JP5507802B2 - 筋肉老化抑制剤 - Google Patents
筋肉老化抑制剤 Download PDFInfo
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- JP5507802B2 JP5507802B2 JP2007186743A JP2007186743A JP5507802B2 JP 5507802 B2 JP5507802 B2 JP 5507802B2 JP 2007186743 A JP2007186743 A JP 2007186743A JP 2007186743 A JP2007186743 A JP 2007186743A JP 5507802 B2 JP5507802 B2 JP 5507802B2
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Description
また本発明は、(a)カテキン類、並びに(b)分岐鎖アミノ酸及びタウリンから選ばれるアミノ酸類を有効成分とする運動機能向上剤を提供するものである。
また本発明は、(a)カテキン類、並びに(b)分岐鎖アミノ酸及びタウリンから選ばれるアミノ酸類を有効成分とする寝たきり予防剤を提供するものである。
また本発明は、(a)カテキン類、並びに(b)分岐鎖アミノ酸及びタウリンから選ばれるアミノ酸類を含有する筋力老化抑制用飲食品、運動機能向上用飲食品又は寝たきり予防用飲食品を提供するものである。
更に本発明は、(a)カテキン類、並びに(b)分岐鎖アミノ酸及びタウリンから選ばれるアミノ酸類の筋肉老化抑制剤、運動機能向上剤又は寝たきり予防剤としての使用を提供するものである。
また、「筋肉老化」とは、加齢に伴って生じる筋肉の衰え、例えば筋機能低下や筋萎縮を指す。「運動機能向上」とは、筋機能(筋力)の低下を抑制させることによって運動能力を維持又は向上することを指す。
また、本発明において、「筋機能低下」とは、筋萎縮に伴って、筋が構造的あるいは質的に変化し、筋力、筋持久力、筋瞬発力が低下することを示す。したがって「筋機能低下の抑制」とは、筋力、筋持久力、筋瞬発力の低下を抑制することを指す。
また、「寝たきり」とは、特に老化、例えば30代以降の中高年においてみられる廃用性筋萎縮とサルコペニアとが複合した症状、例えば、高齢者の脳卒中や骨折等の治療や療養等において運動量が極度に少なくなり、さらに筋機能が低下し、寝かせきり状態からつくられるものを指す。
当該製茶された茶葉には、(1)煎茶、番茶、玉露、てん茶、釜煎り茶等の緑茶類;(2)総称して烏龍茶と呼ばれる鉄観音、色種、黄金桂、武夷岩茶等の半発酵茶;(3)紅茶と呼ばれるダージリン、ウバ、キーマン等の発酵茶が含まれる。
例えば、当該茶抽出物は、特開昭59−219384号、特開平4−20589号、特開平5−260907号、特開平5−306279号等に詳細に例示されている方法で調製することができる。また、市販品を用いることもでき、斯かる市販品としては、三井農林(株)「ポリフェノン」、(株)伊藤園「テアフラン」、太陽化学(株)「サンフェノン」、サントリー(株)「サンウーロン」等が挙げられる。
また、当該抽出物中のカテキン類の含有量は、30〜98質量%、好ましくは40〜90質量%である。また、これらの総ポリフェノール中のカテキン類の含有率は、製造直後でカテキン量が10質量%以上で、好ましくは20質量%以上である。
体カテキン類を用いて熱や酸やアルカリ等の処理により立体異性体である非エピ体に変化させることができる。従って、非エピ体カテキン類を使用する場合には、緑茶類、半発酵茶類又は発酵茶類からの抽出液や茶抽出液の濃縮物を水溶液にして、例えば40〜140℃、0.1分〜120時間加熱処理して得ることができる。また非エピカテキン類含有量の高い茶抽出液の濃縮物を使用してもよい。それらは単独又は併用してもよい。
また、(a)カテキン類の含有量の30〜98重量%、好ましくは40〜90重量%が、エピガロカテキンガレート、ガロカテキンガレート、エピガロカテキン、ガロカテキンから選ばれたものであると、飲料としての呈味が更に優れ、後を引くような収斂性も少なく好ましい。ここでエピガロカテキンガレート、ガロカテキンガレート、エピガロカテキン、ガロカテキンは1種以上含有するが、通常は全て含有される。
各アミノ酸については、ロイシンは飲料500mL当たり100mg〜20000mg含有することが好ましく、500〜4000mg含有するのが更に好ましい。イソロイシンは100mg〜20000mg含有することが好ましく、500〜3000mg含有するのが更に好ましい。バリンは100〜20000mg含有することが好ましく、500
〜3000mg含有するのが更に好ましい。タウリンは100〜10000mg含有することが好ましく、500〜3000mg含有するのが更に好ましい。
また本発明においては、長時間保存時に安定した色調と外観の透明性を呈する飲料に、消費者の嗜好にあわせて茶葉の微粉末のような不溶性化合物をあえて懸濁させた形態の飲料も可能である。尚、本発明の飲料において必ずしも有効成分が溶解している必要はない。
