JP2016514132A5 - - Google Patents
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- Publication number
- JP2016514132A5 JP2016514132A5 JP2016501088A JP2016501088A JP2016514132A5 JP 2016514132 A5 JP2016514132 A5 JP 2016514132A5 JP 2016501088 A JP2016501088 A JP 2016501088A JP 2016501088 A JP2016501088 A JP 2016501088A JP 2016514132 A5 JP2016514132 A5 JP 2016514132A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- days
- bolus dose
- hgh
- xten
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108020001507 fusion proteins Proteins 0.000 claims description 58
- 102000037865 fusion proteins Human genes 0.000 claims description 58
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 36
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 36
- 210000002966 serum Anatomy 0.000 claims description 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 206010056438 Growth hormone deficiency Diseases 0.000 claims description 11
- 230000003442 weekly effect Effects 0.000 claims description 8
- 230000037396 body weight Effects 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 52
- 102000018997 Growth Hormone Human genes 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 239000000122 growth hormone Substances 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 238000004260 weight control Methods 0.000 claims 2
- 241001272720 Medialuna californiensis Species 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 45
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361776618P | 2013-03-11 | 2013-03-11 | |
| US61/776,618 | 2013-03-11 | ||
| US201361810786P | 2013-04-11 | 2013-04-11 | |
| US61/810,786 | 2013-04-11 | ||
| US201361835002P | 2013-06-14 | 2013-06-14 | |
| US61/835,002 | 2013-06-14 | ||
| US201361880701P | 2013-09-20 | 2013-09-20 | |
| US61/880,701 | 2013-09-20 | ||
| US201361911731P | 2013-12-04 | 2013-12-04 | |
| US61/911,731 | 2013-12-04 | ||
| US201461931987P | 2014-01-27 | 2014-01-27 | |
| US61/931,987 | 2014-01-27 | ||
| US201461948457P | 2014-03-05 | 2014-03-05 | |
| US61/948,457 | 2014-03-05 | ||
| PCT/US2014/022850 WO2014164568A1 (en) | 2013-03-11 | 2014-03-10 | Treatment of pediatric growth hormone deficiency with human growth hormone analogues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017039625A Division JP2017101074A (ja) | 2013-03-11 | 2017-03-02 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016514132A JP2016514132A (ja) | 2016-05-19 |
| JP2016514132A5 true JP2016514132A5 (https=) | 2017-04-06 |
Family
ID=51658905
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501088A Withdrawn JP2016514132A (ja) | 2013-03-11 | 2014-03-10 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
| JP2017039625A Withdrawn JP2017101074A (ja) | 2013-03-11 | 2017-03-02 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
| JP2019005944A Pending JP2019056013A (ja) | 2013-03-11 | 2019-01-17 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017039625A Withdrawn JP2017101074A (ja) | 2013-03-11 | 2017-03-02 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
| JP2019005944A Pending JP2019056013A (ja) | 2013-03-11 | 2019-01-17 | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20160158321A1 (https=) |
| EP (1) | EP2968451A4 (https=) |
| JP (3) | JP2016514132A (https=) |
| KR (1) | KR20150124955A (https=) |
| CN (1) | CN105209055A (https=) |
| AU (1) | AU2014249258A1 (https=) |
| BR (1) | BR112015022257A8 (https=) |
| CA (1) | CA2900949A1 (https=) |
| CL (1) | CL2015002456A1 (https=) |
| EA (1) | EA201591529A1 (https=) |
| HK (1) | HK1216617A1 (https=) |
| IL (1) | IL240392A0 (https=) |
| MX (1) | MX2015012175A (https=) |
