JP2016526374A5 - - Google Patents
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- JP2016526374A5 JP2016526374A5 JP2016501252A JP2016501252A JP2016526374A5 JP 2016526374 A5 JP2016526374 A5 JP 2016526374A5 JP 2016501252 A JP2016501252 A JP 2016501252A JP 2016501252 A JP2016501252 A JP 2016501252A JP 2016526374 A5 JP2016526374 A5 JP 2016526374A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361845712P | 2013-07-12 | 2013-07-12 | |
| US61/845,712 | 2013-07-12 | ||
| PCT/JP2014/069122 WO2015005500A1 (en) | 2013-07-12 | 2014-07-11 | Virus like particle comprising pd-1 antigen or pd-1 ligand antigen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526374A JP2016526374A (ja) | 2016-09-05 |
| JP2016526374A5 true JP2016526374A5 (enExample) | 2017-08-10 |
| JP6557208B2 JP6557208B2 (ja) | 2019-08-07 |
Family
ID=52277262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501252A Active JP6557208B2 (ja) | 2013-07-12 | 2014-07-11 | Ｐｄ−１抗原またはｐｄ−１リガンド抗原を含むウイルス様粒子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9637532B2 (enExample) |
| EP (2) | EP3666890A1 (enExample) |
| JP (1) | JP6557208B2 (enExample) |
| KR (1) | KR20160029124A (enExample) |
| CN (1) | CN105358683A (enExample) |
| AR (1) | AR096885A1 (enExample) |
| AU (1) | AU2014288147B2 (enExample) |
| BR (1) | BR112016000303A2 (enExample) |
| CA (1) | CA2916458A1 (enExample) |
| IL (1) | IL243304B (enExample) |
| MX (1) | MX364952B (enExample) |
| TW (1) | TWI676636B (enExample) |
| WO (1) | WO2015005500A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ717682A (en) | 2012-02-16 | 2017-10-27 | Vlp Therapeutics Llc | Virus like particle composition |
| TWI676636B (zh) | 2013-07-12 | 2019-11-11 | Ｖｌｐ醫療股份有限公司 | 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子 |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| ES3040431T3 (en) | 2014-03-12 | 2025-10-31 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| CN106795513B (zh) | 2014-08-08 | 2021-06-11 | Vlp治疗公司 | 包含修饰的包膜蛋白e3的病毒样颗粒 |
| CN106687590B (zh) | 2014-09-11 | 2021-08-03 | Vlp治疗公司 | 黄热病毒病毒样颗粒 |
| WO2016149643A2 (en) * | 2015-03-18 | 2016-09-22 | Omnicyte | Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof |
| US10166281B2 (en) * | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| WO2018067361A1 (en) * | 2016-10-04 | 2018-04-12 | The Curators Of The University Of Missouri | Peptides for molecular detection of pd-l1 |
| WO2018161092A1 (en) | 2017-03-03 | 2018-09-07 | New York University | Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins |
| CA3056807A1 (en) * | 2017-03-17 | 2018-09-20 | Vaximm Ag | Novel pd-l1 targeting dna vaccine for cancer immunotherapy |
| CN118909082A (zh) * | 2017-03-28 | 2024-11-08 | 俄亥俄州创新基金会 | 一种分离的肽 |
| SG11202005792RA (en) | 2017-12-20 | 2020-07-29 | Vlp Therapeutics Llc | Alphavirus replicon particle |
| JP2021512966A (ja) * | 2018-02-07 | 2021-05-20 | イミュジーン、リミテッドＩｍｕｇｅｎｅ Ｌｉｍｉｔｅｄ | ワクチン組成物およびその使用 |
| FR3078536A1 (fr) * | 2018-03-05 | 2019-09-06 | Peptinov Sas | Composition vaccinale anti-pd-1 |
| FR3078535B1 (fr) * | 2018-03-05 | 2024-02-09 | Peptinov Sas | Composition vaccinale anti-pd-l1 |
