JP2016523935A5 - - Google Patents
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- JP2016523935A5 JP2016523935A5 JP2016524673A JP2016524673A JP2016523935A5 JP 2016523935 A5 JP2016523935 A5 JP 2016523935A5 JP 2016524673 A JP2016524673 A JP 2016524673A JP 2016524673 A JP2016524673 A JP 2016524673A JP 2016523935 A5 JP2016523935 A5 JP 2016523935A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 1,2,3,6-tetrahydropyridinyl Chemical group 0.000 claims description 105
- 125000000217 alkyl group Chemical group 0.000 claims description 49
- 125000002947 alkylene group Chemical group 0.000 claims description 44
- 230000035772 mutation Effects 0.000 claims description 42
- 150000001875 compounds Chemical class 0.000 claims description 37
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims description 23
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 201000011510 cancer Diseases 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 15
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 13
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 13
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 13
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 102200116484 rs121913502 Human genes 0.000 claims description 8
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000003386 piperidinyl group Chemical group 0.000 claims description 7
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims description 6
- 125000001153 fluoro group Chemical group F* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims description 4
- 125000003566 oxetanyl group Chemical group 0.000 claims description 4
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 4
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 3
- 125000002971 oxazolyl group Chemical group 0.000 claims description 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 3
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000000335 thiazolyl group Chemical group 0.000 claims description 3
- 125000004917 3-methyl-2-butyl group Chemical group CC(C(C)*)C 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 208000005243 Chondrosarcoma Diseases 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 206010018338 Glioma Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000002393 azetidinyl group Chemical group 0.000 claims description 2
- BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- QXJISXCFLKTKBD-UHFFFAOYSA-N 4-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-(2-phenylpropan-2-yl)-1H-1,3,5-triazine-2,4-diamine Chemical compound C1(CC1)C1=CC(=NN1)C1(NC(=NC(=N1)NC(C)(C1=CC=CC=C1)C)N1CCN(CC1)C)N QXJISXCFLKTKBD-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- HWXBTNAVRSUOJR-UHFFFAOYSA-N 2-hydroxyglutaric acid Chemical compound OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 description 6
- CIDBOZAVUWYIDV-UHFFFAOYSA-N 4-[3-(furan-2-yl)-1H-pyrazol-5-yl]-6-(4-methylpiperazin-1-yl)-2-N-(2-phenylpropan-2-yl)-1H-1,3,5-triazine-2,4-diamine Chemical compound O1C(=CC=C1)C1=CC(=NN1)C1(NC(=NC(=N1)NC(C)(C1=CC=CC=C1)C)N1CCN(CC1)C)N CIDBOZAVUWYIDV-UHFFFAOYSA-N 0.000 description 5
- 108700028369 Alleles Proteins 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- IBLZORXBCNIQKI-UHFFFAOYSA-N 2-N-tert-butyl-4-(2,4-dimethoxyphenyl)-6-pyrrolidin-1-yl-1H-1,3,5-triazine-2,4-diamine Chemical compound COC1=C(C=CC(=C1)OC)C1(NC(=NC(=N1)NC(C)(C)C)N1CCCC1)N IBLZORXBCNIQKI-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- FABWPQRUKYQCKR-UHFFFAOYSA-N 2-N-tert-butyl-4-(2,4-dimethoxyphenyl)-6-morpholin-4-yl-1H-1,3,5-triazine-2,4-diamine Chemical compound COC1=C(C=CC(=C1)OC)C1(NC(=NC(=N1)NC(C)(C)C)N1CCOCC1)N FABWPQRUKYQCKR-UHFFFAOYSA-N 0.000 description 2
