|
US5137877B1
(en)
|
1990-05-14 |
1996-01-30 |
Bristol Myers Squibb Co |
Bifunctional linking compounds conjugates and methods for their production
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6569834B1
(en)
|
1992-12-03 |
2003-05-27 |
George R. Pettit |
Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides
|
|
DE69329425T2
(de)
|
1992-12-16 |
2001-01-18 |
Basf Ag |
Dolastatin analog
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
KR100332254B1
(ko)
|
1993-10-01 |
2002-09-27 |
데이꼬꾸 조끼 세이야꾸 가부시키가이샤 |
신규인펩티드유도체
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
GB9508195D0
(en)
|
1995-04-20 |
1995-06-07 |
Univ British Columbia |
Novel biologically active compounds and compositions,their use and derivation
|
|
CA2225325A1
(en)
|
1997-12-19 |
1999-06-19 |
The University Of British Columbia |
Hemiasterlin analogs
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US7256257B2
(en)
|
2001-04-30 |
2007-08-14 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
EP1531846A4
(en)
|
2002-02-27 |
2006-04-19 |
Us Gov Health & Human Serv |
Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
|
|
US7064211B2
(en)
|
2002-03-22 |
2006-06-20 |
Eisai Co., Ltd. |
Hemiasterlin derivatives and uses thereof
|
|
AU2003228354B8
(en)
|
2002-03-22 |
2010-03-04 |
Eisai R&D Management Co., Ltd. |
Hemiasterlin derivatives and uses thereof in the treatment of cancer
|
|
AU2003263094A1
(en)
|
2002-04-23 |
2003-11-10 |
National Institutes Of Health |
Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin
|
|
ITMI20021391A1
(it)
|
2002-06-25 |
2003-12-29 |
Nicox Sa |
Nitroderivati di inibitori della cicloossigenasi-2
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
US20040121965A1
(en)
|
2002-09-20 |
2004-06-24 |
Wyeth Holdings Corporation |
Method of treating resistant tumors
|
|
RU2005111753A
(ru)
|
2002-09-20 |
2005-11-20 |
Уайт Холдингз Корпорейшн (Us) |
Способ получения промежуточных соединений, используемых в синтезе ингибиторов тубулина
|
|
US20070026478A1
(en)
|
2002-11-21 |
2007-02-01 |
Wyeth |
Hemiasterlin affinity probes and their uses
|
|
US7390910B2
(en)
|
2003-08-08 |
2008-06-24 |
Wyeth |
Compounds for treating tumors
|
|
US7576206B2
(en)
|
2003-08-14 |
2009-08-18 |
Cephalon, Inc. |
Proteasome inhibitors and methods of using the same
|
|
WO2005026169A1
(en)
|
2003-09-15 |
2005-03-24 |
The University Of British Columbia |
Ceratamines a and b, and analogues, syntheses and pharmaceutical compositions thereof
|
|
ATE459364T1
(de)
|
2003-10-22 |
2010-03-15 |
Univ Johns Hopkins |
Verbesserte bakteriolyse-kombinationstherapie für die behandlung von tumoren
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US7078562B2
(en)
|
2004-01-19 |
2006-07-18 |
Mitsubishi Gas Chemical Company, Inc. |
Adamantane derivatives and resin compositions using the same as raw material
|
|
AR054181A1
(es)
*
|
2004-08-26 |
2007-06-06 |
Nicholas Piramal India Ltd |
Prodrogas que contienen enlaces bio-divisibles. composiiciones farmaceuticas
|
|
US20090130136A1
(en)
*
|
2004-09-30 |
2009-05-21 |
Miller Louis H |
Chondroitin Sulphate a Binding Domains
|
|
WO2006132670A2
(en)
|
2004-11-12 |
2006-12-14 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
EP1817341A2
(en)
|
2004-11-29 |
2007-08-15 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
JP5171621B2
(ja)
|
2005-07-07 |
2013-03-27 |
シアトル ジェネティックス, インコーポレイテッド |
フェニルアラニン側鎖修飾をc末端に有するモノメチルバリン化合物
|
|
CN101868452B
(zh)
|
2007-10-10 |
2014-08-06 |
诺华股份有限公司 |
螺环吡咯烷类与其对抗hcv和hiv感染的应用
|
