JP2017501400A5 - - Google Patents
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- JP2017501400A5 JP2017501400A5 JP2016536629A JP2016536629A JP2017501400A5 JP 2017501400 A5 JP2017501400 A5 JP 2017501400A5 JP 2016536629 A JP2016536629 A JP 2016536629A JP 2016536629 A JP2016536629 A JP 2016536629A JP 2017501400 A5 JP2017501400 A5 JP 2017501400A5
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- compound
- cancer
- biomarker
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- 238000000034 method Methods 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 14
- 239000000090 biomarker Substances 0.000 claims 8
- 108010050904 Interferons Proteins 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 7
- 229940079322 interferon Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 101000941994 Homo sapiens Protein cereblon Proteins 0.000 claims 3
- 102100032783 Protein cereblon Human genes 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 2
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims 2
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 2
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 claims 2
- 102100034357 Casein kinase I isoform alpha Human genes 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 2
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 claims 2
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 claims 2
- 101000994700 Homo sapiens Casein kinase I isoform alpha Proteins 0.000 claims 2
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 2
- 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 claims 2
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 claims 2
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 2
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 2
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 2
- 108010044240 IFIH1 Interferon-Induced Helicase Proteins 0.000 claims 2
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 2
- 102100030126 Interferon regulatory factor 4 Human genes 0.000 claims 2
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 claims 2
- 102100027353 Interferon-induced helicase C domain-containing protein 1 Human genes 0.000 claims 2
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 2
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 2
- 229960004942 lenalidomide Drugs 0.000 claims 2
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims 2
- 229960000688 pomalidomide Drugs 0.000 claims 2
- 239000013074 reference sample Substances 0.000 claims 2
- 229960003433 thalidomide Drugs 0.000 claims 2
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 1
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 claims 1
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims 1
- GXAFMKJFWWBYNW-OWHBQTKESA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC2CC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GXAFMKJFWWBYNW-OWHBQTKESA-N 0.000 claims 1
- RSNPAKAFCAAMBH-UHFFFAOYSA-N 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione Chemical compound CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O RSNPAKAFCAAMBH-UHFFFAOYSA-N 0.000 claims 1
- IXZOHGPZAQLIBH-UHFFFAOYSA-N 3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(C2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 IXZOHGPZAQLIBH-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 102100021069 E3 ubiquitin-protein ligase ZFP91 Human genes 0.000 claims 1
- 101710120623 FERM, ARHGEF and pleckstrin domain-containing protein 2 Proteins 0.000 claims 1
- 102100039928 Gamma-interferon-inducible protein 16 Human genes 0.000 claims 1
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 claims 1
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 1
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 claims 1
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims 1
- 101000818429 Homo sapiens E3 ubiquitin-protein ligase ZFP91 Proteins 0.000 claims 1
- 101000960209 Homo sapiens Gamma-interferon-inducible protein 16 Proteins 0.000 claims 1
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 claims 1
- 101001034835 Homo sapiens Interferon alpha-16 Proteins 0.000 claims 1
- 101000959704 Homo sapiens Interferon alpha-5 Proteins 0.000 claims 1
- 101001037247 Homo sapiens Interferon alpha-inducible protein 27-like protein 2 Proteins 0.000 claims 1
