JP2017185252A - ドライアイを治療するためのシステムおよび方法 - Google Patents
ドライアイを治療するためのシステムおよび方法 Download PDFInfo
- Publication number
- JP2017185252A JP2017185252A JP2017100651A JP2017100651A JP2017185252A JP 2017185252 A JP2017185252 A JP 2017185252A JP 2017100651 A JP2017100651 A JP 2017100651A JP 2017100651 A JP2017100651 A JP 2017100651A JP 2017185252 A JP2017185252 A JP 2017185252A
- Authority
- JP
- Japan
- Prior art keywords
- micro stimulator
- controller
- microstimulator
- lacrimal gland
- implantable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36142—Control systems for improving safety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
- A61N1/3787—Electrical supply from an external energy source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
Landscapes
- Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Electrotherapy Devices (AREA)
- Prostheses (AREA)
Abstract
Description
本出願は、2010年11月16日に出願した米国仮出願第61/414,293号、2011年1月18日に出願した米国仮出願第61/433,645号、2011年1月18日に出願した米国仮出願第61/433,649号、および2011年1月18日に出願した米国仮出願第61/433,652号の利益を主張するものである。前記の出願は、参照によりその全体が本明細書に組み込まれる。
本明細書で言及されているすべての刊行物および特許出願は、それぞれの個別の刊行物または特許出願が、具体的かつ個別に指示されて参照により本明細書に組み込まれる場合と同程度に参照により本明細書に組み込まれる。
一実施形態では、微小刺激装置を使用するための方法は、微小刺激装置を涙腺上に、または涙腺内に、または涙腺に隣接して位置決めされている多電極リードに接続することから始めることができる。1つまたは複数の電極を多電極リードから選択して、患者の目の中の涙液産生を活性化することができる。
[項1]
長さ約0.6cmから約1.5cm、および幅約1mmから約1.5mmを有すると共に、受動型刺激回路を備えた、目の病状を治療するための埋め込み可能な微小刺激装置。
[項2]
形状適合性を有する項1に記載の埋め込み可能な微小刺激装置。
[項3]
柔軟である項1に記載の埋め込み可能な微小刺激装置。
[項4]
1つまたは複数の固定要素を備える項1に記載の埋め込み可能な微小刺激装置。
[項5]
前記1つまたは複数の固定要素は、1つまたは複数のフック、バーブ、もしくはアンカーを含む項4に記載の埋め込み可能な微小刺激装置。
[項6]
1つまたは複数のコーティングを備える項1に記載の埋め込み可能な微小刺激装置。
[項7]
前記コーティングは、粘着性を有する項6に記載の埋め込み可能な微小刺激装置。
[項8]
前記回路は、1つまたは複数の電気的安全機能をさらに備える項1に記載の埋め込み可能な微小刺激装置。
[項9]
前記1つまたは複数の安全機能は、1つまたは複数の電流制限整流器を備える項8に記載の埋め込み可能な微小刺激装置。
[項10]
前記1つまたは複数の安全機能は、1つまたは複数のツェナーダイオードを備える項8に記載の埋め込み可能な微小刺激装置。
[項11]
前記電気的安全機能は、刺激構成要素によって放出される電圧を制限するための電圧制限回路を備える項8に記載の埋め込み可能な微小刺激装置。
[項12]
前記電気的安全機能は、刺激構成要素によって放出される電流を制限するための電流制限回路を備える項8に記載の埋め込み可能な微小刺激装置。
[項13]
前記電気的安全機能は、刺激構成要素によって放出される電荷を制限するための電荷出力制限回路を備える項8に記載の埋め込み可能な微小刺激装置。
[項14]
コントローラに結合される項1に記載の埋め込み可能な微小刺激装置。
[項15]
12ゲージ以上の針で目の中に注入可能である項1に記載の埋め込み可能な微小刺激装置。
[項16]
前記受動型刺激回路は、タンク回路を備える項1に記載の埋め込み可能な微小刺激装置。
[項17]
気密封止型である項1に記載の埋め込み可能な微小刺激装置。
[項18]
侵襲の少ない取出しを補助するための1つまたは複数の機能を備える項1に記載の埋め込み可能な微小刺激装置。
[項19]
前記受動型刺激回路は、可変抵抗素子または可変容量素子を備える項1に記載の埋め込み可能な微小刺激装置。
[項20]
前記受動型刺激回路は、1つまたは複数の電極を備える項1に記載の埋め込み可能な微小刺激装置。
[項21]
前記1つまたは複数の電極は、接点であり、前記微小刺激装置内に挟み込まれ、柔軟なリードに結合されるか、または剛体のリードに結合される項20に記載の埋め込み可能な微小刺激装置。
[項22]
前記1つまたは複数の電極は、白金、イリジウム、白金イリジウム、酸化イリジウム、窒化チタン、タンタル、またはこれらの組合せを含む項1に記載の埋め込み可能な微小刺激装置。
[項23]
前記コーティングは、生体吸収性を有する項6に記載の埋め込み可能な微小刺激装置。
[項24]
前記微小刺激装置の前記長さと前記幅は、前記微小刺激装置の一部を涙腺に隣接して配置できるように選択される項1に記載の埋め込み可能な微小刺激装置。
[項25]
前記微小刺激装置の前記長さと前記幅は、前記微小刺激装置全体を涙腺に隣接して配置できるように選択される項1に記載の埋め込み可能な微小刺激装置。
[項26]
前記微小刺激装置の前記長さと前記幅は、前記微小刺激装置を涙腺上に、涙腺の中に部分的に入れて、涙腺の中にすっぽり入れて、または涙腺のあたりに配置できるように選択される項1に記載の埋め込み可能な微小刺激装置。
[項27]
涙腺組織を神経支配する1つまたは複数の神経を刺激することによってドライアイを治療するための方法であって、
微小刺激装置を前記涙腺に隣接して埋め込む段階と、
刺激を前記涙腺に施す段階と
を含む方法。
[項28]
前記微小刺激装置は、前記涙腺に隣接し、患者の目の眼窩内に完全に埋め込まれる項27に記載の方法。
[項29]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺と直接接触している項27に記載の方法。
[項30]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺内に少なくとも部分的に侵入している項27に記載の方法。
[項31]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺内に完全に埋め込まれるか、または前記涙腺内に完全に入っている項27に記載の方法。
[項32]
前記涙腺に隣接するということは、前記涙腺のあたりにあるか、前記涙腺内にすっぽり入っているか、または前記涙腺内に部分的に入っていることである項27に記載の方法。
[項33]
前記微小刺激装置は、前記目の前記眼窩内に完全に埋め込まれる項27に記載の方法。
[項34]
前記刺激は、前記涙腺を神経支配する前記1つまたは複数の神経を選択的に刺激する項27に記載の方法。
[項35]
前記刺激は、前記目を垂直または水平方向に移動することなく前記涙腺を神経支配する前記1つまたは複数の神経を選択的に刺激する項34に記載の方法。
[項36]
前記刺激は、眼筋を刺激することなく前記涙腺を神経支配する前記1つまたは複数の神経を選択的に刺激する項34に記載の方法。
[項37]
前記刺激は、上直筋、外直筋、上眼瞼挙筋、網膜、または対応する運動神経を刺激することなく前記涙腺を神経支配する前記1つまたは複数の神経を選択的に刺激する項34に記載の方法。
[項38]
自律遠心性神経線維は、知覚求心性線維上で選択的に刺激される項34に記載の方法。
[項39]
自律遠心性神経線維は、Aδ痛覚線維上で選択的に刺激される項34に記載の方法。
[項40]
自律遠心性神経線維は、C痛覚線維上で選択的に刺激される項34に記載の方法。
[項41]
前記刺激は、前記涙腺を神経支配する前記1つまたは複数の神経を刺激するだけである項27に記載の方法。
[項42]
前記埋め込みの段階の後、前記微小刺激装置は、前記涙腺に対する窩内に埋め込まれる項27に記載の方法。
[項43]
前記埋め込みの段階の後、前記微小刺激装置は、埋め込み後の前記涙腺に対する窩に形状適合する項27に記載の方法。
[項44]
前記微小刺激装置は、埋め込み後の涙腺の外側面に形状適合する項27に記載の方法。
[項45]
前記埋め込みの段階は、前記微小刺激装置を前記涙腺に対する窩の外側面に形状適合させる段階をさらに含む項27に記載の方法。
[項46]
前記埋め込みの段階の後、前記微小刺激装置は、前記涙腺に対する窩の外側面に形状適合することができる項27に記載の方法。
[項47]
前記微小刺激装置は、12ゲージ以上の針を使用して埋め込まれる項27に記載の方法。
[項48]
前記微小刺激装置を12ゲージ以上の針内に装填する段階と、
前記針の先端部を前記眼の目頭における解剖学的ランドマークを使用して挿入する段階と、
前記針を前記涙腺に近接して位置決めする段階と、
前記針を使用して前記微小刺激装置を配備する段階と
をさらに含む項27に記載の方法。
[項49]
前記解剖学的ランドマークは、前記眼窩の上外側面内に入り眼窩隔膜を通る前記眼窩の側頭面である項48に記載の方法。
[項50]
前記刺激は、約500μAから約25mAの間のパルス振幅を有する電流を含む項27に記載の方法。
[項51]
前記刺激は、パルス振幅、パルス幅、およびパルス周波数を含み、前記パルス振幅、パルス幅、またはパルス周波数のうちの1つまたは複数は、治療期間にわたって変化する項27に記載の方法。
[項52]
前記刺激は、約2Hzから約270Hzの間のパルス周波数を有する項27に記載の方法。
[項53]
前記刺激は、約30Hzから約40Hzの間のパルス周波数を有する項27に記載の方法。
[項54]
前記刺激は、約50μ秒から約2700μ秒の間のパルス幅を有する電流を含む項27に記載の方法。
[項55]
前記埋め込みの段階は、前記眼窩の特徴に基づき埋め込みのための挿入点を識別する段階をさらに含む項27に記載の方法。
[項56]
前記刺激は、測定された変数に応答して調節される項27に記載の方法。
[項57]
前記刺激は、バーストで施される項27に記載の方法。
[項58]
前記刺激は、約500μ秒から約1000μ秒の間のパルス幅を有する電流を含む項27に記載の方法。
[項59]
コントローラを前記微小刺激装置に近接するように位置決めする段階をさらに含む項27に記載の方法。
[項60]
前記コントローラを使用して磁界を発生させる段階をさらに含む項59に記載の方法。
[項61]
前記磁界は、使用者からの入力に基づき調節される項60に記載の方法。
[項62]
前記磁界は、前記微小刺激装置に結合する程度に基づき調節される項60に記載の方法。
[項63]
前記磁界は、前記刺激を発生させるように前記微小刺激装置に結合される項60に記載の方法。
[項64]
前記磁界は、バーストで生成される項60に記載の方法。
[項65]
前記磁界は、約10kHzから約100MHzまでの周波数を有する項60に記載の方法。
[項66]
前記磁界は、約100kHzから約5MHzまでの周波数を有する項60に記載の方法。
[項67]
ドライアイを治療するためのシステムであって、
眼窩内に埋め込むように構成された微小刺激装置と、
前記微小刺激装置に結合する磁界を発生させるためのコントローラと
を備えるシステム。
[項68]
前記コントローラは、ハンドヘルドデバイス内に入れられている項67に記載のシステム。
[項69]
前記コントローラは、粘着材内に少なくとも部分的に収容される項67に記載のシステム。
[項70]
前記コントローラは、粘着材に結合される項67に記載のシステム。
[項71]
前記コントローラは、柔軟性を有する項67に記載のシステム。
[項72]
前記コントローラは、形状適合性を有する項67に記載のシステム。
[項73]
前記コントローラは、柔軟性もしくは形状適合性を有する材料に結合されるか、または少なくとも部分的に収容される項67に記載のシステム。
[項74]
前記微小刺激装置は、約0.6cmから約1.5cmまでの長さ、および約1mmから約1.5mmまでの幅を有し、前記コントローラによって生成される前記磁界を受けるように構成された受動型刺激回路を備える項67に記載のシステム。
[項75]
前記微小刺激装置は、柔軟性を有する項67に記載のシステム。
[項76]
前記微小刺激装置は、形状適合性を有する項67に記載のシステム。
[項77]
前記コントローラは、前記微小刺激装置の1つまたは複数の動作パラメータを検出することができる項67に記載のシステム。
[項78]
前記コントローラの少なくとも一部は、使い捨てである項67に記載のシステム。
[項79]
前記コントローラは、再充電可能である項67に記載のシステム。
[項80]
前記コントローラは、眼鏡フレームに結合されるか、または少なくとも部分的に収容される項67に記載のシステム。
[項81]
前記コントローラは、腕時計に結合されるか、または少なくとも部分的に収容される項67に記載のシステム。
[項82]
涙腺組織を神経支配する1つまたは複数の神経を刺激することによってドライアイを治療するための方法であって、
1つまたは複数の刺激電極を前記涙腺に隣接して位置決めする段階と、
刺激を前記涙腺に施す段階と
を含む方法。
[項83]
前記微小刺激装置は、前記涙腺に隣接して、患者の目の眼窩内に完全に埋め込まれる項82に記載の方法。
[項84]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺と直接接触している項82に記載の方法。
[項85]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺内に少なくとも部分的に侵入している項82に記載の方法。
[項86]
前記微小刺激装置は、前記涙腺に隣接し、前記涙腺内に完全に埋め込まれるか、または前記涙腺内に完全に入っている項82に記載の方法。
[項87]
前記涙腺に隣接するということは、前記涙腺のあたりにあるか、前記涙腺内にすっぽり入っているか、または前記涙腺内に部分的に入っていることである項82に記載の方法。
[項88]
前記微小刺激装置は、前記目の前記眼窩内に完全に埋め込まれる項82に記載の方法。
[項89]
前記1つまたは複数の電極は、パルス発生器に電気的に結合される項82に記載の方法。
[項90]
前記パルス発生器は、埋め込み可能である項82に記載の方法。
[項91]
前記パルス発生器は、前記1つまたは複数の刺激電極に近接して埋め込み可能である項82に記載の方法。
[項92]
前記パルス発生器は、側頭骨に近接して埋め込み可能である項91に記載の方法。
[項93]
前記パルス発生器は、鎖骨下部ポケット内に埋め込み可能である項82に記載の方法。
[項94]
前記パルス発生器は、皮下腹部ポケット内に埋め込み可能である項82に記載の方法。
[項95]
コントローラを前記パルス発生器に近接するように位置決めする段階をさらに含む項82に記載の方法。
2 患者の皮膚
10 涙腺
12 導管
14 涙
16 涙点
18 涙管
20 上眼瞼
22 下眼瞼
24 鼻涙管
26 頬骨突起
28 頬骨
30 目
32 涙嚢
33 上眼窩裂
34 後涙嚢稜
35 下眼窩裂
36 ちょう形骨
40 頭蓋骨
42 眼窩突起
44 眼窩上突起
46 前頭突起
52 眼鏡フレーム
72 乳様突起部
110 コントローラ
111 リード
112 波形
113 電極
114 出力信号
115 コントローラ回路
116 上直筋
117 上斜筋
118 外直筋
119 ハウジング
120 微小刺激装置
121 パルス発生回路
122 骨膜
123 解剖学的標的
124 下直筋
126 下斜筋
128 マイボーム腺
129 内分泌学的結果
130 涙腺
132 皮質組織
133 骨膜
134 海綿状組織
136 電源
138 入力モジュール
140 コントローラ
142 コントローラコイル
144 微小刺激装置コイル
146 ダイオード
148 抵抗器
150 同調コンデンサ
152 組織
160 再捕捉ループ
162 再捕捉磁石
168 微小刺激装置
170 電池
172 パルス発生器
200 虹彩
202 コイル
204 外縁
206 刺激装置
208 センサー
210 刺激リード
220 挿入デバイス
224 ハウジング
226 遠位端
228 デバイス軸
230 固定要素
Claims (34)
- 涙腺に隣接して埋め込まれるように構成されると共に受動型刺激回路を取り囲む本体部を備えた、ドライアイを治療するための埋め込み可能な微小刺激装置であって、前記受動型刺激回路が、印加される磁界の結果として電流を発生させるように構成されたコイルと、刺激を送るための1つまたは複数の電極と、を備え、前記1つまたは複数の電極が前記本体部と一体化され、前記刺激が、前記涙腺を刺激して涙液を発生させるように設定されている、埋め込み可能な微小刺激装置。
- 柔軟である請求項1に記載の埋め込み可能な微小刺激装置。
- 1つまたは複数の固定要素を備える請求項1に記載の埋め込み可能な微小刺激装置。
- 前記1つまたは複数の固定要素は、1つまたは複数のフック、バーブ、もしくはアンカーを含む請求項3に記載の埋め込み可能な微小刺激装置。
- 1つまたは複数のコーティングを備える請求項1に記載の埋め込み可能な微小刺激装置。
- 前記1つまたは複数のコーティングは、粘着剤を備える請求項5に記載の埋め込み可能な微小刺激装置。
- 前記受動型刺激回路は、1つまたは複数の電気的安全機能をさらに備える請求項1に記載の埋め込み可能な微小刺激装置。
- 前記1つまたは複数の安全機能は、1つまたは複数の電流制限整流器を備える請求項7に記載の埋め込み可能な微小刺激装置。