- 0 CC(*)(*)N(*)c1nc(N(*)C2=CCC=CC=CC=C/C=C2)nc(C2CC*CCCCC2)n1 Chemical compound CC(*)(*)N(*)c1nc(N(*)C2=CCC=CC=CC=C/C=C2)nc(C2CC*CCCCC2)n1 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- YDVTUFIUCSNBAX-UHFFFAOYSA-N 2-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-methylpropan-1-ol Chemical compound N=1C(N2CCOCC2)=NC(NC(C)(CO)C)=NC=1NC1=CC=CC=C1 YDVTUFIUCSNBAX-UHFFFAOYSA-N 0.000 description 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- PEKBPYGSPVENLB-UHFFFAOYSA-N 4-tert-butyl-6-morpholin-4-yl-2-N-[4-(trifluoromethoxy)phenyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound CC(C)(C)C1(NC(=NC(=N1)NC1=CC=C(C=C1)OC(F)(F)F)N1CCOCC1)N PEKBPYGSPVENLB-UHFFFAOYSA-N 0.000 description 1
- AUTKINSGDBUQFA-UHFFFAOYSA-N 4-tert-butyl-6-piperidin-1-yl-2-N-[4-(trifluoromethoxy)phenyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound CC(C)(C)C1(NC(=NC(=N1)NC1=CC=C(C=C1)OC(F)(F)F)N1CCCCC1)N AUTKINSGDBUQFA-UHFFFAOYSA-N 0.000 description 1
- HUDHFAKJBKXQFI-UHFFFAOYSA-N CC(C)(C)NC1=NC(N=C(N1)N2CCCCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N Chemical compound CC(C)(C)NC1=NC(N=C(N1)N2CCCCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N HUDHFAKJBKXQFI-UHFFFAOYSA-N 0.000 description 1
- FFNANZAGQQPCRJ-UHFFFAOYSA-N CC(C)(C)NC1=NC(N=C(N1)N2CCOCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N Chemical compound CC(C)(C)NC1=NC(N=C(N1)N2CCOCC2)(C3=CC=C(C=C3)C(F)(F)Cl)N FFNANZAGQQPCRJ-UHFFFAOYSA-N 0.000 description 1
- LHISVJZIXWMRDT-UHFFFAOYSA-N CC(C)(Cc1ccccc1)NC1=NC(N=C(N)N1)(N1CCNCC1)c1nc2ccccc2s1 Chemical compound CC(C)(Cc1ccccc1)NC1=NC(N=C(N)N1)(N1CCNCC1)c1nc2ccccc2s1 LHISVJZIXWMRDT-UHFFFAOYSA-N 0.000 description 1
- QVOGIDAKSOHLCU-UHFFFAOYSA-N CC(C)NC1N=C(C2=CCCCC2)N=C(Nc2ccnc(C(F)(F)F)c2)N1 Chemical compound CC(C)NC1N=C(C2=CCCCC2)N=C(Nc2ccnc(C(F)(F)F)c2)N1 QVOGIDAKSOHLCU-UHFFFAOYSA-N 0.000 description 1
- LBGUTCRGHBUVIE-UHFFFAOYSA-N CC(C)Nc1nc(C(C)(C)C)nc(Nc2ccnc(C(F)(F)F)c2)n1 Chemical compound CC(C)Nc1nc(C(C)(C)C)nc(Nc2ccnc(C(F)(F)F)c2)n1 LBGUTCRGHBUVIE-UHFFFAOYSA-N 0.000 description 1
- ZNQWVWWEICOAES-UHFFFAOYSA-N CC(C)Nc1nc(C(CCC2)=CC2=O)nc(Nc2ccnc(C(F)(F)F)c2)n1 Chemical compound CC(C)Nc1nc(C(CCC2)=CC2=O)nc(Nc2ccnc(C(F)(F)F)c2)n1 ZNQWVWWEICOAES-UHFFFAOYSA-N 0.000 description 1
- JLCNDPQKVSJGKP-UHFFFAOYSA-N CC(C)Nc1nc(Nc2cc(C(F)(F)F)ncc2)nc(C2CC(C)CC(C)C2)n1 Chemical compound CC(C)Nc1nc(Nc2cc(C(F)(F)F)ncc2)nc(C2CC(C)CC(C)C2)n1 JLCNDPQKVSJGKP-UHFFFAOYSA-N 0.000 description 1
- GGAQACUKYHLEJQ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2=O)n1 GGAQACUKYHLEJQ-UHFFFAOYSA-N 0.000 description 1
- OXAIMBZXNPMGMR-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCC2)CC2O)n1 OXAIMBZXNPMGMR-UHFFFAOYSA-N 0.000 description 1
- AKDVJXMVKCYAHJ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)=CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)=CC2=O)n1 AKDVJXMVKCYAHJ-UHFFFAOYSA-N 0.000 description 1
- JFTKDQWJWRGWGU-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)CC2=O)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C(CCN2)CC2=O)n1 JFTKDQWJWRGWGU-UHFFFAOYSA-N 0.000 description 1
- LXENQLISEIFTDK-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CC(C)CCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CC(C)CCC2)n1 LXENQLISEIFTDK-UHFFFAOYSA-N 0.000 description 1
- QHBQSXGAGLFRSN-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCC2)n1 QHBQSXGAGLFRSN-UHFFFAOYSA-N 0.000 description 1
- ZFWJFAVGIMYSMS-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCC2)n1 ZFWJFAVGIMYSMS-UHFFFAOYSA-N 0.000 description 1
