JP2016519669A5 - - Google Patents
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- Publication number
- JP2016519669A5 JP2016519669A5 JP2016502940A JP2016502940A JP2016519669A5 JP 2016519669 A5 JP2016519669 A5 JP 2016519669A5 JP 2016502940 A JP2016502940 A JP 2016502940A JP 2016502940 A JP2016502940 A JP 2016502940A JP 2016519669 A5 JP2016519669 A5 JP 2016519669A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- alkylene
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C1(CC=C)OC(*N=C)*(CCCC=C)C1 Chemical compound *C1(CC=C)OC(*N=C)*(CCCC=C)C1 0.000 description 7
- CMRXZAKSZIVSCC-UHFFFAOYSA-N OCC(CC1(F)F)NC1=O Chemical compound OCC(CC1(F)F)NC1=O CMRXZAKSZIVSCC-UHFFFAOYSA-N 0.000 description 1
- JUZIBPFPQSPBAX-GSVOUGTGSA-N OC[C@@H](CC(C1=O)(F)F)N1I Chemical compound OC[C@@H](CC(C1=O)(F)F)N1I JUZIBPFPQSPBAX-GSVOUGTGSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361799334P | 2013-03-15 | 2013-03-15 | |
| US61/799,334 | 2013-03-15 | ||
| PCT/US2014/028933 WO2014144500A2 (en) | 2013-03-15 | 2014-03-14 | Methods of synthesizing a difluorolactam analog |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519669A JP2016519669A (ja) | 2016-07-07 |
| JP2016519669A5 true JP2016519669A5 (https=) | 2017-04-20 |
| JP6368351B2 JP6368351B2 (ja) | 2018-08-01 |
Family
ID=50693998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502940A Expired - Fee Related JP6368351B2 (ja) | 2013-03-15 | 2014-03-14 | ジフルオロラクタムアナログを合成する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9914725B2 (https=) |
| EP (1) | EP2970234B1 (https=) |
| JP (1) | JP6368351B2 (https=) |
| AU (1) | AU2014229065B2 (https=) |
| CA (1) | CA2903314C (https=) |
| IL (1) | IL241042B (https=) |
| WO (1) | WO2014144500A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802623B (zh) * | 2012-07-19 | 2020-10-30 | 开曼化学股份有限公司 | 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物 |
| HU231033B1 (hu) * | 2016-03-22 | 2019-12-30 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására |
| CN106699604B (zh) * | 2017-01-09 | 2019-01-01 | 四川同晟生物医药有限公司 | 一种沙库比曲及其中间体的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975399A (en) | 1974-08-06 | 1976-08-17 | E. I. Du Pont De Nemours And Company | 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones |
| DE2517771A1 (de) | 1975-04-18 | 1976-10-28 | Schering Ag | Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung |
| CA1085859A (en) | 1975-06-27 | 1980-09-16 | Wilhelm Bartmann | Pyrrolidones and process for their manufacture |
| DE2528664A1 (de) | 1975-06-27 | 1977-01-13 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
| DE2619638A1 (de) | 1976-05-04 | 1977-11-17 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
| US4177346A (en) | 1976-08-06 | 1979-12-04 | Pfizer Inc. | 1,5-Disubstituted-2-pyrrolidones |
| US4320136A (en) | 1980-08-11 | 1982-03-16 | E. I. Du Pont De Nemours And Company | 8-Aza-16,16-difluoroprostanoids |
| US4311644A (en) * | 1981-01-30 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Method for preparing 10,10-difluoro prostacyclin intermediates and new compounds produced thereby |
| US4456613A (en) | 1982-12-27 | 1984-06-26 | E. I. Du Pont De Nemours And Company | 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof |
| PT1339678E (pt) | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| AU2002226035A1 (en) * | 2000-12-07 | 2002-06-18 | Michael P Doyle | Lewis acid catalysis using chiral metal complexes |
| RU2296122C2 (ru) | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
| ES2254726T3 (es) | 2001-07-16 | 2006-06-16 | F. Hoffmann-La Roche Ag | Analogos de prostaglandina como agonistas receptores de ep4. |
| NZ530885A (en) * | 2001-07-23 | 2007-09-28 | Ono Pharmaceutical Co | Remedies for diseases with bone mass loss having EP4 agonist as the active ingredient |
| CA2466757A1 (en) | 2001-12-03 | 2003-06-12 | Merck & Co., Inc. | Method for treating ocular hypertension |
| CA2478653A1 (en) | 2002-03-18 | 2003-09-25 | Pfizer Products Inc. | Methods of treatment with selective ep4 receptor agonists |
| DE60334905D1 (de) | 2002-06-06 | 2010-12-23 | Merck Frosst Canada Ltd | 1,5-disubstituierte pyrrolid-2-on-derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augenkrankheiten wie z.b. glaukom |
| US7419999B2 (en) | 2002-06-10 | 2008-09-02 | Applied Research Systems Ars Holding N.V. | Gamma lactams as prostaglandin agonists and use thereof |
| AU2003275840A1 (en) | 2002-10-25 | 2004-05-13 | Merck Frosst Canada Ltd | 2-pyrrolidones as EP4 receptor agonists |
| ATE394372T1 (de) | 2003-03-03 | 2008-05-15 | Serono Lab | G-lactamderivate als prostaglandinagonisten |
| US8088793B2 (en) | 2007-08-15 | 2012-01-03 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| KR20100086485A (ko) | 2007-10-23 | 2010-07-30 | 알러간, 인코포레이티드 | 치료적 치환된 락탐 |
| US20120270934A1 (en) | 2009-07-03 | 2012-10-25 | Concert Pharmaceuticals, Inc. | Prostacyclin derivatives |
| CA2815179A1 (en) | 2010-11-10 | 2012-05-18 | Actelion Pharmaceuticals Ltd | Lactam derivatives useful as orexin receptor antagonists |
| DK2729445T3 (en) * | 2011-07-04 | 2016-01-18 | Rottapharm Biotech Srl | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS |
| CN107802623B (zh) * | 2012-07-19 | 2020-10-30 | 开曼化学股份有限公司 | 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物 |
-
2014
- 2014-03-14 JP JP2016502940A patent/JP6368351B2/ja not_active Expired - Fee Related
- 2014-03-14 CA CA2903314A patent/CA2903314C/en active Active
- 2014-03-14 US US14/775,591 patent/US9914725B2/en not_active Expired - Fee Related
- 2014-03-14 EP EP14723569.1A patent/EP2970234B1/en active Active
- 2014-03-14 AU AU2014229065A patent/AU2014229065B2/en not_active Ceased
- 2014-03-14 WO PCT/US2014/028933 patent/WO2014144500A2/en not_active Ceased
-
2015
- 2015-09-02 IL IL241042A patent/IL241042B/en unknown
-
2018
- 2018-01-30 US US15/883,724 patent/US20180170918A1/en not_active Abandoned
-
2019
- 2019-03-12 US US16/299,916 patent/US11345690B2/en active Active
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