BR112015027561A8 - formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma - Google Patents

formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma Download PDF

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Publication number
BR112015027561A8
BR112015027561A8 BR112015027561A BR112015027561A BR112015027561A8 BR 112015027561 A8 BR112015027561 A8 BR 112015027561A8 BR 112015027561 A BR112015027561 A BR 112015027561A BR 112015027561 A BR112015027561 A BR 112015027561A BR 112015027561 A8 BR112015027561 A8 BR 112015027561A8
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BR
Brazil
Prior art keywords
glucose
injectable
insulin
formulation
delivery
Prior art date
Application number
BR112015027561A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015027561A2 (pt
Inventor
Arthur Aimetti Alex
G Anderson Daniel
S Langer Robert
Gu Zhen
Original Assignee
Massachusetts Inst Technology
Childrens Medical Ct Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Childrens Medical Ct Corp filed Critical Massachusetts Inst Technology
Publication of BR112015027561A2 publication Critical patent/BR112015027561A2/pt
Publication of BR112015027561A8 publication Critical patent/BR112015027561A8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
BR112015027561A 2013-04-30 2014-04-29 formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma BR112015027561A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817752P 2013-04-30 2013-04-30
US201361864069P 2013-08-09 2013-08-09
PCT/US2014/035927 WO2014179344A1 (en) 2013-04-30 2014-04-29 Injectable nano-network gels for diabetes treatment

Publications (2)

Publication Number Publication Date
BR112015027561A2 BR112015027561A2 (pt) 2017-07-25
BR112015027561A8 true BR112015027561A8 (pt) 2019-12-24

Family

ID=51843897

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015027561A BR112015027561A8 (pt) 2013-04-30 2014-04-29 formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma

Country Status (11)

Country Link
US (1) US20160067190A1 (https=)
EP (1) EP2991673A4 (https=)
JP (1) JP2016517885A (https=)
KR (1) KR20160024853A (https=)
CN (1) CN105813652A (https=)
AU (1) AU2014260024B2 (https=)
BR (1) BR112015027561A8 (https=)
HK (2) HK1222546A1 (https=)
MX (1) MX2015015079A (https=)
RU (1) RU2015151135A (https=)
WO (1) WO2014179344A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970985A1 (en) * 2013-03-14 2016-01-20 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
JP2017538728A (ja) * 2014-12-19 2017-12-28 ケミン、インダストリーズ、インコーポレーテッドＫｅｍｉｎ Ｉｎｄｕｓｔｒｉｅｓ， Ｉｎｃ． イオントフォレシスを用いた生物活性分子の眼内送達
CN104740641B (zh) * 2015-04-08 2019-02-01 烟台大学 一种糖敏感的缓控释微球组合物及其制备方法
TN2017000439A1 (en) * 2015-04-21 2019-04-12 Univ North Carolina State Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
WO2018017861A1 (en) * 2016-07-21 2018-01-25 Boston Scientific Scimed, Inc. Injectable compositions
CN110167537A (zh) 2016-11-07 2019-08-23 北卡罗来纳州立大学 用于增强葡萄糖反应性胰岛素的递送的装有双敏感囊泡的贴剂
DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf
CN106668840B (zh) * 2017-02-10 2020-02-14 南通大学 一种胰岛素控释药物及其制备方法与应用
WO2019055594A1 (en) * 2017-09-13 2019-03-21 North Carolina State University BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY
US11813352B2 (en) 2017-11-21 2023-11-14 North Carolina State University Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response
EP3735262A4 (en) * 2018-01-03 2021-09-29 Penn State Research Foundation GLUCOSE OXIDASE COMPOSITIONS AS ANTICONVULSIVE FOR NEWBORN
KR20250099256A (ko) 2018-01-18 2025-07-01 프레드 허친슨 캔서 센터 세포 활성화 상태를 조절함으로써 생체내 면역 세포의 염증 상태의 변경
CN111195238A (zh) * 2018-10-31 2020-05-26 南方医科大学 一种用于胰岛素口服递送的聚电解质复合物
US20220204654A1 (en) * 2019-04-25 2022-06-30 Massachusetts Institute Of Technology Cyclodextrin supramolecular scaffolds and uses thereof
CN115350267B (zh) * 2022-07-19 2025-01-14 深圳大学 一种级联催化型纳米治疗剂及其制备方法和应用
CN115252537B (zh) * 2022-09-01 2026-02-06 西北大学 用于糖尿病伤口的双层微针贴片及其制备方法
CN116474162B (zh) * 2023-04-28 2024-08-16 吉林大学 一种用于糖尿病慢性创伤修复的自修复水凝胶的制备方法
US20250025411A1 (en) * 2023-07-21 2025-01-23 Massachusetts Institute Of Technology Readily soluble and thermostable glucagon formulations and delivery for mini-dosing and closed -loop prophylactic treatment of hypoglycemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
ES2198579T3 (es) * 1996-07-01 2004-02-01 Universiteit Utrecht Hidrogeles hidrolizables para liberacion controlada.
CA2509382A1 (en) * 2002-12-17 2004-07-08 Todd C. Zion Stimuli-responsive systems for controlled drug delivery
WO2006088473A2 (en) * 2004-04-23 2006-08-24 Panduranga Rao Koritala Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents
EP1595534A1 (en) * 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gel composition comprising charged polymers
TWI394580B (zh) * 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
RU2508093C2 (ru) * 2008-07-01 2014-02-27 Нитто Денко Корпорейшн Фармацевтическая композиция, содержащая микрочастицы с поверхностным покрытием

Also Published As

Publication number Publication date
BR112015027561A2 (pt) 2017-07-25
MX2015015079A (es) 2016-07-05
US20160067190A1 (en) 2016-03-10
CN105813652A (zh) 2016-07-27
JP2016517885A (ja) 2016-06-20
EP2991673A1 (en) 2016-03-09
EP2991673A4 (en) 2016-12-21
AU2014260024A1 (en) 2015-11-19
KR20160024853A (ko) 2016-03-07
HK1222546A1 (zh) 2017-07-07
WO2014179344A1 (en) 2014-11-06
HK1221415A1 (zh) 2017-06-02
AU2014260024B2 (en) 2016-09-15
RU2015151135A (ru) 2017-06-02

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]