JP2016520074A5 - - Google Patents

Info

Publication number

JP2016520074A5

JP2016520074A5 JP2016513321A JP2016513321A JP2016520074A5 JP 2016520074 A5 JP2016520074 A5 JP 2016520074A5 JP 2016513321 A JP2016513321 A JP 2016513321A JP 2016513321 A JP2016513321 A JP 2016513321A JP 2016520074 A5 JP2016520074 A5 JP 2016520074A5

Authority

JP

Japan

Prior art keywords

antigen receptor

chimeric antigen

specific

cell

specific chimeric

Prior art date

2014-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 210000002865 immune cell Anatomy 0.000 claims description 34
• 108010005327 CD19-specific chimeric antigen receptor Proteins 0.000 claims description 28
• 210000004027 cell Anatomy 0.000 claims description 23
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 13
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 13
• 108091033319 polynucleotide Proteins 0.000 claims description 10
• 102000040430 polynucleotide Human genes 0.000 claims description 10
• 239000002157 polynucleotide Substances 0.000 claims description 10
• 230000004068 intracellular signaling Effects 0.000 claims description 8
• 238000000034 method Methods 0.000 claims description 8
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 7
• 108020001756 ligand binding domains Proteins 0.000 claims description 7
• 150000007523 nucleic acids Chemical group 0.000 claims description 7
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 6
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
• 239000012528 membrane Substances 0.000 claims description 4
• 208000004736 B-Cell Leukemia Diseases 0.000 claims description 3
• 208000003950 B-cell lymphoma Diseases 0.000 claims description 3
• 108020004707 nucleic acids Proteins 0.000 claims description 3
• 102000039446 nucleic acids Human genes 0.000 claims description 3
• 230000011664 signaling Effects 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
• 239000013604 expression vector Substances 0.000 claims description 2
• 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
• 230000002757 inflammatory effect Effects 0.000 claims description 2
• 238000002560 therapeutic procedure Methods 0.000 claims description 2
• 210000003289 regulatory T cell Anatomy 0.000 claims 1
• 230000004913 activation Effects 0.000 description 4
• 239000000427 antigen Substances 0.000 description 4
• 102000036639 antigens Human genes 0.000 description 4
• 108091007433 antigens Proteins 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 210000004986 primary T-cell Anatomy 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 239000013598 vector Substances 0.000 description 1