JP2016517885A5 - - Google Patents
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- Publication number
- JP2016517885A5 JP2016517885A5 JP2016511809A JP2016511809A JP2016517885A5 JP 2016517885 A5 JP2016517885 A5 JP 2016517885A5 JP 2016511809 A JP2016511809 A JP 2016511809A JP 2016511809 A JP2016511809 A JP 2016511809A JP 2016517885 A5 JP2016517885 A5 JP 2016517885A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- particles
- insulin
- agent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 36
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 35
- 239000002245 particle Substances 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 19
- 102000004877 Insulin Human genes 0.000 claims description 14
- 108090001061 Insulin Proteins 0.000 claims description 14
- 229940125396 insulin Drugs 0.000 claims description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
- 239000008103 glucose Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000011159 matrix material Substances 0.000 claims description 8
- 239000004026 insulin derivative Substances 0.000 claims description 7
- 102000016938 Catalase Human genes 0.000 claims description 6
- 108010053835 Catalase Proteins 0.000 claims description 6
- 108010015776 Glucose oxidase Proteins 0.000 claims description 6
- 239000004366 Glucose oxidase Substances 0.000 claims description 6
- 229940039227 diagnostic agent Drugs 0.000 claims description 6
- 239000000032 diagnostic agent Substances 0.000 claims description 6
- 229940116332 glucose oxidase Drugs 0.000 claims description 6
- 235000019420 glucose oxidase Nutrition 0.000 claims description 6
- 230000000069 prophylactic effect Effects 0.000 claims description 6
- 230000011664 signaling Effects 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 239000002105 nanoparticle Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 230000003345 hyperglycaemic effect Effects 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 108010004903 glycosylated serum albumin Proteins 0.000 claims description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 238000013270 controlled release Methods 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 230000000541 pulsatile effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361817752P | 2013-04-30 | 2013-04-30 | |
| US61/817,752 | 2013-04-30 | ||
| US201361864069P | 2013-08-09 | 2013-08-09 | |
| US61/864,069 | 2013-08-09 | ||
| PCT/US2014/035927 WO2014179344A1 (en) | 2013-04-30 | 2014-04-29 | Injectable nano-network gels for diabetes treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016517885A JP2016517885A (ja) | 2016-06-20 |
| JP2016517885A5 true JP2016517885A5 (https=) | 2017-06-15 |
Family
ID=51843897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016511809A Pending JP2016517885A (ja) | 2013-04-30 | 2014-04-29 | 糖尿病を処置するための注射可能なナノネットワークゲル |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160067190A1 (https=) |
| EP (1) | EP2991673A4 (https=) |
| JP (1) | JP2016517885A (https=) |
| KR (1) | KR20160024853A (https=) |
| CN (1) | CN105813652A (https=) |
| AU (1) | AU2014260024B2 (https=) |
| BR (1) | BR112015027561A8 (https=) |
| HK (2) | HK1221415A1 (https=) |
| MX (1) | MX2015015079A (https=) |
| RU (1) | RU2015151135A (https=) |
| WO (1) | WO2014179344A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014153114A1 (en) * | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| JP2017538728A (ja) * | 2014-12-19 | 2017-12-28 | ケミン、インダストリーズ、インコーポレーテッドＫｅｍｉｎ Ｉｎｄｕｓｔｒｉｅｓ， Ｉｎｃ． | イオントフォレシスを用いた生物活性分子の眼内送達 |
