JP2017160258A5 - - Google Patents
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- JP2017160258A5 JP2017160258A5 JP2017113544A JP2017113544A JP2017160258A5 JP 2017160258 A5 JP2017160258 A5 JP 2017160258A5 JP 2017113544 A JP2017113544 A JP 2017113544A JP 2017113544 A JP2017113544 A JP 2017113544A JP 2017160258 A5 JP2017160258 A5 JP 2017160258A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pathway activator
- sirtuin pathway
- acid
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 40
- 102000011990 Sirtuin Human genes 0.000 claims 10
- 108050002485 Sirtuin Proteins 0.000 claims 10
- 239000012190 activator Substances 0.000 claims 10
- 230000037361 pathway Effects 0.000 claims 10
- 208000008589 Obesity Diseases 0.000 claims 6
- 235000020824 obesity Nutrition 0.000 claims 6
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 6
- 235000013824 polyphenols Nutrition 0.000 claims 6
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 5
- 229960003105 metformin Drugs 0.000 claims 5
- 229940125708 antidiabetic agent Drugs 0.000 claims 4
- 239000003472 antidiabetic agent Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 230000004584 weight gain Effects 0.000 claims 3
- 235000019786 weight gain Nutrition 0.000 claims 3
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000883 anti-obesity agent Substances 0.000 claims 2
- 229940125710 antiobesity agent Drugs 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- LVRFTAZAXQPQHI-RXMQYKEDSA-N (R)-2-hydroxy-4-methylpentanoic acid Chemical compound CC(C)C[C@@H](O)C(O)=O LVRFTAZAXQPQHI-RXMQYKEDSA-N 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 1
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 claims 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims 1
- 229940122820 Cannabinoid receptor antagonist Drugs 0.000 claims 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims 1
- 229920002079 Ellagic acid Polymers 0.000 claims 1
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 claims 1
- 108010011459 Exenatide Proteins 0.000 claims 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 229940086609 Lipase inhibitor Drugs 0.000 claims 1
- 102100031455 NAD-dependent protein deacetylase sirtuin-1 Human genes 0.000 claims 1
- 102100030710 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Human genes 0.000 claims 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 1
- IIXHQGSINFQLRR-UHFFFAOYSA-N Piceatannol Natural products Oc1ccc(C=Cc2c(O)c(O)c3CCCCc3c2O)cc1O IIXHQGSINFQLRR-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 108091005770 SIRT3 Proteins 0.000 claims 1
- 108010041191 Sirtuin 1 Proteins 0.000 claims 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- LVRFTAZAXQPQHI-UHFFFAOYSA-N alpha-hydroxyisocaproic acid Natural products CC(C)CC(O)C(O)=O LVRFTAZAXQPQHI-UHFFFAOYSA-N 0.000 claims 1
- 235000004883 caffeic acid Nutrition 0.000 claims 1
- 229940074360 caffeic acid Drugs 0.000 claims 1
- 235000021236 calorie-restricted diet Nutrition 0.000 claims 1
- 239000003536 cannabinoid receptor antagonist Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000001368 chlorogenic acid Nutrition 0.000 claims 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims 1
- 229940074393 chlorogenic acid Drugs 0.000 claims 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 230000003291 dopaminomimetic effect Effects 0.000 claims 1
- 229960002852 ellagic acid Drugs 0.000 claims 1
- 235000004132 ellagic acid Nutrition 0.000 claims 1
- 229940030275 epigallocatechin gallate Drugs 0.000 claims 1
- 229960001519 exenatide Drugs 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 229940087603 grape seed extract Drugs 0.000 claims 1
- 235000002532 grape seed extract Nutrition 0.000 claims 1
- 229930005346 hydroxycinnamic acid Natural products 0.000 claims 1
- DEDGUGJNLNLJSR-UHFFFAOYSA-N hydroxycinnamic acid group Chemical group OC(C(=O)O)=CC1=CC=CC=C1 DEDGUGJNLNLJSR-UHFFFAOYSA-N 0.000 claims 1
- 235000010359 hydroxycinnamic acids Nutrition 0.000 claims 1
- 210000001596 intra-abdominal fat Anatomy 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims 1
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- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- CDRPUGZCRXZLFL-OWOJBTEDSA-N piceatannol Chemical compound OC1=CC(O)=CC(\C=C\C=2C=C(O)C(O)=CC=2)=C1 CDRPUGZCRXZLFL-OWOJBTEDSA-N 0.000 claims 1
- 229960003611 pramlintide Drugs 0.000 claims 1
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- NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 230000000862 serotonergic effect Effects 0.000 claims 1
- 235000011888 snacks Nutrition 0.000 claims 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims 1
- 235000021286 stilbenes Nutrition 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
- 239000001717 vitis vinifera seed extract Substances 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508139P | 2011-07-15 | 2011-07-15 | |
| US61/508,139 | 2011-07-15 | ||
| US201261636603P | 2012-04-20 | 2012-04-20 | |
