JP2016523935A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016523935A5 JP2016523935A5 JP2016524673A JP2016524673A JP2016523935A5 JP 2016523935 A5 JP2016523935 A5 JP 2016523935A5 JP 2016524673 A JP2016524673 A JP 2016524673A JP 2016524673 A JP2016524673 A JP 2016524673A JP 2016523935 A5 JP2016523935 A5 JP 2016523935A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1,2,3,6-tetrahydropyridinyl Chemical group 0.000 claims description 105
- 125000000217 alkyl group Chemical group 0.000 claims description 49
- 125000002947 alkylene group Chemical group 0.000 claims description 44
- 230000035772 mutation Effects 0.000 claims description 42
- 150000001875 compounds Chemical class 0.000 claims description 37
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims description 23
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 201000011510 cancer Diseases 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 15
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 13
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 13
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 13
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 102200116484 rs121913502 Human genes 0.000 claims description 8
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000003386 piperidinyl group Chemical group 0.000 claims description 7
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims description 6
- 125000001153 fluoro group Chemical group F* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims description 4
- 125000003566 oxetanyl group Chemical group 0.000 claims description 4
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 4
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 3
- 125000002971 oxazolyl group Chemical group 0.000 claims description 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 3
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000000335 thiazolyl group Chemical group 0.000 claims description 3
- 125000004917 3-methyl-2-butyl group Chemical group CC(C(C)*)C 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 208000005243 Chondrosarcoma Diseases 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 206010018338 Glioma Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000002393 azetidinyl group Chemical group 0.000 claims description 2
- BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- QXJISXCFLKTKBD-UHFFFAOYSA-N 4-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-(2-phenylpropan-2-yl)-1H-1,3,5-triazine-2,4-diamine Chemical compound C1(CC1)C1=CC(=NN1)C1(NC(=NC(=N1)NC(C)(C1=CC=CC=C1)C)N1CCN(CC1)C)N QXJISXCFLKTKBD-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- HWXBTNAVRSUOJR-UHFFFAOYSA-N 2-hydroxyglutaric acid Chemical compound OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 description 6
- CIDBOZAVUWYIDV-UHFFFAOYSA-N 4-[3-(furan-2-yl)-1H-pyrazol-5-yl]-6-(4-methylpiperazin-1-yl)-2-N-(2-phenylpropan-2-yl)-1H-1,3,5-triazine-2,4-diamine Chemical compound O1C(=CC=C1)C1=CC(=NN1)C1(NC(=NC(=N1)NC(C)(C1=CC=CC=C1)C)N1CCN(CC1)C)N CIDBOZAVUWYIDV-UHFFFAOYSA-N 0.000 description 5
- 108700028369 Alleles Proteins 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- IBLZORXBCNIQKI-UHFFFAOYSA-N 2-N-tert-butyl-4-(2,4-dimethoxyphenyl)-6-pyrrolidin-1-yl-1H-1,3,5-triazine-2,4-diamine Chemical compound COC1=C(C=CC(=C1)OC)C1(NC(=NC(=N1)NC(C)(C)C)N1CCCC1)N IBLZORXBCNIQKI-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- FABWPQRUKYQCKR-UHFFFAOYSA-N 2-N-tert-butyl-4-(2,4-dimethoxyphenyl)-6-morpholin-4-yl-1H-1,3,5-triazine-2,4-diamine Chemical compound COC1=C(C=CC(=C1)OC)C1(NC(=NC(=N1)NC(C)(C)C)N1CCOCC1)N FABWPQRUKYQCKR-UHFFFAOYSA-N 0.000 description 2
