JP2016534157A5 - - Google Patents
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- JP2016534157A5 JP2016534157A5 JP2016550681A JP2016550681A JP2016534157A5 JP 2016534157 A5 JP2016534157 A5 JP 2016534157A5 JP 2016550681 A JP2016550681 A JP 2016550681A JP 2016550681 A JP2016550681 A JP 2016550681A JP 2016534157 A5 JP2016534157 A5 JP 2016534157A5
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- Prior art keywords
- cancer
- cell
- lymphoma
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 53
- 201000011510 cancer Diseases 0.000 claims 49
- 210000003719 b-lymphocyte Anatomy 0.000 claims 32
- 230000036210 malignancy Effects 0.000 claims 28
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 22
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 20
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 20
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 16
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims 12
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 12
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims 12
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 11
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 11
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 11
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 11
- 206010006187 Breast cancer Diseases 0.000 claims 10
- 208000026310 Breast neoplasm Diseases 0.000 claims 10
- 206010009944 Colon cancer Diseases 0.000 claims 10
- 206010025323 Lymphomas Diseases 0.000 claims 10
- 208000029742 colonic neoplasm Diseases 0.000 claims 10
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 8
- 229960001507 ibrutinib Drugs 0.000 claims 8
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical group C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 8
- 201000001441 melanoma Diseases 0.000 claims 8
- 201000005787 hematologic cancer Diseases 0.000 claims 7
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 6
- 206010005003 Bladder cancer Diseases 0.000 claims 6
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 6
- 208000034578 Multiple myelomas Diseases 0.000 claims 6
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 6
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 206010038389 Renal cancer Diseases 0.000 claims 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 6
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 6
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 6
- 201000009777 distal biliary tract carcinoma Diseases 0.000 claims 6
- 201000010982 kidney cancer Diseases 0.000 claims 6
- 201000005202 lung cancer Diseases 0.000 claims 6
- 208000020816 lung neoplasm Diseases 0.000 claims 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 6
- 201000002528 pancreatic cancer Diseases 0.000 claims 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 6
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 230000002489 hematologic effect Effects 0.000 claims 5
- 229940124291 BTK inhibitor Drugs 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 4
- 201000004085 CLL/SLL Diseases 0.000 claims 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 4
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 4
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 4
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 4
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 4
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 4
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims 4
- 102000017578 LAG3 Human genes 0.000 claims 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 4
- 206010070308 Refractory cancer Diseases 0.000 claims 4
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 4
- 208000023738 chronic lymphocytic leukemia/small lymphocytic lymphoma Diseases 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 208000024312 invasive carcinoma Diseases 0.000 claims 4
- 230000001394 metastastic effect Effects 0.000 claims 4
- 208000037819 metastatic cancer Diseases 0.000 claims 4
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims 4
- -1 CD86 Proteins 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- 101150051188 Adora2a gene Proteins 0.000 claims 2
- 201000003076 Angiosarcoma Diseases 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 2
- 102100024263 CD160 antigen Human genes 0.000 claims 2
- 102100038077 CD226 antigen Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100025221 CD70 antigen Human genes 0.000 claims 2
- 206010007279 Carcinoid tumour of the gastrointestinal tract Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 102100031351 Galectin-9 Human genes 0.000 claims 2
