JP2016522168A - 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 - Google Patents

抗ｉｌ−４抗体及び二重特異性抗体及びその使用 Download PDF

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JP2016522168A
JP2016522168A JP2016506649A JP2016506649A JP2016522168A JP 2016522168 A JP2016522168 A JP 2016522168A JP 2016506649 A JP2016506649 A JP 2016506649A JP 2016506649 A JP2016506649 A JP 2016506649A JP 2016522168 A JP2016522168 A JP 2016522168A
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seq
amino acid
hvr
antibody
acid sequence
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JP2016522168A5 (enExample
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ダニエル ジー． ヤンスラ，
ダニエル ジー． ヤンスラ，
ナンシー ワイ． チーアン，
ナンシー ワイ． チーアン，
マーク エス． デニス，
マーク エス． デニス，
マイケル ディロン，
マイケル ディロン，
ジェルメーヌ ジー． フー，
ジェルメーヌ ジー． フー，
ジェラルド アール． ナカムラ，
ジェラルド アール． ナカムラ，
クリストフ シュピース，
クリストフ シュピース，
ローレン シー． ウー，
ローレン シー． ウー，
イン チャン，
イン チャン，
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Genentech Inc
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Genentech Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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JP2016506649A 2013-04-05 2014-04-04 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 Pending JP2016522168A (ja)

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US201361808748P 2013-04-05 2013-04-05
US61/808,748 2013-04-05
PCT/US2014/032998 WO2014165771A2 (en) 2013-04-05 2014-04-04 Anti-il-4 antibodies and bispecific antibodies and uses thereof

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JP2016522168A5 JP2016522168A5 (enExample) 2017-05-25

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US (1) US20160207995A1 (enExample)
EP (1) EP2981286A4 (enExample)
JP (1) JP2016522168A (enExample)
KR (1) KR20150139905A (enExample)
CN (1) CN105307676A (enExample)
AR (1) AR095774A1 (enExample)
BR (1) BR112015024553A2 (enExample)
CA (1) CA2905223A1 (enExample)
HK (1) HK1220919A1 (enExample)
MX (1) MX2015013901A (enExample)
RU (1) RU2015141529A (enExample)
TW (1) TW201518321A (enExample)
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JP2022532928A (ja) * 2019-05-24 2022-07-20 サノフイ 全身性硬化症を治療するための方法
JP2024532454A (ja) * 2022-03-03 2024-09-05 ファイザー・インク 多重特異性抗体およびその使用
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
JP2025036274A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
JP2025530670A (ja) * 2022-08-15 2025-09-17 イーファン ファーマシューティカル（シャンハイ）カンパニー リミテッド ＩＬ－１５変異体－Ｆｃ／ＩＬ－１５Ｒαサブユニット－Ｆｃヘテロ二量体及びその使用

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JP2017507939A (ja) * 2014-02-21 2017-03-23 ジェネンテック， インコーポレイテッド 抗ｉｌ−１３／ｉｌ−１７二重特異性抗体及びその使用
RU2739500C2 (ru) 2014-11-05 2020-12-25 Дженентек, Инк. Способы получения двуцепочечных белков в бактериях
CN108064308B (zh) 2014-11-05 2023-06-09 豪夫迈·罗氏有限公司 细菌中产生双链蛋白的方法
EP3271723A1 (en) * 2015-03-16 2018-01-24 F. Hoffmann-La Roche AG Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
CA2980189A1 (en) 2015-04-24 2016-10-27 Genentech, Inc. Multispecific antigen-binding proteins
CN108473558A (zh) * 2015-08-20 2018-08-31 豪夫迈·罗氏有限公司 Fkpa的纯化及其用于生产重组多肽的用途
TWI703158B (zh) * 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
CN105664178B (zh) * 2015-09-24 2019-08-20 洪健 Syk作为肝纤维化/硬化治疗靶点的应用
WO2017096179A1 (en) * 2015-12-02 2017-06-08 Agenus Inc. Antibodies and methods of use thereof
WO2017189805A1 (en) 2016-04-27 2017-11-02 Abbvie Inc. Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
CN107446045A (zh) * 2016-07-22 2017-12-08 北京天广实生物技术股份有限公司 一种抗her2的抗体、其药物组合物及用途
US10377833B2 (en) 2016-07-22 2019-08-13 Beijing Mabworks Biotech Co., Ltd. Bispecific anti-HER2 antibody
TWI787203B (zh) 2016-09-23 2022-12-21 美商建南德克公司 Il-13拮抗劑用於治療異位性皮炎之用途
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
WO2018148254A1 (en) * 2017-02-07 2018-08-16 Children's Hospital Medical Center Treatment of asthma with cysteamine
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
TWI848953B (zh) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN109593773B (zh) * 2018-11-22 2021-07-30 北京利德曼生化股份有限公司 一种应用酵母表达系统表达可溶性生长刺激表达基因2蛋白的方法
CN111494626B (zh) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物
MA55204A (fr) 2019-03-06 2022-01-12 Regeneron Pharma Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer
KR20210143246A (ko) 2019-03-21 2021-11-26 리제너론 파아마슈티컬스, 인크. 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용
KR102697769B1 (ko) * 2020-09-14 2024-08-23 아주대학교산학협력단 인터루킨-4 수용체 알파 서브유닛과 인터루킨-5 수용체 알파 서브유닛에 동시에 결합하는 이중특이항체 및 이의 용도
JP2023550628A (ja) * 2020-11-23 2023-12-04 スカウト バイオ， インコーポレイテッド 抗原結合分子およびその使用
IL311027A (en) 2021-09-15 2024-04-01 Dermira Inc Il-13 inhibitors for the treatment of prurigo nodularis
JP2025501239A (ja) 2021-12-30 2025-01-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｉｌ－４／ｉｌ－１３アンタゴニストを投与することによってアトピーマーチを減弱する方法
KR20250025381A (ko) 2022-06-17 2025-02-21 아포지 바이오로직스, 인크. 인터류킨 13에 결합하는 항체 및 사용 방법
TW202506196A (zh) * 2023-07-28 2025-02-16 大陸商江蘇恒瑞醫藥股份有限公司 含有糖皮質激素的抗體藥物偶聯物的藥物組合物
AR134101A1 (es) * 2023-10-12 2025-12-03 Innovent Biologics Suzhou Co Ltd Anticuerpos anti-tslp y usos de los mismos
AU2024399620A1 (en) 2023-12-14 2026-05-14 Dermira, Inc. Il-13 antibodies for the treatment of perennial allergic rhinitis
CN122374333A (zh) 2023-12-14 2026-07-10 德米拉公司 用于治疗慢性鼻窦炎伴鼻息肉的il-13抗体
TW202600591A (zh) 2024-03-01 2026-01-01 美商德米拉股份有限公司 用於治療發炎後皮膚色素過多或色素過少之ｉｌ—１３抗體
WO2025264972A1 (en) * 2024-06-21 2025-12-26 Apogee Therapeutics, Inc. Antibodies that bind il-4r alpha and antibodies that bind
WO2026153502A1 (zh) * 2025-01-16 2026-07-23 中山康方生物医药有限公司 抗il-4ra抗体、双特异性抗体和药物组合物

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