- 前記1つまたは複数の安全機能は、1つまたは複数のツェナーダイオードを備える請求項7に記載の埋め込み可能な微小刺激装置。
- 前記電気的安全機能は、前記1つまたは複数の電極によって放出される電圧を制限するための電圧制限回路を備える請求項7に記載の埋め込み可能な微小刺激装置。
- 前記電気的安全機能は、前記1つまたは複数の電極によって放出される電流を制限するための電流制限回路を備える請求項7に記載の埋め込み可能な微小刺激装置。
- 前記電気的安全機能は、前記1つまたは複数の電極によって放出される電荷を制限するための電荷出力制限回路を備える請求項7に記載の埋め込み可能な微小刺激装置。
- ワイヤレス方式で又は有線接続を介してコントローラと通信する請求項1に記載の埋め込み可能な微小刺激装置。
- 12ゲージ以上の針で目の中に注入可能である請求項1に記載の埋め込み可能な微小刺激装置。
- 前記受動型刺激回路は、タンク回路を備える請求項1に記載の埋め込み可能な微小刺激装置。
- 気密封止型である請求項1に記載の埋め込み可能な微小刺激装置。
- 侵襲の少ない取出しを補助するための1つまたは複数の機能を備える請求項1に記載の埋め込み可能な微小刺激装置。
- 前記受動型刺激回路は、可変抵抗素子または可変容量素子を備える請求項1に記載の埋め込み可能な微小刺激装置。
- 前記1つまたは複数の電極は、白金、イリジウム、白金イリジウム、酸化イリジウム、窒化チタン、タンタル、またはこれらの組合せを含む請求項1に記載の埋め込み可能な微小刺激装置。
- 前記コーティングは、生体吸収性を有する請求項5に記載の埋め込み可能な微小刺激装置。
- ドライアイを治療するためのシステムであって、
解剖学的構造に形状適合するように構成された本体部と、受動型刺激回路とを備えた、眼窩内に埋め込むように構成された微小刺激装置であって、前記受動型刺激回路が、印加される磁界の結果として電流を発生させるように構成されたコイルと、前記本体部と一体化された1つまたは複数の電極とを備え、前記本体部が前記受動型刺激回路を取り囲んでいる、微小刺激装置と、
前記微小刺激装置に結合する磁界を発生させるためのコントローラと
を備えるシステム。 - 前記コントローラは、ハンドヘルドデバイス内に入れられている請求項21に記載のシステム。
- 前記コントローラは、粘着材内に少なくとも部分的に収容される請求項21に記載のシステム。
- 前記コントローラは、粘着材に結合される請求項21に記載のシステム。
- 前記コントローラは、柔軟性を有する請求項21に記載のシステム。
- 前記コントローラは、形状適合性を有する請求項21に記載のシステム。
- 前記コントローラは、柔軟性もしくは形状適合性を有する材料に結合されるか、または少なくとも部分的に収容される請求項21に記載のシステム。
- 前記微小刺激装置は、約0.6cmから約1.5cmまでの長さ、および約1mmから約1.5mmまでの幅を有する請求項21に記載のシステム。
- 前記微小刺激装置は、柔軟性を有する請求項21に記載のシステム。
- 前記コントローラは、前記微小刺激装置の1つまたは複数の動作パラメータを検出することができる請求項21に記載のシステム。
- 前記コントローラの少なくとも一部は、使い捨てである請求項21に記載のシステム。
- 前記コントローラは、再充電可能である請求項21に記載のシステム。
- 前記コントローラは、眼鏡フレームに結合されるか、または少なくとも部分的に収容される請求項21に記載のシステム。
- 前記コントローラは、腕時計に結合されるか、または少なくとも部分的に収容される請求項21に記載のシステム。
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41429310P | 2010-11-16 | 2010-11-16 | |
US61/414,293 | 2010-11-16 | ||
US201161433652P | 2011-01-18 | 2011-01-18 | |
US201161433645P | 2011-01-18 | 2011-01-18 | |
US201161433649P | 2011-01-18 | 2011-01-18 | |
US61/433,645 | 2011-01-18 | ||
US61/433,649 | 2011-01-18 | ||
US61/433,652 | 2011-01-18 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013539971A Division JP2013542838A (ja) | 2010-11-16 | 2011-11-16 | ドライアイを治療するためのシステムおよび方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017185252A true JP2017185252A (ja) | 2017-10-12 |
JP2017185252A5 JP2017185252A5 (ja) | 2018-12-06 |
JP6522047B2 JP6522047B2 (ja) | 2019-05-29 |
Family
ID=46065035
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013539971A Pending JP2013542838A (ja) | 2010-11-16 | 2011-11-16 | ドライアイを治療するためのシステムおよび方法 |
JP2017100651A Expired - Fee Related JP6522047B2 (ja) | 2010-11-16 | 2017-05-22 | ドライアイを治療するためのシステムおよび方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013539971A Pending JP2013542838A (ja) | 2010-11-16 | 2011-11-16 | ドライアイを治療するためのシステムおよび方法 |
Country Status (9)
Country | Link |
---|---|
US (7) | US8918181B2 (ja) |
EP (1) | EP2640461B1 (ja) |
JP (2) | JP2013542838A (ja) |
CN (1) | CN103313754B (ja) |
AU (1) | AU2011328900B2 (ja) |
CA (1) | CA2817589A1 (ja) |
ES (1) | ES2739490T3 (ja) |
RU (1) | RU2013127313A (ja) |
WO (1) | WO2012068247A1 (ja) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
CN103313754B (zh) | 2010-11-16 | 2015-09-30 | 小利兰·斯坦福大学理事会 | 用于治疗干眼的系统和方法 |
EP2694156B8 (en) * | 2011-04-07 | 2017-08-09 | Oculeve, Inc. | Stimulation devices |
US8857981B2 (en) * | 2012-07-26 | 2014-10-14 | Google Inc. | Facilitation of contact lenses with capacitive sensors |
US9931107B2 (en) | 2012-12-07 | 2018-04-03 | Medtronic, Inc. | Minimally invasive implantable neurostimulation system |
WO2014138709A1 (en) * | 2013-03-08 | 2014-09-12 | Oculeve, Inc. | Devices and methods for treating dry eye in animals |
EP2967817B1 (en) | 2013-03-12 | 2021-03-10 | Oculeve, Inc. | Implant delivery devices and systems |
CN105307718B (zh) * | 2013-04-19 | 2018-05-11 | 奥库利维公司 | 鼻刺激装置和方法 |
EP3689338A1 (en) | 2014-02-25 | 2020-08-05 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
AU358535S (en) | 2014-04-18 | 2014-11-03 | Oculeve | Nasal stimulator device |
WO2016015025A1 (en) * | 2014-07-25 | 2016-01-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
AU2015335776B2 (en) * | 2014-10-22 | 2020-09-03 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
CA2965363A1 (en) * | 2014-10-22 | 2016-04-28 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
AU2015335772B2 (en) | 2014-10-22 | 2020-07-09 | Oculeve, Inc. | Contact lens for increasing tear production |
KR101483402B1 (ko) * | 2014-10-31 | 2015-01-15 | 안선종 | 안구 건조증 치료 및 시력 강화기 |
CA2989814A1 (en) | 2015-06-16 | 2016-12-22 | The Regents Of The University Of Colorado, A Body Corporate | Nasolacrimal implants and related methods for tear stimulation |
ITUB20154761A1 (it) * | 2015-10-29 | 2017-04-29 | Resono Ophthalmic S R L | Sistema di elettrodo e relativo dispositivo per il trattamento di patologie dell?occhio, in particolare dell?occhio secco |
US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
IL243686B (en) | 2016-01-19 | 2022-05-01 | Epitech Mag Ltd | Device for increasing the integrity of the eye epithelium using magnetic pulses |
US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
US10918871B2 (en) * | 2016-02-23 | 2021-02-16 | Verily Life Sciences Llc | Systems and methods for peripheral nervous stimulation for metabolic and endocrine function |
US10695219B2 (en) * | 2016-04-08 | 2020-06-30 | ThermiGen, LLC | Apparatus and method for treatment of dry eye using radio frequency heating |
US10918864B2 (en) | 2016-05-02 | 2021-02-16 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
US10406360B2 (en) * | 2016-09-13 | 2019-09-10 | Richard Charles Niemtzow | Electrical acupuncture eye treatment |
RU2019118600A (ru) | 2016-12-02 | 2021-01-11 | Окулив, Инк. | Аппарат и способ составления прогноза синдрома сухого глаза и рекомендаций по лечению |
IL253677B2 (en) | 2017-07-26 | 2023-06-01 | Epitech Mag Ltd | A magnetic device for the treatment of living tissues |
US11318066B2 (en) | 2018-02-26 | 2022-05-03 | Olympic Ophthalmics, Inc. | Handheld device with vibrational cantilever member for treatment of disorders |
US20210393957A1 (en) * | 2018-10-02 | 2021-12-23 | Tufts Medical Center, Inc. | Systems and Methods for Sensing and Correcting Electrical Activity of Nerve Tissue |
US11607172B2 (en) * | 2018-12-21 | 2023-03-21 | Verily Life Sciences Llc | Impedance sensor for ophthalmic device using shared antenna electrode |
US11298537B2 (en) | 2019-03-26 | 2022-04-12 | Twenty Twenty Therapeutics Llc | Non-invasive periocular device for dry-eye treatment and closed-loop methods for operating same |
US11376432B2 (en) | 2019-03-26 | 2022-07-05 | Twenty Twenty Therapeutics Llc | Non-invasive periocular device for dry-eye treatment |
WO2020206140A1 (en) * | 2019-04-02 | 2020-10-08 | The Regents Of The University Of California | Method and apparatus to modify the cornea using electrochemistry |
US11446495B2 (en) * | 2019-05-14 | 2022-09-20 | Twenty Twenty Therapeutics Llc | Therapeutic devices for placement underneath the eyelid and associated systems, devices, and methods for dry eye treatment |
US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
WO2021086924A1 (en) * | 2019-10-28 | 2021-05-06 | University Of Southern California | System and method to induce epigenetic changes to the cells and tissue of the eye and orbit |
US20220031506A1 (en) * | 2020-08-03 | 2022-02-03 | Twenty Twenty Therapeutics Llc | Ophthalmic devices, systems and methods for treating dry eye |
WO2022187376A1 (en) * | 2021-03-02 | 2022-09-09 | University Of Southern California | Bioelectronic lens (e-lens) system for electrical stimulation and neuroprotection of the retina |
WO2023091611A1 (en) * | 2021-11-19 | 2023-05-25 | I-Lumen Scientific, Inc. | Method and system for eye treatment |
WO2023242367A1 (en) * | 2022-06-15 | 2023-12-21 | Capri Medical Limited | Neural implant system and method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147284A (en) * | 1989-08-17 | 1992-09-15 | Fedorov Svjatoslav N | Device and method for restoration of visual functions |
US20030233135A1 (en) * | 2002-06-14 | 2003-12-18 | Yee Richard W. | Method and apparatus for preventing and treating eyelid problems |
JP2008055000A (ja) * | 2006-08-31 | 2008-03-13 | Nidek Co Ltd | 視覚再生補助装置 |
JP2010051562A (ja) * | 2008-08-28 | 2010-03-11 | Tohoku Univ | 生体の深部刺激方法及び生体深部の刺激装置 |
