JP2016536332A5 - - Google Patents
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- JP2016536332A5 JP2016536332A5 JP2016539564A JP2016539564A JP2016536332A5 JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5 JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183193.5 | 2013-09-05 | ||
| EP13183193 | 2013-09-05 | ||
| PCT/EP2014/069013 WO2015032932A1 (en) | 2013-09-05 | 2014-09-05 | Il-18 binding protein (il-18bp) in inflammatory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Division JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536332A JP2016536332A (ja) | 2016-11-24 |
| JP2016536332A5 true JP2016536332A5 (https=) | 2017-08-10 |
| JP6820743B2 JP6820743B2 (ja) | 2021-01-27 |
Family
ID=49111035
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539564A Active JP6820743B2 (ja) | 2013-09-05 | 2014-09-05 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10858426B2 (https=) |
| EP (2) | EP3978526A1 (https=) |
| JP (2) | JP6820743B2 (https=) |
| KR (2) | KR102512797B1 (https=) |
| CN (2) | CN115925928A (https=) |
| AU (1) | AU2014317035B2 (https=) |
| CL (1) | CL2016000506A1 (https=) |
| CY (1) | CY1124698T1 (https=) |
| DK (1) | DK3041864T3 (https=) |
| ES (1) | ES2892923T3 (https=) |
| HU (1) | HUE055608T2 (https=) |
| IL (1) | IL244169B (https=) |
| LT (1) | LT3041864T (https=) |
| MX (1) | MX385868B (https=) |
| NZ (1) | NZ717671A (https=) |
| PH (1) | PH12016500425B1 (https=) |
| PL (1) | PL3041864T3 (https=) |
| PT (1) | PT3041864T (https=) |
| RU (1) | RU2731713C2 (https=) |
| SG (1) | SG11201601717VA (https=) |
| SI (1) | SI3041864T1 (https=) |
| UA (1) | UA125204C2 (https=) |
| WO (1) | WO2015032932A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115925928A (zh) | 2013-09-05 | 2023-04-07 | Ab2生物股份有限公司 | 炎性疾病中的il-18结合蛋白(il-18bp) |
| US10882905B2 (en) * | 2015-03-05 | 2021-01-05 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| US20180362660A1 (en) * | 2016-05-09 | 2018-12-20 | Schickwann Tsai | Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes |
| GB201614455D0 (en) | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
| DE102016219607B4 (de) * | 2016-10-10 | 2025-04-30 | Siemens Healthineers Ag | Erzeugung einer mit anatomischen Bilddaten korrelierten Ergebniskarte |
| WO2019133799A1 (en) * | 2017-12-29 | 2019-07-04 | University Of Florida Research Foundation | Monoclonal antibodies targeting microtubule-binding domain of tau protein |
| TWI679279B (zh) * | 2018-05-09 | 2019-12-11 | 臺中榮民總醫院 | 檢測成人發作型史笛兒氏症之罹病風險及預後之方法 |
| CA3104362A1 (en) | 2018-06-19 | 2019-12-26 | Shanghaitech University | Human antibodies to human interleukin 18 receptor alpha and beta |
| US12269874B2 (en) | 2018-12-03 | 2025-04-08 | mAbProtein Co., Ltd. | Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof |
| CN110433289B (zh) * | 2019-09-10 | 2024-12-17 | 中山大学附属口腔医院 | 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物 |
| IL292443A (en) * | 2019-11-04 | 2022-06-01 | Medimmune Ltd | Methods for using IL-33 antagonists |
| US20230173021A1 (en) * | 2020-05-06 | 2023-06-08 | Ab2 Bio Sa | IL-18 Binding Protein (IL-18BP) In Respiratory Diseases |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| EP4178614A4 (en) * | 2020-07-08 | 2024-10-30 | Georgia Tech Research Corporation | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF SARS-COV-2 VIRUS INFECTIONS |
| EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
