JP2016516068A5 - - Google Patents
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- JP2016516068A5 JP2016516068A5 JP2016503207A JP2016503207A JP2016516068A5 JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5 JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5
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- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- aryl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*N(*)C(*)C(N(*)*(C)C)=O Chemical compound C*N(*)C(*)C(N(*)*(C)C)=O 0.000 description 2
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792868P | 2013-03-15 | 2013-03-15 | |
| US201361792679P | 2013-03-15 | 2013-03-15 | |
| US61/792,868 | 2013-03-15 | ||
| US61/792,679 | 2013-03-15 | ||
| US201361882056P | 2013-09-25 | 2013-09-25 | |
| US201361882048P | 2013-09-25 | 2013-09-25 | |
| US61/882,048 | 2013-09-25 | ||
| US61/882,056 | 2013-09-25 | ||
| US201461934570P | 2014-01-31 | 2014-01-31 | |
| US61/934,570 | 2014-01-31 | ||
| PCT/US2014/029723 WO2014145068A1 (en) | 2013-03-15 | 2014-03-14 | Compositions, formulations and methods for treating ocular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147238A Division JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516068A JP2016516068A (ja) | 2016-06-02 |
| JP2016516068A5 true JP2016516068A5 (https=) | 2017-04-20 |
| JP6572201B2 JP6572201B2 (ja) | 2019-09-04 |
Family
ID=51529957
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503207A Active JP6572201B2 (ja) | 2013-03-15 | 2014-03-14 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2019147238A Active JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2021064106A Active JP7249374B2 (ja) | 2013-03-15 | 2021-04-05 | 眼疾患を処置するための組成物、製剤、および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147238A Active JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2021064106A Active JP7249374B2 (ja) | 2013-03-15 | 2021-04-05 | 眼疾患を処置するための組成物、製剤、および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (10) | US9440963B2 (https=) |
| EP (3) | EP2967066B1 (https=) |
| JP (3) | JP6572201B2 (https=) |
| KR (1) | KR20150129019A (https=) |
| CN (2) | CN105307498B (https=) |
| AU (2) | AU2014233363B2 (https=) |
| BR (1) | BR112015023753A2 (https=) |
| CA (1) | CA2903871A1 (https=) |
| ES (2) | ES2766326T3 (https=) |
| GB (3) | GB2540638B (https=) |
| HK (2) | HK1206558A1 (https=) |
| IL (2) | IL240786B (https=) |
| MX (1) | MX371382B (https=) |
| MY (1) | MY171945A (https=) |
| PH (2) | PH12015502153B1 (https=) |
| SG (1) | SG11201507131WA (https=) |
| WO (1) | WO2014145068A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| DK3254676T3 (en) | 2009-10-30 | 2019-03-11 | Ix Biopharma Ltd | QUICK-SOLVING SOLID DOSAGE FORM |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| EP3698794A1 (en) | 2009-11-06 | 2020-08-26 | Aerpio Therapeutics, Inc. | Compositions and methods for treating colitis |
| US20180092883A1 (en) * | 2010-10-07 | 2018-04-05 | Aerpio Therapeutics, Inc. | Phosphatase inhibitors for treating ocular diseases |
| JP5965409B2 (ja) | 2010-12-08 | 2016-08-03 | コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc | 創傷滲出液を評価するための統合システム |
| CN103347562B (zh) | 2010-12-08 | 2016-08-10 | 康沃特克科技公司 | 伤口分泌液系统附件 |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| EP3501536B1 (en) | 2011-10-13 | 2025-12-24 | EyePoint Pharmaceuticals, Inc. | Treatment of ocular disease |
| SG11201502425WA (en) * | 2012-10-11 | 2015-05-28 | Ix Biopharma Ltd | Solid dosage form |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| AU2014233363B2 (en) * | 2013-03-15 | 2017-06-29 | EyePoint, Inc. | Compositions, formulations and methods for treating ocular diseases |
| JP6549140B2 (ja) | 2014-02-19 | 2019-07-24 | エアーピオ セラピューティクス インコーポレイテッド | N−ベンジル−3−ヒドロキシ−4−置換ピリジン−2−(1h)−オン |
| EP3116503A4 (en) * | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| WO2016022813A1 (en) | 2014-08-07 | 2016-02-11 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of tie-2 |
| ES2981607T3 (es) * | 2015-09-23 | 2024-10-09 | Eyepoint Pharmaceuticals Inc | Activadores de Tie-2 para uso en el tratamiento de la presión intraocular |
| WO2017075814A1 (zh) * | 2015-11-06 | 2017-05-11 | 华为技术有限公司 | 一种语音漫游方法,移动性管理网元及接入网网元 |
| AU2017299581B2 (en) | 2016-07-20 | 2024-05-23 | EyePoint, Inc. | Humanized monoclonal antibodies that target ve-ptp (hptp-β) |
| CN109996440A (zh) * | 2016-10-21 | 2019-07-09 | 曼宁研究有限公司 | Ve-ptp敲除 |
| CN120058958A (zh) | 2018-09-24 | 2025-05-30 | 视点制药公司 | 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体 |
| CN114072205A (zh) * | 2019-04-18 | 2022-02-18 | 视点制药公司 | 用tie-2激活剂治疗高血压的方法 |
| EP3962482A4 (en) * | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| GB2589400A (en) * | 2019-06-24 | 2021-06-02 | Aerpio Pharmaceuticals Inc | Formulations of tie-2 activators and methods of use thereof |
