JP2017501218A5 - - Google Patents

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Publication number
JP2017501218A5
JP2017501218A5 JP2016558533A JP2016558533A JP2017501218A5 JP 2017501218 A5 JP2017501218 A5 JP 2017501218A5 JP 2016558533 A JP2016558533 A JP 2016558533A JP 2016558533 A JP2016558533 A JP 2016558533A JP 2017501218 A5 JP2017501218 A5 JP 2017501218A5
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JP
Japan
Prior art keywords
substituted
azide
compound
unsubstituted
reagent
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JP2016558533A
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English (en)
Japanese (ja)
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JP6542794B2 (ja
JP2017501218A (ja
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Priority claimed from PCT/US2014/069517 external-priority patent/WO2015089170A1/en
Publication of JP2017501218A publication Critical patent/JP2017501218A/ja
Publication of JP2017501218A5 publication Critical patent/JP2017501218A5/ja
Application granted granted Critical
Publication of JP6542794B2 publication Critical patent/JP6542794B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016558533A 2013-12-12 2014-12-10 二環式アルキル化合物、および合成 Expired - Fee Related JP6542794B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361915415P 2013-12-12 2013-12-12
US61/915,415 2013-12-12
US201461949619P 2014-03-07 2014-03-07
US61/949,619 2014-03-07
PCT/US2014/069517 WO2015089170A1 (en) 2013-12-12 2014-12-10 Bicyclic alkyl compounds and synthesis

Publications (3)

Publication Number Publication Date
JP2017501218A JP2017501218A (ja) 2017-01-12
JP2017501218A5 true JP2017501218A5 (https=) 2018-01-25
JP6542794B2 JP6542794B2 (ja) 2019-07-10

Family

ID=53371797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016558533A Expired - Fee Related JP6542794B2 (ja) 2013-12-12 2014-12-10 二環式アルキル化合物、および合成

Country Status (8)

Country Link
US (1) US10189780B2 (https=)
EP (1) EP3080072A4 (https=)
JP (1) JP6542794B2 (https=)
KR (1) KR102380609B1 (https=)
CN (2) CN108947867A (https=)
CA (1) CA2932039A1 (https=)
TW (1) TWI645901B (https=)
WO (1) WO2015089170A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102243637B1 (ko) 2013-03-14 2021-04-26 리커리엄 아이피 홀딩스, 엘엘씨 바이사이클릭 진통 화합물
CN108947867A (zh) 2013-12-12 2018-12-07 卡利拉制药公司 双环烷基化合物及合成
CA2942144C (en) * 2014-03-07 2023-08-22 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
CN106999451B (zh) 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物
KR101974793B1 (ko) 2015-07-06 2019-05-02 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
KR102444836B1 (ko) 2016-08-23 2022-09-19 리커리엄 아이피 홀딩스, 엘엘씨 교차 커플링 방법
EP3628043A4 (en) 2017-05-15 2021-04-28 Recurium IP Holdings, LLC ANALGESIC COMPOUNDS
SG11202001733VA (en) 2017-09-11 2020-03-30 Recurium Ip Holdings Llc Continuous flow processes for making bicyclic compounds
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
WO2020252661A1 (zh) 2019-06-18 2020-12-24 吉林凯莱英医药化学有限公司 螺浆烷类化合物连续合成的方法
AU2021249010B2 (en) 2020-03-30 2024-09-26 Gilead Sciences, Inc. Solid forms of (S)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1H-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
JP7446475B2 (ja) 2020-04-02 2024-03-08 ギリアード サイエンシーズ, インコーポレイテッド Cot阻害剤化合物を調製するためのプロセス
KR102638594B1 (ko) * 2022-05-30 2024-02-19 경희대학교 산학협력단 신규한 바이사이클로펜테인 화합물 및 그의 제조방법