| WO2019173223A1 (en) * | 2018-03-05 | 2019-09-12 | New York University | Induction and enhancement of antitumor immunity involving sindbis virus vectors expressing immune checkpoint proteins |
| WO2020071869A1 (ko) * | 2018-10-05 | 2020-04-09 | 알엔에이진 주식회사 | 표적 세포 특이적으로 결합하여 다중 면역기능이 강화된 키메라항원 및 이의용도 |
| WO2020142700A1 (en) * | 2019-01-04 | 2020-07-09 | George Mason Research Foundation, Inc. | Binding domain mapping and compounds, compositions, complexes, methods, and kits related thereto |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| BR112022005044A2 (pt) * | 2019-09-17 | 2022-07-05 | Ohio State Innovation Foundation | Peptídeo quimérico, peptídeo sintético, composição farmacêutica, anticorpo, método de tratamento |
| CN111116733B (zh) * | 2019-11-28 | 2021-11-05 | 广东药科大学 | 一种靶向程序性死亡受体1和pd-1配体1相互作用界面的抗原肽和纳米抗体 |
| WO2021169673A1 (en) * | 2020-02-26 | 2021-09-02 | Versitech Limited | Pd-1-based vaccines against coronavirus infection |
| EP4135847A4 (en) | 2020-04-17 | 2024-05-15 | VLP Therapeutics, Inc. | Coronavirus vaccine |
| WO2021221127A1 (en) | 2020-04-30 | 2021-11-04 | Vlp Therapeutics, Inc. | Cytokine immunotherapy |
| WO2024111633A1 (ja) * | 2022-11-24 | 2024-05-30 | 国立大学法人徳島大学 | タンパク質に対する抗体の作製 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8923123D0 (en) | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| CA2123612C (en) | 1991-11-16 | 2002-06-25 | Michel De Wilde | Hybrid protein between cs from plasmodium and h bsag |
| US5580773A (en) | 1992-06-17 | 1996-12-03 | Korea Green Cross Corporation | Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV) |
| JPH07291996A (ja) | 1994-03-01 | 1995-11-07 | Yuu Honshiyo | ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするｄｎａ、そのｄｎａからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物 |
| AU716466B2 (en) | 1995-09-27 | 2000-02-24 | Medical Research Council | Recombinant viruses incorporating a protease cleavable protein |
| WO1999041383A1 (en) | 1998-02-11 | 1999-08-19 | Maxygen, Inc. | Antigen library immunization |
| PT1210428E (pt) * | 1999-08-23 | 2015-07-21 | Genetics Inst Llc | Pd-1, um recetor para b7-4 e suas utilizações |
| US20110262389A1 (en) | 2001-02-13 | 2011-10-27 | Mosca Joseph D | Tumor-derived Biological Antigen Presenting Particles |
| WO2002096939A2 (en) | 2001-05-30 | 2002-12-05 | Transgene S.A. | Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization |
| US7045335B2 (en) | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
| EP1572941A4 (en) | 2002-02-26 | 2009-03-18 | Maxygen Inc | NEW FLAVIVIRUS ANTIGENES |
| PT1537878E (pt) | 2002-07-03 | 2010-11-18 | Ono Pharmaceutical Co | Composições de imunopotenciação |
| US20050031592A1 (en) | 2002-11-13 | 2005-02-10 | Doolan Denise L. | Methods and compositions for inducing immune responses and protective immunity by priming with alpha virus replicon vaccines |
| JP5079981B2 (ja) | 2002-12-13 | 2012-11-21 | アルファバックス，インコーポレイティド | アルファウイルス粒子及び調製方法 |
| KR101518309B1 (ko) | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| MXPA05012754A (es) | 2003-05-29 | 2006-05-17 | Army Medical Res Inst For I | Vacunas virales atenuadas vivas para virus de encefalitis equina oriental. |
| EP1758925A4 (en) * | 2003-12-01 | 2009-04-08 | Dow Global Technologies Inc | PRODUCTION OF A RECOMBINANT ICOSAHEDRIC VIRUS LIKE PARTICLE |