| CN104740641B (zh) * | 2015-04-08 | 2019-02-01 | 烟台大学 | 一种糖敏感的缓控释微球组合物及其制备方法 |
| RU2719584C2 (ru) * | 2015-04-21 | 2020-04-21 | Норт Каролина Стейт Юниверсити | Глюкозочувствительная система доставки инсулина с использованием чувствительных к гипоксии нанокомпозитов |
| JP6757464B2 (ja) * | 2016-07-21 | 2020-09-16 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 注射用組成物 |
| WO2018085809A1 (en) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
| EP3799865B1 (en) * | 2016-12-05 | 2022-06-15 | North Carolina State University | Core-shell microneedle devices and uses thereof |
| CN106668840B (zh) * | 2017-02-10 | 2020-02-14 | 南通大学 | 一种胰岛素控释药物及其制备方法与应用 |
| WO2019055594A1 (en) * | 2017-09-13 | 2019-03-21 | North Carolina State University | BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY |
| CN111629746B (zh) * | 2017-11-21 | 2024-04-16 | 北卡罗来纳州立大学 | 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 |
| EP3735262A4 (en) * | 2018-01-03 | 2021-09-29 | Penn State Research Foundation | GLUCOSE OXIDASE COMPOSITIONS AS ANTICONVULSIVE FOR NEWBORN |
| CN111629715A (zh) | 2018-01-18 | 2020-09-04 | 弗莱德哈钦森癌症研究中心 | 通过调节细胞活化状态改变体内免疫细胞的炎症状态 |
| CN111195238A (zh) * | 2018-10-31 | 2020-05-26 | 南方医科大学 | 一种用于胰岛素口服递送的聚电解质复合物 |
| US20220204654A1 (en) * | 2019-04-25 | 2022-06-30 | Massachusetts Institute Of Technology | Cyclodextrin supramolecular scaffolds and uses thereof |
| CN115350267B (zh) * | 2022-07-19 | 2025-01-14 | 深圳大学 | 一种级联催化型纳米治疗剂及其制备方法和应用 |
| CN115252537B (zh) * | 2022-09-01 | 2026-02-06 | 西北大学 | 用于糖尿病伤口的双层微针贴片及其制备方法 |
| CN116474162B (zh) * | 2023-04-28 | 2024-08-16 | 吉林大学 | 一种用于糖尿病慢性创伤修复的自修复水凝胶的制备方法 |
| US20250025411A1 (en) * | 2023-07-21 | 2025-01-23 | Massachusetts Institute Of Technology | Readily soluble and thermostable glucagon formulations and delivery for mini-dosing and closed -loop prophylactic treatment of hypoglycemia |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US6497903B1 (en) * | 1996-07-01 | 2002-12-24 | Wilhelmus Everhardus Hennink | Hydrolysable hydrogels for controlled release |
| AU2003301064A1 (en) * | 2002-12-17 | 2004-07-14 | Massachusetts Institute Of Technology | Stimuli-responsive systems for controlled drug delivery |
| WO2006088473A2 (en) * | 2004-04-23 | 2006-08-24 | Panduranga Rao Koritala | Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents |
| EP1595534A1 (en) * | 2004-05-13 | 2005-11-16 | Universiteit Utrecht Holding B.V. | Gel composition comprising charged polymers |
| TWI394580B (zh) * | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| JP5841708B2 (ja) * | 2008-07-01 | 2016-01-13 | 日東電工株式会社 | 表面被覆微粒子の医薬組成物 |
-
2014
- 2014-04-29 US US14/787,652 patent/US20160067190A1/en not_active Abandoned
- 2014-04-29 MX MX2015015079A patent/MX2015015079A/es unknown
- 2014-04-29 WO PCT/US2014/035927 patent/WO2014179344A1/en not_active Ceased
- 2014-04-29 EP EP14792285.0A patent/EP2991673A4/en not_active Withdrawn
- 2014-04-29 RU RU2015151135A patent/RU2015151135A/ru not_active Application Discontinuation
- 2014-04-29 KR KR1020157034126A patent/KR20160024853A/ko not_active Withdrawn
- 2014-04-29 HK HK16109650.4A patent/HK1221415A1/zh unknown
- 2014-04-29 AU AU2014260024A patent/AU2014260024B2/en not_active Ceased
- 2014-04-29 HK HK16110684.2A patent/HK1222546A1/zh unknown
- 2014-04-29 BR BR112015027561A patent/BR112015027561A8/pt not_active Application Discontinuation
- 2014-04-29 JP JP2016511809A patent/JP2016517885A/ja active Pending
- 2014-04-29 CN CN201480037463.3A patent/CN105813652A/zh active Pending
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