Family Cites Families (392)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2525381A (en) | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
US2512881A (en) | 1948-10-06 | 1950-06-27 | Donald T Wilson | Kingpin bearing assembly |
US2512882A (en) | 1949-08-17 | 1950-06-27 | R G Truesdale Co Inc | Serum inoculator |
US3620219A (en) | 1969-05-07 | 1971-11-16 | Donald E Barker | Facial nerve stimulator |
US3709228A (en) | 1971-01-07 | 1973-01-09 | D Barker | Apparatus for facial stimulation |
FR2210298A5 (ja) | 1972-12-08 | 1974-07-05 | Commissariat Energie Atomique | |
USD257495S (en) | 1979-05-29 | 1980-11-04 | Hot Shot Products Co. | Housing for an electric cattle prod |
US4684362A (en) | 1981-03-12 | 1987-08-04 | Holt James J | Method for collecting nasal secretions |
US4520825A (en) | 1982-04-30 | 1985-06-04 | Medtronic, Inc. | Digital circuit for control of gradual turn-on of electrical tissue stimulators |
US4495676A (en) | 1982-08-02 | 1985-01-29 | Hartmetz Ii Gerald J | Apparatus for electrically stimulating an animal carcass |
CH677883A5 (ja) | 1982-11-15 | 1991-07-15 | Symtonic Sa | |
US4539988A (en) | 1983-07-05 | 1985-09-10 | Packaging Corporation International | Disposable automatic lancet |
US5025807A (en) | 1983-09-14 | 1991-06-25 | Jacob Zabara | Neurocybernetic prosthesis |
DE3483160D1 (de) | 1983-09-14 | 1990-10-11 | Jacob Zabara | Neurocybernetische prothese. |
US4590942A (en) | 1984-02-17 | 1986-05-27 | Biosonics, Inc. | Apparatus and method for inhibiting nasal secretions |
DE3501095A1 (de) | 1985-01-15 | 1986-07-17 | Gerd Prof. Dr. 8520 Erlangen Kobal | Verfahren zur messung von sensorischen qualitaeten und einrichtung zur durchfuehrung des verfahrens |
JPS61203935A (ja) | 1985-03-07 | 1986-09-09 | 日石三菱株式会社 | 網膜電図測定用電極 |
US4628933A (en) | 1985-07-23 | 1986-12-16 | Michelson Robin P | Method and apparatus for visual prosthesis |
NZ214348A (en) | 1985-11-27 | 1988-07-28 | Walker T H & Sons Ltd | Electrically stunning animals through nose and neck contacts |
US4868154A (en) | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
US4777954A (en) | 1986-06-30 | 1988-10-18 | Nepera Inc. | Conductive adhesive medical electrode assemblies |
US4706680A (en) | 1986-06-30 | 1987-11-17 | Nepera Inc. | Conductive adhesive medical electrode assemblies |
US4957480A (en) | 1988-02-02 | 1990-09-18 | Universal Health Products, Inc. | Method of facial toning |
US4926880A (en) | 1988-11-08 | 1990-05-22 | Microcurrents | Method for relieving sinus and nasal congestion utilizing microcurrents |
US4988358A (en) | 1988-12-28 | 1991-01-29 | Eppley Barry L | Method for promoting hard tissue growth and repair in mammals |
US5259373A (en) | 1989-05-19 | 1993-11-09 | Puritan-Bennett Corporation | Inspiratory airway pressure system controlled by the detection and analysis of patient airway sounds |
US5078733A (en) | 1990-04-12 | 1992-01-07 | Eveleigh Robert B | Pacifier for premature newborns |
US5090422A (en) * | 1990-04-19 | 1992-02-25 | Cardiac Pacemakers, Inc. | Implantable electrode pouch |
US5099829A (en) | 1990-04-25 | 1992-03-31 | Wu An Chuan | Massage device good for eyes |
US5342410A (en) | 1990-10-05 | 1994-08-30 | Eric Braverman | Apparatus and method for increasing the amplitude of P300 waves in the human brain |
US5072724A (en) | 1990-11-23 | 1991-12-17 | Joseph Marcus | Vibrational liquid-wave stimulating therapy mask apparatus for facial health and beauty care |
US5533470A (en) | 1991-07-05 | 1996-07-09 | Rose; Andrew F. | Electronic nose-clip with solar cell |
US5640978A (en) | 1991-11-06 | 1997-06-24 | Diolase Corporation | Method for pain relief using low power laser light |
US5193539A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Implantable microstimulator |
US6063079A (en) | 1995-06-07 | 2000-05-16 | Arthrocare Corporation | Methods for electrosurgical treatment of turbinates |
US5352445A (en) | 1992-05-07 | 1994-10-04 | Lavaux Joseph E | Lavaux tear test lacrimal equilibration time (LET) |
AU2259292A (en) | 1992-06-24 | 1994-01-24 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
US5360438A (en) | 1993-01-26 | 1994-11-01 | Fisher Mary R | Method and device for improving cranial nerve function to improve muscle function and thereby overcome visual/perceptual dysfunction |
AU679496B2 (en) | 1993-01-28 | 1997-07-03 | Pilkington Barnes Hind, Inc. | Material in the manufacture of polymeric articles |
US5345948A (en) | 1993-04-08 | 1994-09-13 | Donnell Jr Francis E O | Method of performing translactrimal laser dacryocystorhinostomy |
US5545617A (en) | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
US5713833A (en) | 1994-01-26 | 1998-02-03 | Milligan; Lee John | Septum nerve stimulator |
EP0742753B1 (en) | 1994-01-31 | 1998-08-26 | Bausch & Lomb Incorporated | Method of cast molding toric contact lenses |
IL108772A0 (en) | 1994-02-24 | 1994-05-30 | Amcor Ltd | Treatment of rhinitis by biostimulative illumination |
AUPM982694A0 (en) | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
US5643336A (en) | 1995-01-09 | 1997-07-01 | Lopez-Claros; Marcelo Enrique | Heating and cooling pad |
US5735817A (en) | 1995-05-19 | 1998-04-07 | Shantha; T. R. | Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures |
US5640764A (en) | 1995-05-22 | 1997-06-24 | Alfred E. Mann Foundation For Scientific Research | Method of forming a tubular feed-through hermetic seal for an implantable medical device |
US5571101A (en) | 1995-05-25 | 1996-11-05 | Ellman; Alan G. | Electrosurgical electrode for DCR surgical procedure |
US5707400A (en) | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
US5607461A (en) | 1995-10-20 | 1997-03-04 | Nexmed, Inc. | Apparatus and method for delivering electrical stimulus to tissue |
DE19549297C2 (de) | 1995-12-22 | 1998-07-02 | Guenter Stielau | Verfahren und Vorrichtung zur Beeinflussung der menschlichen Psyche |
WO1997029802A2 (en) | 1996-02-20 | 1997-08-21 | Advanced Bionics Corporation | Improved implantable microstimulator and systems employing the same |
US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
DE69733261T2 (de) | 1996-08-23 | 2006-01-19 | Osteobiologics, Inc., San Antonio | Tragbares materialprüfgerät |
US5697957A (en) | 1996-08-29 | 1997-12-16 | Pacesetter Ab | Adaptive method and apparatus for extracting an evoked response component from a sensed cardiac signal by suppressing electrode polarization components |
US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
US5800685A (en) | 1996-10-28 | 1998-09-01 | Cardiotronics Systems, Inc. | Electrically conductive adhesive hydrogels |
US7460911B2 (en) * | 1997-02-26 | 2008-12-02 | Alfred E. Mann Foundation For Scientific Research | System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
US6458157B1 (en) | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
US6020445A (en) | 1997-10-09 | 2000-02-01 | Johnson & Johnson Vision Products, Inc. | Silicone hydrogel polymers |
EP1032392A4 (en) | 1997-10-29 | 2001-05-09 | J Med Pharmaceuticals Inc | RHINITIS TREATMENT BY ANTIHISTAMINE / DECONGESTIVUM ADMINISTRATION |
US6083251A (en) | 1997-11-13 | 2000-07-04 | Shindo; Kohei | Eye treatment method and apparatus |
FR2771297B1 (fr) | 1997-11-25 | 2000-02-11 | Pierre Andre Jacques Bige | Sonde bicanaliculaire pour le traitement du larmoiement de l'oeil |
US6050999A (en) | 1997-12-18 | 2000-04-18 | Keravision, Inc. | Corneal implant introducer and method of use |
US5935155A (en) | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
US6324429B1 (en) | 1998-05-08 | 2001-11-27 | Massachusetts Eye And Ear Infirmary | Chronically implantable retinal prosthesis |
CA2336190A1 (en) | 1998-07-06 | 2000-01-13 | Advanced Bionics Corporation | Implantable stimulator system and method for treatment of urinary incontinence |
US6035236A (en) | 1998-07-13 | 2000-03-07 | Bionergy Therapeutics, Inc. | Methods and apparatus for electrical microcurrent stimulation therapy |
US6272382B1 (en) | 1998-07-31 | 2001-08-07 | Advanced Bionics Corporation | Fully implantable cochlear implant system |
US6240316B1 (en) | 1998-08-14 | 2001-05-29 | Advanced Bionics Corporation | Implantable microstimulation system for treatment of sleep apnea |
EP1109490A4 (en) | 1998-09-04 | 2005-03-02 | Wolfe Res Pty Ltd | MEDICAL PROSTHESIS SYSTEM |
US7346389B1 (en) | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