| ES2321212T3 (es) * | 2004-05-18 | 2009-06-03 | Alphavax, Inc. | Vectores alfavirus derivados de tc-83, particulas y metodos antecentes de la invencion. |
| ES2371175T3 (es) | 2004-10-14 | 2011-12-28 | Crucell Holland B.V. | Vacunas de sensibilización/refuerzo de malaria. |
| WO2006088229A1 (ja) | 2005-02-16 | 2006-08-24 | The Circle For The Promotion Of Science And Engineering | 改変されたウイルスカプシドタンパク質及びその使用 |
| KR101510065B1 (ko) | 2005-06-08 | 2015-04-07 | 다나-파버 캔서 인스티튜트 인크. | 예정 세포사 1(ｐｄ-1) 경로를 억제함으로써 지속 감염 및 암을 치료하기 위한 방법 및 조성물 |
| GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
| US20070104689A1 (en) | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| CU23586A1 (es) | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
| EP2468765B1 (en) | 2006-03-03 | 2015-04-22 | ONO Pharmaceutical Co., Ltd. | Tetramer of extracellular domain of PD-L1 |
| US7499304B2 (en) | 2006-07-31 | 2009-03-03 | Sandisk 3D Llc | Systems for high bandwidth one time field-programmable memory |
| US20100120092A1 (en) | 2006-08-30 | 2010-05-13 | Hepgenics Pty Ltd. | Recombinant proteins and virus like particles comprising l and s polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same |
| GB2453155A (en) | 2007-09-26 | 2009-04-01 | Rolls Royce Plc | Co-axial pipe assembly which supplies oil to a bearing in a gas turbine engine |
| US20110035004A1 (en) | 2007-11-14 | 2011-02-10 | Maxwell G | Interfaced medical implant |
| WO2009079185A2 (en) | 2007-11-26 | 2009-06-25 | Novartis Vaccines And Diagnostics, Inc. | Methods of generating alphavirus particles |
| SG171828A1 (en) | 2008-11-26 | 2011-07-28 | Us Gov Health & Human Serv | Virus like particle compositions and methods of use |
| ES2752323T3 (es) | 2009-09-18 | 2020-04-06 | Fraunhofer Usa Inc | Partículas de tipo virus que comprenden proteínas diana fusionadas a proteínas de revestimiento de virus vegetales |
| US8907053B2 (en) * | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012006180A1 (en) | 2010-06-29 | 2012-01-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv immunogens |
| JP5600741B2 (ja) | 2010-07-13 | 2014-10-01 | 帝人株式会社 | 炭素繊維束及びその製造方法、ならびにそれからの成形品 |
| WO2012023995A1 (en) | 2010-08-18 | 2012-02-23 | Takayuki Shiratsuchi | Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes |
| WO2012106356A2 (en) | 2011-01-31 | 2012-08-09 | GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | Virus-like particles and methods of use |
| US9402916B2 (en) | 2011-03-17 | 2016-08-02 | The University Of Birmingham | Re-directed immunotherapy |
| AU2012269907B2 (en) | 2011-06-17 | 2017-05-18 | Bharat Biotech International Limited | Vaccine composition comprising an inactivated chikungunya virus strain |
| EP2731961A4 (en) | 2011-07-12 | 2015-12-09 | Us Government | IDENTIFICATION OF A WEST NIL VIRUS CD4 T-CELL EPITOPS AND USE THEREOF |
| CN102321639B (zh) | 2011-09-08 | 2013-06-26 | 中国疾病预防控制中心病毒病预防控制所 | 基孔肯雅病毒病毒样颗粒的制备方法和应用 |
| CA2850245C (en) * | 2011-10-17 | 2020-04-28 | Herlev Hospital | Pd-l1 based immunotherapy |
| BR112014009887A2 (pt) | 2011-10-25 | 2017-04-25 | Florida Gulf Coast Univ | vacinmas e métodos para desenvolvimento de vacina para indução de imunidade a todos os sorotipos de virus da dengue |