| KR20220044057A (ko) * | 2020-09-29 | 2022-04-06 | 주식회사 에이프릴바이오 | 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도 |
| JP2023549257A (ja) | 2020-11-18 | 2023-11-22 | ノバルティス アーゲー | Nlrc4-gofインフラマソーム病の処置における使用のための二特異性抗体 |
| WO2022109340A1 (en) * | 2020-11-20 | 2022-05-27 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Immunomodulatory clinical biomarker profiles and uses thereof |
| EP4371573A4 (en) | 2021-07-13 | 2025-08-20 | National Univ Corporation Tokai National Higher Education And Research System | MEDICINAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE |
| WO2023067348A1 (en) * | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
| CA3244428A1 (en) | 2022-03-04 | 2023-09-07 | Ab2 Bio Sa | IL-18 BINDING PROTEIN (IL-18BP) IN THE TREATMENT OF VEXAS SYNDROME |
| IL321948A (en) | 2023-01-06 | 2025-09-01 | Lassen Therapeutics Inc | Anti-IL-18 BP antibodies |
| EP4646270A2 (en) | 2023-01-06 | 2025-11-12 | Alector LLC | Anti-il18 binding protein antibodies and methods of use thereof |
| TW202434634A (zh) * | 2023-02-20 | 2024-09-01 | 大陸商瑞石生物醫藥有限公司 | 抗IL-18Rβ抗體、其抗原結合片段及其醫藥應用 |
| AU2024238511A1 (en) * | 2023-03-21 | 2025-10-02 | Coya Therapeutics, Inc. | Biomarkers of amyotrophic lateral sclerosis and uses thereof |
| WO2025253161A1 (en) * | 2024-06-05 | 2025-12-11 | Aprilbio Co., Ltd. | Methods for treating liver diseases using recombinant fusion proteins comprising interleukin-18-binding protein and antigen binding fragment to serum albumin |
| WO2026038145A1 (en) | 2024-08-13 | 2026-02-19 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and methods of using same |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| ATE190629T1 (de) | 1991-01-18 | 2000-04-15 | Amgen Inc | Methoden zur behandlung von durch den tumor nekrose faktor ausgelösten krankheiten |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
| WO1996013590A2 (en) | 1994-10-21 | 1996-05-09 | Innogenetics N.V. | New sequences of hepatitis c virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
| US5756662A (en) | 1995-03-14 | 1998-05-26 | Corixa Corporation | Compounds and methods for the detection of T. cruzi infection |
| US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| TWI335336B (https=) | 2000-02-10 | 2011-01-01 | Abbott Gmbh & Co Kg | |
| NZ520122A (en) * | 2000-02-21 | 2005-04-29 | Applied Research Systems | Use of IL-18 inhibitors |
| EE05056B1 (et) | 2000-05-05 | 2008-08-15 | Applied Research Systems Ars Holding N.V. | IL-18 inhibiitorite kasutamine ravimi valmistamiseks, mis on ette nhtud ateroskleroosi ravimiseks ja/v?i ennetamiseks |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| EA013564B1 (ru) | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| AU2002224417A1 (en) | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| HU229164B1 (en) * | 2001-01-29 | 2013-09-30 | Serono Sa Coinsins Lab | Use of il-18 inhibitors for the treatment and/or prevention of heart disease |
| ES2334773T3 (es) * | 2001-05-16 | 2010-03-16 | Yeda Research And Development Co. Ltd. | Uso de inhibidores de il-18 para el tratamiento o prevencion de la sepsis. |
| PL216228B1 (pl) | 2001-05-25 | 2014-03-31 | Ares Trading Sa | Zastosowanie białka wiążącego IL-18 |
| GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| US20080076708A1 (en) * | 2003-05-13 | 2008-03-27 | Valter Altarocca | Active Variants of the Il-18 Binding Protein and Medical Uses Thereof |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| AU2011224023C1 (en) | 2003-11-12 | 2013-08-29 | Abbvie Inc. | IL-18 binding proteins |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| WO2005087249A1 (ja) | 2004-03-11 | 2005-09-22 | Kurume University | プロテアーゼ阻害剤及び疾患の予防又は治療剤 |
| CA2572921C (en) | 2004-07-09 | 2017-01-03 | The University Of North Carolina At Chapel Hill | Replication-competent and propagation-defective venezuelan equine encephalitis (vee) viral adjuvants |
| EP1793859B1 (en) | 2004-08-20 | 2009-03-25 | Smithkline Beecham Corporation | Treatment of oral and intestinal mucositis by administering human il-18 |
| EP2267024B1 (en) | 2005-06-03 | 2012-05-09 | Ares Trading S.A. | Production of recombinant Il-18 binding protein |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| DE602006021038D1 (de) | 2005-09-15 | 2011-05-12 | Univ Mcgill | Verfahren zur diagnose eines ovarialkarzinoms |
| WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| CA2691039A1 (en) | 2007-05-29 | 2008-12-11 | Yale University | Il-18 and protein kinase r inhibition for the treatment of copd |
| KR20140003467A (ko) * | 2010-12-20 | 2014-01-09 | 메디뮨 리미티드 | 항il-18 항체 및 그의 용도 |
| US9376489B2 (en) * | 2012-09-07 | 2016-06-28 | Novartis Ag | IL-18 binding molecules |
| CN115925928A (zh) | 2013-09-05 | 2023-04-07 | Ab2生物股份有限公司 | 炎性疾病中的il-18结合蛋白(il-18bp) |
| US10882905B2 (en) * | 2015-03-05 | 2021-01-05 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
-
2014
- 2014-09-05 CN CN202210945119.0A patent/CN115925928A/zh active Pending
- 2014-09-05 UA UAA201603367A patent/UA125204C2/uk unknown
- 2014-09-05 AU AU2014317035A patent/AU2014317035B2/en active Active
- 2014-09-05 JP JP2016539564A patent/JP6820743B2/ja active Active
- 2014-09-05 PH PH1/2016/500425A patent/PH12016500425B1/en unknown
- 2014-09-05 EP EP21181013.0A patent/EP3978526A1/en active Pending
- 2014-09-05 SG SG11201601717VA patent/SG11201601717VA/en unknown
- 2014-09-05 RU RU2016112596A patent/RU2731713C2/ru active
- 2014-09-05 NZ NZ717671A patent/NZ717671A/en unknown
- 2014-09-05 US US14/916,917 patent/US10858426B2/en active Active
- 2014-09-05 PL PL14759210T patent/PL3041864T3/pl unknown
- 2014-09-05 EP EP14759210.9A patent/EP3041864B1/en active Active
- 2014-09-05 DK DK14759210.9T patent/DK3041864T3/da active
- 2014-09-05 KR KR1020217034984A patent/KR102512797B1/ko active Active
- 2014-09-05 LT LTEPPCT/EP2014/069013T patent/LT3041864T/lt unknown
- 2014-09-05 KR KR1020167008846A patent/KR102321172B1/ko active Active
- 2014-09-05 PT PT14759210T patent/PT3041864T/pt unknown
- 2014-09-05 SI SI201431879T patent/SI3041864T1/sl unknown
- 2014-09-05 HU HUE14759210A patent/HUE055608T2/hu unknown
- 2014-09-05 MX MX2016002719A patent/MX385868B/es unknown
- 2014-09-05 CN CN201480060413.7A patent/CN105722858A/zh active Pending
- 2014-09-05 ES ES14759210T patent/ES2892923T3/es active Active
- 2014-09-05 WO PCT/EP2014/069013 patent/WO2015032932A1/en not_active Ceased
-
2016
- 2016-02-17 IL IL244169A patent/IL244169B/en active IP Right Grant
- 2016-03-04 CL CL2016000506A patent/CL2016000506A1/es unknown
-
2019
- 2019-11-21 JP JP2019210436A patent/JP2020055821A/ja active Pending
-
2020
- 2020-05-26 US US16/883,735 patent/US11530263B2/en active Active
-
2021
- 2021-09-16 CY CY20211100816T patent/CY1124698T1/el unknown
-
2022
- 2022-11-14 US US18/054,936 patent/US20230250164A1/en active Pending
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