JP2016520082A5 - - Google Patents

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Publication number
JP2016520082A5
JP2016520082A5 JP2016514047A JP2016514047A JP2016520082A5 JP 2016520082 A5 JP2016520082 A5 JP 2016520082A5 JP 2016514047 A JP2016514047 A JP 2016514047A JP 2016514047 A JP2016514047 A JP 2016514047A JP 2016520082 A5 JP2016520082 A5 JP 2016520082A5
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JP
Japan
Prior art keywords
cancer
seq
medicament
medicament according
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2016514047A
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English (en)
Japanese (ja)
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JP2016520082A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/037911 external-priority patent/WO2014186403A2/en
Publication of JP2016520082A publication Critical patent/JP2016520082A/ja
Publication of JP2016520082A5 publication Critical patent/JP2016520082A5/ja
Withdrawn legal-status Critical Current

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JP2016514047A 2013-05-14 2014-05-13 抗ｆｏｌｒ１免疫複合体投与計画 Withdrawn JP2016520082A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361823317P 2013-05-14 2013-05-14
US61/823,317 2013-05-14
US201361828586P 2013-05-29 2013-05-29
US61/828,586 2013-05-29
PCT/US2014/037911 WO2014186403A2 (en) 2013-05-14 2014-05-13 Anti-folr1 immunoconjugate dosing regimens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018143909A Division JP2018197249A (ja) 2013-05-14 2018-07-31 抗ｆｏｌｒ１免疫複合体投与計画

Publications (2)

Publication Number Publication Date
JP2016520082A JP2016520082A (ja) 2016-07-11
JP2016520082A5 true JP2016520082A5 (https=) 2017-06-29

Family

ID=51898993

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016514047A Withdrawn JP2016520082A (ja) 2013-05-14 2014-05-13 抗ｆｏｌｒ１免疫複合体投与計画
JP2018143909A Withdrawn JP2018197249A (ja) 2013-05-14 2018-07-31 抗ｆｏｌｒ１免疫複合体投与計画
JP2021062774A Withdrawn JP2021102648A (ja) 2013-05-14 2021-04-01 抗ｆｏｌｒ１免疫複合体投与計画
JP2023145920A Pending JP2023162436A (ja) 2013-05-14 2023-09-08 抗ｆｏｌｒ１免疫複合体投与計画

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018143909A Withdrawn JP2018197249A (ja) 2013-05-14 2018-07-31 抗ｆｏｌｒ１免疫複合体投与計画
JP2021062774A Withdrawn JP2021102648A (ja) 2013-05-14 2021-04-01 抗ｆｏｌｒ１免疫複合体投与計画
JP2023145920A Pending JP2023162436A (ja) 2013-05-14 2023-09-08 抗ｆｏｌｒ１免疫複合体投与計画

Country Status (14)

Country Link
US (5) US20140363451A1 (https=)
EP (1) EP2997044A4 (https=)
JP (4) JP2016520082A (https=)
KR (4) KR20160020421A (https=)
CN (2) CN105308072A (https=)
AU (3) AU2014265587A1 (https=)
BR (1) BR112015028244A2 (https=)
CA (1) CA2911499A1 (https=)
HK (1) HK1222340A1 (https=)
IL (1) IL268180A (https=)
MX (2) MX2015015735A (https=)
RU (1) RU2015149285A (https=)
SG (2) SG11201509043RA (https=)
WO (1) WO2014186403A2 (https=)

Families Citing this family (31)

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TWI622402B (zh) 2010-02-24 2018-05-01 免疫遺傳股份有限公司 葉酸受體１抗體類和免疫共軛物類及彼等之用途
BR112013025415B1 (pt) 2011-04-01 2021-03-16 Immunogen, Inc uso de um imunoconjugado antirreceptor de folato 1 (folr1)
US9200073B2 (en) 2012-08-31 2015-12-01 Immunogen, Inc. Diagnostic assays and kits for detection of folate receptor 1
CN113150145B (zh) 2013-08-30 2025-02-14 伊缪诺金公司 用于检测叶酸受体1的抗体和测定
PL3055332T3 (pl) * 2013-10-08 2020-02-28 Immunogen, Inc. Schematy dawkowania immunokoniugatu anty-FOLR1
CN116440279B (zh) 2015-09-17 2026-02-24 伊缪诺金公司 包含抗folr1免疫缀合物的治疗组合
CN121177507A (zh) 2016-08-12 2025-12-23 L.E.A.F.控股集团公司 α和γ-D聚谷氨酸化抗叶酸剂及其用途
WO2018031968A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
KR20250035037A (ko) * 2017-09-18 2025-03-11 서트로 바이오파마, 인크. 항-엽산 수용체 알파 항체 접합체 및 이의 용도
CN111867593A (zh) 2018-02-07 2020-10-30 L.E.A.F.控股集团公司 α聚谷氨酸化抗叶酸剂及其用途
EP3749314A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATE METHOTREXATE AND ITS USES
CA3090389A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
US12310966B2 (en) 2018-02-07 2025-05-27 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
WO2019157145A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
EP3749318A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
EP3749319A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES
WO2019157121A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated lometrexol and uses thereof
US12350271B2 (en) 2018-02-14 2025-07-08 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof
JP7462950B2 (ja) 2018-02-14 2024-04-08 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化メトトレキセートおよびその使用
WO2019160735A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
CA3090753A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated pralatrexate and uses thereof
WO2019160734A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
AU2019236091B2 (en) 2018-03-13 2025-06-05 Phanes Therapeutics, Inc. Anti-folate receptor 1 antibodies and uses thereof
MA54088A (fr) * 2018-10-30 2022-03-16 Immunogen Inc Procédés de traitement faisant appel à des immunoconjugués anti-cd123
MA55818A (fr) 2019-04-29 2022-03-16 Immunogen Inc Anticorps et immunoconjugués de fr-alpha biparatopique
CN112794911B (zh) * 2021-04-14 2021-08-03 上海偌妥生物科技有限公司 人源化抗叶酸受体1抗体及其应用
US20250059274A1 (en) * 2021-12-24 2025-02-20 Bio-Thera Solutions, Ltd. ANTI-FRa ANTIBODY, AND ANTIBODY-DRUG CONJUGATE AND USE THEREOF
WO2025036307A1 (zh) * 2023-08-11 2025-02-20 百奥泰生物制药股份有限公司 抗frα抗体药物偶联物在治疗疾病中的应用

Family Cites Families (10)

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US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
WO2004082463A2 (en) * 2003-03-17 2004-09-30 Medical College Of Ohio Folate receptor gene modulation for cancer diagnosis and therapy
EP3101034A1 (en) * 2004-02-12 2016-12-07 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
EP2490715A4 (en) * 2009-10-21 2013-06-26 Immunogen Inc NEW DOSAGE ADMINISTRATION REGIMEN AND METHOD OF TREATMENT
TWI622402B (zh) * 2010-02-24 2018-05-01 免疫遺傳股份有限公司 葉酸受體１抗體類和免疫共軛物類及彼等之用途
BR112013025415B1 (pt) * 2011-04-01 2021-03-16 Immunogen, Inc uso de um imunoconjugado antirreceptor de folato 1 (folr1)
WO2012138749A1 (en) * 2011-04-04 2012-10-11 Immunogen, Inc. Methods for decreasing ocular toxicity of antibody drug conjugates
PL3055332T3 (pl) * 2013-10-08 2020-02-28 Immunogen, Inc. Schematy dawkowania immunokoniugatu anty-FOLR1
CN116440279B (zh) * 2015-09-17 2026-02-24 伊缪诺金公司 包含抗folr1免疫缀合物的治疗组合
MA55818A (fr) * 2019-04-29 2022-03-16 Immunogen Inc Anticorps et immunoconjugués de fr-alpha biparatopique

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