JP2016539996A5 - - Google Patents
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- JP2016539996A5 JP2016539996A5 JP2016538524A JP2016538524A JP2016539996A5 JP 2016539996 A5 JP2016539996 A5 JP 2016539996A5 JP 2016538524 A JP2016538524 A JP 2016538524A JP 2016538524 A JP2016538524 A JP 2016538524A JP 2016539996 A5 JP2016539996 A5 JP 2016539996A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- nitrogen
- sulfur
- oxygen
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 96
- 229910052757 nitrogen Inorganic materials 0.000 description 50
- 125000005842 heteroatom Chemical group 0.000 description 47
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 46
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 46
- 229910052760 oxygen Inorganic materials 0.000 description 46
- 239000001301 oxygen Substances 0.000 description 46
- 229910052717 sulfur Inorganic materials 0.000 description 46
- 239000011593 sulfur Substances 0.000 description 46
- 150000001875 compounds Chemical class 0.000 description 45
- 0 *C(*(*)C(*)=O)C(**1)=C(*)*C1=C1*C(N*)=N**1 Chemical compound *C(*(*)C(*)=O)C(**1)=C(*)*C1=C1*C(N*)=N**1 0.000 description 41
- 229920006395 saturated elastomer Polymers 0.000 description 37
- 125000001931 aliphatic group Chemical group 0.000 description 21
- 229910052736 halogen Inorganic materials 0.000 description 20
- 150000002367 halogens Chemical class 0.000 description 20
- 125000002911 monocyclic heterocycle group Chemical group 0.000 description 16
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 10
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 125000001620 monocyclic carbocycle group Chemical group 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 125000002619 bicyclic group Chemical group 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
- 125000002393 azetidinyl group Chemical group 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000002950 monocyclic group Chemical group 0.000 description 3
- 125000003386 piperidinyl group Chemical group 0.000 description 3
- ZBOAVARJHVEXAV-VYPXRBNDSA-N C/C(/C=N)=C/NC(CC1)CCC1C(O)=O Chemical compound C/C(/C=N)=C/NC(CC1)CCC1C(O)=O ZBOAVARJHVEXAV-VYPXRBNDSA-N 0.000 description 2
- ZPPAFGGDEWACHQ-UHFFFAOYSA-N CC(C)(C)c1ncc(C)[s]1 Chemical compound CC(C)(C)c1ncc(C)[s]1 ZPPAFGGDEWACHQ-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- FLWMZUZXOCURSQ-UHFFFAOYSA-N Cc1n[n](CCC2)c2c1 Chemical compound Cc1n[n](CCC2)c2c1 FLWMZUZXOCURSQ-UHFFFAOYSA-N 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000842 isoxazolyl group Chemical group 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 description 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- ALBOIKUQWILHBQ-ALCCZGGFSA-N CC(C(C(S/C(/C)=C\N)=C)(F)F)=C Chemical compound CC(C(C(S/C(/C)=C\N)=C)(F)F)=C ALBOIKUQWILHBQ-ALCCZGGFSA-N 0.000 description 1
- LMVHALAYUBESJG-UHFFFAOYSA-N CC(C)(C)C1CNCC1 Chemical compound CC(C)(C)C1CNCC1 LMVHALAYUBESJG-UHFFFAOYSA-N 0.000 description 1
- ZGMZDUWNJFJZAW-NSLJVHTKSA-N CC(C)/C(/C=N)=C/NC Chemical compound CC(C)/C(/C=N)=C/NC ZGMZDUWNJFJZAW-NSLJVHTKSA-N 0.000 description 1
- ALUVICSBTSCGOM-KHPPLWFESA-N CCC/C(/SC(C(C)(C)C)=C)=C(\CN)/N Chemical compound CCC/C(/SC(C(C)(C)C)=C)=C(\CN)/N ALUVICSBTSCGOM-KHPPLWFESA-N 0.000 description 1
- WYUIWKFIFOJVKW-UHFFFAOYSA-N Cc(cc1)cc(Cl)c1Cl Chemical compound Cc(cc1)cc(Cl)c1Cl WYUIWKFIFOJVKW-UHFFFAOYSA-N 0.000 description 1
- PTLTZFJYSSVFEC-UHFFFAOYSA-N Cc1cc(CNCC2)c2[s]1 Chemical compound Cc1cc(CNCC2)c2[s]1 PTLTZFJYSSVFEC-UHFFFAOYSA-N 0.000 description 1
