CN105813652A - 用于糖尿病治疗的可注射纳米网络凝胶 - Google Patents

用于糖尿病治疗的可注射纳米网络凝胶 Download PDF

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Publication number
CN105813652A
CN105813652A CN201480037463.3A CN201480037463A CN105813652A CN 105813652 A CN105813652 A CN 105813652A CN 201480037463 A CN201480037463 A CN 201480037463A CN 105813652 A CN105813652 A CN 105813652A
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CN
China
Prior art keywords
insulin
particles
glucose
particle
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480037463.3A
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English (en)
Chinese (zh)
Inventor
D·G·安德森
顾臻
A·A·艾梅蒂
R·S·兰格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Massachusetts Institute of Technology
Original Assignee
Boston Childrens Hospital
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital, Massachusetts Institute of Technology filed Critical Boston Childrens Hospital
Publication of CN105813652A publication Critical patent/CN105813652A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
CN201480037463.3A 2013-04-30 2014-04-29 用于糖尿病治疗的可注射纳米网络凝胶 Pending CN105813652A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361817752P 2013-04-30 2013-04-30
US61/817,752 2013-04-30
US201361864069P 2013-08-09 2013-08-09
US61/864,069 2013-08-09
PCT/US2014/035927 WO2014179344A1 (en) 2013-04-30 2014-04-29 Injectable nano-network gels for diabetes treatment

Publications (1)

Publication Number Publication Date
CN105813652A true CN105813652A (zh) 2016-07-27

Family

ID=51843897

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480037463.3A Pending CN105813652A (zh) 2013-04-30 2014-04-29 用于糖尿病治疗的可注射纳米网络凝胶

Country Status (11)

Country Link
US (1) US20160067190A1 (https=)
EP (1) EP2991673A4 (https=)
JP (1) JP2016517885A (https=)
KR (1) KR20160024853A (https=)
CN (1) CN105813652A (https=)
AU (1) AU2014260024B2 (https=)
BR (1) BR112015027561A8 (https=)
HK (2) HK1221415A1 (https=)
MX (1) MX2015015079A (https=)
RU (1) RU2015151135A (https=)
WO (1) WO2014179344A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668840A (zh) * 2017-02-10 2017-05-17 南通大学 一种胰岛素控释药物及其制备方法与应用
WO2020088306A1 (zh) * 2018-10-31 2020-05-07 南方医科大学 一种用于胰岛素口服递送的聚电解质复合物
CN111343970A (zh) * 2017-09-13 2020-06-26 北卡罗莱纳州立大学 微针贴片局部诱导脂肪组织褐变治疗肥胖症
CN115350267A (zh) * 2022-07-19 2022-11-18 深圳大学 一种级联催化型纳米治疗剂及其制备方法和应用
CN116474162A (zh) * 2023-04-28 2023-07-25 吉林大学 一种用于糖尿病慢性创伤修复的自修复水凝胶的制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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WO2014153114A1 (en) * 2013-03-14 2014-09-25 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
JP2017538728A (ja) * 2014-12-19 2017-12-28 ケミン、インダストリーズ、インコーポレーテッドＫｅｍｉｎ Ｉｎｄｕｓｔｒｉｅｓ， Ｉｎｃ． イオントフォレシスを用いた生物活性分子の眼内送達
CN104740641B (zh) * 2015-04-08 2019-02-01 烟台大学 一种糖敏感的缓控释微球组合物及其制备方法
RU2719584C2 (ru) * 2015-04-21 2020-04-21 Норт Каролина Стейт Юниверсити Глюкозочувствительная система доставки инсулина с использованием чувствительных к гипоксии нанокомпозитов
JP6757464B2 (ja) * 2016-07-21 2020-09-16 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 注射用組成物
WO2018085809A1 (en) 2016-11-07 2018-05-11 North Carolina State University Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery
EP3799865B1 (en) * 2016-12-05 2022-06-15 North Carolina State University Core-shell microneedle devices and uses thereof
CN111629746B (zh) * 2017-11-21 2024-04-16 北卡罗来纳州立大学 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库
EP3735262A4 (en) * 2018-01-03 2021-09-29 Penn State Research Foundation GLUCOSE OXIDASE COMPOSITIONS AS ANTICONVULSIVE FOR NEWBORN
CN111629715A (zh) 2018-01-18 2020-09-04 弗莱德哈钦森癌症研究中心 通过调节细胞活化状态改变体内免疫细胞的炎症状态
US20220204654A1 (en) * 2019-04-25 2022-06-30 Massachusetts Institute Of Technology Cyclodextrin supramolecular scaffolds and uses thereof
CN115252537B (zh) * 2022-09-01 2026-02-06 西北大学 用于糖尿病伤口的双层微针贴片及其制备方法
US20250025411A1 (en) * 2023-07-21 2025-01-23 Massachusetts Institute Of Technology Readily soluble and thermostable glucagon formulations and delivery for mini-dosing and closed -loop prophylactic treatment of hypoglycemia