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 claims 1
- 101001001420 Homo sapiens Interferon gamma receptor 1 Proteins 0.000 claims 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 claims 1
- 101001011382 Homo sapiens Interferon regulatory factor 3 Proteins 0.000 claims 1
- 101001032345 Homo sapiens Interferon regulatory factor 8 Proteins 0.000 claims 1
- 101001032341 Homo sapiens Interferon regulatory factor 9 Proteins 0.000 claims 1
- 101000998500 Homo sapiens Interferon-induced 35 kDa protein Proteins 0.000 claims 1
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 1
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 1
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 1
- 101001082058 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 claims 1
- 101001082063 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 5 Proteins 0.000 claims 1
- 101001034842 Homo sapiens Interferon-induced transmembrane protein 2 Proteins 0.000 claims 1
- 101001034846 Homo sapiens Interferon-induced transmembrane protein 3 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101000952078 Homo sapiens Probable ATP-dependent RNA helicase DDX60 Proteins 0.000 claims 1
- 101000952073 Homo sapiens Probable ATP-dependent RNA helicase DDX60-like Proteins 0.000 claims 1
- 101000665442 Homo sapiens Serine/threonine-protein kinase TBK1 Proteins 0.000 claims 1
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 claims 1
- 101000763579 Homo sapiens Toll-like receptor 1 Proteins 0.000 claims 1
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 1
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 claims 1
- 102100039728 Interferon alpha-16 Human genes 0.000 claims 1
- 102100039948 Interferon alpha-5 Human genes 0.000 claims 1
- 102100040063 Interferon alpha-inducible protein 27-like protein 2 Human genes 0.000 claims 1
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 102100035678 Interferon gamma receptor 1 Human genes 0.000 claims 1
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims 1
- 102100029843 Interferon regulatory factor 3 Human genes 0.000 claims 1
- 102100038069 Interferon regulatory factor 8 Human genes 0.000 claims 1
- 102100038251 Interferon regulatory factor 9 Human genes 0.000 claims 1
- 102100033273 Interferon-induced 35 kDa protein Human genes 0.000 claims 1
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 1
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 1
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 1
- 102100027303 Interferon-induced protein with tetratricopeptide repeats 2 Human genes 0.000 claims 1
- 102100027356 Interferon-induced protein with tetratricopeptide repeats 5 Human genes 0.000 claims 1
- 102100040020 Interferon-induced transmembrane protein 2 Human genes 0.000 claims 1
- 102100040035 Interferon-induced transmembrane protein 3 Human genes 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102100033008 Poly(U)-binding-splicing factor PUF60 Human genes 0.000 claims 1
- 102100037439 Probable ATP-dependent RNA helicase DDX60 Human genes 0.000 claims 1
- 102100037440 Probable ATP-dependent RNA helicase DDX60-like Human genes 0.000 claims 1
- 102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 claims 1
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 claims 1
- 101000697584 Streptomyces lavendulae Streptothricin acetyltransferase Proteins 0.000 claims 1
- 102100027010 Toll-like receptor 1 Human genes 0.000 claims 1
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims 1
- 102100039488 XIAP-associated factor 1 Human genes 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- DAZSWUUAFHBCGE-KRWDZBQOSA-N n-[(2s)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide Chemical compound N([C@@H](C(C)C)C(=O)N1CCCC1)C(=O)CCC1=CC=CC=C1 DAZSWUUAFHBCGE-KRWDZBQOSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361913003P | 2013-12-06 | 2013-12-06 | |
| US61/913,003 | 2013-12-06 | ||
| US201461947963P | 2014-03-04 | 2014-03-04 | |
| US61/947,963 | 2014-03-04 | ||
| US201461990621P | 2014-05-08 | 2014-05-08 | |
| US61/990,621 | 2014-05-08 | ||
| US201462061050P | 2014-10-07 | 2014-10-07 | |
| US62/061,050 | 2014-10-07 | ||
| US201462064413P | 2014-10-15 | 2014-10-15 | |
| US62/064,413 | 2014-10-15 | ||