US6275737B1 (en) | 1998-10-14 | 2001-08-14 | Advanced Bionics Corporation | Transcutaneous transmission pouch |
US5948006A (en) | 1998-10-14 | 1999-09-07 | Advanced Bionics Corporation | Transcutaneous transmission patch |
US6208902B1 (en) | 1998-10-26 | 2001-03-27 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator |
US6366814B1 (en) | 1998-10-26 | 2002-04-02 | Birinder R. Boveja | External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders |
US7076307B2 (en) * | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
US6205359B1 (en) | 1998-10-26 | 2001-03-20 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator |
US6564102B1 (en) | 1998-10-26 | 2003-05-13 | Birinder R. Boveja | Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator |
US6329485B1 (en) | 1998-12-11 | 2001-12-11 | Bausch & Lomb Incorporated | High refractive index hydrogel compositions for ophthalmic implants |
GB2345010B (en) | 1998-12-17 | 2002-12-31 | Electrosols Ltd | A delivery device |
AU772100B2 (en) | 1999-02-08 | 2004-04-08 | Cochlear Limited | Offset coils for radio frequency transcutaneous links |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
WO2000052466A2 (en) | 1999-03-05 | 2000-09-08 | University Of Miami | Measurement of tear fluorescein clearance |
WO2000056393A1 (en) | 1999-03-24 | 2000-09-28 | Second Sight, Llc | Retinal color prosthesis for color sight restoration |
EP1171032A4 (en) | 1999-04-15 | 2008-10-29 | Surgi Vision | PROCESS FOR IN VIVO IMAGING BY MAGNETIC RESONANCE |
US6178352B1 (en) * | 1999-05-07 | 2001-01-23 | Woodside Biomedical, Inc. | Method of blood pressure moderation |
US6200626B1 (en) | 1999-05-20 | 2001-03-13 | Bausch & Lomb Incorporated | Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization |
TWI225398B (en) | 1999-07-14 | 2004-12-21 | R Tech Ueno Ltd | Composition for treatment of external secretion disorders |
US6516227B1 (en) | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
US7177690B2 (en) * | 1999-07-27 | 2007-02-13 | Advanced Bionics Corporation | Implantable system having rechargeable battery indicator |
US6237604B1 (en) | 1999-09-07 | 2001-05-29 | Scimed Life Systems, Inc. | Systems and methods for preventing automatic identification of re-used single use devices |
US6368324B1 (en) | 1999-09-24 | 2002-04-09 | Medtronic Xomed, Inc. | Powered surgical handpiece assemblies and handpiece adapter assemblies |
US6853946B2 (en) | 1999-11-05 | 2005-02-08 | Adam Cohen | Air flow sensing and control for animal confinement system |
EP1110509A1 (en) | 1999-12-21 | 2001-06-27 | Tomaso Vercellotti | Surgical device for bone surgery |
US6885888B2 (en) | 2000-01-20 | 2005-04-26 | The Cleveland Clinic Foundation | Electrical stimulation of the sympathetic nerve chain |
US20040039401A1 (en) | 2000-03-31 | 2004-02-26 | Chow Alan Y. | Implant instrument |
US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
US6284765B1 (en) | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
US6853858B2 (en) | 2000-05-08 | 2005-02-08 | Brainsgate, Ltd. | Administration of anti-inflammatory drugs into the central nervous system |
AU5662001A (en) | 2000-05-08 | 2001-11-20 | Brainsgate Ltd. | Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow |
US7117033B2 (en) | 2000-05-08 | 2006-10-03 | Brainsgate, Ltd. | Stimulation for acute conditions |
US7146209B2 (en) | 2000-05-08 | 2006-12-05 | Brainsgate, Ltd. | Stimulation for treating eye pathologies |
US20020035358A1 (en) * | 2000-05-09 | 2002-03-21 | Ming Wang | Pulsed electromagnetic field therapy for treatment of corneal disorders and injuries |
US6327504B1 (en) | 2000-05-10 | 2001-12-04 | Thoratec Corporation | Transcutaneous energy transfer with circuitry arranged to avoid overheating |
US6592860B1 (en) | 2000-05-30 | 2003-07-15 | Soluble Systems, Llc | Composition and applicator for topical substance delivery |
US6526318B1 (en) | 2000-06-16 | 2003-02-25 | Mehdi M. Ansarinia | Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions |
EP1166820B1 (en) | 2000-06-19 | 2009-09-30 | Medtronic, Inc. | Implantable medical device with external recharging coil |
US6505077B1 (en) | 2000-06-19 | 2003-01-07 | Medtronic, Inc. | Implantable medical device with external recharging coil electrical connection |
US6871099B1 (en) | 2000-08-18 | 2005-03-22 | Advanced Bionics Corporation | Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain |
US6535766B1 (en) | 2000-08-26 | 2003-03-18 | Medtronic, Inc. | Implanted medical device telemetry using integrated microelectromechanical filtering |
US6539253B2 (en) | 2000-08-26 | 2003-03-25 | Medtronic, Inc. | Implantable medical device incorporating integrated circuit notch filters |
ATE490801T1 (de) | 2000-09-13 | 2010-12-15 | Mann Medical Res Organization | Gerät zur konditionierung von muskeln im schlaf |
WO2002032499A1 (en) * | 2000-09-14 | 2002-04-25 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Method and apparatus to treat disorders of gastrointestinal peristalsis |
US6405079B1 (en) | 2000-09-22 | 2002-06-11 | Mehdi M. Ansarinia | Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions |
US6652095B2 (en) | 2000-11-17 | 2003-11-25 | Hsiao-Ching Tung | Orthokeratology and bi-focal contact lens |
US20050251061A1 (en) | 2000-11-20 | 2005-11-10 | Schuler Eleanor L | Method and system to record, store and transmit waveform signals to regulate body organ function |
JP2002159340A (ja) | 2000-11-28 | 2002-06-04 | Ya Man Ltd | 美顔装置 |
US7477947B2 (en) | 2001-01-30 | 2009-01-13 | Erella Pines | System and method for electrical stimulation of salivation |
EP1234553A1 (de) | 2001-02-14 | 2002-08-28 | Boris-Wolfgang Hochleitner | Bioartifizielles Gerät |
JP4781576B2 (ja) * | 2001-02-28 | 2011-09-28 | 株式会社ニデック | 眼内埋め込み型視覚刺激装置 |
NO313683B1 (no) | 2001-03-21 | 2002-11-18 | Turid Bergersen | Anordning for akupressurisk behandling |
JP2004526510A (ja) | 2001-03-30 | 2004-09-02 | ケース ウエスタン リザーブ ユニバーシティ | 選択的生理学的応答を達成するための、陰部神経または陰部神経枝の中、その上またはその付近の成分を選択的に刺激するためのシステムおよび方法 |
US6701189B2 (en) * | 2001-03-30 | 2004-03-02 | Neurocontrol Corporation | Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a universal external controller accommodating different control inputs and/or different control outputs |
US6662052B1 (en) | 2001-04-19 | 2003-12-09 | Nac Technologies Inc. | Method and system for neuromodulation therapy using external stimulator with wireless communication capabilites |
US7369897B2 (en) | 2001-04-19 | 2008-05-06 | Neuro And Cardiac Technologies, Llc | Method and system of remotely controlling electrical pulses provided to nerve tissue(s) by an implanted stimulator system for neuromodulation therapies |
JP2004532849A (ja) | 2001-04-20 | 2004-10-28 | カイロン コーポレイション | 中枢神経系へのポリヌクレオチド薬剤の送達 |
US6907295B2 (en) | 2001-08-31 | 2005-06-14 | Biocontrol Medical Ltd. | Electrode assembly for nerve control |
AT411150B (de) | 2001-05-25 | 2003-10-27 | Nova Technical Res Gmbh | Einrichtung zum einbringen von stoffen |
US6537265B2 (en) | 2001-06-08 | 2003-03-25 | Health Research, Inc. | Method for nasal application of a medicinal substance |
US6792314B2 (en) | 2001-06-18 | 2004-09-14 | Alfred E. Mann Foundation For Scientific Research | Miniature implantable array and stimulation system suitable for eyelid stimulation |
US7054692B1 (en) | 2001-06-22 | 2006-05-30 | Advanced Bionics Corporation | Fixation device for implantable microdevices |
US7031776B2 (en) | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
US20050004625A1 (en) | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US7974693B2 (en) | 2001-08-31 | 2011-07-05 | Bio Control Medical (B.C.M.) Ltd. | Techniques for applying, configuring, and coordinating nerve fiber stimulation |
US7778703B2 (en) * | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
US7885709B2 (en) | 2001-08-31 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation for treating disorders |
US6792312B2 (en) | 2001-09-06 | 2004-09-14 | Medtronic, Inc. | Connector module having internal weld plates |
US20030062050A1 (en) | 2001-10-01 | 2003-04-03 | Bruno Schmidt | Anti-snoring devices and methods |
US6829508B2 (en) | 2001-10-19 | 2004-12-07 | Alfred E. Mann Foundation For Scientific Research | Electrically sensing and stimulating system for placement of a nerve stimulator or sensor |