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WO2004056311A2 (en) * 2002-12-17 2004-07-08 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery

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US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US6497903B1 (en) * 1996-07-01 2002-12-24 Wilhelmus Everhardus Hennink Hydrolysable hydrogels for controlled release
WO2006088473A2 (en) * 2004-04-23 2006-08-24 Panduranga Rao Koritala Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents
EP1595534A1 (en) * 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gel composition comprising charged polymers
TWI394580B (zh) * 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
JP5841708B2 (ja) * 2008-07-01 2016-01-13 日東電工株式会社 表面被覆微粒子の医薬組成物

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WO2004056311A2 (en) * 2002-12-17 2004-07-08 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery

Non-Patent Citations (2)

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QUN WANGA, SYED JAMALB, MICHAEL S. DETAMOREA, AND CORY BERKLANDA: "PLGA-chitosan/PLGA-alginate Nanoparticle Blends as Biodegradable Colloidal Gels for Seeding Human Umbilical Cord Mesenchymal Stem Cells", 《JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A》 *
YONGHAO WU, HUAMIN HU, JINMING HU AND SHIYONG LIU: "Glucose-Regulated Insulin Release from Acid-Disintegrable Microgels Covalently Immobilized with Glucose Oxidase and Catalase", 《MACROMOLECULAR RAPID COMMUNICATIONS》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668840A (zh) * 2017-02-10 2017-05-17 南通大学 一种胰岛素控释药物及其制备方法与应用
CN106668840B (zh) * 2017-02-10 2020-02-14 南通大学 一种胰岛素控释药物及其制备方法与应用
CN111343970A (zh) * 2017-09-13 2020-06-26 北卡罗莱纳州立大学 微针贴片局部诱导脂肪组织褐变治疗肥胖症
WO2020088306A1 (zh) * 2018-10-31 2020-05-07 南方医科大学 一种用于胰岛素口服递送的聚电解质复合物
CN111195238A (zh) * 2018-10-31 2020-05-26 南方医科大学 一种用于胰岛素口服递送的聚电解质复合物
CN115350267A (zh) * 2022-07-19 2022-11-18 深圳大学 一种级联催化型纳米治疗剂及其制备方法和应用
CN116474162A (zh) * 2023-04-28 2023-07-25 吉林大学 一种用于糖尿病慢性创伤修复的自修复水凝胶的制备方法

Also Published As

Publication number Publication date
RU2015151135A (ru) 2017-06-02
JP2016517885A (ja) 2016-06-20
BR112015027561A8 (pt) 2019-12-24
MX2015015079A (es) 2016-07-05
EP2991673A1 (en) 2016-03-09
HK1222546A1 (zh) 2017-07-07
US20160067190A1 (en) 2016-03-10
EP2991673A4 (en) 2016-12-21
WO2014179344A1 (en) 2014-11-06
AU2014260024B2 (en) 2016-09-15
BR112015027561A2 (pt) 2017-07-25
KR20160024853A (ko) 2016-03-07
AU2014260024A1 (en) 2015-11-19
HK1221415A1 (zh) 2017-06-02

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