JP2016516073A5 - - Google Patents
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- Publication number
- JP2016516073A5 JP2016516073A5 JP2016503371A JP2016503371A JP2016516073A5 JP 2016516073 A5 JP2016516073 A5 JP 2016516073A5 JP 2016503371 A JP2016503371 A JP 2016503371A JP 2016503371 A JP2016503371 A JP 2016503371A JP 2016516073 A5 JP2016516073 A5 JP 2016516073A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- esterase inhibitor
- hae
- administration
- esterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 42
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims description 21
- 206010019860 Hereditary angioedema Diseases 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000036765 blood level Effects 0.000 claims 2
- 229940122601 Esterase inhibitor Drugs 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 2
- 229940088950 c1 esterase inhibitor (human) Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 102000016917 Complement C1 Human genes 0.000 description 1
- 108010028774 Complement C1 Proteins 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791399P | 2013-03-15 | 2013-03-15 | |
| US61/791,399 | 2013-03-15 | ||
| PCT/US2014/030309 WO2014145519A2 (en) | 2013-03-15 | 2014-03-17 | C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051361A Division JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516073A JP2016516073A (ja) | 2016-06-02 |
| JP2016516073A5 true JP2016516073A5 (https=) | 2017-04-20 |
| JP6184581B2 JP6184581B2 (ja) | 2017-08-23 |
Family
ID=51538486
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503371A Active JP6184581B2 (ja) | 2013-03-15 | 2014-03-17 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2017051361A Active JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073690A Active JP6473535B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073689A Active JP6473534B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073691A Active JP6473536B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011084A Active JP6877472B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011079A Active JP6877470B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011082A Active JP6877471B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2021032716A Pending JP2021088599A (ja) | 2013-03-15 | 2021-03-02 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051361A Active JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073690A Active JP6473535B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073689A Active JP6473534B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073691A Active JP6473536B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011084A Active JP6877472B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011079A Active JP6877470B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011082A Active JP6877471B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2021032716A Pending JP2021088599A (ja) | 2013-03-15 | 2021-03-02 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (9) | US9616111B2 (https=) |
| EP (3) | EP3508213A1 (https=) |
| JP (9) | JP6184581B2 (https=) |
| KR (4) | KR20150135242A (https=) |
| CN (2) | CN105517559A (https=) |
| AU (3) | AU2014232912A1 (https=) |
| BR (1) | BR112015023207A8 (https=) |
| CA (2) | CA3054718A1 (https=) |
| CY (2) | CY1119419T1 (https=) |
| DE (1) | DE202014011208U1 (https=) |
| DK (2) | DK3290046T3 (https=) |
| EA (1) | EA201591278A1 (https=) |
| ES (2) | ES2713004T3 (https=) |
| GB (1) | GB2530921B (https=) |
| HK (1) | HK1250912B (https=) |
| HR (2) | HRP20171269T1 (https=) |
| HU (2) | HUE041837T2 (https=) |
| IL (2) | IL241549B (https=) |
| LT (2) | LT3290046T (https=) |
| ME (2) | ME03326B (https=) |
| MX (3) | MX389449B (https=) |
| PL (2) | PL3290046T3 (https=) |
| PT (2) | PT3290046T (https=) |
| RS (2) | RS58351B1 (https=) |
| SG (2) | SG11201507616VA (https=) |
| SI (2) | SI3290046T1 (https=) |
| SM (2) | SMT201700415T1 (https=) |
| TR (1) | TR201900319T4 (https=) |
| WO (1) | WO2014145519A2 (https=) |