| US201462077835P | 2014-11-10 | 2014-11-10 | |
| US62/077,835 | 2014-11-10 | ||
| US201462087111P | 2014-12-03 | 2014-12-03 | |
| US62/087,111 | 2014-12-03 | ||
| PCT/US2014/068795 WO2015085172A2 (en) | 2013-12-06 | 2014-12-05 | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019120643A Division JP7142612B2 (ja) | 2013-12-06 | 2019-06-28 | びまん性大細胞型ｂ細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501400A JP2017501400A (ja) | 2017-01-12 |
| JP2017501400A5 true JP2017501400A5 (OSRAM) | 2018-01-18 |
| JP6573611B2 JP6573611B2 (ja) | 2019-09-11 |
Family
ID=53274285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536629A Active JP6573611B2 (ja) | 2013-12-06 | 2014-12-05 | びまん性大細胞型ｂ細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法 |
| JP2019120643A Active JP7142612B2 (ja) | 2013-12-06 | 2019-06-28 | びまん性大細胞型ｂ細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019120643A Active JP7142612B2 (ja) | 2013-12-06 | 2019-06-28 | びまん性大細胞型ｂ細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20160313300A1 (OSRAM) |
| EP (1) | EP3077548B1 (OSRAM) |
| JP (2) | JP6573611B2 (OSRAM) |
| KR (1) | KR102299801B1 (OSRAM) |
| AU (1) | AU2014360328B2 (OSRAM) |
| BR (1) | BR112016012795A2 (OSRAM) |
| CA (2) | CA3206268A1 (OSRAM) |
| EA (1) | EA201691144A1 (OSRAM) |
| ES (1) | ES2903155T3 (OSRAM) |
| IL (2) | IL278381B2 (OSRAM) |
| MX (1) | MX386337B (OSRAM) |
| PH (1) | PH12016501041A1 (OSRAM) |
| WO (1) | WO2015085172A2 (OSRAM) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107445940A (zh) | 2006-09-26 | 2017-12-08 | 细胞基因公司 | 作为抗肿瘤剂的5‑取代的喹唑酮衍生物 |
| SG10201501062SA (en) | 2010-02-11 | 2015-04-29 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| UA113512C2 (xx) | 2011-03-11 | 2017-02-10 | Тверда форма 3-(5-аміно-2-метил-4-оксо-4h-хіназолін-3-іл)піперидин-2,6-діону і її фармацевтична композиція та застосування | |
| WO2014039421A1 (en) | 2012-09-04 | 2014-03-13 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US10607717B2 (en) | 2013-11-06 | 2020-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for subtyping lymphoma types by means of expression profiling |
| AU2014360328B2 (en) | 2013-12-06 | 2021-04-01 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| EP3277272B1 (en) | 2015-03-31 | 2021-08-04 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-agonists |
| EP3304076A4 (en) | 2015-06-02 | 2018-12-19 | Celgene Corporation | Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins |
| US20170038387A1 (en) * | 2015-08-04 | 2017-02-09 | Celgene Corporation | Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| US20180231561A1 (en) * | 2015-08-12 | 2018-08-16 | Celgene Corporation | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| KR20180052747A (ko) * | 2015-09-25 | 2018-05-18 | 셀진 코포레이션 | 미만성 거대 b세포 림프종의 치료 방법 및 약물에 대한 반응성의 예측자로서 바이오마커의 용도 |
| WO2017100259A1 (en) * | 2015-12-08 | 2017-06-15 | Icahn School Of Medicine At Mount Sinai | Pretransplant prediction of post-transplant acute rejection |
| US10830762B2 (en) | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
| CA3010801A1 (en) | 2016-01-08 | 2017-07-13 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
| US11311540B2 (en) | 2016-02-17 | 2022-04-26 | Acetylon Pharmaceuticals, Inc. | Increasing expression of interferon regulated genes with combinations of histone deacetylase inhibitors and immunomodulatory drugs |
| US9868994B2 (en) | 2016-04-08 | 2018-01-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-α agonists |
| CA3020173A1 (en) * | 2016-04-08 | 2017-10-12 | Syros Pharmaceuticals, Inc. | Rara agonists for the treatment of aml and mds |
| EP3445873B1 (en) | 2016-04-20 | 2020-11-04 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Evaluation of mantle cell lymphoma and methods related thereto |
| SG10201607303YA (en) | 2016-09-01 | 2018-04-27 | Agency Science Tech & Res | Antisense oligonucleotides to induce exon skipping |
| BR112019011025A2 (pt) | 2016-12-03 | 2019-10-08 | Juno Therapeutics Inc | métodos para modulação de células t car |
| KR20190104528A (ko) | 2016-12-03 | 2019-09-10 | 주노 쎄러퓨티크스 인코퍼레이티드 | Car-t 세포들 투여를 결정하는 방법 |
| WO2018144445A1 (en) * | 2017-01-31 | 2018-08-09 | Celgene Corporation | Methods for treating hematological cancer and the use of biomarkers as a predictor for responsiveness to treatment compounds |