- 0 CC(*)(*)N(*)c1nc(N(*)C2=CCC=CC=CC=C/C=C2)nc(C2CC*CCCCC2)n1 Chemical compound CC(*)(*)N(*)c1nc(N(*)C2=CCC=CC=CC=C/C=C2)nc(C2CC*CCCCC2)n1 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- YDVTUFIUCSNBAX-UHFFFAOYSA-N 2-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-methylpropan-1-ol Chemical compound N=1C(N2CCOCC2)=NC(NC(C)(CO)C)=NC=1NC1=CC=CC=C1 YDVTUFIUCSNBAX-UHFFFAOYSA-N 0.000 description 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- PEKBPYGSPVENLB-UHFFFAOYSA-N 4-tert-butyl-6-morpholin-4-yl-2-N-[4-(trifluoromethoxy)phenyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound CC(C)(C)C1(NC(=NC(=N1)NC1=CC=C(C=C1)OC(F)(F)F)N1CCOCC1)N PEKBPYGSPVENLB-UHFFFAOYSA-N 0.000 description 1
- AUTKINSGDBUQFA-UHFFFAOYSA-N 4-tert-butyl-6-piperidin-1-yl-2-N-[4-(trifluoromethoxy)phenyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound CC(C)(C)C1(NC(=NC(=N1)NC1=CC=C(C=C1)OC(F)(F)F)N1CCCCC1)N AUTKINSGDBUQFA-UHFFFAOYSA-N 0.000 description 1
- HUDHFAKJBKXQFI-UHFFFAOYSA-N CC(C)(C)NC1=NC(N=C(N1)N2CCCCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N Chemical compound CC(C)(C)NC1=NC(N=C(N1)N2CCCCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N HUDHFAKJBKXQFI-UHFFFAOYSA-N 0.000 description 1
- FFNANZAGQQPCRJ-UHFFFAOYSA-N CC(C)(C)NC1=NC(N=C(N1)N2CCOCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N Chemical compound CC(C)(C)NC1=NC(N=C(N1)N2CCOCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N FFNANZAGQQPCRJ-UHFFFAOYSA-N 0.000 description 1
- LHISVJZIXWMRDT-UHFFFAOYSA-N CC(C)(Cc1ccccc1)NC1=NC(N=C(N)N1)(N1CCNCC1)c1nc2ccccc2s1 Chemical compound CC(C)(Cc1ccccc1)NC1=NC(N=C(N)N1)(N1CCNCC1)c1nc2ccccc2s1 LHISVJZIXWMRDT-UHFFFAOYSA-N 0.000 description 1
- QVOGIDAKSOHLCU-UHFFFAOYSA-N CC(C)NC1N=C(C2=CCCCC2)N=C(Nc2ccnc(C(F)(F)F)c2)N1 Chemical compound CC(C)NC1N=C(C2=CCCCC2)N=C(Nc2ccnc(C(F)(F)F)c2)N1 QVOGIDAKSOHLCU-UHFFFAOYSA-N 0.000 description 1
- LBGUTCRGHBUVIE-UHFFFAOYSA-N CC(C)Nc1nc(C(C)(C)C)nc(Nc2ccnc(C(F)(F)F)c2)n1 Chemical compound CC(C)Nc1nc(C(C)(C)C)nc(Nc2ccnc(C(F)(F)F)c2)n1 LBGUTCRGHBUVIE-UHFFFAOYSA-N 0.000 description 1
- ZNQWVWWEICOAES-UHFFFAOYSA-N CC(C)Nc1nc(C(CCC2)=CC2=O)nc(Nc2ccnc(C(F)(F)F)c2)n1 Chemical compound CC(C)Nc1nc(C(CCC2)=CC2=O)nc(Nc2ccnc(C(F)(F)F)c2)n1 ZNQWVWWEICOAES-UHFFFAOYSA-N 0.000 description 1
- JLCNDPQKVSJGKP-UHFFFAOYSA-N CC(C)Nc1nc(Nc2cc(C(F)(F)F)ncc2)nc(C2CC(C)CC(C)C2)n1 Chemical compound CC(C)Nc1nc(Nc2cc(C(F)(F)F)ncc2)nc(C2CC(C)CC(C)C2)n1 JLCNDPQKVSJGKP-UHFFFAOYSA-N 0.000 description 1
- GGAQACUKYHLEJQ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2=O)n1 GGAQACUKYHLEJQ-UHFFFAOYSA-N 0.000 description 1
- OXAIMBZXNPMGMR-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2O)n1 OXAIMBZXNPMGMR-UHFFFAOYSA-N 0.000 description 1
- AKDVJXMVKCYAHJ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)=CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)=CC2=O)n1 AKDVJXMVKCYAHJ-UHFFFAOYSA-N 0.000 description 1
- JFTKDQWJWRGWGU-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)CC2=O)n1 JFTKDQWJWRGWGU-UHFFFAOYSA-N 0.000 description 1
- LXENQLISEIFTDK-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CC(C)CCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CC(C)CCC2)n1 LXENQLISEIFTDK-UHFFFAOYSA-N 0.000 description 1
- QHBQSXGAGLFRSN-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCC2)n1 QHBQSXGAGLFRSN-UHFFFAOYSA-N 0.000 description 1
- ZFWJFAVGIMYSMS-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCC2)n1 ZFWJFAVGIMYSMS-UHFFFAOYSA-N 0.000 description 1
- JAHQTXGTXGCFLZ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCCC2)n1 JAHQTXGTXGCFLZ-UHFFFAOYSA-N 0.000 description 1
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/079184 WO2015003355A2 (en) | 2013-07-11 | 2013-07-11 | Therapeutically active compounds and their methods of use |
