-DMAC7.html) |
| MX (2) | MX384192B (cg-RX-API-DMAC7.html) |
| PL (2) | PL3973987T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT3107575T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2713406C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015127229A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| CN104755495A (zh) | 2012-08-21 | 2015-07-01 | 赛诺菲 | 通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| RU2698907C2 (ru) | 2012-09-07 | 2019-09-02 | Ридженерон Фармасьютикалз, Инк. | Способы лечения атопического дерматита с помощью антагониста il-4r |
| TWI633891B (zh) * | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑以治療過敏及增強過敏原－特異之免疫療法的方法 |
| PL3010539T3 (pl) | 2013-06-21 | 2020-01-31 | Sanofi Biotechnology | Sposoby leczenia polipowatości nosa przez podawanie antagonisty il-4r |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| EP3838271B1 (en) | 2013-07-12 | 2025-09-03 | Areteia Therapeutics, Inc. | Treating elevated levels of eosinophils and/or basophils |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| MX376691B (es) | 2014-02-28 | 2025-03-07 | Regeneron Pharma | Composición farmaceutica que comprende un antagonista de il-4r para tratar una infección cutánea. |
| KR20230158131A (ko) | 2014-11-14 | 2023-11-17 | 사노피 바이오테크놀로지 | Ｉｌ-4ｒ 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법 |
| US20180056018A1 (en) * | 2016-08-31 | 2018-03-01 | Cephalon, Inc. | Inhalation Systems, Devices and Methods |
| PT3506931T (pt) | 2016-09-01 | 2024-08-21 | Regeneron Pharma | Métodos de prevenção ou de tratamento da alergia mediante a administração de um antagonista de il-4r |
| RU2759630C2 (ru) | 2016-09-22 | 2021-11-16 | Ридженерон Фармасьютикалз, Инк. | Способы лечения тяжелого атопического дерматита путем введения ингибитора il-4r |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| CN110431240A (zh) * | 2017-04-13 | 2019-11-08 | 雷杰纳荣制药公司 | 在编码il33和il1rl1的基因中具有风险等位基因的患者的炎症性肺部疾病的治疗和抑制 |
| EP3645009A4 (en) | 2017-06-27 | 2021-03-31 | The Ohio State Innovation Foundation | LIPONUCLEOTIDE THERAPY FOR COPD |
| US11850283B2 (en) | 2017-06-27 | 2023-12-26 | Ohio State Innovation Foundation | Liponucleotide-based therapy for asthma |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| KR102694419B1 (ko) * | 2017-10-30 | 2024-08-09 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| SG11202009371WA (en) | 2018-05-13 | 2020-10-29 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
| EP3820891A1 (en) * | 2018-07-10 | 2021-05-19 | Regeneron Pharmaceuticals, Inc. | Modifying binding molecules to minimize pre-existing interactions |
| CN110872349A (zh) | 2018-09-04 | 2020-03-10 | 三生国健药业（上海）股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
| CN111514292B (zh) | 2018-12-25 | 2023-06-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
| JP7759255B2 (ja) * | 2018-12-27 | 2025-10-23 | 中山康方生物医▲藥▼有限公司 | ヒトｉｌ４ｒａに対する抗体及びその使用 |
| KR20210143246A (ko) | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
| TWI894144B (zh) * | 2019-05-01 | 2025-08-21 | 法商賽諾菲生物技術公司 | 藉由投予il-33拮抗劑治療或預防哮喘之方法 |
| US12398212B2 (en) | 2019-07-16 | 2025-08-26 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| CN114173816A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗特应性皮炎的方法 |
| CN114173819A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法 |
| JP2023504204A (ja) | 2019-12-09 | 2023-02-01 | サノフィ・バイオテクノロジー | デジタル的に識別されたｉｌ－４／ｉｌ－１３関連障害を治療する方法 |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CN113797331A (zh) * | 2020-06-16 | 2021-12-17 | 三生国健药业（上海）股份有限公司 | 一种稳定的抗IL-4Rα单克隆抗体液体制剂 |
| KR20230067604A (ko) * | 2020-08-05 | 2023-05-16 | 아레테이아 테라퓨틱스, 인코포레이티드 | 중등도 내지 중증 천식의 치료를 위한 덱스프라미펙솔의 용도 |
| BR112023004020A2 (pt) * | 2020-10-05 | 2023-04-25 | Sanofi Biotechnology | Métodos para tratamento de asma em indivíduos pediátricos através da administração de um antagonista de il-4r |
| US20240343815A1 (en) * | 2021-08-26 | 2024-10-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical composition of anti-il4r antibody and use thereof |
| CN117368487A (zh) * | 2023-09-28 | 2024-01-09 | 首都医科大学附属北京同仁医院 | 一种利用局部IgE预测或评估奥马珠单抗在治疗复发性鼻息肉中疗效的方法和应用 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
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| GB8808015D0 (en) | 1988-04-06 | 1988-05-05 | Ritter M A | Chemical compounds |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5714146A (en) | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| EP0604693A1 (en) | 1992-12-29 | 1994-07-06 | Schering-Plough | Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| EP2292665B1 (en) | 2000-05-26 | 2015-07-08 | Immunex Corporation | Use of interleukin-4 antibodies and compositions thereof |