る患者の性別、年齢、体重、症状の程度等によって異なることは明らかである。
(a)カテキン類として、総カテキン量81%の茶抽出物を用いた。また、カテキン類の組成は、ガロカテキン(7%)、ガロカテキンガレート(4%)、エピカテキン(9%)、エピガロカテキン(23%)、エピカテキンガレート(12%)、エピガロカテキンガレート(41%)、その他(4%)であった。また、(b)アミノ酸類として、ロイシンを用いた。
以上のことから、本発明のカテキン類/アミノ酸類の併用は老化に伴う筋力低下抑制剤として有用である。またSAM−P1対照群と比較し、カテキン/ロイシン併用群では筋力が向上したことから、カテキン/ロイシンの併用は運動機能の向上に有効である。
カテキン類として、総カテキン量81%の茶抽出物を用いた。また、カテキン類の組成は、ガロカテキン(7%)、ガロカテキンガレート(4%)、エピカテキン(9%)、エピガロカテキン(23%)、エピカテキンガレート(12%)、エピガロカテキンガレート(41%)、その他(4%)であった。また、アミノ酸類として、ロイシンを用いた。
以上のことから、本発明のカテキン類/アミノ酸類の併用は老化に伴う筋萎縮抑制剤として有用である。
表5に示した配合及び条件で、本発明の筋肉老化抑制用アミノ酸配合茶系飲料を調製した。本飲料の保存安定性及び風味は良好であった。
表6に示した配合及び条件で、本発明の筋肉老化抑制用アミノ酸配合スポーツ飲料を調製した。本飲料の保存安定性及び風味は良好であった。
乳カゼイン3.4g、分離大豆タンパク質1.67g、デキストリン14.86g、ショ糖1.3g、大豆油1.75g、シソ油0.18g、大豆リン脂質0.14g、グリセリン脂肪酸エステル0.07g、ミネラル類0.60g、ビタミン類0.06g、テアフラン90s(伊藤園)0.11g、ロイシン0.18g、イソロイシン0.09g、バリン0.09gに精製水を加え、常法に従い、レトルト殺菌し、カテキン類及びアミノ酸類を含有する筋肉老化抑制用経腸栄養剤(100mL)を得た。ミネラル類は、Na、K、Ca、Mg、P、C1、Feなどの有機又は無機塩混合物、ビタミン類は、ビタミンA、D、E、ビタミンB1、B2、B6、B12、C、ナイアシン、パントテン酸などの混合物を
、国民栄養所要量に合致した量を用いた。
カラギーナンとローカストビーンガムの混合ゲル化剤0.65%、グレープフルーツの50%の濃縮果汁5.0%、クエン酸0.05%、ビタミンC0.05%、テアビゴ(DSMニュートリショナル・プロダクツ)0.54%、ロイシン0.3%、イソロイシン0.15%、バリン0.15%、タウリン0.5%を混合し、これに水を加えて100%に調整し、65℃で溶解した。更に少量のグレープフルーツフレーバーを添加して85℃で5分間保持して殺菌処理後、100mLの容器に分注した。8時間静置して徐冷しながら5℃に冷却して、ゲル化させ、口に含んだ時に口溶け性が良好で、果実風味を有し食感良好なカテキン類及び分岐鎖アミノ酸を含有する筋肉老化抑制用ゼリー食品を得た。
タウリン800mg、ショ糖2000mg、カラメル50mg、安息香酸ナトリウム30mg、ビタミンB1硝酸塩5mg、ビタミンB2 20mg、ビタミンB6 20mg、ビ
タミンC 2000mg、ビタミンE 100mg、ビタミンD3 2000IU、ニコチン酸アミド20mg、ポリフェノン70S(三井農林)50mg、ロイシン200mg、イソロイシン100mg、バリン100mgを適量の精製水に加えて溶解し、リン酸水溶液でpH3に調節した後、更に精製水を加えて全量を50mLとした。これを80℃で30分滅菌して、カテキン類及びアミノ酸類を含有する筋肉老化抑制用飲料を得た。
アスコルビン酸180mg、クエン酸50mg、アスパルテーム12mg、ステアリン酸マグネシウム24mg、結晶セルロース120mg、乳糖274mg、テアフラン90S(伊藤園)300mg、ロイシン600mg、イソロイシン300mg、バリン300mgなる処方で、日本薬局方(製剤総則「錠剤」)に準じて錠剤を製造し、カテキン類及びアミノ酸類を含有する筋肉老化抑制用チュアブル錠剤を得た。
下記処方に基づいて、常法によりカテキン類及びアミノ酸類を含有する老化抑制用錠剤を調製した。成分配合量(重量%):ポリフェノン70S(三井農林)5、ロイシン10、タウリン5、リンゴ酸ナトリウム20、パラチノース20、アスコルビン酸20、ビタミンミックス5、結晶セルロース5、ショ糖エステル4、二酸化ケイ素1、卵殻カルシウム5。
Claims (5)
- (a)非重合体カテキン類、並びに(b)ロイシンを有効成分とする筋肉老化抑制剤。
- 筋力低下抑制剤である請求項1記載の筋肉老化抑制剤。
- 筋萎縮抑制剤である請求項1記載の筋肉老化抑制剤。
- (a)非重合体カテキン類、並びに(b)ロイシンを有効成分とする老化に伴って低下する運動機能向上剤。
- 筋力向上剤である請求項4記載の運動機能向上剤。
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