US6562036B1 (en) | 2001-12-10 | 2003-05-13 | Ellman Alan G | Electrosurgical electrode for rhinoplasty |
JP2003210513A (ja) | 2002-01-23 | 2003-07-29 | Nidek Co Ltd | 眼科用治療装置 |
EP1487535B1 (en) | 2002-03-27 | 2012-06-20 | CVRX, Inc. | Electrode structures for use in cardiovascular reflex control |
US6641799B2 (en) | 2002-04-03 | 2003-11-04 | Nos Spray, Inc. | Nasal spray for decongesting nasal passages |
US6974533B2 (en) | 2002-04-11 | 2005-12-13 | Second Sight Medical Products, Inc. | Platinum electrode and method for manufacturing the same |
US7645262B2 (en) | 2002-04-11 | 2010-01-12 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
US7142909B2 (en) * | 2002-04-11 | 2006-11-28 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
US6604528B1 (en) | 2002-04-22 | 2003-08-12 | Lloyd P. Duncan | Acid reflux and snoring device |
US20050165458A1 (en) | 2002-05-09 | 2005-07-28 | Boveja Birinder R. | Method and system to provide therapy for depression using electroconvulsive therapy(ECT) and pulsed electrical stimulation to vagus nerve(s) |
US20060004423A1 (en) | 2002-05-09 | 2006-01-05 | Boveja Birinder R | Methods and systems to provide therapy or alleviate symptoms of chronic headache, transformed migraine, and occipital neuralgia by providing rectangular and/or complex electrical pulses to occipital nerves |
US8036745B2 (en) | 2004-06-10 | 2011-10-11 | Bio Control Medical (B.C.M.) Ltd. | Parasympathetic pacing therapy during and following a medical procedure, clinical trauma or pathology |
US8204591B2 (en) | 2002-05-23 | 2012-06-19 | Bio Control Medical (B.C.M.) Ltd. | Techniques for prevention of atrial fibrillation |
JP2005528169A (ja) | 2002-06-03 | 2005-09-22 | メド−エル・エレクトロメディツィニシェ・ゲラーテ・ゲーエムベーハー | コイルに対する可撓性相互接続器を有する移植可能なデバイス |
US7860570B2 (en) | 2002-06-20 | 2010-12-28 | Boston Scientific Neuromodulation Corporation | Implantable microstimulators and methods for unidirectional propagation of action potentials |
US20040147973A1 (en) * | 2002-06-27 | 2004-07-29 | Hauser Robert G. | Intra cardiac pacer and method |
US6904868B2 (en) | 2002-07-12 | 2005-06-14 | Robert S. Block | Interactive mobile food dispenser |
CN1301692C (zh) | 2002-09-18 | 2007-02-28 | 阿勒根公司 | 眼植入物导入的器械 |
US7169163B2 (en) | 2002-09-30 | 2007-01-30 | Bruce Becker | Transnasal method and catheter for lacrimal system |
AU2003284018A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
US7349741B2 (en) | 2002-10-11 | 2008-03-25 | Advanced Bionics, Llc | Cochlear implant sound processor with permanently integrated replenishable power source |
US20040092992A1 (en) | 2002-10-23 | 2004-05-13 | Kenneth Adams | Disposable battery powered rotary tissue cutting instruments and methods therefor |
JP2006515999A (ja) | 2002-11-14 | 2006-06-15 | ブレインズゲート リミティド | 刺激のための外科用ツール及び技法 |
US7024241B1 (en) | 2002-12-05 | 2006-04-04 | Pacesetter, Inc. | Pacing pulse waveforms that support simultaneous intracardiac signal sensing and analysis |
TR200202651A2 (tr) | 2002-12-12 | 2004-07-21 | Met�N�Tulgar | VücutÁdışındanÁdirekÁtedaviÁsinyaliÁtransferliÁÁbeyinÁpili |
US7264859B2 (en) | 2002-12-19 | 2007-09-04 | Kimberly-Clark Worldwide, Inc. | Lubricious coating for medical devices |
US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US7228184B2 (en) | 2003-02-22 | 2007-06-05 | Chester Heath | Viral-inhibiting method |
US7321795B2 (en) | 2003-03-24 | 2008-01-22 | Les Bogdanowicz | Compositions for electric stimulation of the eye |
WO2004091453A1 (en) | 2003-04-15 | 2004-10-28 | Eyeborn (Proprietary) Limited | An orbital implant applicator |
US20060074450A1 (en) | 2003-05-11 | 2006-04-06 | Boveja Birinder R | System for providing electrical pulses to nerve and/or muscle using an implanted stimulator |
US7317947B2 (en) | 2003-05-16 | 2008-01-08 | Medtronic, Inc. | Headset recharger for cranially implantable medical devices |
US7058446B2 (en) | 2003-07-10 | 2006-06-06 | Science Medicus, Inc. | Regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US7725176B2 (en) | 2003-07-10 | 2010-05-25 | Schuler Eleanor L | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
JP2005052461A (ja) * | 2003-08-06 | 2005-03-03 | Pop Denshi Kk | 生体への電流印加装置 |
CN1253147C (zh) | 2003-08-13 | 2006-04-26 | 复旦大学 | 一种超多孔水凝胶复合物,其制备方法及其在药剂学中的应用 |
ES2243116B1 (es) | 2003-09-22 | 2007-02-01 | Josep Duran Von Arx | Estimulador nasal. |
US7225032B2 (en) | 2003-10-02 | 2007-05-29 | Medtronic Inc. | External power source, charger and system for an implantable medical device having thermal characteristics and method therefore |
DE10353000A1 (de) | 2003-11-13 | 2005-06-16 | Physiomed Elektromedizin Ag | Vorrichtung zur Elektrotherapie |
WO2005060984A1 (en) * | 2003-12-12 | 2005-07-07 | Yee Richard W | Method and apparatus for preventing and treating eyelid problems |
US7045559B2 (en) | 2003-12-18 | 2006-05-16 | Kimberly-Clark Worldwide, Inc. | Electrically conductive adhesive hydrogels with solubilizer |
WO2005070494A1 (en) | 2004-01-22 | 2005-08-04 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
US20080132969A1 (en) | 2004-02-12 | 2008-06-05 | Ndi Medical, Inc. | Systems and methods for bilateral stimulation of left and right branches of the dorsal genital nerves to treat urologic dysfunctions |
US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
US20050203600A1 (en) * | 2004-03-12 | 2005-09-15 | Scimed Life Systems, Inc. | Collapsible/expandable tubular electrode leads |
CN2693275Y (zh) | 2004-03-30 | 2005-04-20 | 孙作东 | 作用于嗅觉神经的电子治疗仪 |
US7993381B2 (en) | 2004-04-01 | 2011-08-09 | Mac Beam, Inc. | Method and apparatus for treating the body |
US7571007B2 (en) | 2004-04-12 | 2009-08-04 | Advanced Neuromodulation Systems, Inc. | Systems and methods for use in pulse generation |
US8353896B2 (en) | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
US7359751B1 (en) | 2004-05-05 | 2008-04-15 | Advanced Neuromodulation Systems, Inc. | Clinician programmer for use with trial stimulator |
US7402175B2 (en) | 2004-05-17 | 2008-07-22 | Massachusetts Eye & Ear Infirmary | Vision prosthesis orientation |
US20050268472A1 (en) | 2004-06-07 | 2005-12-08 | Bourilkov Jordan T | Shaving systems |
US7330762B2 (en) | 2004-06-07 | 2008-02-12 | Neuro And Cardiac Technologies, Llc | Method and system for providing pulsed electrical stimulation to provide therapy for erectile/sexual dysfunction, prostatitis, prostatitis pain, and chronic pelvic pain |
WO2006007402A2 (en) | 2004-06-16 | 2006-01-19 | University Of Massachusets | Poly (lactid acid) copolymer hydrogels and related methods of drug delivery |
WO2006021957A2 (en) | 2004-08-23 | 2006-03-02 | Brainsgate Ltd. | Concurrent bilateral spg modulation |
US20090099623A1 (en) | 2004-09-13 | 2009-04-16 | Neuronix Ltd. | Systems and methods for treatment of medical conditions related to the central nervous system and for enhancing cognitive functions |
US7641688B2 (en) | 2004-09-16 | 2010-01-05 | Evera Medical, Inc. | Tissue augmentation device |
GB2418143B (en) | 2004-09-21 | 2010-03-17 | Can Do Corp Ltd | Apparatus for behaviour modification |
US7247692B2 (en) | 2004-09-30 | 2007-07-24 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing amphiphilic block copolymers |
WO2006045075A1 (en) | 2004-10-20 | 2006-04-27 | Boston Scientific Limited | Leadless cardiac stimulation systems |
US7647109B2 (en) | 2004-10-20 | 2010-01-12 | Boston Scientific Scimed, Inc. | Leadless cardiac stimulation systems |
US7497836B2 (en) | 2004-10-22 | 2009-03-03 | General Patent Llc | Germicidal method for treating or preventing sinusitis |
CN100574700C (zh) | 2004-10-28 | 2009-12-30 | 桑特拉医学公司 | 使用水凝胶对分析物取样和分析的系统和方法 |
US20060095077A1 (en) * | 2004-10-29 | 2006-05-04 | Tronnes Carole A | Expandable fixation structures |
US8489189B2 (en) * | 2004-10-29 | 2013-07-16 | Medtronic, Inc. | Expandable fixation mechanism |
ATE408432T1 (de) * | 2004-11-02 | 2008-10-15 | Sydney Biotech Pty Ltd | Extraokulare vorrichtung |
US20090264966A1 (en) | 2004-11-02 | 2009-10-22 | Pixeloptics, Inc. | Device for Inductive Charging of Implanted Electronic Devices |
US7547447B2 (en) | 2004-11-15 | 2009-06-16 | Doheny Eye Institute | Bioartificial lacrimal gland |
US20060107958A1 (en) | 2004-11-22 | 2006-05-25 | Sleeper Geoffrey P | Adjustable sealing nasal cannula |
