KR20160029124A - Pd-1 항원 또는 pd-1 리간드 항원을 포함하는 바이러스 유사 입자 - Google Patents
Pd-1 항원 또는 pd-1 리간드 항원을 포함하는 바이러스 유사 입자 Download PDFInfo
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- KR20160029124A KR20160029124A KR1020167003373A KR20167003373A KR20160029124A KR 20160029124 A KR20160029124 A KR 20160029124A KR 1020167003373 A KR1020167003373 A KR 1020167003373A KR 20167003373 A KR20167003373 A KR 20167003373A KR 20160029124 A KR20160029124 A KR 20160029124A
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| JP6824154B2 (ja) | 2014-08-08 | 2021-02-03 | ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC | 修飾エンベロープタンパク質e3を含むウイルス様粒子 |
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| US10166281B2 (en) * | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| WO2018067361A1 (en) * | 2016-10-04 | 2018-04-12 | The Curators Of The University Of Missouri | Peptides for molecular detection of pd-l1 |
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| JP7247097B2 (ja) * | 2017-03-17 | 2023-03-28 | バクシム アクチェンゲゼルシャフト | がん免疫療法のための新規pd-l1標的dnaワクチン |
| BR112019020386A2 (pt) * | 2017-03-28 | 2020-06-09 | Mayo Found Medical Education & Res | vacinas de peptídeos de pd-1 humana e usos das mesmas |
| EP3728611A4 (en) | 2017-12-20 | 2021-09-08 | VLP Therapeutics, Inc. | ALPHAVIRUS REPLICON PARTICLE |
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| FR3078535B1 (fr) * | 2018-03-05 | 2024-02-09 | Peptinov Sas | Composition vaccinale anti-pd-l1 |
| JP7304421B2 (ja) * | 2018-10-05 | 2023-07-06 | アールエヌエージーン インコーポレイテッド | 標的細胞特異的に結合して多重免疫機能が強化されたキメラ抗原及びこの用途 |
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| JP7749543B2 (ja) * | 2019-09-17 | 2025-10-06 | オハイオ・ステイト・イノベーション・ファウンデーション | ヒト抗pd-l1ペプチドワクチン及びその使用方法 |
| CN111116733B (zh) * | 2019-11-28 | 2021-11-05 | 广东药科大学 | 一种靶向程序性死亡受体1和pd-1配体1相互作用界面的抗原肽和纳米抗体 |
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Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8923123D0 (en) | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| AU2927892A (en) | 1991-11-16 | 1993-06-15 | Smithkline Beecham Biologicals (Sa) | Hybrid protein between cs from plasmodium and hbsag |
| US5580773A (en) | 1992-06-17 | 1996-12-03 | Korea Green Cross Corporation | Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV) |
| CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
| WO1997012048A1 (en) | 1995-09-27 | 1997-04-03 | Medical Research Council | Recombinant viruses incorporating a protease cleavable protein |
| JP2002507393A (ja) | 1998-02-11 | 2002-03-12 | マキシジェン, インコーポレイテッド | 抗原ライブラリー免疫 |
| EP1210428B1 (en) * | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| US20110262389A1 (en) | 2001-02-13 | 2011-10-27 | Mosca Joseph D | Tumor-derived Biological Antigen Presenting Particles |
| CA2448908C (en) | 2001-05-30 | 2008-03-18 | Transgene S.A. | Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization |
| DE60233061D1 (de) | 2001-09-06 | 2009-09-03 | Alphavax Inc | Alphavirus replikon-vektorsysteme |
| WO2003102166A2 (en) | 2002-02-26 | 2003-12-11 | Maxygen, Inc. | Novel flavivirus antigens |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
| WO2004043399A2 (en) | 2002-11-13 | 2004-05-27 | The United States Of America As Represented By The Secretary Of The Navy | Methods and compositions for inducing immune responses and protective immunity by priming with alphavirus replicon vaccines |
| CA2509979C (en) | 2002-12-13 | 2013-02-26 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
