JP2017501205A5 - - Google Patents
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- Publication number
- JP2017501205A5 JP2017501205A5 JP2016544593A JP2016544593A JP2017501205A5 JP 2017501205 A5 JP2017501205 A5 JP 2017501205A5 JP 2016544593 A JP2016544593 A JP 2016544593A JP 2016544593 A JP2016544593 A JP 2016544593A JP 2017501205 A5 JP2017501205 A5 JP 2017501205A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- alkoxy
- carbocyclyl
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361921995P | 2013-12-30 | 2013-12-30 | |
| US61/921,995 | 2013-12-30 | ||
| US201462025203P | 2014-07-16 | 2014-07-16 | |
| US62/025,203 | 2014-07-16 | ||
| PCT/US2014/072851 WO2015103317A1 (en) | 2013-12-30 | 2014-12-30 | Therapeutic inhibitory compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501205A JP2017501205A (ja) | 2017-01-12 |
| JP2017501205A5 true JP2017501205A5 (enExample) | 2018-02-08 |
| JP6759100B2 JP6759100B2 (ja) | 2020-09-23 |
Family
ID=53493998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544593A Expired - Fee Related JP6759100B2 (ja) | 2013-12-30 | 2014-12-30 | 治療用阻害化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10266515B2 (enExample) |
| EP (1) | EP3089746A4 (enExample) |
| JP (1) | JP6759100B2 (enExample) |
| KR (1) | KR20160106627A (enExample) |
| CN (1) | CN106061480B (enExample) |
| AU (2) | AU2014373735B2 (enExample) |
| BR (1) | BR112016015449A8 (enExample) |
| CA (1) | CA2935683A1 (enExample) |
| EA (1) | EA032713B1 (enExample) |
| MX (1) | MX2016008688A (enExample) |
| WO (1) | WO2015103317A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| ES2608474T3 (es) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Proceso de producción de compuestos indol cycloalkylcarboxamido |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| HUE14755117T2 (hu) | 2013-08-14 | 2018-12-28 | Kalvista Pharmaceuticals Ltd | Plazma-kallikrein inhibitorok |
| CA2935683A1 (en) | 2013-12-30 | 2015-07-09 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| US9611252B2 (en) | 2013-12-30 | 2017-04-04 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| ES2885181T3 (es) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| AU2015289643B2 (en) * | 2014-07-16 | 2020-10-22 | Attune Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| WO2017087885A1 (en) | 2015-11-19 | 2017-05-26 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers |
| EP3404021A4 (en) | 2016-01-12 | 2019-09-11 | Nippon Chemiphar Co., Ltd. | VOLTAGE-RELATED T-TYPE CALCIUM CHANNEL INHIBITOR |
| DK3464271T3 (da) | 2016-05-31 | 2020-06-15 | Kalvista Pharmaceuticals Ltd | Pyrazolderivater som plasma-kallikreininhibitorer |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| CN110022875A (zh) | 2016-07-11 | 2019-07-16 | 莱福斯希医药公司 | 治疗性抑制化合物 |
| CN107033015B (zh) * | 2017-06-02 | 2019-04-30 | 南京欧信医药技术有限公司 | 一种药物中间体的合成方法 |
| PT3716952T (pt) | 2017-11-29 | 2022-04-14 | Kalvista Pharmaceuticals Ltd | Formas de administração que incluem um inibidor de calicreína plasmática |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| US11497752B2 (en) | 2018-01-30 | 2022-11-15 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| CN112770751A (zh) * | 2018-02-28 | 2021-05-07 | 爱顿制药公司 | 遗传性血管性水肿的治疗 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| EP3765459A1 (en) | 2018-03-13 | 2021-01-20 | Shire Human Genetic Therapies, Inc. | Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof |
| US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| IL311042B1 (en) | 2018-05-29 | 2026-04-01 | Omeros Corp | MASP-2 inhibitors and methods of use |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| WO2020081588A1 (en) | 2018-10-17 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Swi/snf family chromatin remodeling complexes and uses thereof |
| US12384776B2 (en) | 2019-01-29 | 2025-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12509453B2 (en) | 2019-01-29 | 2025-12-30 | Foghorn Therapeutics Inc. | BRM/BRG1 inhibitors and uses thereof |
| CN110256342B (zh) * | 2019-07-16 | 2022-06-07 | 河南省科学院化学研究所有限公司 | 一种2-氰基喹啉衍生物的合成方法 |
| EP4010333A1 (en) * | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| DK4031547T3 (da) | 2019-09-18 | 2024-09-09 | Takeda Pharmaceuticals Co | Plasmakallikreininhibitorer og anvendelser deraf |
| EP4031245A1 (en) | 2019-09-18 | 2022-07-27 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| EP4069676A1 (en) | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| BR112022010895A2 (pt) | 2019-12-04 | 2022-09-06 | Omeros Corp | Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan |
| IL293588B1 (en) | 2019-12-04 | 2026-04-01 | Omeros Corp | 3-Amino-1-methylpyrazin-2(H1)-one derivatives as MASP-2 inhibitors, compositions containing them and uses thereof |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| AU2021213811A1 (en) | 2020-01-29 | 2022-07-28 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2021155264A1 (en) * | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| US12606553B2 (en) | 2021-03-09 | 2026-04-21 | Foghorn Therapeutics Inc. | Crystalline forms, compositions containing same, and methods of their use |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| EP4587434A1 (en) * | 2022-09-15 | 2025-07-23 | Takeda Pharmaceutical Company Limited | N-((isoquinolin-6-yl)methyl)-1h-pyrazole-4-carboxamid derivatives as plasma kallikrein inhibitors for the treatment of hereditary angioedema |
| WO2025001956A1 (zh) * | 2023-06-30 | 2025-01-02 | 远森制药（杭州）有限公司 | 杂芳族甲酰胺类化合物及其在医药上的应用 |
| WO2025160190A1 (en) * | 2024-01-23 | 2025-07-31 | Retune Pharma Inc. | Therapeutic inhibitory compounds |
| WO2025247982A1 (en) * | 2024-05-29 | 2025-12-04 | Grünenthal GmbH | Piperazines which act as sstr4 modulators |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW212792B (enExample) * | 1991-09-13 | 1993-09-11 | Shell Internat Res Schappej B V | |
| IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| TW575562B (en) * | 1998-02-19 | 2004-02-11 | Agrevo Uk Ltd | Fungicides |
| IL149493A0 (en) * | 1999-11-10 | 2002-11-10 | Takeda Chemical Industries Ltd | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
| WO2003082272A1 (en) * | 2002-03-29 | 2003-10-09 | Chiron Corporation | Substituted benzazoles and use thereof as raf kinase inhibitors |
| WO2004078114A2 (en) * | 2003-02-28 | 2004-09-16 | Encysive Pharmaceuticals Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists. |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| KR20070066988A (ko) * | 2005-12-22 | 2007-06-27 | 크리스탈지노믹스(주) | 단백질 키나아제 활성을 저해하는 아미노 피리미딘유도체와 이의 제조방법 및 이를 유효성분으로 함유하는약학 조성물 |
| US20070254894A1 (en) | 2006-01-10 | 2007-11-01 | Kane John L Jr | Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation |
| CA2637620A1 (en) | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| EA200900779A1 (ru) * | 2006-12-14 | 2010-02-26 | Байер Шеринг Фарма Акциенгезельшафт | Производные дигидропиридина, полезные как ингибиторы протеинкиназы |