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 2
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 2
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 2
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 2
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 2
- 101001037261 Homo sapiens Indoleamine 2,3-dioxygenase 2 Proteins 0.000 claims 2
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 2
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 2
- 102100040062 Indoleamine 2,3-dioxygenase 2 Human genes 0.000 claims 2
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 2
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 2
- 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 claims 2
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 2
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 2
- 206010073099 Lobular breast carcinoma in situ Diseases 0.000 claims 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims 2
- 208000027868 Paget disease Diseases 0.000 claims 2
- 208000002163 Phyllodes Tumor Diseases 0.000 claims 2
- 206010071776 Phyllodes tumour Diseases 0.000 claims 2
- 101710094000 Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 206010038111 Recurrent cancer Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000003252 Signet Ring Cell Carcinoma Diseases 0.000 claims 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 2
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 201000005389 breast carcinoma in situ Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 208000022136 colorectal lymphoma Diseases 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000001079 digestive effect Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 claims 2
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 201000004653 inflammatory breast carcinoma Diseases 0.000 claims 2
- 208000030776 invasive breast carcinoma Diseases 0.000 claims 2
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims 2
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- 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000011059 lobular neoplasia Diseases 0.000 claims 2
- 108091005446 macrophage receptors Proteins 0.000 claims 2
- 208000027202 mammary Paget disease Diseases 0.000 claims 2
- 201000010879 mucinous adenocarcinoma Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
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- 201000008123 signet ring cell adenocarcinoma Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims 1
- 108010079505 Endostatins Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
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- 229960003957 dexamethasone Drugs 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 1
- 229960004963 mesalazine Drugs 0.000 claims 1
- 229960002450 ofatumumab Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
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- 229960003433 thalidomide Drugs 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895988P | 2013-10-25 | 2013-10-25 | |
| US61/895,988 | 2013-10-25 | ||
| US201361899764P | 2013-11-04 | 2013-11-04 | |
| US61/899,764 | 2013-11-04 | ||
| US201361911953P | 2013-12-04 | 2013-12-04 | |
| US61/911,953 | 2013-12-04 | ||
| US201461937392P | 2014-02-07 | 2014-02-07 | |
| US61/937,392 | 2014-02-07 | ||
| US201461968312P | 2014-03-20 | 2014-03-20 | |
| US61/968,312 | 2014-03-20 | ||
| US201462023705P | 2014-07-11 | 2014-07-11 | |
| US201462023742P | 2014-07-11 | 2014-07-11 | |
| US62/023,742 | 2014-07-11 | ||
| US62/023,705 | 2014-07-11 | ||
| PCT/US2014/062278 WO2015061752A1 (en) | 2013-10-25 | 2014-10-24 | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019064721A Division JP2019142890A (ja) | 2013-10-25 | 2019-03-28 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534157A JP2016534157A (ja) | 2016-11-04 |
| JP2016534157A5 true JP2016534157A5 (https=) | 2017-12-07 |
| JP6508785B2 JP6508785B2 (ja) | 2019-05-08 |
Family
ID=52993668
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550681A Expired - Fee Related JP6508785B2 (ja) | 2013-10-25 | 2014-10-24 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
| JP2019064721A Ceased JP2019142890A (ja) | 2013-10-25 | 2019-03-28 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
| JP2020210693A Pending JP2021063091A (ja) | 2013-10-25 | 2020-12-18 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019064721A Ceased JP2019142890A (ja) | 2013-10-25 | 2019-03-28 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