EP1671670A1 (fr) | 2004-12-14 | 2006-06-21 | STX Sprl | Appareil pour l'electro-inhibition des muscles de la face |
US20070250119A1 (en) | 2005-01-11 | 2007-10-25 | Wicab, Inc. | Systems and methods for altering brain and body functions and for treating conditions and diseases of the same |
US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
US20120053648A1 (en) | 2005-02-08 | 2012-03-01 | Rolf Neher | Systems and methods for smoking cessation. |
US20070248930A1 (en) | 2005-02-17 | 2007-10-25 | Biolux Research Ltd. | Light therapy apparatus and methods |
US8224444B2 (en) | 2005-02-18 | 2012-07-17 | Bio Control Medical (B.C.M.) Ltd. | Intermittent electrical stimulation |
JP4597702B2 (ja) | 2005-02-24 | 2010-12-15 | ピジョン株式会社 | 口唇閉鎖具 |
US20070060954A1 (en) | 2005-02-25 | 2007-03-15 | Tracy Cameron | Method of using spinal cord stimulation to treat neurological disorders or conditions |
US7555345B2 (en) | 2005-03-11 | 2009-06-30 | Medtronic, Inc. | Implantable neurostimulator device |
US7702385B2 (en) | 2005-11-16 | 2010-04-20 | Boston Scientific Neuromodulation Corporation | Electrode contact configurations for an implantable stimulator |
US7565204B2 (en) * | 2005-03-24 | 2009-07-21 | Alfred E. Mann Foundation For Scientific Research | Implantable device for controlling received power by a power receiving unit therein |
US20060239482A1 (en) | 2005-04-13 | 2006-10-26 | Nagi Hatoum | System and method for providing a waveform for stimulating biological tissue |
JP2008536866A (ja) | 2005-04-15 | 2008-09-11 | ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ | アミン作動性医薬組成物および方法 |
US20060235430A1 (en) | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
JP2006311917A (ja) | 2005-05-09 | 2006-11-16 | Shozo Terauchi | 低周波電気刺激装置 |
US7551958B2 (en) | 2005-05-24 | 2009-06-23 | Cardiac Pacemakers, Inc. | Safety control system for implantable neural stimulator |
US7947076B2 (en) | 2005-06-03 | 2011-05-24 | Medtronic Xomed, Inc. | Nasal valve treatment method and apparatus |
US20060276738A1 (en) | 2005-06-06 | 2006-12-07 | Becker Bruce B | Lacrimal drainage bypass device and method |
ATE496652T1 (de) | 2005-06-09 | 2011-02-15 | Medtronic Inc | Implantierbare medizinische leitung |
US7792591B2 (en) | 2005-06-09 | 2010-09-07 | Medtronic, Inc. | Introducer for therapy delivery elements |
US8606362B2 (en) | 2005-07-08 | 2013-12-10 | Boston Scientific Neuromodulation Corporation | Current output architecture for an implantable stimulator device |
DE102005032989A1 (de) | 2005-07-14 | 2007-01-25 | Imi Intelligent Medical Implants Ag | Extraokulares Epiretinal-Implantat |
US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
US20070016256A1 (en) | 2005-07-18 | 2007-01-18 | Korb Donald R | Method and apparatus for treating gland dysfunction |
US9962558B2 (en) | 2005-08-05 | 2018-05-08 | Gholam A. Peyman | Methods to regulate polarization and enhance function of cells |
US20070031341A1 (en) | 2005-08-08 | 2007-02-08 | Dimauro Thomas M | Methods of delivering therapeutics to the brain |
JP2007044323A (ja) * | 2005-08-11 | 2007-02-22 | Nidek Co Ltd | 視覚再生補助装置 |
ATE481700T1 (de) * | 2005-08-11 | 2010-10-15 | Sleep Diagnostics Pty Ltd | Wachheit erfassende brillen |
US8005526B2 (en) | 2005-08-31 | 2011-08-23 | The Regents Of The University Of Michigan | Biologically integrated electrode devices |
US7805202B2 (en) | 2005-09-30 | 2010-09-28 | Boston Scientific Neuromodulation Corporation | Implantable electrodes and insertion methods and tools |
US8676324B2 (en) | 2005-11-10 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
US7729758B2 (en) | 2005-11-30 | 2010-06-01 | Boston Scientific Neuromodulation Corporation | Magnetically coupled microstimulators |
US7444181B2 (en) | 2005-12-14 | 2008-10-28 | Boston Scientific Neuromodulation Corporation | Techniques for sensing and adjusting a compliance voltage in an implantable stimulator device |
JP2009523503A (ja) | 2006-01-16 | 2009-06-25 | コンティネンス コントロール システムズ インターナショナル プロプライエタリー リミテッド | 身体機能を制御するための刺激装置 |
US8721656B2 (en) | 2006-01-17 | 2014-05-13 | Transcend Medical, Inc. | Glaucoma treatment device |
US8118752B2 (en) | 2006-02-16 | 2012-02-21 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for mapping retinal function |
EP1984066B1 (en) * | 2006-02-16 | 2020-05-06 | Imthera Medical, Inc. | An rfid based system for therapeutic treatment of a patient |
IES20060134A2 (en) | 2006-02-23 | 2007-09-05 | Sensor Technologies And Device | Biomedical surface electrode |
US20070219600A1 (en) | 2006-03-17 | 2007-09-20 | Michael Gertner | Devices and methods for targeted nasal phototherapy |
US20070237797A1 (en) | 2006-03-28 | 2007-10-11 | Gholam A. Peyman | Neural Conduit Agent Dissemination |
US20070250135A1 (en) | 2006-04-21 | 2007-10-25 | Bartz-Schmidt Karl U | Compound subretinal prostheses with extra-ocular parts and surgical technique therefore |
US20070255333A1 (en) | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Neuromodulation therapy for perineal or dorsal branch of pudendal nerve |
US9314369B2 (en) * | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
US20090204142A1 (en) | 2006-05-26 | 2009-08-13 | Becker Bruce B | Nasolacrimal system surgical tool and method |
US20070276314A1 (en) | 2006-05-26 | 2007-11-29 | Becker Bruce B | Nasolacrimal duct probing, intubating and irrigating device |
US20070299462A1 (en) | 2006-06-23 | 2007-12-27 | Becker Bruce B | Nasolacrimal system irrigation and dilatation tool |
US8231218B2 (en) | 2006-06-15 | 2012-07-31 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
US8311634B2 (en) | 2006-06-16 | 2012-11-13 | Second Sight Medical Products Inc. | Apparatus and method for electrical stimulation of human retina |
US20070299420A1 (en) | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an agent using iontophoresis |
US8080047B2 (en) | 2006-08-01 | 2011-12-20 | Mesure Technology Co., Ltd. | Light therapy device |
US8295529B2 (en) | 2006-08-28 | 2012-10-23 | Bcinet, Inc. | Gaming headset with integrated microphone and adapted for olfactory stimulation |
US20090239235A1 (en) | 2006-09-20 | 2009-09-24 | Demaria Christine | Facs- and Reporter Protein-Based System for High Throughput Development of Therapeutic Proteins |
WO2008039921A2 (en) | 2006-09-27 | 2008-04-03 | Huntington Medical Research Institutes | Apparatus and method for treating obstructive sleep apnea |
US20080082057A1 (en) | 2006-09-29 | 2008-04-03 | Korb Donald R | Method and apparatus for diagnosing meibomian gland dysfunction |
US20080082131A1 (en) | 2006-10-03 | 2008-04-03 | Myriam Ivette Llanos | Facial Nerve Stimulator (FNS) |
DE102006048819A1 (de) | 2006-10-10 | 2008-04-17 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Vorrichtung mit einem Grundkörper |
EP2478931B1 (en) | 2006-10-13 | 2015-12-30 | Cyberonics, Inc. | Obstructive sleep apnea treatment device |
JP5443989B2 (ja) | 2006-10-18 | 2014-03-19 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 単一の電流路デカップリングキャパシタを備えた多電極埋込型刺激装置 |
US10856904B2 (en) | 2006-11-30 | 2020-12-08 | Medtronic, Inc. | Flexible introducer |
WO2008084064A1 (en) | 2007-01-09 | 2008-07-17 | Fovea Pharmaceuticals | Apparatus for intra-ocular injection |
DE102007002783A1 (de) | 2007-01-18 | 2008-08-07 | Bayer Materialscience Ag | Hydrogele aus hydrophilen Polyurethan(meth)acrylaten |
AR064985A1 (es) | 2007-01-22 | 2009-05-06 | E Vision Llc | Lente electroactivo flexible |
US20080183242A1 (en) | 2007-01-29 | 2008-07-31 | Nidek Co., Ltd. | Electrical stimulation method for vision improvement |
JP4970069B2 (ja) * | 2007-01-30 | 2012-07-04 | 株式会社ニデック | 視覚再生補助装置 |
US8755896B2 (en) | 2007-02-05 | 2014-06-17 | University Of Southern California | Treatment of consumption disorders with biostimulation |
EP2433673A1 (en) | 2007-02-16 | 2012-03-28 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with wire or film support |
RU2338492C1 (ru) | 2007-02-21 | 2008-11-20 | Андрей Анатольевич Бессонов | Способ лечения недостаточности слезопродукции при синдроме сухости глаза |
US7949403B2 (en) | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
US7879032B1 (en) | 2007-04-16 | 2011-02-01 | Ellman International, Inc. | Disposable electrosurgical handpiece |
US20080269648A1 (en) | 2007-04-30 | 2008-10-30 | Ultra License Holdings, Inc. | Method for increasing saliva and tear production with ultrasound |