| CNPCT/CN2013/079184 | 2013-07-11 | ||
| PCT/CN2014/081958 WO2015003641A1 (en) | 2013-07-11 | 2014-07-10 | Therapeutically active compounds and their methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523935A JP2016523935A (ja) | 2016-08-12 |
| JP2016523935A5 true JP2016523935A5 (enExample) | 2017-08-17 |
| JP6490067B2 JP6490067B2 (ja) | 2019-03-27 |
Family
ID=52279362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524673A Expired - Fee Related JP6490067B2 (ja) | 2013-07-11 | 2014-07-10 | 治療活性化合物およびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10017495B2 (enExample) |
| EP (1) | EP3019484B1 (enExample) |
| JP (1) | JP6490067B2 (enExample) |
| AU (1) | AU2014289745B2 (enExample) |
| CA (1) | CA2917424A1 (enExample) |
| HK (1) | HK1223924A1 (enExample) |
| WO (2) | WO2015003355A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014287121B2 (en) | 2013-07-11 | 2018-11-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| JP6441334B2 (ja) * | 2013-07-16 | 2018-12-19 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 除草性アジン |
| CA2942072C (en) | 2014-03-14 | 2022-07-26 | Agios Pharmaceuticals, Inc. | Pharmaceutical compositions and use of (s)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-( 4-cyanopyridin-2-yl)-n-( 5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| WO2015155272A1 (en) | 2014-04-11 | 2015-10-15 | Basf Se | Diaminotriazine derivatives as herbicides |
| US10029992B2 (en) | 2014-04-23 | 2018-07-24 | Basf Se | Diaminotriazine compounds and their use as herbicides |
| AU2016340740B2 (en) * | 2015-10-21 | 2018-07-19 | NeuForm Pharmaceuticals, Inc. | Deuterated compounds for treating hematologic malignancies, and compositions and methods thereof |
| WO2017140758A1 (en) | 2016-02-19 | 2017-08-24 | Debiopharm International S.A. | Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers |
| US11179360B2 (en) * | 2016-11-02 | 2021-11-23 | University Of Cincinnati | Compositions and methods for treating patients suffering from glioma or leukemia |
| BR112019028101A2 (pt) | 2017-06-30 | 2020-07-28 | Celgene Corporation | composições e métodos para uso de (2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida) |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| WO2019109095A1 (en) * | 2017-12-01 | 2019-06-06 | Beth Israel Deaconess Medical Center, Inc. | Arsenic trioxide and retinoic acid compounds for treatment of idh2-associated disorders |
| AU2020327671A1 (en) | 2019-08-13 | 2022-03-03 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the IL-1 superfamily |
Family Cites Families (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| DE1252822B (enExample) | 1963-02-15 | |||
| BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
| US3867383A (en) | 1971-03-29 | 1975-02-18 | Ciba Geigy Corp | Monoanthranilatoanilino-s-triazines |
| BE793501A (fr) | 1971-12-31 | 1973-06-29 | Ciba Geigy | Composes heterocycliques et produits phytopharmaceutiques qui en contiennent |
| CH606334A5 (enExample) | 1974-06-21 | 1978-10-31 | Ciba Geigy Ag | |
| DE2715984A1 (de) | 1977-04-09 | 1978-10-26 | Basf Ag | Farbstoffzubereitungen fuer cellulose und cellulosehaltiges textilmaterial |
| DE2928485A1 (de) | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| US5041443A (en) | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| ES2058630T3 (es) | 1989-03-03 | 1994-11-01 | Dainippon Pharmaceutical Co | Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen. |
| JPH0499768A (ja) | 1990-08-17 | 1992-03-31 | Dainippon Pharmaceut Co Ltd | ４―（４―フェニルピリジン―２―イル）ピペラジン―１―オキシド誘導体 |
| JPH05140126A (ja) | 1991-11-26 | 1993-06-08 | Hokko Chem Ind Co Ltd | トリアゾール誘導体および除草剤 |