| ZA (3) | ZA201507604B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS58351B1 (sr) | 2013-03-15 | 2019-03-29 | Shire Viropharma Inc | C1-inh kompozicije i postupci za prevenciju i lečenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze |
| EP4162947A1 (en) | 2013-11-22 | 2023-04-12 | Takeda Pharmaceutical Company Limited | Methods of treating antibody-mediated rejection in organ transplant patients with c1-esterase inhibitor |
| US20180036394A1 (en) * | 2015-02-20 | 2018-02-08 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| CN113999875A (zh) * | 2015-05-28 | 2022-02-01 | 康奈尔大学 | 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法 |
| CN108463243B (zh) * | 2015-11-19 | 2022-06-14 | 夏尔人类遗传性治疗公司 | 重组人c1酯酶抑制剂及其用途 |
| US20190175683A1 (en) * | 2016-08-05 | 2019-06-13 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| US20190183991A1 (en) * | 2016-08-23 | 2019-06-20 | Csl Behring Gmbh | Method of preventing acute attacks of hereditary angioedema associated with c1 esterase inhibitor deficiency |
| CN110769848A (zh) * | 2017-05-16 | 2020-02-07 | 瑞士奥克特珐玛公司 | C1-酯酶抑制剂制剂 |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| CA3092163A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Treatment and prevention of pre-eclampsia |
| JP7788711B2 (ja) | 2018-06-22 | 2025-12-19 | 株式会社Junten Bio | 複合状態を有する細胞混合物を用いた、免疫寛容を誘導する抗体、及び誘導されたリンパ球、また誘導されたリンパ球を用いる細胞治療剤及び治療法 |
| US12139537B2 (en) | 2018-06-22 | 2024-11-12 | Junten Bio Co., Ltd. | Antibody inducing immune tolerance, induced lymphocyte, and cell therapy agent therapeutic method using induced lymphocyte |
| US12234287B2 (en) | 2018-06-22 | 2025-02-25 | Junten Bio Co., Ltd. | Method for eliciting infectious immunological tolerance |
| WO2021124793A1 (ja) * | 2019-12-16 | 2021-06-24 | ニプロ株式会社 | 凝集防止剤ならびにそれを用いた医薬組成物および医療用デバイス |
| EP3895726A1 (en) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress |
| CN117120076A (zh) * | 2021-01-27 | 2023-11-24 | 斯帕克治疗公司 | 用于治疗遗传性血管性水肿的组合物和方法 |
| EP4366761A1 (en) | 2021-07-09 | 2024-05-15 | Pharming Intellectual Property B.V. | Using c1 esterase inhibitor to treat viral infection-related symptoms |
| KR20230046146A (ko) | 2021-09-29 | 2023-04-05 | 주식회사 엘지에너지솔루션 | 배터리 제어 시스템 및 방법 |
| WO2025090843A1 (en) * | 2023-10-27 | 2025-05-01 | Kansas State University Research Foundation | Small-molecule inhibitors of c1s protease and classical complement pathway |
| CN119823254B (zh) * | 2025-03-14 | 2025-06-03 | 深圳市卫光生物制品股份有限公司 | 一种c1酯酶抑制剂重组变体及其制备方法和应用 |
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| US5304482A (en) | 1989-03-06 | 1994-04-19 | The Board Of Regents Of The University Of Texas System | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
| WO1992022320A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
| PT716611E (pt) | 1993-09-01 | 2002-06-28 | Sanquin Bloedvoorziening | Metodo para reduzir a lesao do miocardio durante um enfarte do miocardio agudo |
| EP0868191A1 (en) | 1995-12-18 | 1998-10-07 | Stichting Sanquin Bloedvoorziening | Potentiation of complement and coagulation inhibitory properties of c1-inhibitor. |
| AT409336B (de) * | 1999-12-22 | 2002-07-25 | Baxter Ag | Verfahren zur herstellung einer c1-esterase-inhibitor (c1-inh)-hältigen zusammensetzung |
| US7067713B2 (en) * | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
| CA2398707C (en) | 2000-01-31 | 2010-10-26 | Pharming Intellectual Property B.V. | C1 inhibitor produced in the milk of transgenic mammals |
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| DE10112617A1 (de) | 2001-03-14 | 2002-10-02 | Aventis Behring Gmbh | Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren |
| WO2004034971A2 (en) | 2002-09-25 | 2004-04-29 | The Center For Blood Research, Inc. | Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof |
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| CN100431604C (zh) | 2003-05-16 | 2008-11-12 | 法明知识产权股份有限公司 | 用于瞬时性治疗的具有短半衰期的c1抑制剂 |
| US20060233776A1 (en) | 2003-08-19 | 2006-10-19 | Norbert Heimburger | C1-inh as a drug for treating viruses pathogenic to humans |
| US8501705B2 (en) | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