- KUFCFZFIBCYHQN-UHFFFAOYSA-N Cc1cc(COCC2)c2[s]1 Chemical compound Cc1cc(COCC2)c2[s]1 KUFCFZFIBCYHQN-UHFFFAOYSA-N 0.000 description 1
- LCERCHDXDTXTEA-UHFFFAOYSA-N Cc1cc(NCCC2)c2[s]1 Chemical compound Cc1cc(NCCC2)c2[s]1 LCERCHDXDTXTEA-UHFFFAOYSA-N 0.000 description 1
- UFISOUUWLYZFEX-UHFFFAOYSA-N Cc1cc(OCCC2)c2[s]1 Chemical compound Cc1cc(OCCC2)c2[s]1 UFISOUUWLYZFEX-UHFFFAOYSA-N 0.000 description 1
- ZBCOTWQYKCHKQK-UHFFFAOYSA-N Cc1ccc(C(F)(F)F)cn1 Chemical compound Cc1ccc(C(F)(F)F)cn1 ZBCOTWQYKCHKQK-UHFFFAOYSA-N 0.000 description 1
- DQMSQXZUGHBBDL-UHFFFAOYSA-N Cc1nc(CCCC2)c2[s]1 Chemical compound Cc1nc(CCCC2)c2[s]1 DQMSQXZUGHBBDL-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- RDRQUUWCJTYHCT-UHFFFAOYSA-N FC(C1CCNCC1)(F)F Chemical compound FC(C1CCNCC1)(F)F RDRQUUWCJTYHCT-UHFFFAOYSA-N 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- -1 piperizinyl Chemical group 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914886P | 2013-12-11 | 2013-12-11 | |
| US61/914,886 | 2013-12-11 | ||
| PCT/US2014/069853 WO2015089337A1 (en) | 2013-12-11 | 2014-12-11 | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017236092A Division JP6526167B2 (ja) | 2013-12-11 | 2017-12-08 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539996A JP2016539996A (ja) | 2016-12-22 |
| JP2016539996A5 true JP2016539996A5 (https=) | 2018-01-25 |
| JP6431914B2 JP6431914B2 (ja) | 2018-11-28 |
Family
ID=52302344
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538524A Active JP6431914B2 (ja) | 2013-12-11 | 2014-12-11 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
| JP2017236092A Active JP6526167B2 (ja) | 2013-12-11 | 2017-12-08 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
| JP2019087573A Withdrawn JP2019163280A (ja) | 2013-12-11 | 2019-05-07 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
| JP2021041198A Active JP7076022B2 (ja) | 2013-12-11 | 2021-03-15 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017236092A Active JP6526167B2 (ja) | 2013-12-11 | 2017-12-08 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
| JP2019087573A Withdrawn JP2019163280A (ja) | 2013-12-11 | 2019-05-07 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
| JP2021041198A Active JP7076022B2 (ja) | 2013-12-11 | 2021-03-15 | 腫瘍学、神経学及び免疫学におけるヒト疾患の治療に有用なビアリール化合物 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US9809577B2 (https=) |
| EP (3) | EP3080103B9 (https=) |
| JP (4) | JP6431914B2 (https=) |
| KR (1) | KR102413253B1 (https=) |
| CN (3) | CN106459002B (https=) |
| AR (2) | AR098721A1 (https=) |
| AU (2) | AU2014362231B2 (https=) |
| BR (1) | BR112016012860A2 (https=) |
| CA (1) | CA2932608C (https=) |
| CL (2) | CL2016001435A1 (https=) |
| CY (1) | CY1120517T1 (https=) |
| DK (1) | DK3080103T3 (https=) |
| EA (2) | EA030538B1 (https=) |
| ES (1) | ES2678021T3 (https=) |
| HR (1) | HRP20181109T1 (https=) |
| HU (1) | HUE040346T2 (https=) |
| IL (2) | IL246031B (https=) |
| LT (1) | LT3080103T (https=) |
| MX (2) | MX388978B (https=) |
| MY (1) | MY179781A (https=) |
| NZ (1) | NZ721217A (https=) |
| PH (1) | PH12016501107B1 (https=) |
| PL (1) | PL3080103T3 (https=) |
| PT (1) | PT3080103T (https=) |
| RS (1) | RS57662B1 (https=) |
| SA (1) | SA518391170B1 (https=) |
| SG (2) | SG11201604595VA (https=) |
| SI (1) | SI3080103T1 (https=) |
| SM (1) | SMT201800373T1 (https=) |
| TW (3) | TWI608002B (https=) |
| WO (1) | WO2015089337A1 (https=) |