- JAHQTXGTXGCFLZ-UHFFFAOYSA-N CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCCC2)n1 Chemical compound CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2CCCCC2)n1 JAHQTXGTXGCFLZ-UHFFFAOYSA-N 0.000 description 1
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2013/079184 | 2013-07-11 | ||
| PCT/CN2013/079184 WO2015003355A2 (en) | 2013-07-11 | 2013-07-11 | Therapeutically active compounds and their methods of use |
| PCT/CN2014/081958 WO2015003641A1 (en) | 2013-07-11 | 2014-07-10 | Therapeutically active compounds and their methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523935A JP2016523935A (ja) | 2016-08-12 |
| JP2016523935A5 true JP2016523935A5 (enExample) | 2017-08-17 |
| JP6490067B2 JP6490067B2 (ja) | 2019-03-27 |
Family
ID=52279362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524673A Expired - Fee Related JP6490067B2 (ja) | 2013-07-11 | 2014-07-10 | 治療活性化合物およびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10017495B2 (enExample) |
| EP (1) | EP3019484B1 (enExample) |
| JP (1) | JP6490067B2 (enExample) |
| AU (1) | AU2014289745B2 (enExample) |
| CA (1) | CA2917424A1 (enExample) |
| HK (1) | HK1223924A1 (enExample) |
| WO (2) | WO2015003355A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CA2917671A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| PL3022191T3 (pl) * | 2013-07-16 | 2017-08-31 | Basf Se | Chwastobójcze azyny |
| PH12021551647A1 (en) | 2014-03-14 | 2022-06-06 | Agios Pharmaceuticals Inc | Pharmaceutical compositions of therapeutically active compounds |
| US10941122B2 (en) | 2014-04-11 | 2021-03-09 | Basf Se | Diaminotriazine derivatives as herbicides |
| CN106232586A (zh) | 2014-04-23 | 2016-12-14 | 巴斯夫欧洲公司 | 二氨基三嗪化合物及其作为除草剂的用途 |
| AU2016340740B2 (en) * | 2015-10-21 | 2018-07-19 | NeuForm Pharmaceuticals, Inc. | Deuterated compounds for treating hematologic malignancies, and compositions and methods thereof |
| WO2017140758A1 (en) | 2016-02-19 | 2017-08-24 | Debiopharm International S.A. | Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers |
| WO2018085486A1 (en) * | 2016-11-02 | 2018-05-11 | University Of Cincinnati | Compositions and methods for treating patients suffering from glioma or leukemia |
| EP3644999B1 (en) | 2017-06-30 | 2022-12-14 | Celgene Corporation | Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| WO2019109095A1 (en) * | 2017-12-01 | 2019-06-06 | Beth Israel Deaconess Medical Center, Inc. | Arsenic trioxide and retinoic acid compounds for treatment of idh2-associated disorders |
| US20230000913A1 (en) | 2019-08-13 | 2023-01-05 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily |
Family Cites Families (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| DE1252823B (enExample) | 1963-02-15 | |||
| BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
| US3867383A (en) | 1971-03-29 | 1975-02-18 | Ciba Geigy Corp | Monoanthranilatoanilino-s-triazines |
| BE793501A (fr) | 1971-12-31 | 1973-06-29 | Ciba Geigy | Composes heterocycliques et produits phytopharmaceutiques qui en contiennent |
| CH606334A5 (enExample) | 1974-06-21 | 1978-10-31 | Ciba Geigy Ag | |
| DE2715984A1 (de) | 1977-04-09 | 1978-10-26 | Basf Ag | Farbstoffzubereitungen fuer cellulose und cellulosehaltiges textilmaterial |
| DE2928485A1 (de) | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| US5041443A (en) | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| EP0385237B1 (en) | 1989-03-03 | 1994-06-29 | Dainippon Pharmaceutical Co., Ltd. | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same |
| JPH0499768A (ja) | 1990-08-17 | 1992-03-31 | Dainippon Pharmaceut Co Ltd | ４―（４―フェニルピリジン―２―イル）ピペラジン―１―オキシド誘導体 |
