JP2017502088A5 - - Google Patents

Download PDF

Info

Publication number
JP2017502088A5
JP2017502088A5 JP2016563278A JP2016563278A JP2017502088A5 JP 2017502088 A5 JP2017502088 A5 JP 2017502088A5 JP 2016563278 A JP2016563278 A JP 2016563278A JP 2016563278 A JP2016563278 A JP 2016563278A JP 2017502088 A5 JP2017502088 A5 JP 2017502088A5
Authority
JP
Japan
Prior art keywords
disease
chronic
syndrome
lymphoma
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016563278A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017502088A (ja
JP6479850B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2015/050217 external-priority patent/WO2015104688A1/en
Publication of JP2017502088A publication Critical patent/JP2017502088A/ja
Publication of JP2017502088A5 publication Critical patent/JP2017502088A5/ja
Application granted granted Critical
Publication of JP6479850B2 publication Critical patent/JP6479850B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016563278A 2014-01-13 2015-01-12 Irak4阻害剤としての二環式ヘテロシクリル誘導体 Active JP6479850B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN158/CHE/2014 2014-01-13
IN158CH2014 2014-01-13
IN3000CH2014 2014-06-20
IN3000/CHE/2014 2014-06-20
PCT/IB2015/050217 WO2015104688A1 (en) 2014-01-13 2015-01-12 Bicyclic heterocyclyl derivatives as irak4 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019019229A Division JP6750053B2 (ja) 2014-01-13 2019-02-06 Irak4阻害剤としての二環式ヘテロシクリル誘導体

Publications (3)

Publication Number Publication Date
JP2017502088A JP2017502088A (ja) 2017-01-19
JP2017502088A5 true JP2017502088A5 (cg-RX-API-DMAC7.html) 2018-02-15
JP6479850B2 JP6479850B2 (ja) 2019-03-06

Family

ID=53523587

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2016563278A Active JP6479850B2 (ja) 2014-01-13 2015-01-12 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2019019229A Active JP6750053B2 (ja) 2014-01-13 2019-02-06 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2020109507A Active JP6977111B2 (ja) 2014-01-13 2020-06-25 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2021183016A Active JP7262553B2 (ja) 2014-01-13 2021-11-10 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2023063800A Active JP7601937B2 (ja) 2014-01-13 2023-04-11 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2024211949A Active JP7775430B2 (ja) 2014-01-13 2024-12-05 Irak4阻害剤としての二環式ヘテロシクリル誘導体

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2019019229A Active JP6750053B2 (ja) 2014-01-13 2019-02-06 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2020109507A Active JP6977111B2 (ja) 2014-01-13 2020-06-25 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2021183016A Active JP7262553B2 (ja) 2014-01-13 2021-11-10 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2023063800A Active JP7601937B2 (ja) 2014-01-13 2023-04-11 Irak4阻害剤としての二環式ヘテロシクリル誘導体
JP2024211949A Active JP7775430B2 (ja) 2014-01-13 2024-12-05 Irak4阻害剤としての二環式ヘテロシクリル誘導体

Country Status (31)

