JP2017061566A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017061566A5 JP2017061566A5 JP2016247753A JP2016247753A JP2017061566A5 JP 2017061566 A5 JP2017061566 A5 JP 2017061566A5 JP 2016247753 A JP2016247753 A JP 2016247753A JP 2016247753 A JP2016247753 A JP 2016247753A JP 2017061566 A5 JP2017061566 A5 JP 2017061566A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline genistein
- salt
- genistein
- therapeutic composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940045109 Genistein Drugs 0.000 claims 9
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 9
- 235000006539 genistein Nutrition 0.000 claims 9
- -1 genistein calcium salt Chemical class 0.000 claims 8
- 230000001225 therapeutic Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000008421 Amyloidosis, Hereditary, Transthyretin-Related Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 201000003883 cystic fibrosis Diseases 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims 2
- ZCOLJUOHXJRHDI-CMWLGVBASA-N Genistin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 1
- ZGUIQJAPZVGYCM-UHFFFAOYSA-N O.O.[K] Chemical compound O.O.[K] ZGUIQJAPZVGYCM-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002273 genistein derivatives Chemical class 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
Claims (10)
- １１．６、１４．５、２４．５、２５．２におけるピークと、３つのピーク２７．６、２８．０、２８．４°２θ±０．２°２θのうちの少なくとも２つとを有するＸＲＰＤパターンを特徴とする、結晶性ゲニステインカリウム二水和物。
- 結晶性ゲニステインカルシウム塩、結晶性ゲニステインマグネシウム塩、結晶性ゲニステインＬ−リシン塩、結晶性ゲニステインＮ−メチルグルカミン塩、結晶性ゲニステインＮ−エチルグルカミン塩および結晶性ゲニステインジエチルアミン塩からなる群から選択される、結晶性ゲニステイン塩。
- 結晶性ゲニステイン一水和物。
- 治療有効量の請求項１〜３のいずれか１項に記載の少なくとも１種のゲニステイン化合物と、少なくとも１種の薬学的に許容されるキャリアとを含む、治療用組成物。
- 癌を治療または予防するための、請求項４に記載の治療用組成物。
- 癌を治療するための、請求項１〜３のいずれか１項に記載のゲニステイン化合物。
- 慢性炎症、トランスサイレチンアミロイドーシスまたは嚢胞性線維症を治療するための、請求項４に記載の治療用組成物。
- 慢性炎症、トランスサイレチンアミロイドーシスまたは嚢胞性線維症を治療するための、請求項１〜３のいずれか１項に記載のゲニステイン化合物。
- 感染を治療するための、請求項４に記載の治療用組成物。
- 感染を治療するための、請求項１〜３のいずれか１項に記載のゲニステイン化合物。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12177808P | 2008-12-11 | 2008-12-11 | |
| US12178708P | 2008-12-11 | 2008-12-11 | |
| US61/121,778 | 2008-12-11 | ||
| US61/121,787 | 2008-12-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015104213A Division JP6067781B2 (ja) | 2008-12-11 | 2015-05-22 | ゲニステインの結晶形 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017061566A JP2017061566A (ja) | 2017-03-30 |
| JP2017061566A5 true JP2017061566A5 (ja) | 2017-08-03 |
Family
ID=42243089
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540919A Expired - Fee Related JP5898958B2 (ja) | 2008-12-11 | 2009-12-11 | ゲニステインの結晶形 |
| JP2015104213A Expired - Fee Related JP6067781B2 (ja) | 2008-12-11 | 2015-05-22 | ゲニステインの結晶形 |
| JP2016247753A Pending JP2017061566A (ja) | 2008-12-11 | 2016-12-21 | ゲニステインの結晶形 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540919A Expired - Fee Related JP5898958B2 (ja) | 2008-12-11 | 2009-12-11 | ゲニステインの結晶形 |
| JP2015104213A Expired - Fee Related JP6067781B2 (ja) | 2008-12-11 | 2015-05-22 | ゲニステインの結晶形 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9012495B2 (ja) |
| EP (1) | EP2373326B1 (ja) |
| JP (3) | JP5898958B2 (ja) |
| KR (2) | KR101849059B1 (ja) |
| CN (2) | CN104860913B (ja) |
| AU (1) | AU2009324489B2 (ja) |
| BR (1) | BRPI0923504A2 (ja) |
| CA (1) | CA2746652C (ja) |
| HK (1) | HK1164698A1 (ja) |
| IL (2) | IL213473A (ja) |
| WO (1) | WO2010068861A1 (ja) |
| ZA (1) | ZA201105045B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863325B2 (en) | 2008-12-11 | 2011-01-04 | Axcentua Pharmaceuticals Ab | Crystalline genistein sodium salt dihydrate |
| EP2373326B1 (en) * | 2008-12-11 | 2016-03-09 | Axcentua Pharmaceutucals AB | Crystalline forms of genistein |
| WO2011104667A1 (en) * | 2010-02-25 | 2011-09-01 | Anthem Biosciences Private Limited | Basic aminoacid salts of polyphenols |
