CN105491883B - 细胞稳定化 - Google Patents
细胞稳定化 Download PDFInfo
- Publication number
- CN105491883B CN105491883B CN201480044962.5A CN201480044962A CN105491883B CN 105491883 B CN105491883 B CN 105491883B CN 201480044962 A CN201480044962 A CN 201480044962A CN 105491883 B CN105491883 B CN 105491883B
- Authority
- CN
- China
- Prior art keywords
- acid
- cell
- apoptosis
- inhibitor
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- LCOIAYJMPKXARU-VAWYXSNFSA-N O=C(/C=C/c1ccccc1)NC(C(Cl)(Cl)Cl)NC(Nc1cccc2c1nccc2)=S Chemical compound O=C(/C=C/c1ccccc1)NC(C(Cl)(Cl)Cl)NC(Nc1cccc2c1nccc2)=S LCOIAYJMPKXARU-VAWYXSNFSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361834517P | 2013-06-13 | 2013-06-13 | |
| US61/834,517 | 2013-06-13 | ||
| PCT/US2014/042396 WO2015002729A2 (en) | 2013-06-13 | 2014-06-13 | Cell stabilization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105491883A CN105491883A (zh) | 2016-04-13 |
| CN105491883B true CN105491883B (zh) | 2018-11-02 |
Family
ID=52144261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480044962.5A Expired - Fee Related CN105491883B (zh) | 2013-06-13 | 2014-06-13 | 细胞稳定化 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20160135446A1 (enExample) |
| EP (2) | EP3007556B1 (enExample) |
| JP (1) | JP6604942B2 (enExample) |
| CN (1) | CN105491883B (enExample) |
| CA (1) | CA2915250A1 (enExample) |
| WO (1) | WO2015002729A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX358640B (es) | 2008-01-04 | 2018-08-29 | Intellikine Llc | Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas. |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| TWI546305B (zh) | 2011-01-10 | 2016-08-21 | 英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| CN105102000B (zh) | 2012-11-01 | 2021-10-22 | 无限药品公司 | 使用pi3激酶亚型调节剂的癌症疗法 |
| EP3249054A1 (en) | 2012-12-20 | 2017-11-29 | Biomatrica, INC. | Formulations and methods for stabilizing pcr reagents |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| EP3942931A1 (en) | 2014-06-10 | 2022-01-26 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
| CN106687580A (zh) * | 2014-06-10 | 2017-05-17 | 生物马特里卡公司 | 在环境温度下稳定血液样品中的代谢活性细胞 |
| ES2912965T3 (es) | 2015-09-09 | 2022-05-30 | Drawbridge Health Inc | Dispositivos para la recopilación, estabilización y conservación de muestras |
| KR20250047404A (ko) | 2015-12-08 | 2025-04-03 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
| WO2017130756A1 (ja) * | 2016-01-25 | 2017-08-03 | 学校法人 慶應義塾 | 小胞体ストレスを標的とする椎間板変性症に対する治療薬 |
| KR101662975B1 (ko) * | 2016-02-15 | 2016-10-06 | 서울대학교산학협력단 | 간암 치료 또는 예방용 조성물 |
| EP4043475B1 (en) * | 2016-03-31 | 2023-09-20 | Berkeley Lights, Inc. | Nucleic acid stabilization reagent, kits, and methods of use thereof |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| EP3573608A1 (en) | 2017-01-30 | 2019-12-04 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| CN106963769B (zh) * | 2017-03-03 | 2019-10-25 | 深圳大学 | 含pi3k抑制剂和perk抑制剂的药物组合物及其应用 |
| GB201804227D0 (en) * | 2018-03-16 | 2018-05-02 | Univ Warwick | Cryopreserving compositions |
| CN114615886A (zh) * | 2019-08-29 | 2022-06-10 | 得克萨斯大学体系董事会 | 细胞冷冻保存培养基 |
| CN111418579B (zh) * | 2020-04-13 | 2021-05-18 | 广东华夏健康生命科学有限公司 | 一种脂肪组织的保存方法、脂肪组织的保存液及其制备方法 |
| MX2022013838A (es) | 2020-05-04 | 2023-02-22 | Amgen Inc | Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso. |
| CN112210593B (zh) * | 2020-11-12 | 2023-09-19 | 苏州创澜生物科技有限公司 | 一种冻干保护剂、可冻干的pcr试剂及其应用 |
| CN112210594B (zh) * | 2020-11-12 | 2023-09-19 | 苏州创澜生物科技有限公司 | 一种逆转录试剂的冻干保护剂 |
| CN113261557A (zh) * | 2021-05-28 | 2021-08-17 | 广东先康达生物科技有限公司 | 一种干细胞冻存液及干细胞冻存方法 |
| CN115363016B (zh) * | 2022-08-09 | 2023-07-18 | 广州明迅生物科技有限责任公司 | 细胞储存液及其应用 |
| CN115777693B (zh) * | 2023-02-03 | 2023-04-18 | 苏州依科赛生物科技股份有限公司 | 一种细胞冻存液、制备方法、应用方法及用途 |
| WO2025240630A1 (en) * | 2024-05-14 | 2025-11-20 | Abbott Laboratories | Reagent compositions for isothermal amplification of nucleic acids |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| CN1747971A (zh) * | 2002-12-10 | 2006-03-15 | 诺瓦提斯公司 | 抗Nogo A的抗体(“11C7”)及其药物用途 |
| CN101360822A (zh) * | 2005-12-01 | 2009-02-04 | 生物马特里卡公司 | 用于生命科学的样品存储和样品管理的综合 |