| AU665238B2 (en) * | 1992-02-28 | 1995-12-21 | Zenyaku Kogyo Kabushiki Kaisha | S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| FR2735127B1 (fr) | 1995-06-09 | 1997-08-22 | Pf Medicament | Nouvelles piperazines heteroaromatiques utiles comme medicaments. |
| ES2100129B1 (es) | 1995-10-11 | 1998-02-16 | Medichem Sa | Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. |
| JP2000504336A (ja) | 1996-02-02 | 2000-04-11 | ゼネカ・リミテッド | 薬学製剤として有用なヘテロ環式化合物 |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP2000510866A (ja) | 1996-05-20 | 2000-08-22 | ダーウィン・ディスカバリー・リミテッド | Ｔｎｆとｐｄｅ―ｉｖのインヒビターとしてのキノリンスルホンアミド |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| CA2271744A1 (en) | 1996-11-14 | 1998-05-22 | Isao Hashiba | Cyanoethylmelamine derivatives and process for producing the same |
| US6399358B1 (en) | 1997-03-31 | 2002-06-04 | Thomas Jefferson University | Human gene encoding human chondroitin 6-sulfotransferase |
| JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| EP1042305B1 (en) | 1997-12-22 | 2005-06-08 | Bayer Pharmaceuticals Corp. | INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| WO2000002864A1 (en) | 1998-07-10 | 2000-01-20 | Martens Juergen | Precusors for pna-monomers |
| PT2158923E (pt) | 1998-08-06 | 2013-06-04 | Univ Duke | Conjugados de peg-urato oxidase e sua utilização |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| UY25842A1 (es) | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US6274620B1 (en) | 1999-06-07 | 2001-08-14 | Biochem Pharma Inc. | Thiophene integrin inhibitors |
| AU775625B2 (en) | 1999-08-27 | 2004-08-05 | Sugen, Inc. | Phosphate mimics and methods of treatment using phosphatase inhibitors |
| EP1216228B1 (en) | 1999-09-17 | 2008-10-29 | Millennium Pharmaceuticals, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
| JP2003509412A (ja) | 1999-09-17 | 2003-03-11 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| CA2396693A1 (en) | 1999-12-28 | 2001-07-05 | Stephen T. Wrobleski | Cytokine, especially tnf-alpha, inhibitors |
| AU2001245353A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| KR20030024799A (ko) | 2000-07-20 | 2003-03-26 | 뉴로젠 코포레이션 | 캡사이신 수용체 리간드 |
| JP4113323B2 (ja) | 2000-08-07 | 2008-07-09 | 富士フイルム株式会社 | アゾ色素及びそれを含むインクジェット記録用インク、並びにインクジェット記録方法 |
| CA2432799C (en) * | 2000-12-21 | 2008-08-19 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6525091B2 (en) | 2001-03-07 | 2003-02-25 | Telik, Inc. | Substituted diarylureas as stimulators for Fas-mediated apoptosis |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| US7144883B2 (en) | 2001-06-11 | 2006-12-05 | Biovitrum Ab | Bicyclic sulfonamide compounds |
| CA2450934A1 (en) | 2001-06-19 | 2002-12-27 | Marco Dodier | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
| US7038046B2 (en) | 2001-08-17 | 2006-05-02 | Ciba Specialty Chemicals Corporation | Triazine derivatives and their use as sunscreens |
| JP4753336B2 (ja) | 2001-09-04 | 2011-08-24 | 日本化薬株式会社 | 新規アリル化合物及びその製法 |
| US6878196B2 (en) * | 2002-01-15 | 2005-04-12 | Fuji Photo Film Co., Ltd. | Ink, ink jet recording method and azo compound |
| AU2003225800A1 (en) * | 2002-03-15 | 2003-09-29 | Hayley Binch | Azolylaminoazine as inhibitors of protein kinases |
| US20040067234A1 (en) | 2002-07-11 | 2004-04-08 | Paz Einat | Isocitrate dehydrogenase and uses thereof |
| EP1546121B1 (en) | 2002-07-18 | 2012-08-29 | Janssen Pharmaceutica NV | Substituted triazine kinase inhibitors |
| JP2004083610A (ja) | 2002-08-22 | 2004-03-18 | Fuji Photo Film Co Ltd | インクセット、インクカートリッジ、記録方法、プリンター及び記録物 |
| JP2004107220A (ja) | 2002-09-13 | 2004-04-08 | Mitsubishi Pharma Corp | ＴＮＦ−α産生抑制剤 |
| AR042052A1 (es) | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| EP1575580A4 (en) | 2002-12-02 | 2009-06-10 | Arqule Inc | METHOD FOR TREATING CARCINOMA |