Country Link
US (8) US9732095B2 (cg-RX-API-DMAC7.html)
EP (4) EP3805233B1 (cg-RX-API-DMAC7.html)
JP (6) JP6479850B2 (cg-RX-API-DMAC7.html)
KR (4) KR102392684B1 (cg-RX-API-DMAC7.html)
CN (2) CN111362966B (cg-RX-API-DMAC7.html)
AU (6) AU2015205374B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016016158B1 (cg-RX-API-DMAC7.html)
CA (1) CA2935887A1 (cg-RX-API-DMAC7.html)
CU (1) CU24389B1 (cg-RX-API-DMAC7.html)
CY (2) CY1121433T1 (cg-RX-API-DMAC7.html)
DK (3) DK3094329T3 (cg-RX-API-DMAC7.html)
EA (2) EA031913B1 (cg-RX-API-DMAC7.html)
ES (3) ES2846678T3 (cg-RX-API-DMAC7.html)
FI (1) FI3805233T3 (cg-RX-API-DMAC7.html)
HR (3) HRP20181795T1 (cg-RX-API-DMAC7.html)
HU (3) HUE041926T2 (cg-RX-API-DMAC7.html)
IL (7) IL311677B2 (cg-RX-API-DMAC7.html)
LT (3) LT3805233T (cg-RX-API-DMAC7.html)
MX (1) MX359909B (cg-RX-API-DMAC7.html)
MY (1) MY197116A (cg-RX-API-DMAC7.html)
NZ (2) NZ760657A (cg-RX-API-DMAC7.html)
PH (2) PH12016501344A1 (cg-RX-API-DMAC7.html)
PL (3) PL3466955T3 (cg-RX-API-DMAC7.html)
PT (3) PT3805233T (cg-RX-API-DMAC7.html)
RS (3) RS58024B1 (cg-RX-API-DMAC7.html)
SG (2) SG10201811204RA (cg-RX-API-DMAC7.html)
SI (3) SI3805233T1 (cg-RX-API-DMAC7.html)
SM (3) SMT202100063T1 (cg-RX-API-DMAC7.html)
TR (1) TR201815683T4 (cg-RX-API-DMAC7.html)
WO (1) WO2015104688A1 (cg-RX-API-DMAC7.html)
ZA (4) ZA202007276B (cg-RX-API-DMAC7.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
HK1231480A1 (zh) 2014-01-10 2017-12-22 Aurigene Discovery Technologies Limited 作为irak4抑制剂的吲唑化合物
PT3805233T (pt) * 2014-01-13 2024-04-15 Aurigene Oncology Ltd Enantiómeros (r) e (s) de n-(5-(3-hidroxipirrolidin-1-il)-2 morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)oxazole-carboxamida como inibidores de irak4 para o tratamento de cancro
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
MX2018000396A (es) * 2015-07-15 2018-05-02 Aurigene Discovery Tech Ltd Compuestos aza sustituidos como inhibidores de cinasa 4 asociada al receptor de interleucina 1 (irak-4).
EP3719016A1 (en) * 2015-08-04 2020-10-07 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
CA3056893A1 (en) * 2017-03-31 2018-10-04 Aurigene Discovery Technologies Limited Compounds and compositions for treating hematological disorders
JP7366031B2 (ja) 2017-09-22 2023-10-20 カイメラ セラピューティクス, インコーポレイテッド タンパク質分解剤およびそれらの使用
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
RS65572B1 (sr) * 2017-10-31 2024-06-28 Curis Inc Inhibitor irak4 u kombinaciji sa inhibitorom bcl-2 za upotrebu u lečenju kancera
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3305786A3 (de) 2018-01-22 2018-07-25 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
CA3090275A1 (en) 2018-02-14 2019-08-22 Dana-Farber Cancer Institute, Inc. Irak degraders and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
EP3817822A4 (en) 2018-07-06 2022-07-27 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
KR20250167680A (ko) 2018-11-30 2025-12-01 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
US20220089592A1 (en) * 2019-01-18 2022-03-24 Biogen Ma Inc. Imidazo[1,2-a]pyridinyl derivatives as irak4 inhibitors