| PH (1) | PH12015502063A1 (https=) |
| SG (1) | SG11201506732YA (https=) |
| WO (1) | WO2014164568A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| WO2016109823A1 (en) * | 2015-01-02 | 2016-07-07 | Amunix Operation Inc. | Treatment of pediatric growth hormone deficiency with human growth hormone analogues |
| WO2016124817A1 (en) | 2015-02-03 | 2016-08-11 | Beddit Oy | Family sleep monitoring system |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| WO2017136583A1 (en) | 2016-02-02 | 2017-08-10 | Versartis, Inc. | Growth hormone treatment adherence system |
| KR20170096968A (ko) | 2016-02-17 | 2017-08-25 | 주식회사 제넥신 | hGH 융합단백질을 포함하는 성장호르몬 결핍을 치료하기 위한 약학 조성물 |
| US12427186B2 (en) | 2016-08-30 | 2025-09-30 | Genexine, Inc. | Method for treating growth hormone deficiency employing hGH fusion protein |
| US10288629B1 (en) * | 2017-12-19 | 2019-05-14 | Aeterna Zentaris, Inc. | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition |
| EP3728326A4 (en) | 2017-12-21 | 2021-12-15 | Amunix Pharmaceuticals, Inc. | SEPARATING SEGMENTS AND BINDING COMPOSITIONS THEREFORE |
| US11903683B2 (en) | 2018-08-03 | 2024-02-20 | Chelak Medical Solutions Inc | Non-barometric determination of hemodynamic effects of cardiac arrhythmias using signals sensed by an implantable device |
| RU2753191C2 (ru) * | 2019-09-26 | 2021-08-12 | Федеральное государственное бюджетное учреждение науки Институт Биологии Развития им. Н.К. Кольцова Российской Академии Наук | Новый рекомбинантный аналог гормона роста пролонгированного действия |
| CN115260313B (zh) | 2019-12-31 | 2023-07-18 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| CN115322794B (zh) | 2020-01-11 | 2025-09-19 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| KR102599111B1 (ko) * | 2020-01-31 | 2023-11-07 | 울산대학교 산학협력단 | 인슐린유사성장인자-1 융합단백질 및 이의 용도 |
| CN120294343A (zh) * | 2020-07-22 | 2025-07-11 | 阿特纳赞塔里斯有限公司 | 一种通过使用马昔瑞林诊断儿科患者中生长激素缺乏症的筛选方法 |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2748314C (en) * | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
| ES2544982T3 (es) * | 2009-09-02 | 2015-09-07 | Merck Serono S.A. | Método para predecir el nivel de respuesta al crecimiento |
| KR20150021072A (ko) * | 2012-06-05 | 2015-02-27 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 |
-
2014
- 2014-03-10 HK HK16104695.2A patent/HK1216617A1/zh unknown
- 2014-03-10 CA CA2900949A patent/CA2900949A1/en not_active Abandoned
- 2014-03-10 BR BR112015022257A patent/BR112015022257A8/pt active Search and Examination
- 2014-03-10 EP EP14780175.7A patent/EP2968451A4/en not_active Withdrawn
- 2014-03-10 WO PCT/US2014/022850 patent/WO2014164568A1/en not_active Ceased
- 2014-03-10 JP JP2016501088A patent/JP2016514132A/ja not_active Withdrawn
- 2014-03-10 KR KR1020157023667A patent/KR20150124955A/ko not_active Withdrawn
- 2014-03-10 MX MX2015012175A patent/MX2015012175A/es unknown
- 2014-03-10 AU AU2014249258A patent/AU2014249258A1/en not_active Abandoned
- 2014-03-10 EA EA201591529A patent/EA201591529A1/ru unknown
- 2014-03-10 SG SG11201506732YA patent/SG11201506732YA/en unknown
- 2014-03-10 US US14/771,445 patent/US20160158321A1/en not_active Abandoned
- 2014-03-10 CN CN201480011475.9A patent/CN105209055A/zh active Pending
-
2015
- 2015-08-06 IL IL240392A patent/IL240392A0/en unknown
- 2015-09-02 CL CL2015002456A patent/CL2015002456A1/es unknown
- 2015-09-11 PH PH12015502063A patent/PH12015502063A1/en unknown
-
2017
- 2017-03-02 JP JP2017039625A patent/JP2017101074A/ja not_active Withdrawn
-
2019
- 2019-01-17 JP JP2019005944A patent/JP2019056013A/ja active Pending
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