| EP1590364B1 (en) | 2002-12-16 | 2011-10-05 | Genmab A/S | Human monoclonal antibodies against interleukin 8 (il-8) |
| CA2513399A1 (en) | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| US7358262B2 (en) | 2003-01-29 | 2008-04-15 | Whitehead Institute For Biomedical Research | Identification of genotype-selective anti-tumor agents |
| WO2004073619A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2004074438A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| JP4629657B2 (ja) | 2003-04-11 | 2011-02-09 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型化活性化合物 |
| US7226920B2 (en) | 2003-08-06 | 2007-06-05 | Vertex Pharmaceuticals Inc. | Aminotriazole compounds useful as inhibitors of protein kinases |
| CA2542031A1 (en) | 2003-10-10 | 2005-04-21 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives for treatment of hyperproliferative disorders |
| JP4099768B2 (ja) | 2003-11-10 | 2008-06-11 | 富士電機デバイステクノロジー株式会社 | 電子写真感光体および該電子写真感光体に起因する干渉縞有無の判定方法 |
| US20070196395A1 (en) | 2003-12-12 | 2007-08-23 | Mackerell Alexander | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain |
| KR20070007055A (ko) | 2003-12-24 | 2007-01-12 | 사이오스 인코퍼레이티드 | Ｔｇｆ-베타 억제제를 이용한 악성 신경교종의 치료법 |
| JP2005264016A (ja) | 2004-03-19 | 2005-09-29 | Fuji Photo Film Co Ltd | インクジェット記録用インク、インクセット及びインクジェット記録方法 |
| US7335770B2 (en) * | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| GB0412526D0 (en) | 2004-06-05 | 2004-07-14 | Leuven K U Res & Dev | Type 2 diabetes |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| CA2581454A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyrimidine compounds, process for their preparation and compositions containing them |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| JP2008526723A (ja) | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体 |
| AU2006208834A1 (en) | 2005-01-25 | 2006-08-03 | Astrazeneca Ab | Chemical compounds |
| SG2014009484A (en) | 2005-04-11 | 2014-05-29 | Savient Pharmaceuticals Inc | A variant form of urate oxidase and use thereof |
| AU2006254834B2 (en) | 2005-06-08 | 2012-09-20 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| EA015937B1 (ru) | 2005-08-26 | 2011-12-30 | Мерк Сероно С.А. | Производные пиразина и их применение в качестве ингибиторов pi3k |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| WO2007095812A1 (en) * | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| TW200815426A (en) | 2006-06-28 | 2008-04-01 | Astrazeneca Ab | New pyridine analogues II 333 |
| US20100297673A1 (en) * | 2006-09-20 | 2010-11-25 | Reddy Us Therapeutics | Methods and compositions for upregulation of peroxiredoxin activity |
| EP2086329B1 (en) | 2006-10-26 | 2014-07-23 | The Arizona Board of Regents on behalf of the University of Arizona | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance |
| HUP0600810A3 (en) | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| US20100234341A1 (en) | 2006-12-04 | 2010-09-16 | Marion Lanier | Substituted pyrimidines as adenosine receptor antagonists |
| CA2913963A1 (en) | 2006-12-08 | 2008-06-19 | Millenium Pharmaceuticals, Inc. | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
| WO2008076883A2 (en) | 2006-12-15 | 2008-06-26 | Abraxis Bioscience, Inc. | Triazine derivatives and their therapeutical applications |
| WO2008131547A1 (en) | 2007-04-30 | 2008-11-06 | Prometic Biosciences Inc. | 'triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives' |
| AU2008262291A1 (en) | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| SG183049A1 (en) | 2007-07-20 | 2012-08-30 | Nerviano Medical Sciences Srl | Substituted indazole derivatives active as kinase inhibitors |
