JP2016537030A5 - - Google Patents
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- Publication number
- JP2016537030A5 JP2016537030A5 JP2016553749A JP2016553749A JP2016537030A5 JP 2016537030 A5 JP2016537030 A5 JP 2016537030A5 JP 2016553749 A JP2016553749 A JP 2016553749A JP 2016553749 A JP2016553749 A JP 2016553749A JP 2016537030 A5 JP2016537030 A5 JP 2016537030A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- mutant
- propeller
- propeller nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000039446 nucleic acids Human genes 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 238000000034 method Methods 0.000 claims 20
- 241000224016 Plasmodium Species 0.000 claims 15
- 102100040487 Keratin, type I cytoskeletal 13 Human genes 0.000 claims 14
- 239000000523 sample Substances 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108700028369 Alleles Proteins 0.000 claims 6
- 108091005461 Nucleic proteins Proteins 0.000 claims 6
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims 2
- 239000003430 antimalarial agent Substances 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 claims 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
- 101100519158 Arabidopsis thaliana PCR2 gene Proteins 0.000 claims 1
- 101100519159 Arabidopsis thaliana PCR3 gene Proteins 0.000 claims 1
- 101100519160 Arabidopsis thaliana PCR4 gene Proteins 0.000 claims 1
- 101100519161 Arabidopsis thaliana PCR5 gene Proteins 0.000 claims 1
- 101100519162 Arabidopsis thaliana PCR6 gene Proteins 0.000 claims 1
- 235000001258 Cinchona calisaya Nutrition 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101150102573 PCR1 gene Proteins 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229960003677 chloroquine Drugs 0.000 claims 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000003205 genotyping method Methods 0.000 claims 1
- 238000009830 intercalation Methods 0.000 claims 1
- 229960001962 mefloquine Drugs 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229960000948 quinine Drugs 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904651P | 2013-11-15 | 2013-11-15 | |
| US61/904,651 | 2013-11-15 | ||
| US201462062439P | 2014-10-10 | 2014-10-10 | |
| US62/062,439 | 2014-10-10 | ||
| PCT/IB2014/002910 WO2015071759A1 (en) | 2013-11-15 | 2014-11-14 | A molecular marker of plasmodium falciparum artemisinin resistance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220442A Division JP2020043873A (ja) | 2013-11-15 | 2019-12-05 | 熱帯熱マラリア原虫アルテミシニン耐性の分子マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537030A JP2016537030A (ja) | 2016-12-01 |
| JP2016537030A5 true JP2016537030A5 (https=) | 2017-12-28 |
| JP6667445B2 JP6667445B2 (ja) | 2020-03-18 |
Family
ID=52440720
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553749A Active JP6667445B2 (ja) | 2013-11-15 | 2014-11-14 | 熱帯熱マラリア原虫アルテミシニン耐性の分子マーカー |
| JP2019220442A Pending JP2020043873A (ja) | 2013-11-15 | 2019-12-05 | 熱帯熱マラリア原虫アルテミシニン耐性の分子マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220442A Pending JP2020043873A (ja) | 2013-11-15 | 2019-12-05 | 熱帯熱マラリア原虫アルテミシニン耐性の分子マーカー |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10900093B2 (https=) |
| EP (1) | EP3068903B1 (https=) |
| JP (2) | JP6667445B2 (https=) |
| KR (1) | KR102283408B1 (https=) |
| CN (1) | CN105940115B (https=) |
| AU (1) | AU2014349828B2 (https=) |
| BR (1) | BR112016011046A2 (https=) |
| ES (1) | ES2720728T3 (https=) |
| WO (1) | WO2015071759A1 (https=) |
| ZA (1) | ZA201602703B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3497237B1 (en) | 2016-08-10 | 2022-05-04 | Institut Pasteur | Methods and reagents for detecting piperaquine-resistant plasmodium falciparum malaria |
| CN109504791A (zh) * | 2018-12-29 | 2019-03-22 | 潮州市人民医院 | 用于检测疟原虫青蒿素耐药性相关k13基因突变的试剂盒 |
| CN109897901A (zh) * | 2019-02-27 | 2019-06-18 | 四川国际旅行卫生保健中心 | 检测恶性疟原虫k13基因突变位点的特异性引物组及其应用 |
| CN109797207A (zh) * | 2019-02-27 | 2019-05-24 | 四川国际旅行卫生保健中心 | 一种检测恶性疟原虫k13基因四个抗性突变位点的方法 |
| CN112592395A (zh) * | 2020-12-11 | 2021-04-02 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | 一种恶性疟原虫RIFIN重组蛋白PfRIFIN-54的构建、制备及用途 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| JP2650159B2 (ja) | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| CA2005589C (en) | 1988-12-16 | 2001-02-06 | Akzo Nobel Nv | Self-sustained, sequence replication system |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| EP1820858B1 (en) | 1991-03-01 | 2009-08-12 | Dyax Corporation | Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| TWI521064B (zh) * | 2007-05-28 | 2016-02-11 | 國立大學法人愛媛大學 | 用於偵測瘧原蟲之引子（二） |
| CN100535125C (zh) * | 2007-06-28 | 2009-09-02 | 中国疾病预防控制中心寄生虫病预防控制所 | 用于扩增恶性疟原虫药物抗性相关基因的多重pcr引物及方法 |
-
2014
- 2014-11-14 WO PCT/IB2014/002910 patent/WO2015071759A1/en not_active Ceased
- 2014-11-14 KR KR1020167015777A patent/KR102283408B1/ko not_active Expired - Fee Related
- 2014-11-14 BR BR112016011046A patent/BR112016011046A2/pt not_active IP Right Cessation
- 2014-11-14 EP EP14833371.9A patent/EP3068903B1/en active Active
- 2014-11-14 US US15/036,064 patent/US10900093B2/en active Active
- 2014-11-14 ES ES14833371T patent/ES2720728T3/es active Active
- 2014-11-14 JP JP2016553749A patent/JP6667445B2/ja active Active
- 2014-11-14 AU AU2014349828A patent/AU2014349828B2/en active Active
- 2014-11-14 CN CN201480062113.2A patent/CN105940115B/zh active Active
-
2016
- 2016-04-19 ZA ZA2016/02703A patent/ZA201602703B/en unknown
-
2019
- 2019-12-05 JP JP2019220442A patent/JP2020043873A/ja active Pending
-
2020
- 2020-12-16 US US17/124,478 patent/US11732312B2/en active Active
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