| WO2018165482A1 (en) * | 2017-03-10 | 2018-09-13 | Memorial Sloan Kettering Cancer Center | Methods for treatment or prevention of leukemia |
| PT3618842T (pt) | 2017-05-01 | 2024-01-12 | Juno Therapeutics Inc | Combinação de uma terapia celular e de um composto imunomodulador |
| MX2019014268A (es) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva. |
| US20220225597A1 (en) | 2017-06-29 | 2022-07-21 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| US20210024997A1 (en) * | 2017-10-16 | 2021-01-28 | Massachusetts Institute Of Technology | Cell atlas of healthy and diseased tissues |
| MA49911A (fr) | 2017-11-01 | 2020-06-24 | Juno Therapeutics Inc | Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| KR20200116081A (ko) | 2017-12-01 | 2020-10-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포의 투약 및 조절 방법 |
| KR20200110745A (ko) | 2017-12-15 | 2020-09-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항 - ｃｃｔ5 결합 분자 및 이의 사용 방법 |
| WO2019191112A1 (en) * | 2018-03-26 | 2019-10-03 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
| CN110448548B (zh) * | 2018-05-08 | 2023-05-05 | 四川大学华西医院 | Ifitm2抑制剂在制备治疗乙型肝炎的药物中的用途 |
| MX2020012548A (es) * | 2018-05-23 | 2021-05-13 | Celgene Corp | Métodos para el tratamiento de mieloma múltiple y uso de biomarcadores para 4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1-oxoiso indolin-4-il)oxi)metil)bencil)piperazin-1- il)-3-fluorobenzonitril o. |
| US12263190B2 (en) | 2018-11-08 | 2025-04-01 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
| AU2019381827A1 (en) | 2018-11-16 | 2021-06-10 | Juno Therapeutics, Inc. | Methods of dosing engineered T cells for the treatment of B cell malignancies |
| JP7695882B2 (ja) | 2018-11-30 | 2025-06-19 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法を用いた処置のための方法 |
| CN109583222A (zh) * | 2018-12-07 | 2019-04-05 | 浪潮(北京)电子信息产业有限公司 | 分布式文件系统元数据服务器回收客户端权限方法及装置 |
| SG11202107976SA (en) | 2019-01-29 | 2021-08-30 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1) |
| EA202192738A1 (ru) | 2019-04-12 | 2022-03-17 | С4 Терапьютикс, Инк. | Трициклические соединения, обеспечивающие разрушение белка ikaros и белка aiolos |
| WO2020231937A1 (en) * | 2019-05-10 | 2020-11-19 | University Of Massachusetts | Irf2 as a prognostic biomarker and target for augmenting immunotherapy |
| US20220265821A1 (en) * | 2019-07-19 | 2022-08-25 | Pascal Biosciences Inc. | Composition and methods of targeting the pre-b cell receptor for the treatment of leukemias and lymphomas |
| WO2021102420A1 (en) * | 2019-11-22 | 2021-05-27 | The Regents Of The University Of California | Interferon signaling as a cancer biomarker |
| JP2023505150A (ja) * | 2019-12-02 | 2023-02-08 | セルジーン コーポレーション | がんの処置のための治療法 |
| WO2021118353A1 (en) * | 2019-12-11 | 2021-06-17 | Erasmus University Medical Center Rotterdam | Method for monitoring of deep remissions in multiple myeloma and other plasma cell dyscrasias |
| CN111187755B (zh) * | 2020-02-20 | 2021-10-22 | 中国人民解放军军事科学院军事医学研究院 | 抗tpd52单克隆抗体杂交瘤细胞株及其单克隆抗体与应用 |
| US11366101B1 (en) | 2020-12-31 | 2022-06-21 | Elephas Biosciences Corporation | Ex vivo systems and methods for determining the effect of a drug or other agent on a tissue |
| EP4277901A1 (en) | 2021-01-13 | 2023-11-22 | Monte Rosa Therapeutics, Inc. | Isoindolinone compounds |
| EP4288565A4 (en) * | 2021-02-03 | 2025-04-23 | Curis, Inc. | BIOMARKERS FOR FIMEPINOSTAT THERAPY |
| KR102629955B1 (ko) * | 2021-02-19 | 2024-01-25 | 가톨릭대학교 산학협력단 | Ewsr1의 발현 또는 활성 촉진제를 포함하는 비알콜성 지방간염 예방 또는 치료용 약학적 조성물 |
| CN113025720B (zh) * | 2021-04-28 | 2022-12-27 | 深圳市人民医院 | 一种用于检测原发性乳腺弥漫性大b细胞淋巴瘤的标志物及其试剂盒和应用 |
| US20240245664A1 (en) * | 2021-09-08 | 2024-07-25 | The Curators Of The University Of Missouri | Methods of using usp15 inhibitors |
| US20250283174A1 (en) * | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
| KR20250029137A (ko) | 2022-06-22 | 2025-03-04 | 주노 쎄러퓨티크스 인코퍼레이티드 | Cd19-표적화된 car t 세포의 2차 요법을 위한 치료 방법 |
| EP4611798A1 (en) | 2022-11-02 | 2025-09-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025164957A1 (ko) * | 2024-01-31 | 2025-08-07 | 남부대학교산학협력단 | 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| ES2161715T3 (es) | 1992-03-04 | 2001-12-16 | Univ California | Hibridacion genomica comparativa (hgc). |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| WO2007086915A2 (en) | 2005-05-12 | 2007-08-02 | Applied Genomics, Inc. | Reagents and methods for use in cancer diagnosis, classification and therapy |