| JPH05140126A (ja) | 1991-11-26 | 1993-06-08 | Hokko Chem Ind Co Ltd | トリアゾール誘導体および除草剤 |
| EP0629622B1 (en) * | 1992-02-28 | 1998-11-11 | Zenyaku Kogyo Kabushikikaisha | S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| FR2735127B1 (fr) | 1995-06-09 | 1997-08-22 | Pf Medicament | Nouvelles piperazines heteroaromatiques utiles comme medicaments. |
| ES2100129B1 (es) | 1995-10-11 | 1998-02-16 | Medichem Sa | Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. |
| AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO1997044322A1 (en) | 1996-05-20 | 1997-11-27 | Darwin Discovery Limited | Quinoline sulfonamides as tnf inhibitors and as pde-iv inhibitors |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| CA2271744A1 (en) | 1996-11-14 | 1998-05-22 | Isao Hashiba | Cyanoethylmelamine derivatives and process for producing the same |
| US6399358B1 (en) | 1997-03-31 | 2002-06-04 | Thomas Jefferson University | Human gene encoding human chondroitin 6-sulfotransferase |
| JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| IL136737A0 (en) | 1997-12-22 | 2001-06-14 | Bayer Ag | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| WO2000002864A1 (en) | 1998-07-10 | 2000-01-20 | Martens Juergen | Precusors for pna-monomers |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| CA2338665C (en) | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| UY25842A1 (es) | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US6274620B1 (en) | 1999-06-07 | 2001-08-14 | Biochem Pharma Inc. | Thiophene integrin inhibitors |
| ATE309207T1 (de) | 1999-08-27 | 2005-11-15 | Sugen Inc | Phosphat-mimetika sowie behandlungsmethoden unter verwendung von phosphatase-inhibitoren |
| NZ517828A (en) | 1999-09-17 | 2003-10-31 | Millennium Pharm Inc | Inhibitors having activity against mammalian factor Xa |
| ES2316383T3 (es) | 1999-09-17 | 2009-04-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| EP1246823A1 (en) | 1999-12-28 | 2002-10-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| JP4113323B2 (ja) | 2000-08-07 | 2008-07-09 | 富士フイルム株式会社 | アゾ色素及びそれを含むインクジェット記録用インク、並びにインクジェット記録方法 |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| US6525091B2 (en) | 2001-03-07 | 2003-02-25 | Telik, Inc. | Substituted diarylureas as stimulators for Fas-mediated apoptosis |
| WO2002088101A2 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| KR20090019894A (ko) | 2001-06-11 | 2009-02-25 | 바이오비트럼 에이비(피유비엘) | 치환 술폰아미드 화합물, ｃｎｓ 장애, 비만 및 ⅱ 형 당뇨병 치료용 약제로서의 이들의 사용 방법 |
| HUP0402352A2 (hu) | 2001-06-19 | 2005-02-28 | Bristol-Myers Squibb Co. | Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| DE60238066D1 (de) | 2001-08-17 | 2010-12-02 | Basf Se | Triazinderivate und deren verwendung als sonnenschutzmittel |
| JP4753336B2 (ja) | 2001-09-04 | 2011-08-24 | 日本化薬株式会社 | 新規アリル化合物及びその製法 |
| US6878196B2 (en) * | 2002-01-15 | 2005-04-12 | Fuji Photo Film Co., Ltd. | Ink, ink jet recording method and azo compound |
| ATE433973T1 (de) * | 2002-03-15 | 2009-07-15 | Vertex Pharma | Azolylaminoazine als inhibitoren von proteinkinasen |
| US20040067234A1 (en) | 2002-07-11 | 2004-04-08 | Paz Einat | Isocitrate dehydrogenase and uses thereof |
| SI2256108T1 (sl) | 2002-07-18 | 2016-05-31 | Janssen Pharmaceutica N.V. | Substituirani triazinski kinazni inhibitorji |
| JP2004083610A (ja) | 2002-08-22 | 2004-03-18 | Fuji Photo Film Co Ltd | インクセット、インクカートリッジ、記録方法、プリンター及び記録物 |
| JP2004107220A (ja) | 2002-09-13 | 2004-04-08 | Mitsubishi Pharma Corp | ＴＮＦ−α産生抑制剤 |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| WO2004050033A2 (en) | 2002-12-02 | 2004-06-17 | Arqule, Inc. | Method of treating cancers |