US12459940B2 (en) 2019-07-10 2025-11-04 Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. Oxazole compound as multi-targeted inhibitor of IRAK4 and BTK
ES2960521T3 (es) 2019-07-18 2024-03-05 Bristol Myers Squibb Co Compuestos de pirazolo[3,4-D]pirrolo[1,2-B]piridazinilo útiles como inhibidores de IRAK4
EP3999508B1 (en) 2019-07-18 2023-08-30 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
WO2021016289A1 (en) * 2019-07-23 2021-01-28 Bristol-Myers Squibb Company Thienopyridinyl and thiazolopyridinyl compounds useful as irak4 inhibitors
WO2021026181A1 (en) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company Bicyclic heterocyclic compounds useful as irak4 inhibitors
EP3772513A1 (en) * 2019-08-09 2021-02-10 C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening Shp2 inhibitors
WO2021066559A1 (en) 2019-10-02 2021-04-08 Kainos Medicine, Inc. N-(1h-imidazol-2-yl)benzamide compound and pharmaceutical composition comprising the same as active ingredient
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021127190A1 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US12391702B2 (en) 2020-02-03 2025-08-19 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors
CA3177852A1 (en) 2020-04-04 2021-10-07 Pfizer Inc. Methods of treating coronavirus disease 2019
US20230151025A1 (en) 2020-04-07 2023-05-18 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
US20230322754A1 (en) * 2020-04-28 2023-10-12 Kymera Therapeutics, Inc. Irak inhibitors and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
MX2023001296A (es) * 2020-08-03 2023-02-22 Curis Inc Composiciones y metodos para tratar enfermedades y trastornos.
CN116507627A (zh) 2020-11-02 2023-07-28 勃林格殷格翰国际有限公司 作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物
MX2023005591A (es) * 2020-11-18 2023-05-29 Curis Inc Metodos de tratamiento de enfermedades y trastornos.
EP4269409A4 (en) * 2020-12-25 2024-12-11 Medshine Discovery Inc. AMIDE-OXAZOLE COMPOUND
JP2024503300A (ja) 2020-12-30 2024-01-25 カイメラ セラピューティクス, インコーポレイテッド Irak分解剤およびそれらの使用
CN116867494A (zh) 2021-02-15 2023-10-10 凯麦拉医疗公司 Irak4降解剂和其用途
TW202245788A (zh) 2021-02-15 2022-12-01 美商凱麥拉醫療公司 Irak4降解劑及其用途
US12178821B2 (en) 2021-04-08 2024-12-31 Curis, Inc. Combination therapies for the treatment of cancer
WO2022236058A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
AU2022378630A1 (en) 2021-10-29 2024-05-09 Kymera Therapeutics, Inc. Irak4 degraders and synthesis thereof
JP7746587B2 (ja) 2021-12-23 2025-09-30 ハンチョウ ポリメド バイオファーマシューティカルズ インコーポレイテッド 5員縮合6員化合物、製造方法、医薬組成物、及び応用
TW202330546A (zh) * 2021-12-31 2023-08-01 香港商愛科諾生物醫藥(香港)有限公司 具有irak4抑制活性的化合物,包含其的藥物組合物,及其應用
JP2025504059A (ja) 2022-01-31 2025-02-06 カイメラ セラピューティクス, インコーポレイテッド Irakデグレーダー及びその使用
WO2023183377A1 (en) 2022-03-23 2023-09-28 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors
KR20250083546A (ko) * 2022-10-13 2025-06-10 카이메라 쎄라퓨틱스 인코포레이티드 Irak4 분해자의 염 형태
AR130870A1 (es) * 2022-10-25 2025-01-29 Kymera Therapeutics Inc Degradadores de irak y usos de los mismos
WO2025130871A1 (zh) * 2023-12-20 2025-06-26 爱科诺生物医药(香港)有限公司 具有irak4和flt3蛋白双重降解活性的化合物,包含其的药物组合物,及其应用
CN119119080A (zh) * 2024-09-06 2024-12-13 上海信诺维生物医药有限公司 一种irak4的蛋白降解剂