| CN102947082A (zh) * | 2010-04-06 | 2013-02-27 | 金沃特公司 | 生物材料的稳定化的化学脱水 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US918A (en) | 1838-09-14 | Improvement in the mode of regulating windmills | ||
| US7037A (en) | 1850-01-22 | Grid-ikon slide-valve | ||
| JPH0244514B2 (ja) * | 1981-09-14 | 1990-10-04 | Nippon Oil Co Ltd | Biseibutsuseikintainokoteika*zoshokuho |
| EP0522134A1 (en) * | 1991-01-11 | 1993-01-13 | COBE Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material |
| US5242792A (en) * | 1991-02-25 | 1993-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| JP4421681B2 (ja) * | 1995-10-19 | 2010-02-24 | バイオ‐オリジン エルエルシー | 生殖細胞および胚の生存および機能を改善する方法および組成物 |
| US6057117A (en) | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
| AU4920397A (en) | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| US6821963B2 (en) | 1997-07-01 | 2004-11-23 | Warner-Lambert Company | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
| US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| WO1999014321A1 (en) * | 1997-09-17 | 1999-03-25 | The Walter And Eliza Hall Institute Of Medical Research | Novel therapeutic molecules |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | グリコーゲンシンターゼキナーゼ3のインヒビター |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US7001770B1 (en) | 1998-10-15 | 2006-02-21 | Canji, Inc. | Calpain inhibitors and their applications |
| EP1144371B1 (en) | 1999-01-13 | 2005-11-09 | Warner-Lambert Company Llc | Benzenesulphonamide derivatives and their use as mek inhibitors |
| GB9910580D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| IL149778A0 (en) * | 1999-11-22 | 2002-11-10 | Universal Preservation Technologies Inc | Preservation of sensitive biological material |
| AU784748B2 (en) | 1999-12-17 | 2006-06-08 | Novartis Vaccines And Diagnostics, Inc. | Bicyclic inhibitors of glycogen synthase kinase 3 |
| ATE384704T1 (de) | 1999-12-17 | 2008-02-15 | Novartis Vaccines & Diagnostic | Pyrazin-basierte hemmer der glycogen-synthase- kinase 3 |
| JP3694730B2 (ja) * | 2000-03-02 | 2005-09-14 | 国立大学法人京都大学 | 組織の冷却保存液 |
| US7001905B2 (en) | 2000-03-15 | 2006-02-21 | Warner-Lambert Company | Substituted diarylamines as MEK inhibitors |
| US6448245B1 (en) | 2000-05-04 | 2002-09-10 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of and compounds for inhibiting calpains |
| US6608632B2 (en) | 2000-06-12 | 2003-08-19 | Sharp Laboratories Of America, Inc. | Methods and systems for improving display resolution in images using sub-pixel sampling and visual error filtering |
| PT1319064E (pt) | 2000-07-27 | 2008-02-29 | Novartis Vaccines & Diagnostic | Polipéptidos de gsk3 |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US20040110267A1 (en) * | 2000-12-15 | 2004-06-10 | Stratagene | Room temperature stable competent cells |
| CA2441733A1 (en) | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| AU2003221888B2 (en) * | 2002-04-11 | 2008-11-06 | Medimmune, Llc | Preservation of bioactive materials by spray drying |
| GB0218800D0 (en) | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
| JP2007516161A (ja) | 2003-06-20 | 2007-06-21 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノピリドン誘導体 |
| GB0314607D0 (en) * | 2003-06-23 | 2003-07-30 | Univ Cambridge Tech | Preservation method |
| AU2004203373A1 (en) | 2003-07-25 | 2005-02-10 | University Of Chicago | Identification of novel factors that block programmed cell death or apoptosis by targeting JNK |
| US7314755B2 (en) * | 2003-10-15 | 2008-01-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Preservation of eukaryotic cells using reversible pore formation |
| US7795256B2 (en) | 2003-10-24 | 2010-09-14 | Ucb Pharma S.A. | Thieno-pyridinone derivatives as kinase inhibitors |
| US20080176209A1 (en) * | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| ES2243131B1 (es) | 2004-05-07 | 2007-02-01 | Consejo Sup. Investig. Cientificas | Tiamidas derivadas de bifenilo como inhibidores de calpaina. |
| MY144232A (en) | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