| ES2373947T3 (es) | 2002-12-16 | 2012-02-10 | Genmab A/S | Anticuerpos monoclonales humanos contra interleucina 8 (il-8). |
| AU2004204778B2 (en) | 2003-01-10 | 2008-05-22 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| US7358262B2 (en) | 2003-01-29 | 2008-04-15 | Whitehead Institute For Biomedical Research | Identification of genotype-selective anti-tumor agents |
| WO2004073619A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2004074438A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| EP1618090A1 (en) | 2003-04-11 | 2006-01-25 | Novo Nordisk A/S | 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| EP1663211B1 (en) | 2003-08-06 | 2010-01-20 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| US7582645B2 (en) | 2003-10-10 | 2009-09-01 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives for treatment of hyperproliferative disorders |
| JP4099768B2 (ja) | 2003-11-10 | 2008-06-11 | 富士電機デバイステクノロジー株式会社 | 電子写真感光体および該電子写真感光体に起因する干渉縞有無の判定方法 |
| WO2005060956A1 (en) | 2003-12-12 | 2005-07-07 | University Of Maryland, Baltimore | IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN |
| EP1708712A1 (en) | 2003-12-24 | 2006-10-11 | Scios, Inc. | Treatment of malignant gliomas with tgf-beta inhibitors |
| JP2005264016A (ja) | 2004-03-19 | 2005-09-29 | Fuji Photo Film Co Ltd | インクジェット記録用インク、インクセット及びインクジェット記録方法 |
| US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| GB0412526D0 (en) | 2004-06-05 | 2004-07-14 | Leuven K U Res & Dev | Type 2 diabetes |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| AU2005286593A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| JP2008526723A (ja) | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体 |
| CA2594708A1 (en) | 2005-01-25 | 2006-08-03 | Astrazeneca Ab | Chemical compounds |
| US7811800B2 (en) | 2005-04-11 | 2010-10-12 | Savient Pharmaceuticals, Inc. | Variant form of urate oxidase and use thereof |
| ES2624863T3 (es) | 2005-06-08 | 2017-07-17 | Millennium Pharmaceuticals, Inc. | Métodos para identificación, evaluación, y tratamiento de pacientes con terapia de cáncer |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| WO2007023186A1 (en) | 2005-08-26 | 2007-03-01 | Laboratoires Serono S.A. | Pyrazine derivatives and use as pi3k inhibitors |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| WO2007095812A1 (en) * | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| TW200815426A (en) | 2006-06-28 | 2008-04-01 | Astrazeneca Ab | New pyridine analogues II 333 |
| WO2008036835A2 (en) | 2006-09-20 | 2008-03-27 | Reddy Us Therapeutics | Methods and compositions for upregulation of peroxiredoxin activity |
| EP2086329B1 (en) | 2006-10-26 | 2014-07-23 | The Arizona Board of Regents on behalf of the University of Arizona | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance |
| HUP0600810A3 (en) | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| WO2008070661A1 (en) | 2006-12-04 | 2008-06-12 | Neurocrine Biosciences, Inc. | Substituted pyrimidines as adenosine receptor antagonists |
| NZ578180A (en) | 2006-12-08 | 2012-02-24 | Millennium Pharm Inc | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
| CA2672893C (en) | 2006-12-15 | 2016-02-23 | Abraxis Bioscience, Inc. | Triazine derivatives and their therapeutical applications |
| US8258295B2 (en) | 2007-04-30 | 2012-09-04 | Prometic Biosciences Inc. | Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives |
| JP2010529193A (ja) | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
| EA018503B1 (ru) | 2007-07-20 | 2013-08-30 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Замещенные производные индазола, активные как ингибиторы киназы |