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| US20090098142A1 (en) | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| TW200902555A (en) | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
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| DK2769992T3 (da) | 2006-10-02 | 2021-03-22 | Regeneron Pharma | Humane antistoffer med høj affinitet for human IL-4-receptor |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| EP2022507A1 (en) | 2007-08-07 | 2009-02-11 | Universität Hamburg | Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| DK2245064T3 (da) * | 2007-12-21 | 2014-10-27 | Medimmune Ltd | BINDINGSELEMENTER TIL INTERLEUKIN-4-RECEPTOR-ALFA (IL-4Ralfa) |
| US20120004205A1 (en) | 2008-12-01 | 2012-01-05 | Cincinnati Children's Hospital Medical Center | Il-13 induced gene signature for eosinophilic esophagitis |
| EP2414520A2 (en) | 2009-03-31 | 2012-02-08 | Altair Therapeutics, Inc. | Methods of modulating an immune response to a viral infection |
| WO2011156000A2 (en) * | 2010-06-07 | 2011-12-15 | Aerovance, Inc. | Use of il-4/il-13 antagonists to treat eosinophilic disorders |
| NZ609557A (en) | 2010-10-06 | 2014-12-24 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| US20130281876A1 (en) * | 2010-10-15 | 2013-10-24 | Medimmune Limited | Therapies for improving pulmonary function |
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| RU2014122189A (ru) * | 2011-11-01 | 2015-12-10 | МЕДИММЬЮН, ЭлЭлСи | Способы снижения частоты и тяжести острых приступов астмы |
| CN104755495A (zh) * | 2012-08-21 | 2015-07-01 | 赛诺菲 | 通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| RU2698907C2 (ru) | 2012-09-07 | 2019-09-02 | Ридженерон Фармасьютикалз, Инк. | Способы лечения атопического дерматита с помощью антагониста il-4r |
| PL3010539T3 (pl) | 2013-06-21 | 2020-01-31 | Sanofi Biotechnology | Sposoby leczenia polipowatości nosa przez podawanie antagonisty il-4r |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| KR20230158131A (ko) | 2014-11-14 | 2023-11-17 | 사노피 바이오테크놀로지 | Ｉｌ-4ｒ 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법 |
| KR102694419B1 (ko) * | 2017-10-30 | 2024-08-09 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| BR112023004020A2 (pt) | 2020-10-05 | 2023-04-25 | Sanofi Biotechnology | Métodos para tratamento de asma em indivíduos pediátricos através da administração de um antagonista de il-4r |
-
2015
- 2015-02-19 IL IL315136A patent/IL315136A/en unknown
- 2015-02-20 HU HUE21191120A patent/HUE065844T2/hu unknown
- 2015-02-20 PT PT157089913T patent/PT3107575T/pt unknown
- 2015-02-20 EP EP21191120.1A patent/EP3973987B1/en active Active
- 2015-02-20 KR KR1020237041236A patent/KR20230167770A/ko not_active Ceased
- 2015-02-20 ES ES21191120T patent/ES2977332T3/es active Active
- 2015-02-20 EP EP15708991.3A patent/EP3107575B1/en active Active
- 2015-02-20 KR KR1020257035292A patent/KR20250154567A/ko active Pending
- 2015-02-20 MX MX2016010854A patent/MX384192B/es unknown
- 2015-02-20 RU RU2016136364A patent/RU2713406C2/ru active
- 2015-02-20 KR KR1020167025669A patent/KR102368450B1/ko active Active
- 2015-02-20 AU AU2015218808A patent/AU2015218808B2/en active Active
- 2015-02-20 PT PT211911201T patent/PT3973987T/pt unknown
- 2015-02-20 WO PCT/US2015/016852 patent/WO2015127229A1/en not_active Ceased
- 2015-02-20 EP EP24150594.0A patent/EP4382164A3/en active Pending
- 2015-02-20 ES ES15708991T patent/ES2897631T3/es active Active
- 2015-02-20 US US14/627,728 patent/US10137193B2/en active Active
- 2015-02-20 CA CA2940295A patent/CA2940295A1/en active Pending
- 2015-02-20 PL PL21191120.1T patent/PL3973987T3/pl unknown
- 2015-02-20 CN CN201580020533.9A patent/CN106232140A/zh active Pending
- 2015-02-20 PL PL15708991T patent/PL3107575T3/pl unknown
- 2015-02-20 KR KR1020227006120A patent/KR20220029765A/ko not_active Ceased
- 2015-02-20 JP JP2016552595A patent/JP6673840B2/ja active Active
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2016
- 2016-08-19 MX MX2021008113A patent/MX2021008113A/es unknown
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2018
- 2018-10-11 US US16/157,708 patent/US20190125865A1/en not_active Abandoned
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2020
- 2020-11-26 AU AU2020277191A patent/AU2020277191B2/en active Active
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2021
- 2021-03-29 US US17/215,604 patent/US20210322546A1/en active Pending
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2023
- 2023-08-30 JP JP2023139455A patent/JP7636487B2/ja active Active
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2024
- 2024-06-06 AU AU2024203849A patent/AU2024203849A1/en active Pending
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2025
- 2025-02-12 JP JP2025020415A patent/JP2025072593A/ja active Pending
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