JP2017223685A5 - - Google Patents

Info

Publication number

JP2017223685A5

JP2017223685A5 JP2017139448A JP2017139448A JP2017223685A5 JP 2017223685 A5 JP2017223685 A5 JP 2017223685A5 JP 2017139448 A JP2017139448 A JP 2017139448A JP 2017139448 A JP2017139448 A JP 2017139448A JP 2017223685 A5 JP2017223685 A5 JP 2017223685A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

group

hvr

biomarker

Prior art date

2017-07-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001413 amino acids Chemical class 0.000 claims 66
• 229910052717 sulfur Inorganic materials 0.000 claims 22
• 239000000090 biomarker Substances 0.000 claims 19
• 238000000034 method Methods 0.000 claims 17
• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 229910052740 iodine Inorganic materials 0.000 claims 14
• 229910052757 nitrogen Inorganic materials 0.000 claims 12
• 229910052698 phosphorus Inorganic materials 0.000 claims 12
• 239000005557 antagonist Substances 0.000 claims 11
• 102100033016 Integrin beta-7 Human genes 0.000 claims 8
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 108010021315 integrin beta7 Proteins 0.000 claims 8
• 210000004698 lymphocyte Anatomy 0.000 claims 8
• 229910052700 potassium Inorganic materials 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 230000000968 intestinal effect Effects 0.000 claims 6
• 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 5
• 206010009900 Colitis ulcerative Diseases 0.000 claims 4
• 208000011231 Crohn disease Diseases 0.000 claims 4
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
• 210000005259 peripheral blood Anatomy 0.000 claims 4
• 239000011886 peripheral blood Substances 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 102000006495 integrins Human genes 0.000 claims 3
• 108010044426 integrins Proteins 0.000 claims 3
• 230000004043 responsiveness Effects 0.000 claims 3
• USWINTIHFQKJTR-UHFFFAOYSA-N 3-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C=C(S(O)(=O)=O)C(O)=CC2=C1 USWINTIHFQKJTR-UHFFFAOYSA-N 0.000 claims 2
• LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical compound C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 claims 2
• HBZVNWNSRNTWPS-UHFFFAOYSA-N 6-amino-4-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C(O)C2=CC(N)=CC=C21 HBZVNWNSRNTWPS-UHFFFAOYSA-N 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 229910052805 deuterium Inorganic materials 0.000 claims 2
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000001647 drug administration Methods 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1