|
US20090155289A1
(en)
|
2007-11-01 |
2009-06-18 |
Steve Roberts |
Furin-cleavable peptide linkers for drug-ligand conjugates
|
|
CN106986926A
(zh)
|
2008-01-30 |
2017-07-28 |
皮里斯股份公司 |
具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
HUE045093T2
(hu)
*
|
2008-11-21 |
2019-12-30 |
Kobenhavns Univ University Of Copenhagen |
Immunválasz kiváltása
|
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
BR112012006686B8
(pt)
|
2009-09-25 |
2021-05-25 |
Astellas Pharma Inc |
compostos de amida substituída, composições farmacêuticas contendo os ditos compostos, e uso dos mesmos para prevenir e/ou tratar doenças causadas pelo lpa
|
|
CN103200950B
(zh)
|
2010-06-10 |
2016-03-16 |
西雅图基因公司 |
新颖的耳他汀衍生物及其用途
|
|
FR2963241B1
(fr)
*
|
2010-07-30 |
2014-10-24 |
Inst Rech Developpement Ird |
Vaccin contre le paludisme gestationnel
|
|
PH12012500542A1
(en)
|
2010-09-24 |
2012-11-12 |
Astellas Pharma Inc |
Substituted amide compound
|
|
WO2012113847A1
(en)
|
2011-02-25 |
2012-08-30 |
Lonza Ltd |
Branched linker for protein drug conjugates
|
|
EP2686337B1
(en)
|
2011-03-16 |
2016-11-02 |
Council of Scientific & Industrial Research |
Oligopeptides and process for preparation thereof
|
|
WO2012135440A1
(en)
|
2011-03-30 |
2012-10-04 |
Arizona Board Of Regents, For And On Behalf Of, Arizona State University |
Auristatin tyramine phosphate salts and auristatin aminoquinoline derivatives and prodrugs thereof
|
|
KR102023496B1
(ko)
|
2011-04-21 |
2019-09-20 |
시애틀 지네틱스, 인크. |
신규 결합제-약물 콘주게이트 (adc) 및 그의 용도
|
|
US20130190248A1
(en)
|
2011-07-26 |
2013-07-25 |
Agensys, Inc. |
Substituted peptide analogs
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
MY168297A
(en)
|
2011-11-17 |
2018-10-23 |
Pfizer |
Cytotoxic Peptides and Antibody Drug Conjugates Thereof
|
|
AU2013217986B2
(en)
*
|
2012-02-09 |
2017-04-27 |
Var2 Pharmaceuticals Aps |
Targeting of chondroitin sulfate glycans
|
|
US9981046B2
(en)
|
2012-05-15 |
2018-05-29 |
Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. |
Drug-conjugates, conjugation methods, and uses thereof
|
|
US10800856B2
(en)
|
2012-06-07 |
2020-10-13 |
Ambrx, Inc. |
Prostate-specific membrane antigen antibody drug conjugates
|
|
SG11201408494UA
(en)
|
2012-06-19 |
2015-02-27 |
Ambrx Inc |
Anti-cd70 antibody drug conjugates
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はahi1の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
RU2015129800A
(ru)
|
2012-12-21 |
2017-01-30 |
Биоэллаенс К. В. |
Гидрофильные саморазрушающиеся линкеры и их конъюгаты
|
|
RS56169B1
(sr)
|
2013-02-14 |
2017-11-30 |
Bristol Myers Squibb Co |
Jedinjenja tubulisina, metode pripreme i primena
|
|
PL2968440T3
(pl)
|
2013-03-15 |
2019-12-31 |
Zymeworks Inc. |
Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania
|
|
WO2015057876A1
(en)
|
2013-10-15 |
2015-04-23 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
BR112016012538A2
(pt)
|
2013-12-17 |
2017-09-26 |
Novartis Ag |
peptídeos citotóxicos e conjugados dos mesmos
|
|
RU2729194C2
(ru)
|
2013-12-27 |
2020-08-05 |
Займворкс Инк. |
Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов
|
|
AU2014373640B2
(en)
|
2013-12-27 |
2018-08-30 |
Var2 Pharmaceuticals Aps |
VAR2CSA-drug conjugates
|
|
AU2015318556C1
(en)
|
2014-09-17 |
2021-01-07 |
Zymeworks Bc Inc. |
Cytotoxic and anti-mitotic compounds, and methods of using the same
|
|
US10077287B2
(en)
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
US10975112B2
(en)
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|