| NZ717682A (en) | 2012-02-16 | 2017-10-27 | Vlp Therapeutics Llc | Virus like particle composition |
| US9821050B2 (en) | 2012-04-02 | 2017-11-21 | The University Of North Carolina At Chapel Hill | Chimeric dengue virus E glycoproteins comprising mutant domain I and domain II hinge regions |
| PT2850431T (pt) * | 2012-05-16 | 2018-07-23 | Immune Design Corp | Vacinas para hsv-2 |
| CN105431535A (zh) | 2013-06-03 | 2016-03-23 | Vlp治疗有限责任公司 | 疟疾疫苗 |
| TWI676636B (zh) | 2013-07-12 | 2019-11-11 | Ｖｌｐ醫療股份有限公司 | 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子 |
| US10060924B2 (en) | 2014-03-18 | 2018-08-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Distinguishing flavivirus infection using a recombinant mutant envelope protein |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| CN106795513B (zh) | 2014-08-08 | 2021-06-11 | Vlp治疗公司 | 包含修饰的包膜蛋白e3的病毒样颗粒 |
| CN106687590B (zh) | 2014-09-11 | 2021-08-03 | Vlp治疗公司 | 黄热病毒病毒样颗粒 |
| US9363353B1 (en) | 2014-12-04 | 2016-06-07 | Hon Man Ashley Chik | Mobile phone docks with multiple circulating phone connectors |
| KR102713707B1 (ko) | 2014-12-31 | 2024-10-04 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 신규 다가 나노입자 기반 백신 |
| JPWO2016199936A1 (ja) | 2015-06-12 | 2018-04-05 | 国立大学法人三重大学 | ヒトパラインフルエンザ２型ウイルスベクター及びワクチン |
| WO2016210127A1 (en) | 2015-06-25 | 2016-12-29 | Technovax, Inc. | Flavivirus and alphavirus virus-like particles (vlps) |
| JP6896700B2 (ja) | 2015-07-16 | 2021-06-30 | バハラ バイオテック インターナショナル リミテッド | ワクチン組成物 |
| MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
| US10166281B2 (en) | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| WO2017150683A1 (en) | 2016-03-04 | 2017-09-08 | Vlp Therapeutics, Llc | Zika virus virus like particle |
| CN106085974B (zh) | 2016-06-07 | 2019-08-09 | 博奥生物集团有限公司 | 一种寨卡病毒假病毒颗粒及其制备方法 |
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2014
- 2014-07-10 TW TW103123759A patent/TWI676636B/zh not_active IP Right Cessation
- 2014-07-10 US US14/328,268 patent/US9637532B2/en not_active Expired - Fee Related
- 2014-07-11 KR KR1020167003373A patent/KR20160029124A/ko not_active Withdrawn
- 2014-07-11 MX MX2016000381A patent/MX364952B/es active IP Right Grant
- 2014-07-11 EP EP19219213.6A patent/EP3666890A1/en not_active Withdrawn
- 2014-07-11 CN CN201480039571.4A patent/CN105358683A/zh active Pending
- 2014-07-11 JP JP2016501252A patent/JP6557208B2/ja active Active
- 2014-07-11 AU AU2014288147A patent/AU2014288147B2/en not_active Expired - Fee Related
- 2014-07-11 AR ARP140102570A patent/AR096885A1/es unknown
- 2014-07-11 EP EP14823398.4A patent/EP3019600B1/en active Active
- 2014-07-11 CA CA2916458A patent/CA2916458A1/en not_active Abandoned
- 2014-07-11 WO PCT/JP2014/069122 patent/WO2015005500A1/en not_active Ceased
- 2014-07-11 BR BR112016000303A patent/BR112016000303A2/pt not_active Application Discontinuation
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2015
- 2015-12-23 IL IL243304A patent/IL243304B/en not_active IP Right Cessation
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2017
- 2017-04-27 US US15/498,971 patent/US10464986B2/en active Active
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