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL54795A (en) 1978-05-26 1980-10-26 Yeda Res & Dev Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types
EP0449831A4 (en) * 1988-06-03 1992-05-20 Board Of Regents The University Of Texas System Compounds and methods based on 1.1.1)propellane
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5262417A (en) 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
JPH04502317A (ja) 1988-12-06 1992-04-23 ジ・アップジョン・カンパニー 抗菌性キノロン化合物
US5404550A (en) * 1991-07-25 1995-04-04 Tandem Computers Incorporated Method and apparatus for executing tasks by following a linked list of memory packets
JP3665567B2 (ja) 1998-03-17 2005-06-29 ファイザー・プロダクツ・インク ビシクロ[2.2.1]ヘプタンおよび関連化合物
AU3898000A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Treatment of neuropathic pain or fibromyalgia
DE10025946A1 (de) 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
WO2001091736A2 (en) 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
DE10164348A1 (de) 2001-12-28 2003-07-17 Basf Ag Verfahren zur Herstellung von 1-Methoypropanol-2
EA010132B1 (ru) 2003-12-22 2008-06-30 Пфайзер Инк. Производные триазола в качестве антагонистов вазопрессина
EP1789028A2 (en) 2004-08-24 2007-05-30 Neuromolecular Pharmaceuticals Inc Compositions for treating nociceptive pain
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
JP2008120797A (ja) 2006-10-19 2008-05-29 Dainippon Sumitomo Pharma Co Ltd N−置換フェニルアセトアミド誘導体からなる医薬
RU2468011C2 (ru) 2006-12-27 2012-11-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолина и изохинолинона
US20100093696A1 (en) 2007-02-06 2010-04-15 Pfizer Inc. 2-amino pyrimidine compounds
DK2217597T3 (da) 2007-10-01 2011-06-20 Comentis Inc Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom
TW201010997A (en) 2008-06-18 2010-03-16 Pfizer Ltd Nicotinamide derivatives
CA2771710A1 (en) 2009-09-18 2011-03-24 Zalicus Pharmaceuticals Ltd. Aryl sulphone derivatives as calcium channel blockers
CA2804147A1 (en) 2010-06-30 2012-01-05 Upsher-Smith Laboratories, Inc. Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid
RU2013120966A (ru) 2010-10-08 2014-11-20 Эббви Инк. ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
TW201305178A (zh) 2010-10-29 2013-02-01 Glenmark Pharmaceuticals Sa 作為mPGES-1抑制物的三環化合物
ES2581848T3 (es) 2011-04-05 2016-09-07 Pfizer Limited Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas relacionadas con tropomiosina
MY162167A (en) * 2011-04-22 2017-05-31 Pfizer Substituted acetyl-coa carboxylase inhibitors
SMT202400031T1 (it) 2011-04-22 2024-03-13 Signal Pharm Llc Diamminocarbossammide e diamminocarbonitrile pirimidine sostituite, loro composizioni e metodi di trattamento con esse
AU2012295802B2 (en) 2011-08-12 2017-03-30 Nissan Chemical Industries, Ltd. Tricyclic heterocyclic compounds and JAK inhibitors
US9493481B2 (en) 2012-02-23 2016-11-15 Vanderbilt University Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
WO2013131018A1 (en) 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Biaryl inhibitors of the sodium channel
CA2870240A1 (en) 2012-04-27 2013-10-31 Nippon Zoki Pharmaceutical Co., Ltd. Analgesic
KR102243637B1 (ko) 2013-03-14 2021-04-26 리커리엄 아이피 홀딩스, 엘엘씨 바이사이클릭 진통 화합물
WO2014169226A2 (en) 2013-04-12 2014-10-16 Philadelphia Health & Education Corporation D/B/A Drexel University Of Medicine Methods of diagnosing and treating chronic pain
DK3013805T3 (en) 2013-06-28 2018-04-23 Evotec Int Gmbh Sulfoximine-substituted quinazolines and their use as MNK1 and / or MNK2 kinase inhibitors
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
JP6211195B2 (ja) 2013-08-12 2017-10-11 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 呼吸器合胞体ウイルス感染症の処置および予防のための新規アザ−オキソ−インドール
BR112016008632A8 (pt) 2013-10-21 2020-03-17 Merck Patent Gmbh compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica
CN103588668A (zh) 2013-10-28 2014-02-19 史克勇 化合物
CN103588672A (zh) 2013-10-28 2014-02-19 史克勇 一种治疗癌性疼痛的药物
CN108947867A (zh) 2013-12-12 2018-12-07 卡利拉制药公司 双环烷基化合物及合成
EP3082819B1 (en) 2013-12-20 2020-06-17 Signal Pharmaceuticals, LLC Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
CA2942144C (en) 2014-03-07 2023-08-22 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
US20150291606A1 (en) 2014-04-11 2015-10-15 The University Of North Carolina At Chapel Hill Mertk-specific pyrrolopyrimidine compounds
US20170197939A1 (en) 2014-04-15 2017-07-13 Pfizer Inc. Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
EP3134397A1 (en) 2014-04-24 2017-03-01 Novartis AG Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
CN107001283B (zh) 2014-07-31 2021-05-25 国家健康与医学研究院 Flt3受体拮抗剂
CN106999451B (zh) 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物

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