| US8415340B2 (en) | 2007-07-25 | 2013-04-09 | Bristol-Myers Squibb Company | Triazine kinase inhibitors |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| EA201070451A1 (ru) | 2007-10-10 | 2010-10-29 | Такеда Фармасьютикал Компани Лимитед | Амидные соединения |
| EP2209376B1 (en) * | 2007-10-11 | 2013-03-06 | GlaxoSmithKline LLC | Novel seh inhibitors and their use |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP5277685B2 (ja) | 2008-03-26 | 2013-08-28 | 富士ゼロックス株式会社 | 電子写真感光体、画像形成装置、プロセスカートリッジ及び画像形成方法 |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| US20090281089A1 (en) | 2008-04-11 | 2009-11-12 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| CN101575408B (zh) * | 2008-05-09 | 2013-10-30 | Mca技术有限公司 | 用作阻燃剂和光稳定剂的聚三嗪基化合物 |
| CN102119157A (zh) * | 2008-06-11 | 2011-07-06 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症和骨髓增生性疾病的三环2，4-二氨基-l，3，5-三嗪衍生物 |
| US8054553B2 (en) * | 2008-06-12 | 2011-11-08 | Orbotech Ltd. | Illumination angle control using dichroic filters |
| FR2932483A1 (fr) | 2008-06-13 | 2009-12-18 | Cytomics Systems | Composes utiles pour le traitement des cancers. |
| TW201028381A (en) | 2008-07-14 | 2010-08-01 | Shionogi & Co | Pyridine derivative having ttk inhibition activity |
| ES2755139T3 (es) | 2008-09-03 | 2020-04-21 | Univ Johns Hopkins | Alteraciones genéticas en la citrato deshidrogenasa y otros genes en gliomas malignos |
| US20100144722A1 (en) | 2008-09-03 | 2010-06-10 | Dr. Reddy's Laboratories Ltd. | Novel heterocyclic compounds as gata modulators |
| JP2010079130A (ja) | 2008-09-29 | 2010-04-08 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| EP2370417A2 (en) | 2008-11-21 | 2011-10-05 | Millennium Pharmaceuticals, Inc. | Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders |
| JP2010181540A (ja) | 2009-02-04 | 2010-08-19 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| PT2394999E (pt) | 2009-02-06 | 2014-05-02 | Nippon Shinyaku Co Ltd | Derivado de aminopirazina e medicamento correspondente |
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ， インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| DK2427441T3 (en) | 2009-05-04 | 2017-03-20 | Agios Pharmaceuticals Inc | PKM2 Activators for use in the treatment of cancer |
| WO2010130638A1 (en) | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
| BRPI1010887A2 (pt) | 2009-06-08 | 2016-12-27 | California Capital Equity Llc | derivados de triazina e suas aplicações terapêuticas. |
| EP2440050A4 (en) | 2009-06-08 | 2013-04-03 | California Capital Equity Llc | TRIAZINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
| KR20120026611A (ko) | 2009-06-09 | 2012-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 헷지호그 신호전달의 피리딜-트리아진 억제제 |
| JP2012529517A (ja) * | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ベンジル置換トリアジン誘導体類及びそれらの治療応用 |
| AU2010258825B2 (en) | 2009-06-09 | 2014-08-21 | Nantbio, Inc. | Ureidophenyl substituted triazine derivatives and their therapeutical applications |
| CR20170071A (es) | 2009-06-29 | 2017-03-28 | Agios Pharmaceuticals Inc | Compuestos terapeuticos y composiciones |
| US20120101587A1 (en) | 2009-07-10 | 2012-04-26 | Milux Holding Sa | Knee joint device and method |
| JP2013503846A (ja) | 2009-09-01 | 2013-02-04 | ファイザー・インク | ベンズイミダゾール誘導体 |
| US20120189670A1 (en) | 2009-09-14 | 2012-07-26 | Kirkpatrick D Lynn | Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same |
| JP5473851B2 (ja) | 2009-09-30 | 2014-04-16 | 富士フイルム株式会社 | 高分子フィルム、位相差フィルム、偏光板及び液晶表示装置 |
| US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| IN2012DN03312A (enExample) | 2009-10-22 | 2015-10-23 | Fibrotech Therapeutics Pty Ltd | |
