JP2016530299A5 - - Google Patents
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- Publication number
- JP2016530299A5 JP2016530299A5 JP2016540401A JP2016540401A JP2016530299A5 JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5 JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- decane
- amino
- pyrimidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874545P | 2013-09-06 | 2013-09-06 | |
| US61/874,545 | 2013-09-06 | ||
| US201361899943P | 2013-11-05 | 2013-11-05 | |
| US61/899,943 | 2013-11-05 | ||
| US201462004385P | 2014-05-29 | 2014-05-29 | |
| US62/004,385 | 2014-05-29 | ||
| PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530299A JP2016530299A (ja) | 2016-09-29 |
| JP2016530299A5 true JP2016530299A5 (cg-RX-API-DMAC7.html) | 2017-10-12 |
| JP6470290B2 JP6470290B2 (ja) | 2019-02-13 |
Family
ID=51743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540401A Expired - Fee Related JP6470290B2 (ja) | 2013-09-06 | 2014-09-05 | トリプトファンヒドロキシラーゼ阻害薬としてのスピロ環式化合物 |
Country Status (30)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
| WO2018060949A1 (en) | 2016-09-30 | 2018-04-05 | Roivant Sciences Gmbh | Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases |
| AR110150A1 (es) * | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
| US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
| KR20210102887A (ko) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| EP3880203A1 (en) * | 2018-11-16 | 2021-09-22 | Altavant Sciences GmbH | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension |
| US20200188398A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating sarcoidosis-associated pulmonary hypertension |
| WO2020128614A1 (en) * | 2018-12-17 | 2020-06-25 | Altavant Sciences Gmbh | Method for treating interstital lung disease |
| KR20210133953A (ko) | 2019-01-30 | 2021-11-08 | 알타반트 사이언시스 게엠베하 | 로다트리스타트 에틸로 폐동맥 고혈압을 치료하기 위한 투여 요법 및 방법 |
| EP3938043A1 (en) * | 2019-03-15 | 2022-01-19 | Altavant Sciences GmbH | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing |
| US20220409627A1 (en) * | 2019-12-02 | 2022-12-29 | Altavant Sciences Gmbh | Treatment of lower airways disorders |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| JP2023512025A (ja) * | 2020-01-31 | 2023-03-23 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性肺高血圧症をロダトリスタットで処置するための投与量および方法 |
| WO2023062595A1 (en) * | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
| WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
| CN120769851A (zh) * | 2023-02-09 | 2025-10-10 | 美国杰龙生物医药公司 | 端粒酶抑制剂化合物 |
| WO2025008449A1 (en) | 2023-07-05 | 2025-01-09 | Institut National de la Santé et de la Recherche Médicale | Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis |
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| CN1053010A (zh) | 1989-05-16 | 1991-07-17 | 梅迪斯化学药物工厂普特两合股份公司 | 药物制剂 |
| NZ334257A (en) | 1996-08-28 | 2000-11-24 | Procter & Gamble | Spirocyclic metalloprotease inhibitors |
| WO2001066531A1 (de) | 2000-03-07 | 2001-09-13 | Aventis Pharma Deutschland Gmbh | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| WO2004111004A1 (en) | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
| EP1636205A1 (en) | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| EP1984344B1 (en) | 2005-12-29 | 2012-09-26 | Lexicon Pharmaceuticals, Inc. | Multicyclic amino acid derivatives and methods of their use |
| UA99270C2 (en) | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
| WO2008100412A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperidine derivatives |
| CN101679395B (zh) | 2007-05-16 | 2012-06-13 | 伊莱利利公司 | 三唑基氨基嘧啶化合物 |
| BRPI0814105A2 (pt) | 2007-07-11 | 2015-02-03 | Lexicon Pharmaceuticals Inc | Métodos e composições para o tratamento de hipertensão pulmonar e doenças e distúrbios relacionados |
| US20090029993A1 (en) | 2007-07-26 | 2009-01-29 | Qingyun Liu | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein |
| US20100255001A1 (en) | 2007-09-24 | 2010-10-07 | Universität Zürich Prorektorat Mnw | Blockers of serotonin and its receptors for the treatment of hepatitis |
| NZ588737A (en) | 2008-03-31 | 2012-05-25 | Univ Columbia | Methods of diagnosing, preventing and treating bone mass diseases |
| CN104045626B (zh) | 2008-05-30 | 2017-01-11 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| CN101591332B (zh) | 2008-05-30 | 2014-04-16 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| TW201022267A (en) * | 2008-10-23 | 2010-06-16 | Gruenenthal Gmbh | Substituierte pyrimidin-und triazin-derivate |
| WO2010056992A1 (en) | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| WO2010109442A1 (en) | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| EP2444402A4 (en) | 2009-06-16 | 2012-11-07 | Ono Pharmaceutical Co | COMPOUND HAVING A SPIRO BINDING CYCLIC GROUP AND USE THEREOF |
| US8796297B2 (en) * | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
| WO2011053977A1 (en) | 2009-11-02 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
| EP2496231A1 (en) | 2009-11-05 | 2012-09-12 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| EP2504008A1 (en) | 2009-11-23 | 2012-10-03 | Lexicon Pharmaceuticals, Inc. | Methods and assays for the treatment of irritable bowel syndrome |