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494911A (en) 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US7189716B2 (en) * 2003-01-03 2007-03-13 Bristol-Myers Squibb Company Tyrosine kinase inhibitors
US7651469B2 (en) 2003-04-25 2010-01-26 Cook Incorporated Low friction coated marked wire guide for over the wire insertion of a catheter
PL1618092T3 (pl) 2003-05-01 2011-02-28 Bristol Myers Squibb Co Związki amidopirazolowe z podstawnikami arylowymi jako inhibitory kinazy
JP5279987B2 (ja) 2003-05-20 2013-09-04 味の素株式会社 アミド誘導体
EP1628661A2 (en) 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
EP1493795A1 (de) 2003-07-04 2005-01-05 Collano AG Klebstoffzusammensetzung
BRPI0415167A (pt) 2003-10-07 2006-11-28 Renovis Inc composto de amina como ligandos de canal de ìon e usos dos mesmos
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
MXPA06012104A (es) 2004-04-22 2007-01-25 Bayer Cropscience Lp Metodo y composicion para controlar malas hierbas.
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
TW200628159A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp IL-12 modulatory compounds
MX2007007227A (es) 2004-12-17 2007-08-21 Lilly Co Eli Derivados de tiazolopiridinona como antagonistas del receptor mch.
US7838543B2 (en) 2004-12-17 2010-11-23 Eli Lilly And Company MCH receptor antagonists
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
EP1987028A2 (en) 2006-02-10 2008-11-05 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
MX2008012482A (es) 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
US20080293785A1 (en) 2006-04-11 2008-11-27 Connolly Peter J Substituted benzothiazole kinase inhibitors
AU2007292924A1 (en) * 2006-09-07 2008-03-13 Biogen Idec Ma Inc. IRAK modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
MX2009002377A (es) * 2006-09-07 2009-03-13 Biogen Idec Inc Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1.
WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Lxr 및 fxr 조절자
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CN101772500A (zh) 2007-06-14 2010-07-07 先灵公司 作为蛋白质激酶抑制剂的咪唑并吡嗪
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
ES2457418T3 (es) 2007-07-16 2014-04-25 Abbvie Inc. Indazoles, bencisoxazoles y bencisotiazoles como inhibidores de proteína cinasas
EP2183224B1 (en) 2007-08-08 2013-11-06 Merck Serono S.A. 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis
CA2714414A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. Certain substituted amides, method of making, and method of use thereof
EP2311842A3 (en) 2008-06-24 2011-07-13 Takeda Pharmaceutical Company Limited PI3K/M TOR inhibitors
AU2009316786A1 (en) 2008-11-19 2010-05-27 Merck Sharp & Dohme Corp. Inhibitors of diacylglycerol acyltransferase
WO2010071819A1 (en) * 2008-12-19 2010-06-24 Schering Corporation Bicyclic heterocyclic derivatives and methods of use thereof
CN102264701A (zh) 2008-12-23 2011-11-30 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮脲
EP2440058A4 (en) 2009-06-12 2012-11-21 Dana Farber Cancer Inst Inc MELTED HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
KR20120059558A (ko) 2009-08-19 2012-06-08 암비트 바이오사이언시즈 코포레이션 바이아릴 화합물 및 이의 사용 방법
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
PT2488486T (pt) 2009-10-13 2019-11-05 Ligand Pharm Inc Compostos de moléculas pequenas de mimética de fator de crescimento hematopoiético e utilizações dos mesmos
CN102939283B (zh) 2010-04-22 2015-06-03 詹森药业有限公司 可用作己酮糖激酶抑制剂的吲唑化合物
US20130053382A1 (en) 2010-04-30 2013-02-28 Sunil Paliwal Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1)
HUE033644T2 (en) 2010-06-24 2017-12-28 Chemocentryx Inc C5AR antagonists
MX358682B (es) 2010-07-13 2018-08-31 Hoffmann La Roche Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
PT2730564T (pt) 2010-11-19 2018-07-24 Ligand Pharm Inc Aminas heterocíclicas e suas utilizações
BR122021014375B1 (pt) 2010-12-20 2021-11-30 Merck Serono S.A. Processo para preparação de derivados de indazolil triazol
US9320786B2 (en) 2011-04-12 2016-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CN104066730B (zh) 2011-10-14 2017-03-08 埃姆比特生物科学公司 杂环化合物及其作为iii型受体酪氨酸激酶调节剂的用途
CN104394869A (zh) 2011-10-20 2015-03-04 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
US9221809B2 (en) * 2011-10-31 2015-12-29 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
JP6372666B2 (ja) 2012-11-03 2018-08-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
CA2907960C (en) 2013-05-22 2021-10-19 Children's Hospital Medical Center Combination therapy for mds
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
HK1231480A1 (zh) 2014-01-10 2017-12-22 Aurigene Discovery Technologies Limited 作为irak4抑制剂的吲唑化合物
PT3805233T (pt) * 2014-01-13 2024-04-15 Aurigene Oncology Ltd Enantiómeros (r) e (s) de n-(5-(3-hidroxipirrolidin-1-il)-2 morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)oxazole-carboxamida como inibidores de irak4 para o tratamento de cancro
KR20160118345A (ko) 2014-02-06 2016-10-11 애브비 인코포레이티드 6-헤테로아릴옥시- 및 6-아릴옥시-퀴놀린-2-카복사미드 및 이의 용도
MX2016017147A (es) 2014-06-20 2017-06-07 Aurigene Discovery Tech Ltd Compuestos de indazole substituidos como inhibidores de irak4.
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
UY36660A (es) 2015-04-30 2016-11-30 Bayer Pharma AG Combinaciones de inhibidores de irak4
HK1249509A1 (zh) 2015-07-15 2018-11-02 Aurigene Discovery Technologies Limited 作为irak-4抑制剂的吲唑及氮杂吲唑化合物
MX2018000396A (es) 2015-07-15 2018-05-02 Aurigene Discovery Tech Ltd Compuestos aza sustituidos como inhibidores de cinasa 4 asociada al receptor de interleucina 1 (irak-4).
EP3719016A1 (en) 2015-08-04 2020-10-07 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
US20170035881A1 (en) 2015-10-19 2017-02-09 Acerta Pharma B.V. Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor
WO2018081738A1 (en) 2016-10-28 2018-05-03 Children's Hospital Medical Center Treatment of diseases associated with activated irak
CA3056893A1 (en) 2017-03-31 2018-10-04 Aurigene Discovery Technologies Limited Compounds and compositions for treating hematological disorders
RS65572B1 (sr) 2017-10-31 2024-06-28 Curis Inc Inhibitor irak4 u kombinaciji sa inhibitorom bcl-2 za upotrebu u lečenju kancera
KR20250167680A (ko) 2018-11-30 2025-12-01 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
WO2020264499A1 (en) 2019-06-28 2020-12-30 Kymera Therapeutics, Inc. Irak degraders and uses thereof
MX2023001296A (es) 2020-08-03 2023-02-22 Curis Inc Composiciones y metodos para tratar enfermedades y trastornos.
MX2023005591A (es) 2020-11-18 2023-05-29 Curis Inc Metodos de tratamiento de enfermedades y trastornos.
US12178821B2 (en) 2021-04-08 2024-12-31 Curis, Inc. Combination therapies for the treatment of cancer
AU2023269214A1 (en) 2022-05-11 2024-10-10 Curis, Inc. Treating diseases and disorders with irak4-modifying compounds
CN121218988A (zh) 2023-06-01 2025-12-26 柯里斯公司 治疗未接受bcl2抑制剂的受试者的癌症的方法
AU2024281302A1 (en) 2023-06-01 2025-12-11 Curis, Inc. Methods of treating cancer in subjects with prior immune checkpoint inhibitor exposure

