JP2019510733A5 - - Google Patents
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- JP2019510733A5 JP2019510733A5 JP2018530560A JP2018530560A JP2019510733A5 JP 2019510733 A5 JP2019510733 A5 JP 2019510733A5 JP 2018530560 A JP2018530560 A JP 2018530560A JP 2018530560 A JP2018530560 A JP 2018530560A JP 2019510733 A5 JP2019510733 A5 JP 2019510733A5
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- Japan
- Prior art keywords
- amino acid
- acid sequence
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- variable region
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- Prior art date
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021049294A JP2021100957A (ja) | 2015-12-15 | 2021-03-23 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2022096901A JP7286845B2 (ja) | 2015-12-15 | 2022-06-15 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562267735P | 2015-12-15 | 2015-12-15 | |
| US62/267,735 | 2015-12-15 | ||
| US201662309169P | 2016-03-16 | 2016-03-16 | |
| US62/309,169 | 2016-03-16 | ||
| US201662359036P | 2016-07-06 | 2016-07-06 | |
| US62/359,036 | 2016-07-06 | ||
| PCT/US2016/066698 WO2017106372A1 (en) | 2015-12-15 | 2016-12-14 | Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021049294A Division JP2021100957A (ja) | 2015-12-15 | 2021-03-23 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510733A JP2019510733A (ja) | 2019-04-18 |
| JP2019510733A5 true JP2019510733A5 (https=) | 2020-01-30 |
| JP6858779B2 JP6858779B2 (ja) | 2021-04-14 |
Family
ID=59057509
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530560A Active JP6858779B2 (ja) | 2015-12-15 | 2016-12-14 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2021049294A Pending JP2021100957A (ja) | 2015-12-15 | 2021-03-23 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2022096901A Active JP7286845B2 (ja) | 2015-12-15 | 2022-06-15 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2023085801A Active JP7790837B2 (ja) | 2015-12-15 | 2023-05-24 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2025130097A Pending JP2025160458A (ja) | 2015-12-15 | 2025-08-04 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021049294A Pending JP2021100957A (ja) | 2015-12-15 | 2021-03-23 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2022096901A Active JP7286845B2 (ja) | 2015-12-15 | 2022-06-15 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2023085801A Active JP7790837B2 (ja) | 2015-12-15 | 2023-05-24 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
| JP2025130097A Pending JP2025160458A (ja) | 2015-12-15 | 2025-08-04 | キメラ及びヒト化抗ヒトｃｔｌａ４モノクローナル抗体ならびにその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10618960B2 (https=) |
| EP (2) | EP3389699B1 (https=) |
| JP (5) | JP6858779B2 (https=) |
| KR (2) | KR20250108763A (https=) |
| CN (2) | CN116063492A (https=) |
| AU (3) | AU2016370648B2 (https=) |
| BR (1) | BR112018012113A2 (https=) |
| CA (1) | CA3006984C (https=) |
| DK (1) | DK3389699T5 (https=) |
| ES (1) | ES2979210T3 (https=) |
| FI (1) | FI3389699T3 (https=) |
| HR (1) | HRP20240719T1 (https=) |
| HU (1) | HUE066907T2 (https=) |
| IL (3) | IL310404A (https=) |
| LT (1) | LT3389699T (https=) |
| MX (3) | MX2018006925A (https=) |
| MY (1) | MY186974A (https=) |
| PL (1) | PL3389699T3 (https=) |
| PT (1) | PT3389699T (https=) |
| RS (1) | RS65703B1 (https=) |
| SG (1) | SG11201804969PA (https=) |
| SI (1) | SI3389699T1 (https=) |
| SM (1) | SMT202400211T1 (https=) |
| TW (1) | TWI739781B (https=) |
| WO (1) | WO2017106372A1 (https=) |
| ZA (1) | ZA201804077B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA53355A (fr) | 2015-05-29 | 2022-03-16 | Agenus Inc | Anticorps anti-ctla-4 et leurs procédés d'utilisation |
| ES3059995T3 (en) * | 2016-09-19 | 2026-03-24 | Oncoc4 Inc | Cd80 and cd86 binding protein compositions and uses thereof |
| DK3551660T5 (da) | 2016-12-07 | 2024-09-02 | Agenus Inc | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf |
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| JP2021502100A (ja) * | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体 |
| KR102834864B1 (ko) * | 2018-02-02 | 2025-07-16 | 온코씨4, 아이앤씨. | 개선된 면역치료 효과를 갖지만 약화된 부작용을 갖는 돌연변이 항-ctla-4 항체 |
| WO2019148444A1 (en) * | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| WO2019152413A1 (en) * | 2018-02-02 | 2019-08-08 | Oncoimmune, Inc. | Methods of selecting and designing safer and more effective anti-ctla-4 antibodies for cancer therapy |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| CN112399973B (zh) * | 2018-06-05 | 2022-12-16 | 江苏康宁杰瑞生物制药有限公司 | 二聚体及其用途 |
| EP3617230A1 (en) * | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| KR20210108978A (ko) | 2018-12-21 | 2021-09-03 | 오제 이뮈노테라프틱스 | 이작용성 항-pd-1/il-7 분자 |
| SG11202106764YA (en) * | 2018-12-27 | 2021-07-29 | Gigagen Inc | Anti-ctla-4 binding proteins and methods of use thereof |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
| JP7440724B2 (ja) * | 2020-04-13 | 2024-02-29 | ビオシオン インコーポレイテッド | Ｃｔｌａ４に結合する抗体及びその使用 |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| JP2024508207A (ja) | 2020-12-02 | 2024-02-26 | ブイアイビー ブイゼットダブリュ | がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト |
| WO2022169269A1 (ko) * | 2021-02-03 | 2022-08-11 | 주식회사 유틸렉스 | 항 ctla-4 항체 및 이의 용도 |
| MX2023011964A (es) | 2021-04-09 | 2024-01-08 | Ose Immunotherapeutics | Nuevo andamio para moléculas bifuncionales con propiedades mejoradas. |
| EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| JP7345889B2 (ja) * | 2021-06-17 | 2023-09-19 | 株式会社ニューギン | 遊技機 |
| AU2022359021A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| EP4392156A4 (en) * | 2021-10-08 | 2025-06-25 | Kashiv Biosciences, LLC | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| JP2024540152A (ja) * | 2021-10-29 | 2024-10-31 | オンコシーフォー、インク． | 抗ｃｔｌａ－４抗体投与レジメン |
| EP4431528A1 (en) * | 2021-10-29 | 2024-09-18 | Longbio Pharma (Suzhou) Co., Ltd. | Isolated antigen binding protein and use thereof |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| JP2025525886A (ja) | 2022-08-02 | 2025-08-07 | オーエスイー・イミュノセラピューティクス | Ｃｄ２８に対する多機能性分子 |
| JP2025531229A (ja) | 2022-09-16 | 2025-09-19 | オンコシーフォー、インク． | 腺様嚢胞がんを処置するための抗ｃｔｌａ－４抗体の使用 |
| EP4680728A1 (en) | 2023-03-17 | 2026-01-21 | Quell Therapeutics Limited | Treg therapy |
| EP4687991A1 (en) | 2023-03-30 | 2026-02-11 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
| WO2024200820A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| KR20260005250A (ko) | 2023-04-28 | 2026-01-09 | 온코씨4, 아이앤씨. | 항-ctla-4 항체와 항-pd-1 항체의 조합 및 이의 치료적 용도 |
| EP4724498A2 (en) * | 2023-06-09 | 2026-04-15 | The Regents of the University of California | Methods for identifying and correcting tumor humoral immune dysfunction |
| WO2025133186A1 (en) | 2023-12-22 | 2025-06-26 | OncoC4, Inc. | Anti-ctla-4 antibody for treatment of patients with prostate cancer and combination therapy with a radioligand therapeutic agent |
| WO2025201659A1 (en) | 2024-03-28 | 2025-10-02 | BioNTech SE | Combination therapy comprising therapeutic rna cancer vaccines and anti-ctla4 antibodies for cancer treatment |
| WO2025234450A1 (ja) * | 2024-05-08 | 2025-11-13 | 学校法人帝京平成大学 | 改変がん細胞及びそれを含むがんワクチン組成物 |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2026041780A2 (en) | 2024-08-23 | 2026-02-26 | BioNTech SE | Combination therapy comprising anti-ctla4 antibodies and chemotherapy for cancer treatment |
| WO2026057739A1 (en) | 2024-09-12 | 2026-03-19 | BioNTech SE | Combination therapy comprising anti-ctla4 antibodies and anti-pd-1 antibodies for platinum-resistant ovarian cancer treatment |
| WO2026068705A1 (en) | 2024-09-26 | 2026-04-02 | Ose Immunotherapeutics | Lipid-based nanoparticles comprising non-glycosylated fc domains and uses thereof |
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| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
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| US20080152655A1 (en) * | 2004-09-08 | 2008-06-26 | The Ohio State University Research Foundation | Combination Therapy With Anti-Ctla4 and Anti-4-1BB Antibodies |
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| WO2013142796A2 (en) * | 2012-03-23 | 2013-09-26 | Bristol-Myers Squibb Company | Methods of treatments using ctla4 antibodies |
| EP3508215A3 (en) | 2012-12-03 | 2019-10-02 | Bristol-Myers Squibb Company | Enhancing anti-cancer activity of immunomodulatory fc fusion proteins |
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| CN104292334B (zh) * | 2014-04-25 | 2018-11-27 | 河南省健康伟业生物医药研究股份有限公司 | 一种全人源抗ctla-4单克隆抗体、制备方法及应用 |
| ES3059995T3 (en) | 2016-09-19 | 2026-03-24 | Oncoc4 Inc | Cd80 and cd86 binding protein compositions and uses thereof |
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2016
- 2016-12-14 ES ES16876612T patent/ES2979210T3/es active Active
- 2016-12-14 KR KR1020257022200A patent/KR20250108763A/ko active Pending
- 2016-12-14 CA CA3006984A patent/CA3006984C/en active Active
- 2016-12-14 AU AU2016370648A patent/AU2016370648B2/en active Active
- 2016-12-14 LT LTEPPCT/US2016/066698T patent/LT3389699T/lt unknown
- 2016-12-14 BR BR112018012113A patent/BR112018012113A2/pt active Search and Examination
- 2016-12-14 US US16/062,350 patent/US10618960B2/en active Active
- 2016-12-14 MX MX2018006925A patent/MX2018006925A/es unknown
- 2016-12-14 HU HUE16876612A patent/HUE066907T2/hu unknown
- 2016-12-14 SM SM20240211T patent/SMT202400211T1/it unknown
- 2016-12-14 CN CN202210802423.XA patent/CN116063492A/zh active Pending
- 2016-12-14 IL IL310404A patent/IL310404A/en unknown
- 2016-12-14 DK DK16876612.9T patent/DK3389699T5/da active
- 2016-12-14 WO PCT/US2016/066698 patent/WO2017106372A1/en not_active Ceased
- 2016-12-14 EP EP16876612.9A patent/EP3389699B1/en active Active
- 2016-12-14 PT PT168766129T patent/PT3389699T/pt unknown
- 2016-12-14 FI FIEP16876612.9T patent/FI3389699T3/fi active
- 2016-12-14 PL PL16876612.9T patent/PL3389699T3/pl unknown
- 2016-12-14 HR HRP20240719TT patent/HRP20240719T1/hr unknown
- 2016-12-14 CN CN201680073425.2A patent/CN108430499B/zh active Active
- 2016-12-14 IL IL296354A patent/IL296354B2/en unknown
- 2016-12-14 RS RS20240735A patent/RS65703B1/sr unknown
- 2016-12-14 SI SI201631826T patent/SI3389699T1/sl unknown
- 2016-12-14 IL IL259988A patent/IL259988B2/en unknown
- 2016-12-14 EP EP24164173.7A patent/EP4374926A3/en active Pending
- 2016-12-14 JP JP2018530560A patent/JP6858779B2/ja active Active
- 2016-12-14 KR KR1020187017368A patent/KR102830926B1/ko active Active
- 2016-12-14 SG SG11201804969PA patent/SG11201804969PA/en unknown
- 2016-12-14 MY MYPI2018000904A patent/MY186974A/en unknown
- 2016-12-15 TW TW105141656A patent/TWI739781B/zh active
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2018
- 2018-06-07 MX MX2025001302A patent/MX2025001302A/es unknown
- 2018-06-07 MX MX2025001300A patent/MX2025001300A/es unknown
- 2018-06-18 ZA ZA2018/04077A patent/ZA201804077B/en unknown
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2020
- 2020-02-27 US US16/803,972 patent/US11629188B2/en active Active
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2021
- 2021-03-23 JP JP2021049294A patent/JP2021100957A/ja active Pending
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2022
- 2022-06-15 JP JP2022096901A patent/JP7286845B2/ja active Active
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2023
- 2023-03-22 US US18/188,098 patent/US12473362B2/en active Active
- 2023-05-19 AU AU2023203169A patent/AU2023203169B2/en active Active
- 2023-05-24 JP JP2023085801A patent/JP7790837B2/ja active Active
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2025
- 2025-08-04 JP JP2025130097A patent/JP2025160458A/ja active Pending
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2026
- 2026-02-05 AU AU2026200849A patent/AU2026200849A1/en active Pending