| JP2020210693A Pending JP2021063091A (ja) | 2013-10-25 | 2020-12-18 | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20150118222A1 (https=) |
| EP (1) | EP3060251A4 (https=) |
| JP (3) | JP6508785B2 (https=) |
| KR (1) | KR20160066554A (https=) |
| CN (1) | CN105848680A (https=) |
| AU (2) | AU2014339816B2 (https=) |
| BR (1) | BR112016009200A8 (https=) |
| CA (1) | CA2927794A1 (https=) |
| EA (1) | EA201690746A1 (https=) |
| IL (1) | IL245042A0 (https=) |
| MX (1) | MX2016005283A (https=) |
| TW (2) | TWI660739B (https=) |
| WO (1) | WO2015061752A1 (https=) |
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10058621B2 (en) * | 2015-06-25 | 2018-08-28 | Immunomedics, Inc. | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| CA2730930C (en) | 2008-07-16 | 2015-01-13 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| SG10201503168VA (en) | 2010-04-22 | 2015-06-29 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| CA3007787C (en) | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| HRP20160305T1 (hr) | 2010-10-26 | 2016-07-01 | Mars, Incorporated | Borati kao inhibitori arginaze |
| JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス，インク． | Ｂｒｕｔｏｎ型チロシンキナーゼの阻害剤 |
| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| US9199997B2 (en) | 2011-11-29 | 2015-12-01 | Ono Pharmaceutical Co., Ltd. | Purinone derivative hydrochloride |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| KR20210033067A (ko) | 2012-06-04 | 2021-03-25 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| CA2902686C (en) | 2013-04-25 | 2017-01-24 | Beigene, Ltd. | Fused heterocyclic compounds as protein kinase inhibitors |
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| HUP0004421A3 (en) | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
| RU2192281C2 (ru) | 1996-10-11 | 2002-11-10 | Бристол-Маерс Сквибб Компани | Способы и композиции для иммуномодуляции |
| EP0966465B1 (en) | 1997-03-14 | 2003-07-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
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| JP2006500921A (ja) | 2002-07-30 | 2006-01-12 | ブリストル−マイヤーズ スクイブ カンパニー | ヒト４−１ｂｂに対するヒト化抗体 |
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| US20050250106A1 (en) | 2003-04-24 | 2005-11-10 | David Epstein | Gene knock-down by intracellular expression of aptamers |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| WO2006039644A2 (en) * | 2004-10-01 | 2006-04-13 | Medarex, Inc. | Methods of treating cd30 positive lymphomas |
| PT1907424E (pt) * | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| US20090098137A1 (en) * | 2006-04-05 | 2009-04-16 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
| DK2526933T3 (en) * | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| JP5832721B2 (ja) * | 2007-03-14 | 2015-12-16 | バイオンシル・エス．アール．エル．Ｂｉｏｎｓｉｌ Ｓ．Ｒ．Ｌ． | 上皮腫瘍細胞における薬剤耐性のモジュレータ化合物 |
| US20100261776A1 (en) * | 2008-11-07 | 2010-10-14 | The Research Foundation Of State University Of New York | Bruton's tyrosine kinase as anti-cancer drug target |
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| TW201427664A (zh) * | 2012-11-02 | 2014-07-16 | Pharmacyclics Inc | Ｔｅｃ家族激酶抑制劑佐劑療法 |
-
2014
- 2014-10-24 EA EA201690746A patent/EA201690746A1/ru unknown
- 2014-10-24 CA CA2927794A patent/CA2927794A1/en not_active Abandoned
- 2014-10-24 US US14/523,782 patent/US20150118222A1/en not_active Abandoned
- 2014-10-24 AU AU2014339816A patent/AU2014339816B2/en not_active Expired - Fee Related
- 2014-10-24 TW TW106113264A patent/TWI660739B/zh not_active IP Right Cessation
- 2014-10-24 TW TW103136913A patent/TWI617309B/zh not_active IP Right Cessation
- 2014-10-24 KR KR1020167013770A patent/KR20160066554A/ko not_active Withdrawn
- 2014-10-24 MX MX2016005283A patent/MX2016005283A/es unknown
- 2014-10-24 EP EP14855030.4A patent/EP3060251A4/en not_active Withdrawn
- 2014-10-24 BR BR112016009200A patent/BR112016009200A8/pt not_active Application Discontinuation
- 2014-10-24 JP JP2016550681A patent/JP6508785B2/ja not_active Expired - Fee Related
- 2014-10-24 WO PCT/US2014/062278 patent/WO2015061752A1/en not_active Ceased
- 2014-10-24 CN CN201480071331.2A patent/CN105848680A/zh active Pending
-
2016
- 2016-04-11 IL IL245042A patent/IL245042A0/en unknown
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2019
- 2019-03-28 JP JP2019064721A patent/JP2019142890A/ja not_active Ceased
-
2020
- 2020-01-24 US US16/752,231 patent/US20200397895A1/en not_active Abandoned
- 2020-08-27 AU AU2020223721A patent/AU2020223721A1/en not_active Abandoned
- 2020-12-18 JP JP2020210693A patent/JP2021063091A/ja active Pending
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