WO2008143955A2 (en) | 2007-05-14 | 2008-11-27 | The Regents Of The University Of Colorado | Laser fusion of tissue layers |
SE531172C2 (sv) | 2007-05-16 | 2009-01-13 | Rhinomed Ab | Vibrationsanordning avsedd att användas i kroppskaviteter, företrädesvis i näshålan |
US8032222B2 (en) | 2007-06-19 | 2011-10-04 | Loushin Michael K H | Device for electrically and mechanically stimulating a compartment in a body |
US7758190B2 (en) | 2007-06-20 | 2010-07-20 | Tearscience, Inc. | Tear film measurement |
US7676276B2 (en) | 2007-07-02 | 2010-03-09 | Manuel L Karell | Stimulator combined with an intranasal respiratory method and device for improved breathing |
US8145322B1 (en) | 2007-07-19 | 2012-03-27 | Second Sight Medical Products, Inc. | Flexible circuit electrode array device and a method for backside processing of a flexible circuit electrode device |
ES2566537T3 (es) | 2007-07-20 | 2016-04-13 | Boston Scientific Neuromodulation Corporation | Sistema de estimulación para controlar el orden de reclutamiento neuronal y efecto clínico |
EP2185236B1 (en) | 2007-07-27 | 2015-10-07 | Second Sight Medical Products | Implantable device for the brain |
WO2009018518A1 (en) | 2007-08-02 | 2009-02-05 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods and systems for achieving a physiological response by pudendal nerve stimulation and bockade |
US8088120B2 (en) | 2007-09-05 | 2012-01-03 | Maya Worsoff | Method and apparatus for alleviating nasal congestion |
CN101861135A (zh) | 2007-09-07 | 2010-10-13 | Qlt栓塞输送公司 | 泪道植入物检测 |
US8315689B2 (en) | 2007-09-24 | 2012-11-20 | MRI Interventions, Inc. | MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools |
US8019419B1 (en) * | 2007-09-25 | 2011-09-13 | Dorin Panescu | Methods and apparatus for leadless, battery-less, wireless stimulation of tissue |
JP5600062B2 (ja) | 2007-10-03 | 2014-10-01 | ポリィノボ バイオマテリアルズ ピーティワイ リミテッド | 高弾性率ポリウレタン及びポリウレタン/尿素組成物 |
US20090093446A1 (en) | 2007-10-05 | 2009-04-09 | Winston Laboratories, Inc. | Method for alleviating keratoconjunctivitis sicca |
JP2011500143A (ja) | 2007-10-09 | 2011-01-06 | イムセラ・メディカル・インコーポレーテッド | 選択的刺激のための装置、システム、及び方法 |
US7873421B2 (en) | 2007-10-23 | 2011-01-18 | Manuel L Karell | Nasal dilator adapted to provide electrical stimulation |
AU2008329716B2 (en) * | 2007-11-26 | 2012-04-19 | Micro Transponder Inc. | Implantable transponder systems and methods |
WO2009070705A2 (en) * | 2007-11-26 | 2009-06-04 | Microtransponder Inc. | Transfer coil architecture |
US8457757B2 (en) | 2007-11-26 | 2013-06-04 | Micro Transponder, Inc. | Implantable transponder systems and methods |
GB2456002A (en) | 2007-12-31 | 2009-07-01 | William M Hung | A method for the manufacture of silicone hydrogel contact lenses in which filler material is introduced, the lens formed and the filler extracted. |
US8165694B2 (en) | 2008-01-29 | 2012-04-24 | Boston Scientific Neuromodulation Corporation | Thermal management of implantable medical devices |
USD613408S1 (en) | 2008-02-06 | 2010-04-06 | Tearscience, Inc. | Eye treatment head gear |
USD617443S1 (en) | 2008-02-06 | 2010-06-08 | Tearscience, Inc. | Eye treatment goggles |
USD614303S1 (en) | 2008-02-06 | 2010-04-20 | Tearscience, Inc. | Eye treatment apparatus |
US9079042B2 (en) * | 2008-03-20 | 2015-07-14 | Pixium Vision Sa | Power supply for a retina implant |
US7832355B2 (en) | 2008-04-01 | 2010-11-16 | Frances Kay Mills | Animal feeder |
US8543211B2 (en) | 2008-04-10 | 2013-09-24 | ElectroCore, LLC | Methods and apparatus for deep brain stimulation |
US7846124B2 (en) | 2008-05-07 | 2010-12-07 | Becker Bruce B | Punctal anchor for lacrimal stent, introducer tool and method |
EP2318091B1 (en) | 2008-05-09 | 2016-09-14 | Medtronic, Inc. | Peripheral nerve field stimulation control |
WO2009137121A1 (en) | 2008-05-09 | 2009-11-12 | Medtronic, Inc. | Programming techniques for peripheral nerve field stimulation |
US8349610B2 (en) | 2008-05-20 | 2013-01-08 | Cantimer, Inc. | Methods, systems and devices for analyzing a surfactant-treated biological fluid sample |
DE102008002228A1 (de) * | 2008-06-05 | 2009-12-10 | Biotronik Crm Patent Ag | Langgestrecktes Implantat mit externer Energieeinkopplung |
US8626306B2 (en) | 2008-06-12 | 2014-01-07 | Second Sight Medical Products, Inc. | Visual prosthesis for control of spatiotemporal interactions |
ITRM20080309A1 (it) | 2008-06-12 | 2009-12-13 | Massimo Filippello | Metodo di trattamento oculare per la prevenzione della presbiopia e del glaucoma e mezzi per effettuare tale trattamento |
NL2001697C2 (en) | 2008-06-18 | 2009-12-22 | Nasophlex B V | Nose stimulator for producing a stimulation signal to a nose. |
NL2001698C2 (en) | 2008-06-18 | 2009-12-22 | Nasophlex B V | Cardioverter / defibrillator. |
US8945086B2 (en) | 2008-07-01 | 2015-02-03 | Bruce Becker | Retrobulbar needle and methods of use |
TW201006453A (en) | 2008-07-08 | 2010-02-16 | Qlt Plug Delivery Inc | Lacrimal implant body including comforting agent |
WO2010027743A1 (en) | 2008-08-25 | 2010-03-11 | Alpha Synergy Development, Inc. | Pharmaceutical compositions and methods for the treatment of dry eye |
WO2010033804A1 (en) | 2008-09-19 | 2010-03-25 | Avedro, Inc. | Eye therapy system |
JP2012504472A (ja) | 2008-10-01 | 2012-02-23 | アヴェドロ・インコーポレーテッド | 眼治療システム |
GB2476219B (en) | 2008-10-22 | 2013-01-02 | Advanced Neuromodulation Sys | Method for processing electrodes for stimulation lead |
US8448273B2 (en) | 2008-10-29 | 2013-05-28 | Smartsilk Corporation Inc. | Pillow and cover for a pillow |
US9895470B2 (en) | 2008-12-05 | 2018-02-20 | Semprus Biosciences Corp. | Non-fouling, anti-microbial, anti-thrombogenic graft—from compositions |
EP2373234A1 (en) | 2008-12-16 | 2011-10-12 | Aardvark Medical, Inc. | Methods and systems for delivery of fluids, aerosols and acoustic energy to tissue surfaces, cavities and obstructed passages such as intranasal ostia |
USD614774S1 (en) | 2008-12-18 | 2010-04-27 | Tearscience, Inc. | Ocular imaging apparatus |
EP2376188A1 (en) | 2008-12-19 | 2011-10-19 | Neurodan A/S | Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation |
US20100161004A1 (en) | 2008-12-22 | 2010-06-24 | Integrated Sensing Systems, Inc. | Wireless dynamic power control of an implantable sensing device and methods therefor |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
WO2010076904A1 (en) | 2008-12-29 | 2010-07-08 | Seung-Won Jeong | Rhinitis laser-aroma therapy apparatus |
US8235932B2 (en) | 2009-01-09 | 2012-08-07 | Becker Bruce B | Side-by-side lacrimal intubation threader and method |
US8494641B2 (en) * | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US9233254B2 (en) | 2009-02-17 | 2016-01-12 | Boston Scientific Neuromodulation Corporation | Selectable boost converter and charge pump for compliance voltage generation in an implantable stimulator device |
WO2010099818A1 (en) | 2009-03-03 | 2010-09-10 | Ao Technology Ag | Thermoreversible polysaccharide hydrogel |
CN101503491B (zh) | 2009-03-10 | 2011-11-30 | 海昌隐形眼镜有限公司 | 一种高透氧氟硅氧烷水凝胶接触镜材料及其制备方法 |
WO2010115109A1 (en) | 2009-04-02 | 2010-10-07 | Avedro, Inc. | Eye therapy system |
WO2010123704A2 (en) | 2009-04-24 | 2010-10-28 | Medtronic, Inc. | Incontinence therapy |
CA2764477A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations, methods of manufacture, and methods of using same |
US20100318159A1 (en) | 2009-06-12 | 2010-12-16 | Boston Scientific Neuromodulation Corporation | Miniature remote controller for implantable medical device |
EP2456499A4 (en) | 2009-07-21 | 2015-07-08 | Leonard V Covello | DEVICES AND METHODS FOR MINIMALLY INVASIVE ACCESS TO SINUS AND TREATMENT OF SINUSITIS |
JP5578540B2 (ja) | 2009-07-31 | 2014-08-27 | 株式会社ニデック | 視覚再生補助装置及び視覚再生補助装置の製造方法 |
USD640977S1 (en) | 2009-09-25 | 2011-07-05 | C. R. Bard, Inc. | Charging station for a battery operated biopsy device |
AU2009222439B2 (en) | 2009-09-28 | 2011-07-21 | Cochlear Limited | Method and circuitry for measurement and control of stimulation current |
CA2776697A1 (en) | 2009-10-05 | 2011-04-14 | The Regents Of The University Of California | Extracranial implantable devices, systems and methods for the treatment of neuropsychiatric disorders |
