CN105814013A - 双环烷基化合物及合成 - Google Patents

双环烷基化合物及合成 Download PDF

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Publication number
CN105814013A
CN105814013A CN201480067673.7A CN201480067673A CN105814013A CN 105814013 A CN105814013 A CN 105814013A CN 201480067673 A CN201480067673 A CN 201480067673A CN 105814013 A CN105814013 A CN 105814013A
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substituted
compound
unsubstituted
group
transition metal
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CN201480067673.7A
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Chinese (zh)
Inventor
凯文·杜安·邦克
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Zeno Royalty Milestone Co Ltd
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Kalyra Pharmaceuticals Inc
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Priority to CN201810723613.6A priority Critical patent/CN108947867A/zh
Publication of CN105814013A publication Critical patent/CN105814013A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/06—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
    • B01J27/06—Halogens; Compounds thereof
    • B01J27/128—Halogens; Compounds thereof with iron group metals or platinum group metals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/04—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing carboxylic acids or their salts
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    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2217—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
    • B01J31/28—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of the platinum group metals, iron group metals or copper
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    • C07C23/18—Polycyclic halogenated hydrocarbons
    • C07C23/20—Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic
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    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
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    • C07C265/00—Derivatives of isocyanic acid
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    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • C07C29/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups with molecular oxygen only
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/24—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing five carbon atoms
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    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/48—Ring-opening reactions
    • B01J2231/482—Ring-opening reactions asymmetric reactions, e.g. kinetic resolution of racemates
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    • B01J2531/84—Metals of the iron group
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    • C07C2602/00—Systems containing two condensed rings
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    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201480067673.7A 2013-12-12 2014-12-10 双环烷基化合物及合成 Pending CN105814013A (zh)

Priority Applications (1)

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CN201810723613.6A CN108947867A (zh) 2013-12-12 2014-12-10 双环烷基化合物及合成

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361915415P 2013-12-12 2013-12-12
US61/915,415 2013-12-12
US201461949619P 2014-03-07 2014-03-07
US61/949,619 2014-03-07
PCT/US2014/069517 WO2015089170A1 (en) 2013-12-12 2014-12-10 Bicyclic alkyl compounds and synthesis

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CN105814013A true CN105814013A (zh) 2016-07-27

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US (1) US10189780B2 (https=)
EP (1) EP3080072A4 (https=)
JP (1) JP6542794B2 (https=)
KR (1) KR102380609B1 (https=)
CN (2) CN105814013A (https=)
CA (1) CA2932039A1 (https=)
TW (1) TWI645901B (https=)
WO (1) WO2015089170A1 (https=)

Cited By (3)

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CN106232567A (zh) * 2014-03-07 2016-12-14 卡利拉制药公司 螺桨烷衍生物及合成
CN109661399A (zh) * 2016-08-23 2019-04-19 芝诺罗耶尔蒂里程碑有限责任公司 交叉偶联方法
US10975035B2 (en) 2014-09-17 2021-04-13 Recurium Ip Holdings, Llc Bicyclic compounds

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