| US201261636598P | 2012-04-20 | 2012-04-20 | |
| US201261636605P | 2012-04-20 | 2012-04-20 | |
| US201261636608P | 2012-04-20 | 2012-04-20 | |
| US201261636597P | 2012-04-20 | 2012-04-20 | |
| US201261636610P | 2012-04-20 | 2012-04-20 | |
| US61/636,608 | 2012-04-20 | ||
| US61/636,605 | 2012-04-20 | ||
| US61/636,597 | 2012-04-20 | ||
| US61/636,603 | 2012-04-20 | ||
| US61/636,598 | 2012-04-20 | ||
| US61/636,610 | 2012-04-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520397A Division JP6158801B2 (ja) | 2011-07-15 | 2012-07-13 | 代謝経路を変調させるための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017160258A JP2017160258A (ja) | 2017-09-14 |
| JP2017160258A5 true JP2017160258A5 (enExample) | 2017-10-26 |
Family
ID=47519040
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520397A Active JP6158801B2 (ja) | 2011-07-15 | 2012-07-13 | 代謝経路を変調させるための組成物および方法 |
| JP2017113544A Pending JP2017160258A (ja) | 2011-07-15 | 2017-06-08 | 代謝経路を変調させるための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520397A Active JP6158801B2 (ja) | 2011-07-15 | 2012-07-13 | 代謝経路を変調させるための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US8623924B2 (enExample) |
| EP (2) | EP3466418A1 (enExample) |
| JP (2) | JP6158801B2 (enExample) |
| KR (1) | KR20140054066A (enExample) |
| CN (3) | CN108261547A (enExample) |
| AU (2) | AU2012284267B2 (enExample) |
| BR (1) | BR112014000895A2 (enExample) |
| CA (1) | CA2841748C (enExample) |
| HK (2) | HK1250656A1 (enExample) |
| IL (1) | IL230467B (enExample) |
| MX (1) | MX2014000419A (enExample) |
| PH (1) | PH12014500198A1 (enExample) |
| RU (2) | RU2017129378A (enExample) |
| SG (1) | SG10201609673QA (enExample) |
| WO (1) | WO2013012760A1 (enExample) |
| ZA (1) | ZA201400553B (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3466418A1 (en) | 2011-07-15 | 2019-04-10 | NuSirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| WO2013149258A2 (en) * | 2012-03-30 | 2013-10-03 | Charles Drew University of Medicine and Science | Compositions and methods for treating or preventing metabolic syndrome disorders |
| SG11201503774PA (en) | 2012-11-13 | 2015-06-29 | Nusirt Sciences Inc | Compositions and methods for increasing energy metabolism |
| AU2014207707B2 (en) * | 2013-01-15 | 2018-11-01 | Nusirt Sciences, Inc. | Treating pulmonary conditions |
| WO2014111580A1 (en) * | 2013-01-18 | 2014-07-24 | Procell Sprl | Urolithin b for muscle growth |
| MX370090B (es) | 2013-02-01 | 2019-10-25 | Centro De Investig En Alimentacion Y Desarrollo A C | Un método y un sistema para el tratamiento integral de aguas residuales de una industria del maíz. |
| SG11201507390SA (en) * | 2013-03-14 | 2015-10-29 | Abbott Lab | Treatment of insulin resistance associated with prolonged physical inactivity |
| US20160000737A1 (en) * | 2013-03-15 | 2016-01-07 | Nusirt Sciences, Inc. | Treatment of pets with sirtuin activators |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| WO2015052086A1 (en) | 2013-10-09 | 2015-04-16 | Nestec S.A. | Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome |
| US9138453B2 (en) * | 2013-10-14 | 2015-09-22 | Biomarker Pharmaceuticals, Inc. | Nutrient combinations for affecting an aging process |
| WO2015094772A1 (en) * | 2013-12-18 | 2015-06-25 | Abbott Laboratories | Methods for increasing skeletal muscle protein synthesis using green tea extract |
| MX2016011063A (es) * | 2014-02-27 | 2016-11-30 | Nusirt Sciences Inc | Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica. |
| EP3122348B1 (en) | 2014-03-27 | 2020-05-27 | Winterfield, Roland, W. | Beta-hydroxy beta-methylbutyrate for alleviating statin myopathy |
| JP6309343B2 (ja) * | 2014-05-21 | 2018-04-11 | 協和発酵バイオ株式会社 | ３−ヒドロキシ−３−メチル酪酸カルシウム含有錠剤およびその製造方法 |
| EP3197437A4 (en) * | 2014-09-24 | 2018-05-23 | NuSirt Sciences, Inc. | Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia |
| ITMI20141843A1 (it) * | 2014-10-27 | 2016-04-27 | Giovannini Luca | Associazioni sinergiche stimolanti l¿espressione di sirtuina 1 |
| US20170368018A1 (en) * | 2014-12-19 | 2017-12-28 | Halo Life Science, Llc | Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels |
| KR101984116B1 (ko) | 2015-01-12 | 2019-05-31 | 켄달리온 테라퓨틱스 인코포레이티드 | 마이크로-액적 전달 장치 및 방법 |
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2012
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- 2012-07-13 KR KR1020147003866A patent/KR20140054066A/ko not_active Ceased
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- 2012-07-13 CN CN201810140657.6A patent/CN108261547A/zh active Pending
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- 2012-07-13 US US13/549,399 patent/US8623924B2/en active Active
- 2012-07-13 RU RU2017129378A patent/RU2017129378A/ru not_active Application Discontinuation
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- 2012-07-13 US US13/549,381 patent/US8617886B2/en active Active
- 2012-07-13 EP EP12814141.3A patent/EP2731599B1/en active Active
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