JP2016522221A5 - - Google Patents
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- Publication number
- JP2016522221A5 JP2016522221A5 JP2016519695A JP2016519695A JP2016522221A5 JP 2016522221 A5 JP2016522221 A5 JP 2016522221A5 JP 2016519695 A JP2016519695 A JP 2016519695A JP 2016519695 A JP2016519695 A JP 2016519695A JP 2016522221 A5 JP2016522221 A5 JP 2016522221A5
- Authority
- JP
- Japan
- Prior art keywords
- dehydrated
- acid
- cells
- formulation
- apoptosis inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- 238000002360 preparation method Methods 0.000 claims 13
- 238000009472 formulation Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 10
- 239000000158 apoptosis inhibitor Substances 0.000 claims 10
- 230000018044 dehydration Effects 0.000 claims 9
- 238000006297 dehydration reaction Methods 0.000 claims 9
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 8
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000000914 phenoxymethylpenicillanyl group Chemical group CC1(S[C@H]2N([C@H]1C(=O)*)C([C@H]2NC(COC2=CC=CC=C2)=O)=O)C 0.000 claims 6
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 4
- FTEDXVNDVHYDQW-UHFFFAOYSA-N BAPTA Chemical compound OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(O)=O)CC(O)=O FTEDXVNDVHYDQW-UHFFFAOYSA-N 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical group OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 4
- 229960003237 betaine Drugs 0.000 claims 4
- 239000002738 chelating agent Substances 0.000 claims 4
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 4
- 229960003330 pentetic acid Drugs 0.000 claims 4
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 2
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims 2
- FCKYPQBAHLOOJQ-NXEZZACHSA-N 2-[[(1r,2r)-2-[bis(carboxymethyl)amino]cyclohexyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)[C@@H]1CCCC[C@H]1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-NXEZZACHSA-N 0.000 claims 2
- BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 claims 2
- FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002441 reversible effect Effects 0.000 claims 2
- 239000000176 sodium gluconate Substances 0.000 claims 2
- 229940005574 sodium gluconate Drugs 0.000 claims 2
- 235000012207 sodium gluconate Nutrition 0.000 claims 2
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 229960002429 proline Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361834517P | 2013-06-13 | 2013-06-13 | |
| US61/834,517 | 2013-06-13 | ||
| PCT/US2014/042396 WO2015002729A2 (en) | 2013-06-13 | 2014-06-13 | Cell stabilization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522221A JP2016522221A (ja) | 2016-07-28 |
| JP2016522221A5 true JP2016522221A5 (enExample) | 2017-07-20 |
| JP6604942B2 JP6604942B2 (ja) | 2019-11-13 |
Family
ID=52144261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519695A Expired - Fee Related JP6604942B2 (ja) | 2013-06-13 | 2014-06-13 | 細胞安定化 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20160135446A1 (enExample) |
| EP (2) | EP3007556B1 (enExample) |
| JP (1) | JP6604942B2 (enExample) |
| CN (1) | CN105491883B (enExample) |
| CA (1) | CA2915250A1 (enExample) |
| WO (1) | WO2015002729A2 (enExample) |
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| EP2641966A4 (en) * | 2010-11-19 | 2014-04-30 | Seiren Kabushiki Kaisha | VITRIFIED MEMORY SOLUTION FOR CELLS |
-
2014
- 2014-06-13 EP EP14819510.0A patent/EP3007556B1/en active Active
- 2014-06-13 WO PCT/US2014/042396 patent/WO2015002729A2/en not_active Ceased
- 2014-06-13 EP EP19209890.3A patent/EP3632208A1/en not_active Withdrawn
- 2014-06-13 US US14/895,475 patent/US20160135446A1/en not_active Abandoned
- 2014-06-13 CA CA2915250A patent/CA2915250A1/en not_active Abandoned
- 2014-06-13 JP JP2016519695A patent/JP6604942B2/ja not_active Expired - Fee Related
- 2014-06-13 CN CN201480044962.5A patent/CN105491883B/zh not_active Expired - Fee Related
-
2017
- 2017-12-21 US US15/850,805 patent/US20180184644A1/en active Pending
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