| US20070099209A1 (en) | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US8445198B2 (en) * | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| JP5523831B2 (ja) | 2006-08-30 | 2014-06-18 | セルジーン コーポレイション | ５−置換イソインドリン化合物 |
| US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
| US20100004253A1 (en) * | 2006-09-19 | 2010-01-07 | Novartis Ag | Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors |
| EP2068924A4 (en) * | 2007-05-03 | 2011-07-20 | Medimmune Llc | INTERFERON ALPHA INDUCED PHARMACODYNAMIC MARKERS |
| EP2235535B1 (en) * | 2007-12-07 | 2014-11-12 | Celgene Corporation | Biomarkers for predicting the sensitivity of cells to immunomodulatory compounds during treatment of non-hodgkin's lymphoma |
| US20090325176A1 (en) * | 2008-06-05 | 2009-12-31 | Wyeth | Gene Expression Profiles Associated with Asthma Exacerbation Attacks |
| US20100190656A1 (en) | 2008-08-08 | 2010-07-29 | Integrated Diagnostics, Inc. | Breast Cancer Specific Markers and Methods of Use |
| EP3354646A1 (en) | 2008-10-29 | 2018-08-01 | Celgene Corporation | Isoindoline compounds for use in the treatment of cancer |
| EP2419727A1 (en) * | 2009-04-14 | 2012-02-22 | Schering Corporation | Interferon-alfa sensitivity biomarkers |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| KR101692297B1 (ko) * | 2009-10-20 | 2017-01-04 | 도오쿄 인스티튜드 오브 테크놀로지 | 탈리도마이드 표적 인자를 이용한 스크리닝 방법 |
| SG10201501062SA (en) | 2010-02-11 | 2015-04-29 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| US8420385B2 (en) | 2010-04-21 | 2013-04-16 | Puritan Medical Products Company, Llc | Collection device and material |
| US20110301102A1 (en) * | 2010-06-07 | 2011-12-08 | Telik, Inc. | Compositions and methods for treating myelodysplastic syndrome |
| EP3025715A1 (en) * | 2011-03-11 | 2016-06-01 | Celgene Corporation | Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
| AU2012229333B2 (en) | 2011-03-11 | 2016-12-22 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing responsiveness to lenalidomide, thalidomide, and/or other thalidomide analogs |
| US9365640B2 (en) * | 2011-04-29 | 2016-06-14 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| CA2835179A1 (en) | 2011-05-06 | 2012-11-15 | Xentech | Markers for cancer prognosis and therapy and methods of use |
| CA2871535A1 (en) * | 2012-01-13 | 2013-07-18 | Celgene Corporation | Biomarkers for the treatment of hepatocellular carcinoma |
| ES2872967T3 (es) | 2012-06-29 | 2021-11-03 | Celgene Corp | Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS) |
| SI2882442T1 (sl) * | 2012-08-09 | 2021-11-30 | Celgene Corporation | Metode zdravljenja raka z uporabo 3-(4-((4-(morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin- 2,6-diona |
| KR102223060B1 (ko) | 2013-04-17 | 2021-03-05 | 시그날 파마소티칼 엘엘씨 | 암 치료를 위한 TOR 키나제 억제제 및 ＩＭｉＤ 화합물을 포함하는 조합요법 |
| US20160282354A1 (en) * | 2013-11-08 | 2016-09-29 | The Broad Institute, Inc. | Compositions and methods for selecting a treatment for b-cell neoplasias |
| AU2014360328B2 (en) | 2013-12-06 | 2021-04-01 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers |
| EA201691143A1 (ru) | 2013-12-06 | 2016-11-30 | Селджин Корпорейшн | Способы лечения гематологических злокачественных опухолей и применение биомаркеров в качестве показателя клинической чувствительности к иммуномодулирующей терапии |
| US20170242014A1 (en) | 2014-10-13 | 2017-08-24 | Celgene Corporaton | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| EP3304076A4 (en) | 2015-06-02 | 2018-12-19 | Celgene Corporation | Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins |
| US20170038387A1 (en) | 2015-08-04 | 2017-02-09 | Celgene Corporation | Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| US20180231561A1 (en) | 2015-08-12 | 2018-08-16 | Celgene Corporation | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| KR20180052747A (ko) | 2015-09-25 | 2018-05-18 | 셀진 코포레이션 | 미만성 거대 b세포 림프종의 치료 방법 및 약물에 대한 반응성의 예측자로서 바이오마커의 용도 |
| CA3010801A1 (en) | 2016-01-08 | 2017-07-13 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
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