| AU2011215963A1 (en) | 2010-02-10 | 2012-08-02 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease |
| WO2011103196A1 (en) * | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
| PH12013500084A1 (en) | 2010-07-14 | 2015-09-11 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
| PH12013500661A1 (en) * | 2010-10-08 | 2017-08-23 | Abbvie Inc | FURO[3,2-d]PYRIMIDINE COMPOUNDS |
| TW201245183A (en) | 2010-11-05 | 2012-11-16 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| JP6203182B2 (ja) | 2011-10-17 | 2017-09-27 | レクシコン ファーマシューティカルズ インコーポレイテッド | （ｓ）−エチル２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）ピリミジン−４−イル）フェニル）プロパノエートの固形剤 |
| WO2013074889A1 (en) | 2011-11-17 | 2013-05-23 | The Trustees Of Columbia University In The City Of New York | Methods of treating and preventing leukemia and other cancers of the blood and bone |
| WO2013105063A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| US20140378463A1 (en) | 2012-01-13 | 2014-12-25 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| WO2013105066A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Salts of an ip receptor agonist |
| UY34572A (es) | 2012-01-13 | 2013-09-02 | Novartis Ag | Compuestos heterocíclicos agonistas del receptor ip |
| WO2013105061A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused dihydropyrido [2,3 -b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| EP2802585A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | Fused piperidines as ip receptor agonists for the treatment of pah and related disorders |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| WO2013148978A1 (en) | 2012-03-30 | 2013-10-03 | Lexicon Pharmaceuticals, Inc. | Methods and compositions for the treatment of necrotizing enterocolitis |
| WO2014082034A1 (en) | 2012-11-26 | 2014-05-30 | Lexicon Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome |
| US9937173B2 (en) | 2013-02-15 | 2018-04-10 | Mcmaster University | Method of treating obesity |
| WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| AR098436A1 (es) | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
| JP6561055B2 (ja) | 2013-11-19 | 2019-08-14 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 三環式イミダゾール化合物 |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| EP3061761A1 (en) | 2015-02-24 | 2016-08-31 | Max-Delbrück-Centrum für Molekulare Medizin | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same |
| MA42034A (fr) | 2015-05-04 | 2018-03-14 | Actelion Pharmaceuticals Ltd | Composés pipéridiniques tricycliques |
-
2014
- 2014-05-09 UA UAA201603580A patent/UA119247C2/uk unknown
- 2014-09-05 ES ES14786383T patent/ES2780828T3/es active Active
- 2014-09-05 HR HRP20200098TT patent/HRP20200098T1/hr unknown
- 2014-09-05 HU HUE14786383A patent/HUE047574T2/hu unknown
- 2014-09-05 PL PL14786383T patent/PL3041842T3/pl unknown
- 2014-09-05 DK DK14786383.1T patent/DK3041842T3/da active
- 2014-09-05 CN CN201480060427.9A patent/CN105764902B/zh not_active Expired - Fee Related
- 2014-09-05 CA CA2922933A patent/CA2922933C/en active Active
- 2014-09-05 JP JP2016540401A patent/JP6470290B2/ja not_active Expired - Fee Related
- 2014-09-05 EA EA201690534A patent/EA032304B1/ru not_active IP Right Cessation
- 2014-09-05 WO PCT/US2014/054202 patent/WO2015035113A1/en not_active Ceased
- 2014-09-05 PE PE2016000340A patent/PE20160648A1/es unknown
- 2014-09-05 LT LTEP14786383.1T patent/LT3041842T/lt unknown
- 2014-09-05 PT PT147863831T patent/PT3041842T/pt unknown
- 2014-09-05 KR KR1020167009029A patent/KR102336075B1/ko not_active Expired - Fee Related
- 2014-09-05 SG SG10202013041QA patent/SG10202013041QA/en unknown
- 2014-09-05 AU AU2014315109A patent/AU2014315109B2/en not_active Ceased
- 2014-09-05 SG SG10201802118QA patent/SG10201802118QA/en unknown
- 2014-09-05 SI SI201431461T patent/SI3041842T1/sl unknown
- 2014-09-05 MX MX2016002936A patent/MX371191B/es active IP Right Grant
- 2014-09-05 EP EP14786383.1A patent/EP3041842B8/en active Active
- 2014-09-05 MY MYPI2016000415A patent/MY186265A/en unknown
- 2014-09-05 RS RS20200059A patent/RS59871B1/sr unknown
- 2014-09-05 US US14/477,948 patent/US9199994B2/en active Active
- 2014-09-05 TW TW103130893A patent/TWI652267B/zh not_active IP Right Cessation
- 2014-09-05 AR ARP140103327A patent/AR097571A1/es active IP Right Grant
-
2015
- 2015-09-01 US US14/841,868 patent/US9512122B2/en not_active Expired - Fee Related
-
2016
- 2016-02-28 IL IL244315A patent/IL244315B/en active IP Right Grant
- 2016-03-03 PH PH12016500416A patent/PH12016500416B1/en unknown
- 2016-03-04 CL CL2016000509A patent/CL2016000509A1/es unknown
- 2016-04-06 EC ECIEPI201614324A patent/ECSP16014324A/es unknown
- 2016-09-28 US US15/278,130 patent/US9750740B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/645,054 patent/US10045988B2/en active Active
-
2018
- 2018-05-14 US US15/978,361 patent/US10350208B2/en active Active
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2019
- 2019-05-30 US US16/426,698 patent/US10660893B2/en active Active
-
2020
- 2020-01-15 CY CY20201100036T patent/CY1122652T1/el unknown
- 2020-04-16 US US16/850,542 patent/US10946018B2/en not_active Expired - Fee Related
-
2021
- 2021-03-15 US US17/201,750 patent/US11759462B2/en active Active
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