JP2016534153A5 - - Google Patents
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- JP2016534153A5 JP2016534153A5 JP2016547977A JP2016547977A JP2016534153A5 JP 2016534153 A5 JP2016534153 A5 JP 2016534153A5 JP 2016547977 A JP2016547977 A JP 2016547977A JP 2016547977 A JP2016547977 A JP 2016547977A JP 2016534153 A5 JP2016534153 A5 JP 2016534153A5
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- JP
- Japan
- Prior art keywords
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000009472 formulation Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000000654 additive Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- 230000000996 additive effect Effects 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 229960003136 leucine Drugs 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000004067 bulking agent Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 235000019454 L-leucine Nutrition 0.000 claims 1
- 239000004395 L-leucine Substances 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000004469 amino acid formulation Substances 0.000 claims 1
- 230000009084 cardiovascular function Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000000647 trehalose group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889887P | 2013-10-11 | 2013-10-11 | |
| US61/889,887 | 2013-10-11 | ||
| PCT/US2014/060039 WO2015054574A1 (en) | 2013-10-11 | 2014-10-10 | Spray dry formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019024568A Division JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534153A JP2016534153A (ja) | 2016-11-04 |
| JP2016534153A5 true JP2016534153A5 (OSRAM) | 2017-11-16 |
| JP6483714B2 JP6483714B2 (ja) | 2019-03-13 |
Family
ID=52813663
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547977A Active JP6483714B2 (ja) | 2013-10-11 | 2014-10-10 | 噴霧乾燥製剤 |
| JP2019024568A Active JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
| JP2021001507A Pending JP2021063119A (ja) | 2013-10-11 | 2021-01-07 | 噴霧乾燥製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019024568A Active JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
| JP2021001507A Pending JP2021063119A (ja) | 2013-10-11 | 2021-01-07 | 噴霧乾燥製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9925184B2 (OSRAM) |
| EP (1) | EP3054937B1 (OSRAM) |
| JP (3) | JP6483714B2 (OSRAM) |
| CN (2) | CN106132403B (OSRAM) |
| AU (3) | AU2014331796B2 (OSRAM) |
| CA (1) | CA2926793C (OSRAM) |
| ES (1) | ES2959419T3 (OSRAM) |
| WO (1) | WO2015054574A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| CA2897651C (en) | 2013-01-10 | 2021-09-21 | Pulmokine, Inc. | Non-selective kinase inhibitors |
| US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
| EA031604B1 (ru) | 2013-10-25 | 2019-01-31 | Инсмед Инкорпорейтед | Трепростинильные соединения, композиции и способы их использования |
| EP3221291B1 (en) | 2014-11-18 | 2021-03-31 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| WO2017132601A1 (en) * | 2016-01-29 | 2017-08-03 | Mannkind Corporation | Dry powder inhaler |
| IL262720B2 (en) * | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| CA3027970A1 (en) * | 2016-06-17 | 2017-12-21 | United Therapeutics Corporation | Extracellular vesicles with enhanced potency |
| CN110087653A (zh) | 2016-10-27 | 2019-08-02 | 普尔莫凯恩股份有限公司 | 用于治疗肺高血压的组合疗法 |
| CN115919780A (zh) | 2017-09-22 | 2023-04-07 | 维克图拉公司 | 含有硬脂酸镁的干粉组合物 |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| US20210038510A1 (en) * | 2018-02-08 | 2021-02-11 | Pulmokine, Inc. | Formulations of kinase inhibitors and prostanoids |
| CN112789033A (zh) * | 2018-10-02 | 2021-05-11 | 学校法人名城大学 | 吸入粉末剂、其评价方法及其用途 |
| KR20220002600A (ko) * | 2019-04-29 | 2022-01-06 | 인스메드 인코포레이티드 | 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법 |
| JP2022532431A (ja) | 2019-05-16 | 2022-07-14 | エアロベイト セラピューティクス， インコーポレイテッド | イマチニブ製剤、その製造および使用 |
| US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
| WO2021201258A1 (ja) * | 2020-04-01 | 2021-10-07 | 株式会社ＳｔａｔｅＡｒｔ | 核酸含有組成物、核酸含有組成物の製造方法及び核酸導入方法 |
| US20240325390A1 (en) * | 2020-11-23 | 2024-10-03 | Aerovate Therapeutics, Inc. | Imatinib formulations, manufacture, and uses thereof |
| US20240228462A1 (en) | 2021-05-07 | 2024-07-11 | Gb002, Inc. | Crystalline forms of n-{3-[(1s)-1-{[6-(3,4-dimethoxyphenyl)pyrazin-2- yl]amino}ethyl]phenyl}-5-methylpyridine-3-carboxamide and related products and methods |
| CN119677525A (zh) | 2022-08-10 | 2025-03-21 | Gb002股份有限公司 | 用于治疗动脉性肺动脉高压（pah）的酪氨酸激酶抑制剂和激活素2型受体拮抗剂的组合疗法 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118401A (en) | 1977-10-19 | 1978-10-03 | American Hoechst Corporation | Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor |
| JPS5488231A (en) | 1977-12-22 | 1979-07-13 | Sumitomo Chem Co Ltd | 3-phenyloxymethylaniline derivative, its preparation, and herbicides consisting of it |
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| US5648369A (en) | 1991-11-20 | 1997-07-15 | University Of Kentucky Research Foundation | Aminoalkylpyridine compounds which are useful as anitconvulsant drugs, excitatory amino acid inhibitors and NMDA sigma receptor antagonists |
| SK27198A3 (en) | 1995-08-30 | 1998-09-09 | Bayer Ag | Acylaminosalicylic acid amides and their uses as pesticides |
| JPH09268169A (ja) | 1996-04-01 | 1997-10-14 | Otsuka Chem Co Ltd | サリチル酸アニリド誘導体、それを有効成分として含む植物病害防除剤 |
| ATE364374T1 (de) | 1997-08-11 | 2007-07-15 | Pfizer Prod Inc | Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| CA2382821A1 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US6458849B1 (en) | 1999-09-23 | 2002-10-01 | G.D. Searle & Co. | use of substituted N,N-disubstituted mercapto amino compounds for inhibiting cholesteryl ester transfer protein activity |
| WO2001028993A2 (en) | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Tyrosine kinase inhibitors |
| HUP0203323A3 (en) | 1999-10-19 | 2004-01-28 | Merck & Co Inc | Tyrosine kinase inhibitors and pharmaceutical compositions containing them |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP2003523390A (ja) | 2000-02-25 | 2003-08-05 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害薬 |
| WO2002060492A1 (en) | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd | Methods of inhibiting kinases |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| CA2486187C (en) | 2002-05-23 | 2013-02-19 | Cytopia Pty Ltd. | Kinase inhibitors |
| US7122550B2 (en) | 2002-05-23 | 2006-10-17 | Cytopia Pty Ltd | Protein kinase inhibitors |
| US6776309B2 (en) | 2002-05-23 | 2004-08-17 | Ben Z. Cohen | Medically accurate pump system |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| TW200410688A (en) | 2002-06-26 | 2004-07-01 | Ono Pharmaceutical Co | Therapeutics for diseases from vasoconstriction or vasodilatation |
| EP1545523A1 (en) | 2002-07-03 | 2005-06-29 | Astex Technology Limited | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS |
| WO2004006858A2 (en) | 2002-07-15 | 2004-01-22 | Myriad Genetics, Inc | Compounds, compositions, and methods employing same |
| AU2003272007A1 (en) | 2002-10-25 | 2004-05-13 | The Administrators Of The Tulane Educational Fund | Use of n-5-4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension |
| AU2002953255A0 (en) | 2002-12-11 | 2003-01-02 | Cytopia Research Pty Ltd | Protein kinase inhibitors |
| WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| FR2858459B1 (fr) | 2003-08-01 | 2006-03-10 | Commissariat Energie Atomique | Commutateur micro-mecanique bistable, methode d'actionnement et procede de realisation correspondant |
| AR045731A1 (es) | 2003-08-06 | 2005-11-09 | Vertex Pharma | Compuestos de aminotriazol utiles como inhibidores de quinasas de proteinas |
| KR101167573B1 (ko) | 2003-11-07 | 2012-07-30 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 개선된 약학적 성질을 갖는 퀴놀리논 화합물의 약학적으로허용가능한 염 |
| ATE497949T1 (de) | 2003-12-03 | 2011-02-15 | Ym Biosciences Australia Pty | Tubulininhibitoren |
| JP4808628B2 (ja) | 2003-12-03 | 2011-11-02 | ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド | アゾール系キナーゼ阻害剤 |
| GB2432834A (en) | 2004-01-12 | 2007-06-06 | Cytopia Res Pty Ltd | Selective Kinase Inhibitors |
| WO2005114219A2 (en) | 2004-05-20 | 2005-12-01 | Wyeth | Assays to identify irreversibly binding inhibitors of receptor tyrosine kinases |
| JP2006111553A (ja) | 2004-10-13 | 2006-04-27 | Dainippon Sumitomo Pharma Co Ltd | スルホニルオキシインドール誘導体及びそれを含有する医薬組成物 |
| JP5075832B2 (ja) | 2005-11-10 | 2012-11-21 | バイエル・ファルマ・アクチェンゲゼルシャフト | 肺高血圧を処置するためのジアリールウレア |
| WO2007087575A2 (en) | 2006-01-24 | 2007-08-02 | University Of Chicago | Compositions and methods for treating pulmonary hypertension |
| AU2007220047B2 (en) | 2006-02-28 | 2013-08-01 | Ym Biosciences Australia Pty Ltd | Inhibition of JAK2 as a treatment of pulmonary arterial hypertension |
| WO2007124382A2 (en) | 2006-04-19 | 2007-11-01 | Novartis Vaccines And Diagnostics, Inc. | Inhaled imipenem |
| EP3048099A3 (en) | 2006-11-15 | 2016-09-21 | YM BioSciences Australia Pty Ltd | Inhibitors of kinase activity |
| EP2152688A1 (en) | 2007-05-04 | 2010-02-17 | Irm Llc | Compounds and compositions as c-kit and pdgfr kinase inhibitors |
| BRPI0811617A2 (pt) | 2007-05-04 | 2017-06-06 | Irm Llc | derivados de primidina e composições como inibidores de c-kit e pdgfr quinase. |
| MX2010002004A (es) | 2007-08-22 | 2010-03-11 | Irm Llc | Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa. |
| WO2009026204A1 (en) | 2007-08-22 | 2009-02-26 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| MX2010006033A (es) | 2007-12-20 | 2010-07-16 | Bayer Schering Pharma Ag | 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso. |
| CA2732789A1 (en) | 2008-08-13 | 2010-02-18 | Novartis Ag | Treatment of pulmonary arterial hypertension |
| DE102009004197A1 (de) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| WO2010102066A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Dextran polymer powder for inhalation administration of pharmaceuticals |
| WO2010132827A1 (en) | 2009-05-15 | 2010-11-18 | Bend Research, Inc. | Low-molecular dextran for powder inhalations |
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| JOP20120023B1 (ar) * | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
| JP6012716B2 (ja) * | 2011-05-19 | 2016-10-25 | サヴァラ，インク． | 乾燥粉末バンコマイシン組成物および関連する方法 |
| WO2013033167A1 (en) | 2011-09-01 | 2013-03-07 | Irm Llc | Compounds and compositions as c-kit kinase inhibitors |
| US9199981B2 (en) | 2011-09-01 | 2015-12-01 | Novartis Ag | Compounds and compositions as C-kit kinase inhibitors |
| EP2988738A4 (en) * | 2013-01-10 | 2016-11-09 | Pulmokine Inc | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS |
| CA2897651C (en) * | 2013-01-10 | 2021-09-21 | Pulmokine, Inc. | Non-selective kinase inhibitors |
| US20150044288A1 (en) | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| WO2015179369A1 (en) | 2014-05-20 | 2015-11-26 | Infinity Pharmaceuticals, Inc. | Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors |
-
2014
- 2014-10-10 CA CA2926793A patent/CA2926793C/en active Active
- 2014-10-10 EP EP14852309.5A patent/EP3054937B1/en active Active
- 2014-10-10 AU AU2014331796A patent/AU2014331796B2/en active Active
- 2014-10-10 US US15/028,347 patent/US9925184B2/en active Active
- 2014-10-10 ES ES14852309T patent/ES2959419T3/es active Active
- 2014-10-10 CN CN201480067999.XA patent/CN106132403B/zh active Active
- 2014-10-10 CN CN202010266778.2A patent/CN111743901B/zh active Active
- 2014-10-10 JP JP2016547977A patent/JP6483714B2/ja active Active
- 2014-10-10 WO PCT/US2014/060039 patent/WO2015054574A1/en not_active Ceased
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2017
- 2017-11-10 US US15/809,054 patent/US20180193336A1/en not_active Abandoned
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2019
- 2019-02-14 JP JP2019024568A patent/JP6823095B2/ja active Active
-
2020
- 2020-04-16 AU AU2020202556A patent/AU2020202556A1/en not_active Abandoned
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2021
- 2021-01-07 JP JP2021001507A patent/JP2021063119A/ja active Pending
-
2022
- 2022-05-27 AU AU2022203611A patent/AU2022203611A1/en not_active Abandoned