| KR101518309B1 (ko) | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| WO2005000881A2 (en) | 2003-05-29 | 2005-01-06 | United States Army Medical Research Institute For Infectious Diseases | Live attenuated viral vaccines for eastern equine encephalitis virus |
| JP2007512842A (ja) | 2003-12-01 | 2007-05-24 | ダウ グローバル テクノロジーズ インコーポレイティド | シュードモナスにおける組換え二十面体ウイルス様粒子の生産 |
| US20050266550A1 (en) | 2004-05-18 | 2005-12-01 | Alphavax, Inc. | TC-83-derived alphavirus vectors, particles and methods |
| EA016648B1 (ru) | 2004-10-14 | 2012-06-29 | Круселл Холланд Б.В. | Применение дефектного по репликации рекомбинантного аденовируса, содержащего гетерологичную нуклеиновую кислоту, кодирующую антиген cs возбудителя малярии, и белкового антигена, содержащего белок cs или его фрагмент, для лечения или профилактики малярии |
| US20090298955A1 (en) | 2005-02-16 | 2009-12-03 | Konica Minolta Holdings, Inc. | Altered virus capsid protein and use thereof |
| EP3130350A1 (en) | 2005-06-08 | 2017-02-15 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway |
| GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
| US20070104689A1 (en) | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| CU23586A1 (es) | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
| JP5093097B2 (ja) | 2006-03-03 | 2012-12-05 | 小野薬品工業株式会社 | 細胞表面機能分子の細胞外領域多量体 |
| US7499304B2 (en) | 2006-07-31 | 2009-03-03 | Sandisk 3D Llc | Systems for high bandwidth one time field-programmable memory |
| WO2008025067A1 (en) | 2006-08-30 | 2008-03-06 | Hepgenics Pty Ltd | Recombinant proteins and virus like particles comprising l and s polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same |
| GB2453155A (en) | 2007-09-26 | 2009-04-01 | Rolls Royce Plc | Co-axial pipe assembly which supplies oil to a bearing in a gas turbine engine |
| US20110035004A1 (en) | 2007-11-14 | 2011-02-10 | Maxwell G | Interfaced medical implant |
| CA2705787A1 (en) | 2007-11-26 | 2009-06-25 | Novartis Ag | Methods of generating alphavirus particles |
| CN102317308A (zh) * | 2008-11-26 | 2012-01-11 | 美国国有健康与人类服务部 | 类病毒组合物颗粒及其使用方法 |
| ES2752323T3 (es) | 2009-09-18 | 2020-04-06 | Fraunhofer Usa Inc | Partículas de tipo virus que comprenden proteínas diana fusionadas a proteínas de revestimiento de virus vegetales |
| US8907053B2 (en) * | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012006180A1 (en) | 2010-06-29 | 2012-01-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv immunogens |
| KR101837219B1 (ko) | 2010-07-13 | 2018-03-09 | 데이진 가부시키가이샤 | 탄소섬유다발 및 그 제조 방법, 및 그로부터의 성형품 |
| WO2012023995A1 (en) | 2010-08-18 | 2012-02-23 | Takayuki Shiratsuchi | Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes |
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| CA2830349C (en) | 2011-03-17 | 2019-07-16 | The University Of Birmingham | Re-directed immunotherapy |
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| CN102321639B (zh) | 2011-09-08 | 2013-06-26 | 中国疾病预防控制中心病毒病预防控制所 | 基孔肯雅病毒病毒样颗粒的制备方法和应用 |
| BR112014009526B8 (pt) * | 2011-10-17 | 2023-01-17 | Herlev Hospital | Composição de vacina compreendendo pd-l1, kit de partes compreendendo tal composição e uso dos mesmos para tratar ou prevenir câncer |
| SG11201401733VA (en) | 2011-10-25 | 2014-09-26 | Florida Gulf Coast University | Vaccines and methods for creating a vaccine for inducing immunity to all dengue virus serotypes |
| AU2013221187B9 (en) | 2012-02-16 | 2018-01-04 | Vlp Therapeutics, Inc. | Virus like particle composition |