USD638128S1 (en) | 2009-10-06 | 2011-05-17 | Tearscience, Inc. | Ocular device design |
US8571677B2 (en) | 2009-10-21 | 2013-10-29 | Medtronic, Inc. | Programming techniques for stimulation with utilization of case electrode |
IL202462A0 (en) | 2009-12-02 | 2010-06-30 | Feldman Joseph | Device for treatment of rhinitis by biostimulative illumination |
US8622993B2 (en) | 2009-12-18 | 2014-01-07 | Healthpartners Research Foundation | Device and method for delivering therapeutic substances to the maxillary sinus of a patient |
US8620442B2 (en) | 2010-01-27 | 2013-12-31 | Second Sight Medical Products, Inc. | Multi-electrode integration in a visual prosthesis |
US20110202121A1 (en) | 2010-02-16 | 2011-08-18 | Shin-Heng Wen | Electrical nerve stimulator |
WO2011103291A1 (en) | 2010-02-18 | 2011-08-25 | Dow Corning Corporation | Siloxane surface-modified hydrogel and hydrogel microparticle compositions |
DE212011100038U1 (de) | 2010-03-05 | 2012-07-17 | Endostim, Inc. | Vorrichtungs- und Implantationssystem für elektrische Stimulation von biologischen Systemen |
TWM389271U (en) | 2010-03-23 | 2010-09-21 | Guo-Ren Ye | Healthcare eyeglasses |
US8364272B2 (en) | 2010-04-30 | 2013-01-29 | Medtronic, Inc. | Brain stimulation programming |
EP2563464B1 (en) | 2010-04-30 | 2018-06-06 | Second Sight Medical Products, Inc. | Improved biocompatible bonding method |
US9522980B2 (en) | 2010-05-06 | 2016-12-20 | Johnson & Johnson Vision Care, Inc. | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same |
US8968783B2 (en) | 2010-05-27 | 2015-03-03 | Covidien Lp | Hydrogel implants with varying degrees of crosslinking |
AP2012006639A0 (en) | 2010-06-04 | 2012-12-31 | Us Gov Ct Disease Contr & Prev | Nasal aerosol delivery system |
US8942819B2 (en) | 2010-06-16 | 2015-01-27 | Cardiac Pacemakers, Inc. | Automatic neural stimulation titration sweep |
EP2591023A2 (en) | 2010-07-05 | 2013-05-15 | Reluceo Inc. | Degradable superabsorbent polymers |
JP2012115545A (ja) | 2010-12-02 | 2012-06-21 | Nidek Co Ltd | 生体組織用刺激回路 |
JP5776165B2 (ja) | 2010-11-05 | 2015-09-09 | 株式会社ニデック | 生体組織用刺激回路 |
US9937355B2 (en) | 2010-11-08 | 2018-04-10 | Zoll Medical Corporation | Remote medical device alarm |
US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
CN103313754B (zh) | 2010-11-16 | 2015-09-30 | 小利兰·斯坦福大学理事会 | 用于治疗干眼的系统和方法 |
WO2012075176A1 (en) | 2010-11-30 | 2012-06-07 | Optovue, Inc. | Tear film and tear meniscus dynamics with time-lapse optical coherence tomography |
US9364674B2 (en) | 2010-11-30 | 2016-06-14 | Ian A. Cook | Pulse generator for cranial nerve stimulation |
US20110081333A1 (en) | 2010-12-10 | 2011-04-07 | Shantha Totada R | Apparatus and system for treatment and prevention of bags under eyes |
US8706233B2 (en) | 2011-01-28 | 2014-04-22 | Medtronic, Inc. | Stimulation therapy including substantially simultaneous bilateral stimulation |
EP2497530A3 (en) | 2011-03-07 | 2013-06-19 | Giancarlo Barolat | Modular nerve stimulation system |
JP5419174B2 (ja) | 2011-03-28 | 2014-02-19 | 国立大学法人 新潟大学 | 嚥下誘発装置 |
EP2691149B1 (en) | 2011-03-28 | 2019-02-27 | Med-El Elektromedizinische Geraete GmbH | System for treating apnea using evoked swallow |
EP2694156B8 (en) | 2011-04-07 | 2017-08-09 | Oculeve, Inc. | Stimulation devices |
EP4159273A1 (en) | 2011-05-13 | 2023-04-05 | Saluda Medical Pty Ltd | Implantable device for controlling a neural stimulus |
US8944052B2 (en) | 2011-05-26 | 2015-02-03 | Ivan Osorio | Apparatus and methods for delivery of therapeutic agents to mucous or serous membrane |
US20120316557A1 (en) | 2011-06-08 | 2012-12-13 | Tyco Healthcare Group Lp | Septoplasty Instrument |
US8986301B2 (en) | 2012-06-13 | 2015-03-24 | Aerin Medical Inc. | Methods and devices to treat nasal airways |
EP3549543B8 (en) | 2011-06-14 | 2023-08-23 | Aerin Medical, Inc. | Device for treating nasal airways |
US20120330376A1 (en) | 2011-06-27 | 2012-12-27 | Equine OrthoCare, LLC | Systems and methods for making and using electrical stimulation systems for providing therapy to large animals |
EP2747836B1 (en) | 2011-08-26 | 2017-04-26 | Louis Scerbo | Facial rejuvinating apparatus |
US8965511B2 (en) | 2011-08-30 | 2015-02-24 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for reducing hypertension |
CA2848370C (en) | 2011-09-22 | 2020-01-14 | Djo, Llc | Devices and systems for treating pain with electrical stimulation |
US8996125B2 (en) | 2011-09-23 | 2015-03-31 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for treating cardiovascular disease |
US9173811B2 (en) | 2011-09-29 | 2015-11-03 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for treating depression and similar mental conditions |
CN106955417B (zh) | 2011-10-11 | 2021-08-20 | 杜克大学 | 医疗刺激系统 |
NZ624726A (en) | 2011-11-04 | 2016-01-29 | Cymabay Therapeutics Inc | Methods for treating gout flares |
-
2011
- 2011-11-16 CN CN201180064627.8A patent/CN103313754B/zh not_active Expired - Fee Related
- 2011-11-16 JP JP2013539971A patent/JP2013542838A/ja active Pending
- 2011-11-16 AU AU2011328900A patent/AU2011328900B2/en not_active Ceased
- 2011-11-16 CA CA2817589A patent/CA2817589A1/en not_active Abandoned
- 2011-11-16 RU RU2013127313/14A patent/RU2013127313A/ru not_active Application Discontinuation
- 2011-11-16 WO PCT/US2011/060989 patent/WO2012068247A1/en active Application Filing
- 2011-11-16 EP EP11842076.9A patent/EP2640461B1/en not_active Not-in-force
- 2011-11-16 US US13/298,042 patent/US8918181B2/en active Active
- 2011-11-16 ES ES11842076T patent/ES2739490T3/es active Active
-
2014
- 2014-12-04 US US14/561,107 patent/US9095723B2/en not_active Expired - Fee Related
-
2015
- 2015-08-03 US US14/816,846 patent/US20150335900A1/en not_active Abandoned
-
2017
- 2017-05-22 JP JP2017100651A patent/JP6522047B2/ja not_active Expired - Fee Related
- 2017-12-01 US US15/828,950 patent/US10143846B2/en active Active
-
2018
- 2018-11-19 US US16/195,719 patent/US10722718B2/en active Active
-
2020
- 2020-06-24 US US16/911,221 patent/US11771908B2/en active Active
-
2023
- 2023-09-06 US US18/242,939 patent/US20230405339A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147284A (en) * | 1989-08-17 | 1992-09-15 | Fedorov Svjatoslav N | Device and method for restoration of visual functions |
US20030233135A1 (en) * | 2002-06-14 | 2003-12-18 | Yee Richard W. | Method and apparatus for preventing and treating eyelid problems |
JP2008055000A (ja) * | 2006-08-31 | 2008-03-13 | Nidek Co Ltd | 視覚再生補助装置 |
JP2010051562A (ja) * | 2008-08-28 | 2010-03-11 | Tohoku Univ | 生体の深部刺激方法及び生体深部の刺激装置 |
Also Published As
Publication number | Publication date |
---|---|
CA2817589A1 (en) | 2012-05-24 |
US20150088156A1 (en) | 2015-03-26 |
EP2640461A1 (en) | 2013-09-25 |
US9095723B2 (en) | 2015-08-04 |
JP6522047B2 (ja) | 2019-05-29 |
US20210008379A1 (en) | 2021-01-14 |
AU2011328900A1 (en) | 2013-05-02 |
WO2012068247A1 (en) | 2012-05-24 |
US20230405339A1 (en) | 2023-12-21 |
RU2013127313A (ru) | 2014-12-27 |
EP2640461B1 (en) | 2019-06-19 |
US11771908B2 (en) | 2023-10-03 |
US20180154161A1 (en) | 2018-06-07 |
EP2640461A4 (en) | 2014-11-12 |
AU2011328900B2 (en) | 2015-03-19 |
US8918181B2 (en) | 2014-12-23 |
US20150335900A1 (en) | 2015-11-26 |
CN103313754B (zh) | 2015-09-30 |
US10722718B2 (en) | 2020-07-28 |
US20190290922A1 (en) | 2019-09-26 |
JP2013542838A (ja) | 2013-11-28 |
ES2739490T3 (es) | 2020-01-31 |
US20120130398A1 (en) | 2012-05-24 |
CN103313754A (zh) | 2013-09-18 |
US10143846B2 (en) | 2018-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11771908B2 (en) | Systems and methods for treatment of dry eye | |
JP6746767B2 (ja) | 埋込型マイクロ刺激ユニット | |
US10328262B2 (en) | Stimulation devices and methods | |
AU2018236684B2 (en) | Systems and methods for treatment of dry eye | |
BR112013012122A2 (pt) | sistemas e métodos para tratamento de olho seco |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180409 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180709 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180806 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20181024 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190401 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190423 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6522047 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |