JP2016534034A5 - - Google Patents
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- Publication number
- JP2016534034A5 JP2016534034A5 JP2016519871A JP2016519871A JP2016534034A5 JP 2016534034 A5 JP2016534034 A5 JP 2016534034A5 JP 2016519871 A JP2016519871 A JP 2016519871A JP 2016519871 A JP2016519871 A JP 2016519871A JP 2016534034 A5 JP2016534034 A5 JP 2016534034A5
- Authority
- JP
- Japan
- Prior art keywords
- pcv2
- polypeptide
- infection
- sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 241001673669 Porcine circovirus 2 Species 0.000 claims 17
- 101100382437 Porcine circovirus 2 Cap gene Proteins 0.000 claims 13
- 208000015181 infectious disease Diseases 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 235000001014 amino acid Nutrition 0.000 claims 10
- 230000002163 immunogen Effects 0.000 claims 10
- 230000035772 mutation Effects 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 241000701447 unidentified baculovirus Species 0.000 claims 5
- 239000013612 plasmid Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
- 208000003322 Coinfection Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- 101710113540 ORF2 protein Proteins 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 101710090523 Putative movement protein Proteins 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 206010058874 Viraemia Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 235000021053 average weight gain Nutrition 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 208000010753 nasal discharge Diseases 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361885871P | 2013-10-02 | 2013-10-02 | |
| US61/885,871 | 2013-10-02 | ||
| PCT/US2014/058793 WO2015051099A1 (en) | 2013-10-02 | 2014-10-02 | Pcv2 orf2 protein variant and virus like particles composed thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534034A JP2016534034A (ja) | 2016-11-04 |
| JP2016534034A5 true JP2016534034A5 (cg-RX-API-DMAC10.html) | 2017-11-09 |
| JP6778104B2 JP6778104B2 (ja) | 2020-10-28 |
Family
ID=51795768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519871A Active JP6778104B2 (ja) | 2013-10-02 | 2014-10-02 | Ｐｃｖ２ ｏｒｆ２タンパク質変種および前記を含むウイルス様粒子 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US9505808B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3052516B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6778104B2 (cg-RX-API-DMAC10.html) |
| KR (2) | KR102409183B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN105658660B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2014329524B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2924228C (cg-RX-API-DMAC10.html) |
| DK (1) | DK3052516T3 (cg-RX-API-DMAC10.html) |
| EA (1) | EA035265B1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2778425T3 (cg-RX-API-DMAC10.html) |
| MX (1) | MX373884B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015051099A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| DK2275132T3 (da) | 2005-12-29 | 2021-05-17 | Boehringer Ingelheim Animal Health Usa Inc | Multivalente pcv2-immunogeniske sammensætninger og fremgangsmåder til at fremstille dem |
| CA2635430A1 (en) | 2005-12-29 | 2007-08-23 | Boehringer Ingelheim Vetmedica, Inc. | Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs |
| WO2008073464A2 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| KR20100113582A (ko) | 2008-01-23 | 2010-10-21 | 베링거잉겔하임베트메디카인코퍼레이티드 | Ｐｃｖ2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법 |
| ES2778425T3 (es) | 2013-10-02 | 2020-08-10 | Boehringer Ingelheim Animal Health Usa Inc | Variante de la proteína ORF2 del PCV2 y partículas similares a virus compuestas por esta |
| US10555994B2 (en) * | 2015-03-30 | 2020-02-11 | Boehringer Ingelheim Animal Health USA Inc. | PCV2 ORF2 carrier platform |
| HK1252427A1 (zh) * | 2015-05-14 | 2019-05-24 | Boehringer Ingelheim Animal Health USA Inc. | 猪环状病毒生产方法和pcv2疫苗 |
| CN104984335A (zh) * | 2015-07-14 | 2015-10-21 | 浙江诺倍威生物技术有限公司 | 猪圆环病毒双亚型orf2共表达载体构建及疫苗制备 |
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| US10431889B2 (en) * | 2016-04-22 | 2019-10-01 | The Charles Stark Draper Laboratory, Inc. | Low-loss compact transmit impedance matching tuning technique |
| CN106399138B (zh) * | 2016-09-07 | 2019-11-12 | 复旦大学 | 猪圆环病毒ii型口服病毒样颗粒疫苗及其制备方法和应用 |
| CN106399350B (zh) * | 2016-09-07 | 2020-02-21 | 复旦大学 | 一种猪圆环病毒ii型病毒样颗粒疫苗及其制备方法 |
| EP4570264A3 (en) * | 2016-11-03 | 2026-01-21 | Boehringer Ingelheim Vetmedica GmbH | Vaccine against porcine parvovirus |
| CN106834242B (zh) * | 2017-03-02 | 2021-02-23 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-233株及其构建方法 |
| CN106834241B (zh) * | 2017-03-02 | 2021-01-19 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-402株及其构建方法 |
| CN107245477B (zh) * | 2017-06-06 | 2020-06-30 | 广东海大畜牧兽医研究院有限公司 | 一种猪圆环病毒2型病毒样颗粒的制备方法及通过该方法获得的病毒样颗粒 |
| PL3697804T3 (pl) | 2017-10-17 | 2024-01-03 | Intervet International B.V. | Rekombinowana ekspresja białka orf2 pcv2b w komórkach owadzich |
| CN108484725A (zh) * | 2018-03-16 | 2018-09-04 | 广东海大畜牧兽医研究院有限公司 | 一种区分检测pcv2野毒抗体与疫苗抗体的多肽及其在elisa检测试剂盒中的应用 |
| CN110358742B (zh) * | 2019-07-05 | 2020-12-22 | 武汉科前生物股份有限公司 | 猪圆环病毒2b型和2d型的二价亚单位疫苗及其制备方法 |
| CN111415356B (zh) * | 2020-03-17 | 2020-12-29 | 推想医疗科技股份有限公司 | 肺炎征象的分割方法、装置、介质及电子设备 |
| CN112010949B (zh) * | 2020-08-03 | 2021-07-27 | 山东绿都生物科技有限公司 | 一种重组pcv2病毒样颗粒蜂胶疫苗及其制备方法 |
| CN114250259B (zh) * | 2020-09-21 | 2024-07-19 | 成都史纪生物制药有限公司 | 一种猪圆环2型病毒Cap蛋白病毒样颗粒的发酵培养基 |
| TWI867524B (zh) * | 2022-05-09 | 2024-12-21 | 福又達生物科技股份有限公司 | 豬環狀病毒第二型及豬瘟病毒次單位雙價疫苗 |
| EP4704977A1 (en) | 2023-05-03 | 2026-03-11 | Boehringer Ingelheim Vetmedica GmbH | Immunogenic composition useful for self-administration by pigs |
| AR132582A1 (es) | 2023-05-03 | 2025-07-16 | Boehringer Ingelheim Vetmedica Gmbh | Método para inducir una respuesta inmunitaria |
| CN118063562B (zh) * | 2024-03-11 | 2025-04-01 | 天康生物制药有限公司 | 优化的猪圆环病毒2型Cap蛋白及其病毒样颗粒和应用 |
| WO2026099754A1 (en) | 2024-11-06 | 2026-05-15 | Boehringer Ingelheim Vetmedica Gmbh | Method for reducing virus shedding, tissue colonization, and lymphoid depletion caused by or associated with pcv2 infection |
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2014
- 2014-10-02 ES ES14789683T patent/ES2778425T3/es active Active
- 2014-10-02 WO PCT/US2014/058793 patent/WO2015051099A1/en not_active Ceased
- 2014-10-02 DK DK14789683.1T patent/DK3052516T3/da active
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- 2014-10-02 CA CA2924228A patent/CA2924228C/en active Active
- 2014-10-02 EP EP14789683.1A patent/EP3052516B1/en active Active
- 2014-10-02 KR KR1020227019654A patent/KR20220083861A/ko not_active Ceased
- 2014-10-02 CN CN201480054488.4A patent/CN105658660B/zh active Active
- 2014-10-02 US US14/504,839 patent/US9505808B2/en active Active
- 2014-10-02 AU AU2014329524A patent/AU2014329524B2/en active Active
- 2014-10-02 MX MX2016004063A patent/MX373884B/es active IP Right Grant
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