| EP1598428A1 (en) | 2004-05-18 | 2005-11-23 | Georg Dewald | Methods and kits to detect Hereditary angioedema type III |
| CA2654440C (en) | 2005-06-06 | 2013-09-03 | Girish J. Kotwal | Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury |
| JP5219819B2 (ja) | 2005-10-21 | 2013-06-26 | カタリスト・バイオサイエンシーズ・インコーポレイテッド | 補体活性化を阻害する修飾プロテアーゼ |
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| KR101956585B1 (ko) | 2011-09-24 | 2019-03-11 | 체에스엘 베링 게엠베하 | 면역글로불린과 ｃ1-억제제를 사용하는 병용 치료요법 |
| JP6127063B2 (ja) | 2011-12-22 | 2017-05-10 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 中枢神経系の続発性浮腫の治療のためのｃ１インヒビターの使用 |
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| JP6935245B2 (ja) * | 2017-06-29 | 2021-09-15 | 大和ハウス工業株式会社 | 収容ラック |
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-
2014
- 2014-03-17 RS RS20190198A patent/RS58351B1/sr unknown
- 2014-03-17 SI SI201431032T patent/SI3290046T1/sl unknown
- 2014-03-17 SI SI201430368T patent/SI2968434T1/sl unknown
- 2014-03-17 SG SG11201507616VA patent/SG11201507616VA/en unknown
- 2014-03-17 SG SG10201707598QA patent/SG10201707598QA/en unknown
- 2014-03-17 DK DK17177676.8T patent/DK3290046T3/en active
- 2014-03-17 EP EP18206413.9A patent/EP3508213A1/en not_active Withdrawn
- 2014-03-17 PL PL17177676T patent/PL3290046T3/pl unknown
- 2014-03-17 CA CA3054718A patent/CA3054718A1/en not_active Abandoned
- 2014-03-17 EP EP17177676.8A patent/EP3290046B1/en active Active
- 2014-03-17 EP EP14762343.3A patent/EP2968434B1/en not_active Revoked
- 2014-03-17 KR KR1020157022897A patent/KR20150135242A/ko not_active Ceased
- 2014-03-17 PT PT17177676T patent/PT3290046T/pt unknown
- 2014-03-17 KR KR1020217033628A patent/KR102430453B1/ko active Active
- 2014-03-17 GB GB1519921.9A patent/GB2530921B/en active Active
- 2014-03-17 HU HUE17177676A patent/HUE041837T2/hu unknown
- 2014-03-17 PL PL14762343T patent/PL2968434T3/pl unknown
- 2014-03-17 AU AU2014232912A patent/AU2014232912A1/en not_active Abandoned
- 2014-03-17 EA EA201591278A patent/EA201591278A1/ru unknown
- 2014-03-17 HU HUE14762343A patent/HUE036224T2/hu unknown
- 2014-03-17 WO PCT/US2014/030309 patent/WO2014145519A2/en not_active Ceased
- 2014-03-17 ES ES17177676T patent/ES2713004T3/es active Active
- 2014-03-17 DE DE202014011208.8U patent/DE202014011208U1/de not_active Expired - Lifetime
- 2014-03-17 LT LTEP17177676.8T patent/LT3290046T/lt unknown
- 2014-03-17 CA CA2904543A patent/CA2904543C/en active Active
- 2014-03-17 HR HRP20171269TT patent/HRP20171269T1/hr unknown
- 2014-03-17 KR KR1020217004777A patent/KR20210021146A/ko not_active Ceased
- 2014-03-17 ME MEP-2019-45A patent/ME03326B/me unknown
- 2014-03-17 MX MX2020004724A patent/MX389449B/es unknown
- 2014-03-17 ES ES14762343.3T patent/ES2639833T3/es active Active
- 2014-03-17 BR BR112015023207A patent/BR112015023207A8/pt not_active Application Discontinuation
- 2014-03-17 CN CN201480014712.7A patent/CN105517559A/zh active Pending
- 2014-03-17 RS RS20170802A patent/RS56285B1/sr unknown
- 2014-03-17 LT LTEP14762343.3T patent/LT2968434T/lt unknown
- 2014-03-17 JP JP2016503371A patent/JP6184581B2/ja active Active
- 2014-03-17 PT PT147623433T patent/PT2968434T/pt unknown
- 2014-03-17 CN CN202010362851.6A patent/CN111529708A/zh active Pending
- 2014-03-17 KR KR1020227016244A patent/KR102579789B1/ko active Active
- 2014-03-17 MX MX2015011281A patent/MX373965B/es active IP Right Grant
- 2014-03-17 DK DK14762343.3T patent/DK2968434T3/en active
- 2014-03-17 SM SM20170415T patent/SMT201700415T1/it unknown
- 2014-03-17 TR TR2019/00319T patent/TR201900319T4/tr unknown
- 2014-03-17 SM SM20190141T patent/SMT201900141T1/it unknown
- 2014-03-17 ME MEP-2017-182A patent/ME02865B/me unknown
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2015
- 2015-08-28 MX MX2021011946A patent/MX2021011946A/es unknown
- 2015-09-10 IL IL241549A patent/IL241549B/en active IP Right Grant
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2017
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2018
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