| EP2509600B1 (en) | 2009-12-09 | 2017-08-02 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds for use in the treatment of cancer characterized as having an idh mutation |
| NZ578968A (en) | 2010-02-10 | 2011-03-31 | Allans Sheetmetal And Engineering Services | Fuel feed system for a pellet fire |
| US20130197106A1 (en) | 2010-04-01 | 2013-08-01 | Agios Pharmaceuticals, Inc | Methods of identifying a candidate compound |
| US20130109643A1 (en) | 2010-05-10 | 2013-05-02 | The Johns Hopkins University | Metabolic inhibitor against tumors having an idh mutation |
| US10064885B2 (en) | 2010-07-09 | 2018-09-04 | Massachusetts Institute Of Technology | Metabolic gene, enzyme, and flux targets for cancer therapy |
| WO2012009678A1 (en) | 2010-07-16 | 2012-01-19 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their method of use |
| TWI557123B (zh) | 2010-10-21 | 2016-11-11 | 梅迪維新技術公司 | 結晶型（８Ｓ，９Ｒ）－５－氟－８－（４－氟苯基）－９－（１－甲基－１Ｈ－１，２，４－三唑－５－基）－８，９－二氫－２Ｈ－吡啶并［４，３，２－ｄｅ］呔－３（７Ｈ）－酮甲苯磺酸鹽 |
| SG10201601507YA (en) | 2010-11-29 | 2016-04-28 | Galleon Pharmaceuticals Inc | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| WO2012173682A2 (en) | 2011-03-29 | 2012-12-20 | The Broad Institute, Inc. | Compounds and methods for the treatment of isocitrate dehydrognase related diseases |
| CA2834692A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| TWI555737B (zh) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| AU2012280725B2 (en) | 2011-07-07 | 2017-02-02 | Merck Patent Gmbh | Substituted azaheterocycles for the treatment of cancer |
| ES2627120T3 (es) * | 2011-07-08 | 2017-07-26 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicamento para el tratamiento del cáncer de hígado |
| US9167820B2 (en) | 2011-07-22 | 2015-10-27 | University Of Louisville Research Foundation, Inc. | Anti-biofilm compounds |
| EP2771337B1 (en) * | 2011-09-27 | 2017-08-02 | Novartis AG | 3-(pyrimidin-4-yl)-oxazolidin-2-ones as inhibitors of mutant idh |
| CN102659765B (zh) * | 2011-12-31 | 2014-09-10 | 沈阳药科大学 | 嘧啶及三嗪类化合物的制备方法和应用 |
| KR101893112B1 (ko) | 2012-01-06 | 2018-08-30 | 아지오스 파마슈티컬스 아이엔씨. | 치료학적으로 활성인 화합물 및 이의 이용 방법 |
| CA2860858A1 (en) | 2012-01-19 | 2013-07-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| EP2634259A1 (en) | 2012-03-01 | 2013-09-04 | Deutsches Krebsforschungszentrum | Means and methods for the determination of (D)-2-hydroxyglutarate (D2HG) |
| US20150011751A1 (en) | 2012-03-09 | 2015-01-08 | Carna Biosciences, Inc. | Novel triazine derivative |
| WO2014015422A1 (en) | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
| WO2014062511A1 (en) | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| EA035349B1 (ru) | 2012-11-21 | 2020-05-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ЗАМЕЩЕННЫЕ ПИРИМИДИНОВЫЕ ОБРАТНЫЕ ИНГИБИТОРЫ Bmi-1 |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| PE20160744A1 (es) | 2013-07-11 | 2016-08-01 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
-
2013
- 2013-07-11 WO PCT/CN2013/079184 patent/WO2015003355A2/en not_active Ceased
-
2014
- 2014-07-10 HK HK16112112.0A patent/HK1223924A1/zh unknown
- 2014-07-10 AU AU2014289745A patent/AU2014289745B2/en not_active Ceased
- 2014-07-10 WO PCT/CN2014/081958 patent/WO2015003641A1/en not_active Ceased
- 2014-07-10 US US14/903,952 patent/US10017495B2/en active Active
- 2014-07-10 EP EP14823630.0A patent/EP3019484B1/en active Active
- 2014-07-10 CA CA2917424A patent/CA2917424A1/en not_active Abandoned
- 2014-07-10 JP JP2016524673A patent/JP6490067B2/ja not_active Expired - Fee Related
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