| JP2010518146A (ja) * | 2007-02-16 | 2010-05-27 | グラクソ グループ リミテッド | ベンゾフラン化合物 |
| EP2002834A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors |
| WO2009083553A1 (en) * | 2007-12-31 | 2009-07-09 | Rheoscience A/S | Azine compounds as glucokinase activators |
| WO2009119088A1 (ja) * | 2008-03-25 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| US20090270407A1 (en) * | 2008-04-25 | 2009-10-29 | E. I. Du Pont De Nemours And Company | Fungicidal isoxazolidines |
| EP2326625A1 (en) | 2008-07-18 | 2011-06-01 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives and their use as hstamine h3 antagonists |
| MX2011004570A (es) | 2008-10-31 | 2011-06-17 | Merck Sharp & Dohme | Antagonistas del receptor p2x3 para el tratamiento del dolor. |
| CN102365278B (zh) * | 2009-03-26 | 2015-05-06 | 先正达参股股份有限公司 | 杀虫化合物 |
| GB201004739D0 (en) * | 2010-03-22 | 2010-05-05 | Prosidion Ltd | Receptor modulators |
| US9290485B2 (en) * | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| RU2632900C2 (ru) * | 2010-11-19 | 2017-10-11 | Лиганд Фармасьютикалс Инкорпорейтед | Гетероциклические амины и их применение |
| GB201021103D0 (en) * | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
| CN102904742B (zh) | 2011-07-29 | 2015-10-07 | 华为终端有限公司 | 对可执行节点的操作方法及系统 |
| US20150017156A1 (en) | 2011-09-16 | 2015-01-15 | The Ohio State University | Esx-mediated transcription modulators and related methods |
| EP2780014A4 (en) * | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US20140378474A1 (en) | 2012-01-27 | 2014-12-25 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| EP2807156A1 (en) | 2012-01-27 | 2014-12-03 | Novartis AG | Aminopyridine derivatives as plasma kallikrein inhibitors |
| HRP20171459T1 (hr) * | 2012-12-07 | 2017-11-03 | F. Hoffmann - La Roche Ag | Piridin-2-amidi korisni kao agonisti cb2 |
| EP2999697B1 (en) | 2013-05-23 | 2017-04-19 | Kalvista Pharmaceuticals Limited | Heterocyclic derivates |
| HUE14755117T2 (hu) * | 2013-08-14 | 2018-12-28 | Kalvista Pharmaceuticals Ltd | Plazma-kallikrein inhibitorok |
| US9611252B2 (en) | 2013-12-30 | 2017-04-04 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| CA2935683A1 (en) | 2013-12-30 | 2015-07-09 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| AU2015289643B2 (en) * | 2014-07-16 | 2020-10-22 | Attune Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| CN110022875A (zh) | 2016-07-11 | 2019-07-16 | 莱福斯希医药公司 | 治疗性抑制化合物 |
-
2014
- 2014-12-30 CA CA2935683A patent/CA2935683A1/en not_active Abandoned
- 2014-12-30 EA EA201691354A patent/EA032713B1/ru unknown
- 2014-12-30 MX MX2016008688A patent/MX2016008688A/es unknown
- 2014-12-30 CN CN201480076616.5A patent/CN106061480B/zh not_active Expired - Fee Related
- 2014-12-30 WO PCT/US2014/072851 patent/WO2015103317A1/en not_active Ceased
- 2014-12-30 US US14/800,631 patent/US10266515B2/en not_active Expired - Fee Related
- 2014-12-30 KR KR1020167020567A patent/KR20160106627A/ko not_active Ceased
- 2014-12-30 BR BR112016015449A patent/BR112016015449A8/pt active Search and Examination
- 2014-12-30 AU AU2014373735A patent/AU2014373735B2/en not_active Ceased
- 2014-12-30 EP EP14877414.4A patent/EP3089746A4/en not_active Withdrawn
- 2014-12-30 JP JP2016544593A patent/JP6759100B2/ja not_active Expired - Fee Related
-
2019
- 2019-04-02 US US16/373,391 patent/US20200031799A1/en not_active Abandoned
-
2020
- 2020-03-03 AU AU2020201550A patent/AU2020201550A1/en not_active Abandoned
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