DK3290046T3 - C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK - Google Patents

C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK Download PDF

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Publication number
DK3290046T3
DK3290046T3 DK17177676.8T DK17177676T DK3290046T3 DK 3290046 T3 DK3290046 T3 DK 3290046T3 DK 17177676 T DK17177676 T DK 17177676T DK 3290046 T3 DK3290046 T3 DK 3290046T3
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Prior art keywords
esterase inhibitor
composition
use according
hae
units
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DK17177676.8T
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Danish (da)
English (en)
Inventor
Cynthia Gallagher
Stephen Ruddy
Mark Cornell Manning
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Shire Viropharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK17177676.8T 2013-03-15 2014-03-17 C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK DK3290046T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791399P 2013-03-15 2013-03-15
EP14762343.3A EP2968434B1 (en) 2013-03-15 2014-03-17 C1-inh compositions for use in the prevention and treatment of hereditary angioedema (hae).

Publications (1)

Publication Number Publication Date
DK3290046T3 true DK3290046T3 (en) 2019-03-18

Family

ID=51538486

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17177676.8T DK3290046T3 (en) 2013-03-15 2014-03-17 C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK
DK14762343.3T DK2968434T3 (en) 2013-03-15 2014-03-17 C1-INH compositions for use in the prevention and treatment of hereditary angioedema (HAE).

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14762343.3T DK2968434T3 (en) 2013-03-15 2014-03-17 C1-INH compositions for use in the prevention and treatment of hereditary angioedema (HAE).

Country Status (30)

Country Link
US (9) US9616111B2 (https=)
EP (3) EP3508213A1 (https=)
JP (9) JP6184581B2 (https=)
KR (4) KR20150135242A (https=)
CN (2) CN105517559A (https=)
AU (3) AU2014232912A1 (https=)
BR (1) BR112015023207A8 (https=)
CA (2) CA3054718A1 (https=)
CY (2) CY1119419T1 (https=)
DE (1) DE202014011208U1 (https=)
DK (2) DK3290046T3 (https=)
EA (1) EA201591278A1 (https=)
ES (2) ES2713004T3 (https=)
GB (1) GB2530921B (https=)
HK (1) HK1250912B (https=)
HR (2) HRP20171269T1 (https=)
HU (2) HUE041837T2 (https=)
IL (2) IL241549B (https=)
LT (2) LT3290046T (https=)
ME (2) ME03326B (https=)
MX (3) MX389449B (https=)
PL (2) PL3290046T3 (https=)
PT (2) PT3290046T (https=)
RS (2) RS58351B1 (https=)
SG (2) SG11201507616VA (https=)
SI (2) SI3290046T1 (https=)
SM (2) SMT201700415T1 (https=)
TR (1) TR201900319T4 (https=)
WO (1) WO2014145519A2 (https=)
ZA (3) ZA201507604B (https=)

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JP2019073546A (ja) 2019-05-16
US20200261556A1 (en) 2020-08-20
JP6473534B2 (ja) 2019-02-20
JP6877470B2 (ja) 2021-05-26
JP2019073545A (ja) 2019-05-16
PL2968434T3 (pl) 2018-01-31
AU2018229558B2 (en) 2020-03-05
RS56285B1 (sr) 2017-12-29
US10201595B2 (en) 2019-02-12
US20180110843A1 (en) 2018-04-26
EA201591278A1 (ru) 2016-03-31
US20170224788A1 (en) 2017-08-10
JP6877472B2 (ja) 2021-05-26
CA2904543C (en) 2019-10-08
KR102430453B1 (ko) 2022-08-05
NZ710730A (en) 2021-07-30
US10130690B2 (en) 2018-11-20
TR201900319T4 (tr) 2019-02-21
AU2020203183A1 (en) 2020-06-04
LT3290046T (lt) 2019-03-12
JP2017105847A (ja) 2017-06-15
PL3290046T3 (pl) 2019-05-31
WO2014145519A3 (en) 2014-12-31
KR20210129267A (ko) 2021-10-27
GB2530921B (en) 2017-09-20
ME03326B (me) 2019-10-20
EP2968434A4 (en) 2016-03-02
HK1250912B (en) 2020-01-10
KR102579789B1 (ko) 2023-09-15
US20180153972A1 (en) 2018-06-07
KR20220070049A (ko) 2022-05-27
RS58351B1 (sr) 2019-03-29
EP3290046A1 (en) 2018-03-07
PT3290046T (pt) 2019-02-18
MX2020004724A (es) 2022-01-18
HUE041837T2 (hu) 2019-05-28
CY1121653T1 (el) 2020-07-31
ZA201806793B (en) 2020-01-29
CN111529708A (zh) 2020-08-14
US11364288B2 (en) 2022-06-21
SI2968434T1 (sl) 2017-11-30
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HK1220403A1 (en) 2017-05-05
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US20160015795A1 (en) 2016-01-21
KR20150135242A (ko) 2015-12-02
EP3290046B1 (en) 2019-01-02
SMT201700415T1 (it) 2017-11-15
ZA201507604B (en) 2018-05-30
CA3054718A1 (en) 2014-09-18
IL276153B (en) 2022-06-01
MX2021011946A (es) 2021-11-17
CA2904543A1 (en) 2014-09-18
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ME02865B (me) 2018-04-20
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JP2021088599A (ja) 2021-06-10
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US11534482B2 (en) 2022-12-27
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US20180085441A1 (en) 2018-03-29
BR112015023207A8 (pt) 2018-01-23
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US10080788B2 (en) 2018-09-25
US20190160158A1 (en) 2019-05-30
DE202014011208U1 (de) 2018-08-23
US10105423B2 (en) 2018-10-23
SMT201900141T1 (it) 2019-05-10
AU2020203183B2 (en) 2022-06-02
US20190160157A1 (en) 2019-05-30
BR112015023207A2 (pt) 2017-11-21
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