| ZA (1) | ZA201706244B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PT2473049T (pt) * | 2009-09-04 | 2019-03-04 | Sunesis Pharmaceuticals Inc | Inibidores de tirosina quinase de bruton |
| AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
| EP3080103B9 (en) * | 2013-12-11 | 2018-09-19 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| EP3307731A1 (en) * | 2015-06-10 | 2018-04-18 | Biogen MA Inc. | Adipate forms and compositions of biaryl inhibitors of bruton's tyrosine kinase |
| EP3307732A1 (en) | 2015-06-10 | 2018-04-18 | Biogen MA Inc. | Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase |
| EP3388428B1 (en) * | 2015-12-07 | 2021-08-04 | Suzhou Sinovent Pharmaceuticals Company | Five-membered heterocyclic amides wnt pathway inhibitor |
| JO3793B1 (ar) * | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
| JO3794B1 (ar) * | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| CN118147079A (zh) * | 2016-03-31 | 2024-06-07 | 来恩生物医药私人有限公司 | 表达外源病毒特异性t细胞受体(tcr)的非活化t细胞 |
| EP3476848A4 (en) | 2016-06-27 | 2020-01-15 | Hangzhou Rex Pharmaceutical Co., Ltd | BENZOFURANE-PYRAZOLE-AMINE PROTEIN KINASE INHIBITOR |
| JP7214632B2 (ja) | 2016-07-21 | 2023-01-30 | バイオジェン エムエー インク． | ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物 |
| WO2018124001A1 (ja) | 2016-12-27 | 2018-07-05 | 国立研究開発法人理化学研究所 | Ｂｍｐシグナル阻害化合物 |
| JP7145874B2 (ja) * | 2017-04-14 | 2022-10-03 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| RU2020126188A (ru) | 2018-01-10 | 2022-02-10 | Альинки Байофарма | Соединения тетрагидроизохинолина |
| BR112020014428A2 (pt) | 2018-01-19 | 2020-12-01 | Cytokinetics, Inc. | composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco |
| US20190330226A1 (en) * | 2018-04-26 | 2019-10-31 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| US10899753B2 (en) | 2018-05-14 | 2021-01-26 | Biogen Ma Inc. | Inhibiting agents for Bruton's tyrosine kinase |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| US12109193B2 (en) | 2018-07-31 | 2024-10-08 | Loxo Oncology Inc. | Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide |
| EP3866926A1 (en) * | 2018-10-15 | 2021-08-25 | Biogen MA Inc. | Crystalline polymorphs of bruton's tyrosine kinase inhibitors |
| WO2020118683A1 (en) * | 2018-12-14 | 2020-06-18 | Lynk Pharmaceuticals Co. Ltd. | Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| WO2020232330A1 (en) | 2019-05-15 | 2020-11-19 | Biogen Ma Inc. | Inhibiting agents for bruton's tyrosine kinase |
| CN110627775B (zh) * | 2019-10-24 | 2026-01-30 | 特科罗生物科技(成都)有限公司 | 一种小分子化合物 |
| EP4081514A1 (en) * | 2019-12-23 | 2022-11-02 | Biogen MA Inc. | Btk inhibitors |
| CN116917279A (zh) * | 2020-08-07 | 2023-10-20 | 渤健马萨诸塞州股份有限公司 | Btk抑制剂 |
| EP4192587A1 (en) | 2020-08-07 | 2023-06-14 | Biogen MA Inc. | Btk inhibitors |
| US20240216330A1 (en) | 2021-04-02 | 2024-07-04 | Biogen Ma Inc. | Combination treatment methods of multiple sclerosis |
| IL309528A (en) * | 2021-06-21 | 2024-02-01 | Beigene Switzerland Gmbh | (R)-glutrimide CRBN ligands and methods of use |
| AU2022424178A1 (en) | 2021-12-30 | 2024-07-11 | Beone Medicines I Gmbh | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| CN116891437B (zh) * | 2022-04-06 | 2025-10-28 | 长春金赛药业有限责任公司 | 氨基酸衍生物、药物组合物及其制备方法和应用 |
| CN120457122A (zh) | 2023-01-04 | 2025-08-08 | Ab科学有限公司 | 微管蛋白聚合抑制剂 |
| CN117088851A (zh) * | 2023-07-13 | 2023-11-21 | 特科罗生物科技(成都)有限公司 | 一种嘧啶胺类nuak抑制剂及其制备方法和用途 |
| WO2026012424A1 (zh) * | 2024-07-10 | 2026-01-15 | 江苏恒瑞医药股份有限公司 | 一种杂芳基类化合物、其制备方法及其在医药上的应用 |
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