JP2017186332A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2017186332A JP2017186332A JP2017072261A JP2017072261A JP2017186332A JP 2017186332 A JP2017186332 A JP 2017186332A JP 2017072261 A JP2017072261 A JP 2017072261A JP 2017072261 A JP2017072261 A JP 2017072261A JP 2017186332 A JP2017186332 A JP 2017186332A
- Authority
- JP
- Japan
- Prior art keywords
- silica
- weight
- fluorine
- composition
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 84
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 41
- NJNWCIAPVGRBHO-UHFFFAOYSA-N 2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical group OCC[N+](C)(C)C#P=O NJNWCIAPVGRBHO-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920000642 polymer Polymers 0.000 claims abstract description 22
- 150000002222 fluorine compounds Chemical class 0.000 claims abstract description 17
- 229920001577 copolymer Polymers 0.000 claims description 15
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical group CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 claims description 12
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 12
- 210000000214 mouth Anatomy 0.000 claims description 11
- SOGAXMICEFXMKE-UHFFFAOYSA-N alpha-Methyl-n-butyl acrylate Natural products CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 6
- 239000011775 sodium fluoride Substances 0.000 claims description 6
- 235000013024 sodium fluoride Nutrition 0.000 claims description 6
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
- -1 fluoride ions Chemical class 0.000 abstract description 51
- 238000001179 sorption measurement Methods 0.000 abstract description 28
- 238000004062 sedimentation Methods 0.000 abstract description 2
- 229910052731 fluorine Inorganic materials 0.000 description 33
- 239000011737 fluorine Substances 0.000 description 33
- 230000001737 promoting effect Effects 0.000 description 24
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- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 13
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- 238000013329 compounding Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 239000000178 monomer Substances 0.000 description 10
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- 229910052586 apatite Inorganic materials 0.000 description 8
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
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- 208000002925 dental caries Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
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- 235000010724 Wisteria floribunda Nutrition 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
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- 235000003599 food sweetener Nutrition 0.000 description 3
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
- 229950004354 phosphorylcholine Drugs 0.000 description 3
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
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- RUYKUXOULSOEPZ-UHFFFAOYSA-N [2-hydroxy-3-(2-methylprop-2-enoyloxy)propyl]-trimethylazanium Chemical compound CC(=C)C(=O)OCC(O)C[N+](C)(C)C RUYKUXOULSOEPZ-UHFFFAOYSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
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- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
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- 239000000919 ceramic Substances 0.000 description 2
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- 238000007796 conventional method Methods 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- DWYMPOCYEZONEA-UHFFFAOYSA-N fluorophosphoric acid Chemical compound OP(O)(F)=O DWYMPOCYEZONEA-UHFFFAOYSA-N 0.000 description 2
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- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
表1〜4に示す組成の処置液を作製した。表1〜4において各成分の数値の単位は重量%であり、フッ素イオン濃度のみppmで示す。
下記の方法により、各処置液のフッ素吸着促進効果を評価した。歯面の代替として、化学的性質が類似のハイドロキシアパタイトの粉末(CHTセラミックハイドロキシアパタイト TypeI担体、平均粒子径:80μm2/g、バイオ・ラッドラボラトリーズ株式会社)(以下、アパタイトと略す。)を使用した。
101%以上: +
103%以上: ++
105%以上: +++
表5に示す組成の処置液を作製した。表5において各成分の数値の単位は重量%であり、フッ素イオン濃度のみppmで示す。ここで、増粘性シリカとしては、Sorbosil TC15(PQ Corporation社製、吸油量300g/100g)、研磨性シリカとしては、Zeodent 113(J.M.Huber Corporation社製、吸油量90g/100g)を用いた。
前述した方法により評価し、比較例1で沈着したフッ素イオン量に対する、実施例1〜4で沈着したフッ素イオン量の割合を算出した。
各組成物約5gをガラス製スクリュー管瓶(容量6mL)に充填し、室温で1日間静置した。静置後の外観を観察し、如何に示す判定基準によってケーキングの有無を評価した。
〇:上下に激しく20回振って撹拌させた際、全てのシリカが溶液中に分散される。
×:上下に激しく20回振って撹拌させた際、容器底部に一部のシリカが分散せずに付着している。
得られた結果を表5に示す。
以下の処方で、各組成物を常法にしたがって作製し、フッ素吸着促進効果を評価した。その結果、いずれの組成物においてもフッ素吸着促進効果が確認された。
Claims (4)
- ホスホリルコリン基含有重合体、フッ素化合物、および、4重量%以上のシリカを含む口腔用組成物。
- ホスホリルコリン基含有重合体の配合量が0.005〜0.1重量%である請求項1に記載の口腔用組成物。
- ホスホリルコリン基含有重合体が2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体である請求項1または2に記載の口腔用組成物。
- フッ素化合物がフッ化ナトリウムまたはモノフルオロリン酸ナトリウムである請求項1〜3のいずれかに記載の口腔用組成物。
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JP2002104948A (ja) * | 2000-07-24 | 2002-04-10 | Kao Corp | 口腔用組成物 |
WO2013047826A1 (ja) * | 2011-09-28 | 2013-04-04 | ライオン株式会社 | 口腔用組成物 |
WO2016031461A1 (ja) * | 2014-08-29 | 2016-03-03 | 日油株式会社 | 象牙質知覚過敏症緩和用口腔組成物 |
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JPH11130643A (ja) * | 1997-10-28 | 1999-05-18 | Lion Corp | 口腔用組成物 |
JP5206938B2 (ja) * | 2007-12-25 | 2013-06-12 | ライオン株式会社 | 口腔用組成物 |
JP5485677B2 (ja) * | 2009-12-16 | 2014-05-07 | 花王株式会社 | 口腔用組成物 |
JP5458911B2 (ja) * | 2010-01-28 | 2014-04-02 | 日油株式会社 | 口腔用微生物付着防止剤 |
JP6672665B2 (ja) * | 2015-09-24 | 2020-03-25 | 日油株式会社 | 口腔用組成物 |
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WO2013047826A1 (ja) * | 2011-09-28 | 2013-04-04 | ライオン株式会社 | 口腔用組成物 |
WO2016031461A1 (ja) * | 2014-08-29 | 2016-03-03 | 日油株式会社 | 象牙質知覚過敏症緩和用口腔組成物 |
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WO2022081430A1 (en) * | 2020-10-15 | 2022-04-21 | Advantage Silver Dental Arrest, Llc | A thickened silver diamine fluoride composition |
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