Similar Documents

Publication Publication Date Title
JP2017502088A5 (cg-RX-API-DMAC7.html)
JP2017505337A5 (cg-RX-API-DMAC7.html)
ES2975436T3 (es) Enantiómeros (R) y (S) de n-(5-(3-hidroxipirrolidin-1-il)-2-morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4- il)oxazol-carboxamida como inhibidores de IRAK4 para el tratamiento del cáncer
JP2017518348A5 (cg-RX-API-DMAC7.html)
CN105348266B (zh) 取代的3‑氯‑n‑[3‑(嘧啶‑2‑基氨基)苯基]丙酰胺或其盐
JP2015528801A5 (cg-RX-API-DMAC7.html)
JP2016531870A5 (cg-RX-API-DMAC7.html)
IL303987A (en) IRAK joints and their uses
ES2794779T3 (es) Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de JAK
ES2600161T3 (es) Compuestos para uso en el tratamiento de enfermedades mediadas por linfocitos T
JP2015503618A5 (cg-RX-API-DMAC7.html)
BR112020020196A2 (pt) compostos que visam brm e métodos de uso associados
RU2016140870A (ru) Ингибиторы irak и их применения
RU2016110852A (ru) Ингибиторы irak и их применения
AU2014324595A1 (en) Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
HK1231480A1 (zh) 作为irak4抑制剂的吲唑化合物
CA2691507A1 (en) 5-membered heterocyclic amides and related compounds
TW200951139A (en) Chemical compounds 293
US11753418B2 (en) Compounds for the modulation of Myc activity
JPWO2022147465A5 (cg-RX-API-DMAC7.html)
CA2992981A1 (en) Aminonaphthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases
CN105189497B (zh) 作为janus激酶抑制剂的n-(2-氰基杂环基)吡唑并吡啶酮
WO2021018118A1 (en) Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 1 proteins
CA3003559A1 (en) Fused thiazolopyrimidine derivatives as mnks inhibitors
AU2020346936A1 (en) Novel tricyclic aromatic heterocyclic compound, preparation method therefor, pharmaceutical composition and application thereof