| CN102442991B (zh) * | 2010-10-12 | 2015-03-11 | 上海睿智化学研究有限公司 | 一种金雀异黄素维生素b6共晶、其晶体及其制备方法 |
| CN102442989B (zh) * | 2010-10-12 | 2015-04-08 | 上海睿智化学研究有限公司 | 一种金雀异黄素盐、其晶体及其制备方法 |
| CN102442990B (zh) * | 2010-10-12 | 2015-03-11 | 上海睿智化学研究有限公司 | 一种金雀异黄素烟酰胺共晶、其晶体及其制备方法 |
| CN105963246B (zh) * | 2016-05-06 | 2018-12-25 | 荆楚理工学院 | 一种染料木素盐口服溶液剂及制备方法和应用 |
| CN105853350A (zh) * | 2016-05-24 | 2016-08-17 | 荆楚理工学院 | 一种染料木素溶液及制备方法和应用 |
| CN109666014A (zh) * | 2018-12-12 | 2019-04-23 | 荆门医药工业技术研究院 | 一种染料木素衍生物盐的制备方法及其应用 |
| EP4255415A1 (en) | 2020-12-03 | 2023-10-11 | Delta 4 GmbH | Genistein for use in the treatment of focal segmental glomerulosclerosis (fsgs) |
| WO2023212130A1 (en) | 2022-04-28 | 2023-11-02 | GreenStone Biosciences, Inc. | Treatment of the adverse cardiovascular effects of cannabinoids |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
| PT656786E (pt) * | 1992-05-19 | 2004-11-30 | Novogen Res Pty Ltd | Utilizacao de extractos do fitoestrogenio isoflavona de soja ou trevo |
| DE4331233A1 (de) * | 1993-09-15 | 1995-03-16 | Basf Ag | Verfahren zur Herstellung von Hydroxyoxaalkylmelaminen |
| US5569459A (en) * | 1995-02-15 | 1996-10-29 | Bio-Virus Research Incorporated | Pharmaceutical compositions for the management of premenstrual syndrome and alleviation of menopausal disorders |
| US5554519A (en) | 1995-08-07 | 1996-09-10 | Fermalogic, Inc. | Process of preparing genistein |
| PL179170B1 (pl) * | 1995-09-15 | 2000-07-31 | Inst Lekow | Nowe zwiazki,pochodne genisteiny PL PL PL PL |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
| ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| GB9613455D0 (en) * | 1996-06-27 | 1996-08-28 | Aston Molecules Ltd | Analogues or derivatives of quercetin |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| US5981775A (en) | 1998-09-16 | 1999-11-09 | Board Of Trustees Operating Michigan State University | Process for the preparation of isoflavones |
| US6194469B1 (en) * | 1998-12-11 | 2001-02-27 | Board Of Trustees Operating Michigan State Univeristy | Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AUPQ520300A0 (en) * | 2000-01-21 | 2000-02-17 | Novogen Research Pty Ltd | Food product and process |
| KR20030013433A (ko) | 2000-05-31 | 2003-02-14 | 아스트라제네카 아베 | 혈관 손상 활성을 가진 인돌 유도체 |
| ES2219259T3 (es) * | 2000-06-16 | 2004-12-01 | Linnea S.A. | Complejo soluble en agua de un extracto de ginkgo biloba, procedimiento para su preparacion y composicion que lo comprende. |
| EE200300015A (et) | 2000-07-07 | 2004-10-15 | Angiogene Pharmaceuticals Limited | Kolhinooli derivaadid kui angiogeneesi inhibiitorid |
| AU6623301A (en) | 2000-07-07 | 2002-01-21 | Angiogene Pharm Ltd | Colchinol derivatives as vascular damaging agents |
| US6541613B2 (en) * | 2000-12-15 | 2003-04-01 | Uyrex Corporation | Isoflavone derivatives |
| PL205635B1 (pl) * | 2001-04-09 | 2010-05-31 | Inst Farmaceutyczny | Nowe pochodne genisteiny i zawierające je środki farmaceutyczne |
| CN100348592C (zh) * | 2001-12-28 | 2007-11-14 | 中国人民解放军第二军医大学 | 3，7，8－三取代－5－羟基苯并－γ－吡喃酮类化合物及其制备方法 |
| US20040023981A1 (en) | 2002-07-24 | 2004-02-05 | Yu Ren | Salt forms with tyrosine kinase activity |
| MY136174A (en) | 2002-12-24 | 2008-08-29 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
| US7803786B2 (en) * | 2004-06-17 | 2010-09-28 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
| ATE473737T1 (de) * | 2004-07-20 | 2010-07-15 | Furfural Espanol S A | Verwendung von 2,3-dehydronaringenin-derivaten zur behandlung von entzündungsprozessen und diese derivate enthaltende pharmazeutische zusammensetzung |
| DE602006016741D1 (de) | 2005-02-15 | 2010-10-21 | Dsm Ip Assets Bv | Zusammensetzungen mit polysacchariden |
| JP5134535B2 (ja) * | 2005-06-29 | 2013-01-30 | ディーエスエム アイピー アセッツ ビー．ブイ． | イソフラボンナノ粒子およびその使用 |