| KR20100038108A (ko) | 2007-07-25 | 2010-04-12 | 브리스톨-마이어스 스큅 컴퍼니 | 트리아진 키나제 억제제 |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| BRPI0818366A2 (pt) | 2007-10-10 | 2015-04-07 | Takeda Pharmaceutical | Composto, pró-droga, medicamento, método inibidor de faah, métodos de profilaxia ou tratamento para ansiedade, ou depressão, ou de alívio da dor, e de profilaxia ou tratamento para dor inflamatória ou dor neuropática, e, uso do composto. |
| ES2404580T3 (es) * | 2007-10-11 | 2013-05-28 | Glaxosmithkline Llc | Novedosos inhibidores de la ehs y uso de los mismos |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| JP5277685B2 (ja) | 2008-03-26 | 2013-08-28 | 富士ゼロックス株式会社 | 電子写真感光体、画像形成装置、プロセスカートリッジ及び画像形成方法 |
| US20090281089A1 (en) | 2008-04-11 | 2009-11-12 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| CN101575408B (zh) * | 2008-05-09 | 2013-10-30 | Mca技术有限公司 | 用作阻燃剂和光稳定剂的聚三嗪基化合物 |
| KR20110017445A (ko) * | 2008-06-11 | 2011-02-21 | 아스트라제네카 아베 | 암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-ｌ,3,5-트리아진 유도체 |
| US8054553B2 (en) * | 2008-06-12 | 2011-11-08 | Orbotech Ltd. | Illumination angle control using dichroic filters |
| FR2932483A1 (fr) | 2008-06-13 | 2009-12-18 | Cytomics Systems | Composes utiles pour le traitement des cancers. |
| WO2010007756A1 (ja) | 2008-07-14 | 2010-01-21 | 塩野義製薬株式会社 | Ｔｔｋ阻害作用を有するピリジン誘導体 |
| DK2326735T3 (en) | 2008-09-03 | 2017-01-16 | Univ Johns Hopkins | Genetic changes of isocitrate dehydrogenase and other genes in malignant glioma |
| WO2010028179A1 (en) | 2008-09-03 | 2010-03-11 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds as gata modulators |
| JP2010079130A (ja) | 2008-09-29 | 2010-04-08 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| US20100273808A1 (en) | 2008-11-21 | 2010-10-28 | Millennium Pharmaceticals, Inc. | Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders |
| JP2010181540A (ja) | 2009-02-04 | 2010-08-19 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| KR101677778B1 (ko) | 2009-02-06 | 2016-11-18 | 니뽄 신야쿠 가부시키가이샤 | 아미노피라진 유도체 및 의약 |
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ， インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| EP2427441B1 (en) | 2009-05-04 | 2016-12-14 | Agios Pharmaceuticals, Inc. | Pkm2 activators for use in the treatment of cancer |
| WO2010130638A1 (en) | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
| WO2010144338A1 (en) | 2009-06-08 | 2010-12-16 | Abraxis Bioscience, Llc | Triazine derivatives and their therapeutical applications |
| JP2012529513A (ja) * | 2009-06-08 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | トリアジン誘導体類及びそれらの治療応用 |
| BRPI1011527A2 (pt) | 2009-06-09 | 2016-07-26 | California Capital Equity Llc | derivados de triazina substituídos com ureidofenil e suas aplicações terapêuticas. |
| CA2765044A1 (en) * | 2009-06-09 | 2010-12-16 | California Capital Equity, Llc | Benzyl substituted triazine derivatives and their therapeutical applications |
| AU2010258974A1 (en) | 2009-06-09 | 2012-01-12 | California Capital Equity, Llc | Pyridil-triazine inhibitors of hedgehog signaling |
| AR077292A1 (es) | 2009-06-29 | 2011-08-17 | Agios Pharmaceuticals Inc | Derivados de piperazin - quinolin sulfonamidas y composiciones farmaceuticas |
| WO2011005208A1 (en) | 2009-07-10 | 2011-01-13 | Milux Holding S.A. | Knee joint device and method |
| JP2013503846A (ja) | 2009-09-01 | 2013-02-04 | ファイザー・インク | ベンズイミダゾール誘導体 |
| EP2477625A4 (en) | 2009-09-14 | 2012-10-24 | Phusis Therapeutics Inc | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS COMPRISING PLECKSTRINE HOMOLOGY DOMAIN INHIBITORS AND METHODS OF USE |
| JP5473851B2 (ja) * | 2009-09-30 | 2014-04-16 | 富士フイルム株式会社 | 高分子フィルム、位相差フィルム、偏光板及び液晶表示装置 |
