JP2016522168A - 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 - Google Patents

抗ｉｌ−４抗体及び二重特異性抗体及びその使用 Download PDF

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JP2016522168A
JP2016522168A JP2016506649A JP2016506649A JP2016522168A JP 2016522168 A JP2016522168 A JP 2016522168A JP 2016506649 A JP2016506649 A JP 2016506649A JP 2016506649 A JP2016506649 A JP 2016506649A JP 2016522168 A JP2016522168 A JP 2016522168A
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seq
amino acid
hvr
antibody
acid sequence
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JP2016522168A5 (enExample
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ダニエル ジー． ヤンスラ，
ダニエル ジー． ヤンスラ，
ナンシー ワイ． チーアン，
ナンシー ワイ． チーアン，
マーク エス． デニス，
マーク エス． デニス，
マイケル ディロン，
マイケル ディロン，
ジェルメーヌ ジー． フー，
ジェルメーヌ ジー． フー，
ジェラルド アール． ナカムラ，
ジェラルド アール． ナカムラ，
クリストフ シュピース，
クリストフ シュピース，
ローレン シー． ウー，
ローレン シー． ウー，
イン チャン，
イン チャン，
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Genentech Inc
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Genentech Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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JP2016506649A 2013-04-05 2014-04-04 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 Pending JP2016522168A (ja)

Applications Claiming Priority (3)

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US201361808748P 2013-04-05 2013-04-05
US61/808,748 2013-04-05
PCT/US2014/032998 WO2014165771A2 (en) 2013-04-05 2014-04-04 Anti-il-4 antibodies and bispecific antibodies and uses thereof

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JP2016522168A true JP2016522168A (ja) 2016-07-28
JP2016522168A5 JP2016522168A5 (enExample) 2017-05-25