| WO2013151764A1 (en) | 2012-04-02 | 2013-10-10 | The University Of North Carolina At Chapel Hill | Methods and compositions for dengue virus epitopes |
| LT2850431T (lt) * | 2012-05-16 | 2018-06-25 | Immune Design Corp. | Vakcinos, skirtos hsv-2 |
| AU2014275772B2 (en) | 2013-06-03 | 2020-01-02 | Vlp Therapeutics, Inc. | Malaria vaccine |
| US9637532B2 (en) | 2013-07-12 | 2017-05-02 | Vlp Therapeutics, Llc | Virus like particle comprising PD-1 antigen or PD-1 ligand antigen |
| WO2015139784A1 (en) | 2014-03-18 | 2015-09-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Distinguishing flavivirus infection using a recombinant mutant envelope protein |
| JP6824154B2 (ja) | 2014-08-08 | 2021-02-03 | ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC | 修飾エンベロープタンパク質e3を含むウイルス様粒子 |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| WO2016038895A1 (en) | 2014-09-11 | 2016-03-17 | Vlp Therapeutics, Llc | Flavivirus virus like particle |
| US9363353B1 (en) | 2014-12-04 | 2016-06-07 | Hon Man Ashley Chik | Mobile phone docks with multiple circulating phone connectors |
| SG11201705264WA (en) | 2014-12-31 | 2017-07-28 | The Usa As Represented By The Secretary Detp Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
| EP3309251A4 (en) | 2015-06-12 | 2019-03-13 | Mie University | HUMAN PARAIN FLUENZA TYPE 2 VIRUS VIRUS VECTOR AND VACCINE |
| WO2016210127A1 (en) | 2015-06-25 | 2016-12-29 | Technovax, Inc. | Flavivirus and alphavirus virus-like particles (vlps) |
| MY187459A (en) | 2015-07-16 | 2021-09-23 | Bharat Biotech Int Ltd | Vaccine compositions |
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| US10166281B2 (en) | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| WO2017150683A1 (en) | 2016-03-04 | 2017-09-08 | Vlp Therapeutics, Llc | Zika virus virus like particle |
| CN106085974B (zh) | 2016-06-07 | 2019-08-09 | 博奥生物集团有限公司 | 一种寨卡病毒假病毒颗粒及其制备方法 |
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- 2014-07-11 EP EP19219213.6A patent/EP3666890A1/en not_active Withdrawn
- 2014-07-11 AU AU2014288147A patent/AU2014288147B2/en not_active Expired - Fee Related
- 2014-07-11 MX MX2016000381A patent/MX364952B/es active IP Right Grant
- 2014-07-11 KR KR1020167003373A patent/KR20160029124A/ko not_active Withdrawn
- 2014-07-11 CN CN201480039571.4A patent/CN105358683A/zh active Pending
- 2014-07-11 CA CA2916458A patent/CA2916458A1/en not_active Abandoned
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2015
- 2015-12-23 IL IL243304A patent/IL243304B/en not_active IP Right Cessation
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2017
- 2017-04-27 US US15/498,971 patent/US10464986B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6557208B2 (ja) | 2019-08-07 |
| IL243304B (en) | 2020-02-27 |
| WO2015005500A1 (en) | 2015-01-15 |
| US20150017194A1 (en) | 2015-01-15 |
| EP3019600A1 (en) | 2016-05-18 |
| MX2016000381A (es) | 2016-09-07 |
| US20170233450A1 (en) | 2017-08-17 |
| CA2916458A1 (en) | 2015-01-15 |
| AU2014288147B2 (en) | 2020-04-09 |
| AU2014288147A1 (en) | 2016-01-21 |
| US9637532B2 (en) | 2017-05-02 |
| IL243304A0 (en) | 2016-03-31 |
| US10464986B2 (en) | 2019-11-05 |
| AR096885A1 (es) | 2016-02-03 |
| BR112016000303A2 (pt) | 2017-12-12 |
| MX364952B (es) | 2019-05-14 |
| CN105358683A (zh) | 2016-02-24 |
| JP2016526374A (ja) | 2016-09-05 |
| EP3019600B1 (en) | 2019-12-25 |
| TWI676636B (zh) | 2019-11-11 |
| EP3666890A1 (en) | 2020-06-17 |
| EP3019600A4 (en) | 2017-04-12 |
| TW201536812A (zh) | 2015-10-01 |
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