| US20070037875A1 (en) | 2005-08-11 | 2007-02-15 | The Scripps Research Institute | Genistein inhibition of transthyretin amyloidosis |
| WO2007061254A1 (en) | 2005-11-25 | 2007-05-31 | B & C Biopharm. Co., Ltd. | Genistein derivatives and anti-fungal composition containing the same |
| EP2074223A4 (en) | 2006-09-15 | 2010-03-10 | Foldrx Pharmaceuticals Inc | TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS |
| JP2008094751A (ja) * | 2006-10-11 | 2008-04-24 | Ono Pharmaceut Co Ltd | プランルカスト水和物含有医薬組成物 |
| EP2373326B1 (en) | 2008-12-11 | 2016-03-09 | Axcentua Pharmaceutucals AB | Crystalline forms of genistein |
-
2009
- 2009-12-11 EP EP09832607.7A patent/EP2373326B1/en not_active Not-in-force
- 2009-12-11 CN CN201510205311.6A patent/CN104860913B/zh not_active Expired - Fee Related
- 2009-12-11 JP JP2011540919A patent/JP5898958B2/ja not_active Expired - Fee Related
- 2009-12-11 CA CA2746652A patent/CA2746652C/en not_active Expired - Fee Related
- 2009-12-11 KR KR1020177021179A patent/KR101849059B1/ko active IP Right Grant
- 2009-12-11 US US13/133,085 patent/US9012495B2/en not_active Expired - Fee Related
- 2009-12-11 WO PCT/US2009/067664 patent/WO2010068861A1/en active Application Filing
- 2009-12-11 BR BRPI0923504-3A patent/BRPI0923504A2/pt not_active IP Right Cessation
- 2009-12-11 KR KR1020117016045A patent/KR20110106355A/ko active Search and Examination
- 2009-12-11 CN CN200980155203.5A patent/CN102292097B/zh not_active Expired - Fee Related
- 2009-12-11 AU AU2009324489A patent/AU2009324489B2/en not_active Ceased
-
2011
- 2011-06-09 IL IL213473A patent/IL213473A/en not_active IP Right Cessation
- 2011-07-08 ZA ZA2011/05045A patent/ZA201105045B/en unknown
-
2012
- 2012-05-31 HK HK12105339.5A patent/HK1164698A1/xx not_active IP Right Cessation
-
2014
- 2014-11-27 IL IL235943A patent/IL235943A0/en unknown
-
2015
- 2015-04-20 US US14/691,251 patent/US9492425B2/en not_active Expired - Fee Related
- 2015-05-22 JP JP2015104213A patent/JP6067781B2/ja not_active Expired - Fee Related
-
2016
- 2016-12-21 JP JP2016247753A patent/JP2017061566A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017061566A5 (ja) | ||
| EP4331677A3 (en) | Methods of treating feline coronavirus infections | |
| JP2015193630A5 (ja) | ||
| MX2018005382A (es) | Compuestos de biaril-monobactam y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. | |
| JP2012512164A5 (ja) | ||
| WO2017035413A3 (en) | Carbamate, ester, and ketone compounds for treatment of immune and inflammatory disorders | |
| JP2015528502A5 (ja) | ||
| PH12015502628A1 (en) | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | |
| JP2014507446A5 (ja) | ||
| JP2017524735A5 (ja) | ||
| PH12020550107A1 (en) | Chromane monobactam compounds for the treatment of bacterial infections | |
| MX2015016344A (es) | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. | |
| MX2018010878A (es) | Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. | |
| RU2018114480A (ru) | Соли и твердые формы монобактамного антибиотика | |
| WO2015187542A8 (en) | Histone deacetylase inhibitors and compositions and methods of use thereof | |
| EA201592255A1 (ru) | Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания | |
| CL2018002807A1 (es) | Métodos de tratamiento de cánceres pediátricos. | |
| JP2013507408A5 (ja) | ||
| WO2016164763A8 (en) | Compositions and methods for treating cns disorders | |
| JP2015516419A5 (ja) | ||
| MX2015008288A (es) | Derivados de piridona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral. | |
| MX2019002369A (es) | Compuestos para el tratamiento de enfermedades asociadas con una disfuncion mitocondrial. | |
| IL307992A (en) | Parasitic formulations containing isoxazoline and methods for treating blepharitis | |
| JP2016515550A5 (ja) | ||
| JP2014148552A5 (ja) |