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US (1) US20160207995A1 (enExample)
EP (1) EP2981286A4 (enExample)
JP (1) JP2016522168A (enExample)
KR (1) KR20150139905A (enExample)
CN (1) CN105307676A (enExample)
AR (1) AR095774A1 (enExample)
BR (1) BR112015024553A2 (enExample)
CA (1) CA2905223A1 (enExample)
HK (1) HK1220919A1 (enExample)
MX (1) MX2015013901A (enExample)
RU (1) RU2015141529A (enExample)
TW (1) TW201518321A (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532928A (ja) * 2019-05-24 2022-07-20 サノフイ 全身性硬化症を治療するための方法
JP2024532454A (ja) * 2022-03-03 2024-09-05 ファイザー・インク 多重特異性抗体およびその使用
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
JP2025036274A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
JP7784898B2 (ja) 2019-05-24 2025-12-12 サノフイ 全身性硬化症を治療するための方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016011027A2 (pt) * 2013-12-20 2017-12-05 Genentech Inc método de produção de um anticorpo, anticorpos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, método de tratamento de asma e método de tratamento de um distúrbio
JP2017507939A (ja) * 2014-02-21 2017-03-23 ジェネンテック， インコーポレイテッド 抗ｉｌ−１３／ｉｌ−１７二重特異性抗体及びその使用
EP3215525B1 (en) 2014-11-05 2020-07-29 Genentech, Inc. Methods of producing two chain proteins in bacteria
US10112994B2 (en) * 2014-11-05 2018-10-30 Genentech, Inc. Methods of producing two chain proteins in bacteria
CN107430117A (zh) * 2015-03-16 2017-12-01 豪夫迈·罗氏有限公司 检测和定量IL‑13的方法和在诊断和治疗Th2相关疾病中的用途
JP6952605B2 (ja) 2015-04-24 2021-10-20 ジェネンテック， インコーポレイテッド 多特異性抗原結合タンパク質
KR20180048731A (ko) * 2015-08-20 2018-05-10 제넨테크, 인크. 재조합 폴리펩티드를 제조하기 위한 fkpa의 정제 및 그의 용도
TWI703158B (zh) * 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
CN105664178B (zh) * 2015-09-24 2019-08-20 洪健 Syk作为肝纤维化/硬化治疗靶点的应用
EP3383430A4 (en) * 2015-12-02 2019-12-18 Agenus Inc. ANTIBODIES AND METHOD FOR USE THEREOF
WO2017189805A1 (en) 2016-04-27 2017-11-02 Abbvie Inc. Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
CN107446045A (zh) * 2016-07-22 2017-12-08 北京天广实生物技术股份有限公司 一种抗her2的抗体、其药物组合物及用途
US10377833B2 (en) 2016-07-22 2019-08-13 Beijing Mabworks Biotech Co., Ltd. Bispecific anti-HER2 antibody
JP6995844B2 (ja) 2016-09-23 2022-02-04 ジェネンテック， インコーポレイテッド アトピー性皮膚炎を治療するためのｉｌ－１３アンタゴニストの使用
MA46770A (fr) 2016-11-09 2019-09-18 Agenus Inc Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation
US20200093764A1 (en) * 2017-02-07 2020-03-26 Children's Hospital Medical Center Treatment of asthma with cysteamine
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
TWI848953B (zh) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN109593773B (zh) * 2018-11-22 2021-07-30 北京利德曼生化股份有限公司 一种应用酵母表达系统表达可溶性生长刺激表达基因2蛋白的方法
CN111518211B (zh) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
CA3129963A1 (en) 2019-03-06 2020-09-10 Regeneron Pharmaceuticals, Inc. Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
MX2021011141A (es) 2019-03-21 2022-01-19 Regeneron Pharma Combinacion de inhibidores de la via de il-4/il-13 y ablacion de celulas plasmaticas para el tratamiento de alergia.
KR102697769B1 (ko) * 2020-09-14 2024-08-23 아주대학교산학협력단 인터루킨-4 수용체 알파 서브유닛과 인터루킨-5 수용체 알파 서브유닛에 동시에 결합하는 이중특이항체 및 이의 용도
AU2021383841A1 (en) * 2020-11-23 2023-06-22 Scout Bio, Inc. Antigen-binding molecules and uses thereof
WO2023044313A1 (en) 2021-09-15 2023-03-23 Dermira, Inc. Il-13 inhibitors for the treatment of prurigo nodularis
CN118355034A (zh) 2021-12-30 2024-07-16 瑞泽恩制药公司 施用il-4/il-13拮抗剂以减弱特应性进程的方法
EP4540284A2 (en) 2022-06-17 2025-04-23 Apogee Therapeutics, Inc. Antibodies that bind interleukin 13 and methods of use
TW202506196A (zh) * 2023-07-28 2025-02-16 大陸商江蘇恒瑞醫藥股份有限公司 含有糖皮質激素的抗體藥物偶聯物的藥物組合物
WO2025077831A1 (en) * 2023-10-12 2025-04-17 Innovent Biologics (Suzhou) Co., Ltd. Anti-il-4ra/tslp antibodies and uses thereof
WO2025128990A1 (en) 2023-12-14 2025-06-19 Dermira, Inc. Il-13 antibodies for the treatment of perennial allergic rhinitis
WO2025128984A1 (en) 2023-12-14 2025-06-19 Dermira, Inc. Il-13 antibodies for the treatment of chronic rhinosinusitis with nasal polyps
WO2025184453A1 (en) 2024-03-01 2025-09-04 Dermira, Inc. Il-13 antibodies for the treatment of post-inflammatory hyperpigmentation or hypopigmentation of skin