| ES2255848B1 (es) | 2004-12-16 | 2007-07-01 | Consejo Superior Investig. Cientificas | Derivados de isoquinolina como inhibidores de calpaina. |
| PT1928454E (pt) | 2005-05-10 | 2014-12-04 | Intermune Inc | Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress |
| WO2007002433A1 (en) | 2005-06-22 | 2007-01-04 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors |
| EP1913127A2 (en) * | 2005-08-11 | 2008-04-23 | The President and Fellows of Harvard College | Methods and compositions for dried cellular forms |
| WO2008048228A2 (en) * | 2005-08-12 | 2008-04-24 | Department Of The Army | Glycine stabilized lyophilized plasma |
| EP1934174B1 (en) | 2005-10-07 | 2011-04-06 | Exelixis, Inc. | Azetidines as mek inhibitors for the treatment of proliferative diseases |
| GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
| US8372861B2 (en) | 2006-02-27 | 2013-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of the unfolded protein response and methods for their use |
| CN101454004B (zh) | 2006-04-18 | 2013-12-04 | 阿迪亚生命科学公司 | 作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类 |
| WO2008007463A1 (fr) * | 2006-07-12 | 2008-01-17 | Nippon Zenyaku Kogyo Co., Ltd. | Composition de dilution et de stockage de sperme |
| ATE539752T1 (de) | 2006-08-16 | 2012-01-15 | Exelixis Inc | Verwendung von pi3k- und mek-modulatoren bei der krebsbehandlung |
| ES2535166T3 (es) | 2007-09-04 | 2015-05-06 | The Scripps Research Institute | Pirimidinil-aminas sustituidas como inhibidores de proteína-quinasas |
| US8178555B2 (en) | 2008-06-24 | 2012-05-15 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| US8492427B2 (en) | 2008-07-01 | 2013-07-23 | Genentech, Inc. | Isoindolones derivatives as MEK kinase inhibitors and methods of use |
| WO2010046949A1 (ja) * | 2008-10-22 | 2010-04-29 | Inui Hiroaki | 細胞をガラス化保存する方法および細胞のガラス化保存用容器 |
| MX2011004175A (es) * | 2008-10-22 | 2011-05-31 | Nederlanden Staat | Mezcla de conservacion y uso de la misma. |
| WO2010132508A2 (en) | 2009-05-11 | 2010-11-18 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
| AU2010254235B2 (en) * | 2009-05-26 | 2015-04-02 | Advanced Bionutrition Corporation | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| BR112012033715A2 (pt) | 2010-07-02 | 2016-11-22 | Gilead Sciences Inc | inibidores de quinase de regulação de sinal de apoptose. |
| EP2598661B1 (en) * | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| WO2012018638A2 (en) * | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| US20120028933A1 (en) * | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| US8664244B2 (en) | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| JP6333513B2 (ja) * | 2010-11-19 | 2018-05-30 | セーレン株式会社 | 細胞のガラス化保存液 |
-
2014
- 2014-06-13 EP EP14819510.0A patent/EP3007556B1/en active Active
- 2014-06-13 CN CN201480044962.5A patent/CN105491883B/zh not_active Expired - Fee Related
- 2014-06-13 CA CA2915250A patent/CA2915250A1/en not_active Abandoned
- 2014-06-13 US US14/895,475 patent/US20160135446A1/en not_active Abandoned
- 2014-06-13 EP EP19209890.3A patent/EP3632208A1/en not_active Withdrawn
- 2014-06-13 JP JP2016519695A patent/JP6604942B2/ja not_active Expired - Fee Related
- 2014-06-13 WO PCT/US2014/042396 patent/WO2015002729A2/en not_active Ceased
-
2017
- 2017-12-21 US US15/850,805 patent/US20180184644A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| CN1747971A (zh) * | 2002-12-10 | 2006-03-15 | 诺瓦提斯公司 | 抗Nogo A的抗体(“11C7”)及其药物用途 |
| CN101360822A (zh) * | 2005-12-01 | 2009-02-04 | 生物马特里卡公司 | 用于生命科学的样品存储和样品管理的综合 |
| CN102947082A (zh) * | 2010-04-06 | 2013-02-27 | 金沃特公司 | 生物材料的稳定化的化学脱水 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3632208A1 (en) | 2020-04-08 |
| JP6604942B2 (ja) | 2019-11-13 |
| EP3007556B1 (en) | 2020-05-20 |
| CN105491883A (zh) | 2016-04-13 |
| US20160135446A1 (en) | 2016-05-19 |
| JP2016522221A (ja) | 2016-07-28 |
| WO2015002729A3 (en) | 2015-05-07 |
| EP3007556A4 (en) | 2017-03-08 |
| EP3007556A2 (en) | 2016-04-20 |
| WO2015002729A2 (en) | 2015-01-08 |
| CA2915250A1 (en) | 2015-01-08 |
| US20180184644A1 (en) | 2018-07-05 |
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