| US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
| ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| JP5967827B2 (ja) * | 2009-12-09 | 2016-08-10 | アジオス ファーマシューティカルズ， インコーポレイテッド | Ｉｄｈ変異体をもつことを特徴とする癌治療用の治療的活性化合物 |
| NZ578968A (en) | 2010-02-10 | 2011-03-31 | Allans Sheetmetal And Engineering Services | Fuel feed system for a pellet fire |
| US20130197106A1 (en) | 2010-04-01 | 2013-08-01 | Agios Pharmaceuticals, Inc | Methods of identifying a candidate compound |
| WO2011143160A2 (en) | 2010-05-10 | 2011-11-17 | The Johns Hopkins University | Metabolic inhibitor against tumors having an idh mutation |
| WO2012006506A1 (en) | 2010-07-09 | 2012-01-12 | Massachusetts Institute Of Technology | Metabolic gene, enzyme, and flux targets for cancer therapy |
| BR112013001122B1 (pt) | 2010-07-16 | 2021-06-08 | Agios Pharmaceuticals, Inc | composto de fórmula ii, uso do composto e composição farmacêutica compreendendo dito composto |
| AR083502A1 (es) | 2010-10-21 | 2013-02-27 | Biomarin Pharm Inc | Sal tosilada de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-dihidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalina |
| JP5907986B2 (ja) | 2010-11-29 | 2016-04-26 | ガリオン ファーマシューティカルズ インコーポレイテッド | 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物 |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| EP2691391A4 (en) * | 2011-03-29 | 2014-09-10 | Broad Inst Inc | COMPOUNDS AND METHODS OF TREATING DISORDERS MEDIATED BY ISOCITRATE DEHYDROGENASE |
| CN103608016A (zh) | 2011-05-03 | 2014-02-26 | 安吉奥斯医药品有限公司 | 丙酮酸激酶激活剂在治疗中的用途 |
| TW201636330A (zh) | 2011-05-24 | 2016-10-16 | 拜耳知識產權公司 | 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| WO2013004332A1 (en) | 2011-07-07 | 2013-01-10 | Merck Patent Gmbh | Substituted azaheterocycles for the treatment of cancer |
| EP2729146B1 (en) | 2011-07-08 | 2017-03-08 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for treatment of liver cancer |
| EP2734519B1 (en) | 2011-07-22 | 2016-05-04 | University Of Louisville Research Foundation, Inc. | Anti-biofilm compounds |
| JP6026544B2 (ja) * | 2011-09-27 | 2016-11-16 | ノバルティス アーゲー | 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類 |
| CN102659765B (zh) * | 2011-12-31 | 2014-09-10 | 沈阳药科大学 | 嘧啶及三嗪类化合物的制备方法和应用 |
| CA2860623A1 (en) * | 2012-01-06 | 2013-07-11 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| WO2013107405A1 (en) | 2012-01-19 | 2013-07-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP2634259A1 (en) | 2012-03-01 | 2013-09-04 | Deutsches Krebsforschungszentrum | Means and methods for the determination of (D)-2-hydroxyglutarate (D2HG) |
| EP2824099A4 (en) | 2012-03-09 | 2015-11-11 | Carna Biosciences Inc | NOVEL TRIAZINE DERIVATIVE |
| WO2014015422A1 (en) | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
| JP6385352B2 (ja) | 2012-10-15 | 2018-09-05 | アジオス ファーマシューティカルズ， インコーポレイテッド | 治療化合物および組成物 |
| KR20220143164A (ko) | 2012-11-21 | 2022-10-24 | 피티씨 테라퓨틱스, 인크. | 치환된 리버스 피리미딘 ｂｍｉ-1 저해제 |
| SG11201600058XA (en) | 2013-07-11 | 2016-02-26 | Agios Pharmaceuticals Inc | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
-
2013
- 2013-07-11 WO PCT/CN2013/079184 patent/WO2015003355A2/en not_active Ceased
-
2014
- 2014-07-10 EP EP14823630.0A patent/EP3019484B1/en active Active
- 2014-07-10 HK HK16112112.0A patent/HK1223924A1/zh unknown
- 2014-07-10 CA CA2917424A patent/CA2917424A1/en not_active Abandoned
- 2014-07-10 AU AU2014289745A patent/AU2014289745B2/en not_active Ceased
- 2014-07-10 US US14/903,952 patent/US10017495B2/en active Active
- 2014-07-10 JP JP2016524673A patent/JP6490067B2/ja not_active Expired - Fee Related
- 2014-07-10 WO PCT/CN2014/081958 patent/WO2015003641A1/en not_active Ceased