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506359A (ja) * 1989-12-20 1992-11-05 シェリング・コーポレーション ヒトインターロイキン―４の抗体アンタゴニスト
JPH09510095A (ja) * 1994-03-10 1997-10-14 シェーリング コーポレイション ヒトインターロイキン−４に対するヒト化モノクローナル抗体
JP2005504524A (ja) * 2001-06-28 2005-02-17 ドマンティス リミテッド 二重特異性リガンドとその利用
WO2006106905A1 (ja) * 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha 会合制御によるポリペプチド製造方法
JP2007161724A (ja) * 2003-12-23 2007-06-28 Tanox Inc 新規抗ｉｌ１３抗体およびその使用
JP2011501671A (ja) * 2007-10-15 2011-01-13 サノフィ−アベンティス Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用
JP2011155980A (ja) * 2004-06-09 2011-08-18 Wyeth Llc ヒトインターロイキン−１３に対する抗体およびそれらの使用
WO2011133886A2 (en) * 2010-04-23 2011-10-27 Genentech, Inc. Production of heteromultimeric proteins
JP2012522524A (ja) * 2009-04-07 2012-09-27 ロシュ グリクアート アクチェンゲゼルシャフト 二重特異的抗−ＥｒｂＢ−３／抗−ｃ−Ｍｅｔ抗体
JP2012528110A (ja) * 2009-05-28 2012-11-12 グラクソ グループ リミテッド Ｉｌ−１３結合タンパク質

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309636B1 (en) * 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
CN101255196A (zh) * 2002-06-28 2008-09-03 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
WO2006029459A1 (en) * 2004-09-13 2006-03-23 Evogenix, Inc Antibodies specific for hepatocellular carcinoma and other carcinomas and uses thereof
DK2285408T3 (en) * 2008-06-05 2019-02-04 Ablynx Nv AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506359A (ja) * 1989-12-20 1992-11-05 シェリング・コーポレーション ヒトインターロイキン―４の抗体アンタゴニスト
JPH09510095A (ja) * 1994-03-10 1997-10-14 シェーリング コーポレイション ヒトインターロイキン−４に対するヒト化モノクローナル抗体
JP2005504524A (ja) * 2001-06-28 2005-02-17 ドマンティス リミテッド 二重特異性リガンドとその利用
JP2007161724A (ja) * 2003-12-23 2007-06-28 Tanox Inc 新規抗ｉｌ１３抗体およびその使用
JP2011155980A (ja) * 2004-06-09 2011-08-18 Wyeth Llc ヒトインターロイキン−１３に対する抗体およびそれらの使用
WO2006106905A1 (ja) * 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha 会合制御によるポリペプチド製造方法
JP2011501671A (ja) * 2007-10-15 2011-01-13 サノフィ−アベンティス Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用
JP2012522524A (ja) * 2009-04-07 2012-09-27 ロシュ グリクアート アクチェンゲゼルシャフト 二重特異的抗−ＥｒｂＢ−３／抗−ｃ−Ｍｅｔ抗体
JP2012528110A (ja) * 2009-05-28 2012-11-12 グラクソ グループ リミテッド Ｉｌ−１３結合タンパク質
WO2011133886A2 (en) * 2010-04-23 2011-10-27 Genentech, Inc. Production of heteromultimeric proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AM. J. RESPIR. CELL MOL. BIOL. (2013) VOL.49, NO.1, PP.37-46 (PUBLISHED ONLINE 28 FEB. 2013), JPN6018008851, ISSN: 0003757410 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532928A (ja) * 2019-05-24 2022-07-20 サノフイ 全身性硬化症を治療するための方法
JP7784898B2 (ja) 2019-05-24 2025-12-12 サノフイ 全身性硬化症を治療するための方法
JP2024532454A (ja) * 2022-03-03 2024-09-05 ファイザー・インク 多重特異性抗体およびその使用
JP2024532455A (ja) * 2022-03-03 2024-09-05 ファイザー・インク 多重特異性抗体およびその使用
JP7654346B2 (ja) 2022-03-03 2025-04-01 ファイザー・インク 多重特異性抗体およびその使用
JP7665098B2 (ja) 2022-03-03 2025-04-18 ファイザー・インク 多重特異性抗体およびその使用
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
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