| US11613534B2 (en) | 2019-10-29 | 2023-03-28 | EyePoint Pharmaceuticals, Inc. | Small molecule activators of Tie-2 |
| EP4164690A1 (en) * | 2020-06-16 | 2023-04-19 | Amy Ripka | Small molecule ve-ptp inhibitors |
| WO2022133232A1 (en) * | 2020-12-18 | 2022-06-23 | EyePoint Pharmaceuticals, Inc. | Methods for manufacture of small molecule activators of tie-2 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2025128706A1 (en) * | 2023-12-11 | 2025-06-19 | Massachusetts Eye And Ear Infirmary | Methods of using tie-2 activators |
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| US5078486A (en) | 1989-10-13 | 1992-01-07 | Evans David W | Self-calibrating vision test apparatus |
| US5688781A (en) | 1994-08-19 | 1997-11-18 | Bristol-Myers Squibb Company | Method for treating vascular leak syndrome |
| WO1996031598A1 (en) | 1995-04-06 | 1996-10-10 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligands, methods of making and uses thereof |
| US20030040463A1 (en) | 1996-04-05 | 2003-02-27 | Wiegand Stanley J. | TIE-2 ligands, methods of making and uses thereof |
| US6455031B1 (en) * | 1997-06-18 | 2002-09-24 | David G Davies | Methods and compositions for controlling biofilm development |
| US5980929A (en) | 1998-03-13 | 1999-11-09 | Johns Hopkins University, School Of Medicine | Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation |
| US5919813C1 (en) | 1998-03-13 | 2002-01-29 | Univ Johns Hopkins Med | Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy |
| PT1165115E (pt) | 1999-03-26 | 2003-10-31 | Univ California | Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2 |
| US6455035B1 (en) * | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| NZ536196A (en) | 2000-06-23 | 2006-12-22 | Schering Ag | Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use (II) |
| CA2431319A1 (en) * | 2000-12-11 | 2002-06-20 | Hiroto Bando | Pharmaceutical composition having an improved water solubility |
| SE518981C2 (sv) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | Autoinjektor |
| US7166435B2 (en) * | 2001-08-06 | 2007-01-23 | The Quigley Corporation | Compositions and methods for reducing the transmissivity of illnesses |
| US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| WO2003090686A2 (en) | 2002-04-25 | 2003-11-06 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| US7226755B1 (en) | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
| US7507568B2 (en) | 2002-09-25 | 2009-03-24 | The Proctor & Gamble Company | Three dimensional coordinates of HPTPbeta |
| AU2003279911A1 (en) * | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
| US6946479B2 (en) | 2002-11-09 | 2005-09-20 | The Procter & Gamble Company | N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones |
| US6930117B2 (en) | 2002-11-09 | 2005-08-16 | The Procter & Gamble Company | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones |
| WO2004060373A1 (ja) * | 2002-12-27 | 2004-07-22 | Santen Pharmaceutical Co., Ltd. | 滲出型加齢黄斑変性治療剤 |
| WO2004091480A2 (en) | 2003-04-09 | 2004-10-28 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| MXPA05012723A (es) * | 2003-05-30 | 2006-02-08 | Genentech Inc | Tratamiento con anticuerpos anti-vgf. |
| US20050059639A1 (en) | 2003-09-11 | 2005-03-17 | Wei Edward T. | Ophthalmic compositions and method for treating eye discomfort and pain |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| JP2008509085A (ja) * | 2004-06-02 | 2008-03-27 | バルティオン テクニリーネン トゥトキムスケスクス | T細胞タンパク質チロシンホスファターゼの活性化方法およびそれに基づく治療方法 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US7893040B2 (en) | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
| HRP20100559T1 (hr) | 2005-11-29 | 2010-11-30 | Glaxosmithkline Llc | Liječenje neovaskularnih poremećaja oka, poput makularne degeneracije, angioidnih strija, uveitisa i edema makule |
| CA2633211A1 (en) | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer |
| JP5133071B2 (ja) * | 2006-02-09 | 2013-01-30 | 第一三共株式会社 | 抗癌医薬組成物 |
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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| CN101583357B (zh) * | 2006-08-29 | 2013-03-20 | 新加坡国立癌症中心 | Mtor拮抗剂和血管生成抑制剂用于制备治疗癌症的药物的用途 |
| PT2076290T (pt) | 2006-10-27 | 2017-01-17 | Sunnybrook Health Sciences Center | Agonistas de tie 2 multiméricos e utilizações dos mesmos na estimulação da angiogénese |
| ES2365931T3 (es) | 2006-12-13 | 2011-10-13 | Shl Group Ab | Inyector automático. |
| CN101678170B (zh) | 2007-03-23 | 2012-05-30 | Shl集团有限责任公司 | 自动注射器 |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| DK2162170T3 (da) | 2007-07-06 | 2011-06-14 | Shl Group Ab | Enkeltskudsinjektionssprøjte med dobbeltfjedre |
| JP4934841B2 (ja) | 2007-09-18 | 2012-05-23 | エス・ホー・エル・グループ・アクチボラゲット | 針挿入を伴う自動注射装置 |
| KR101710727B1 (ko) * | 2008-03-31 | 2017-02-27 | 가부시키가이샤 시세이도 | 혈관의 성숙화, 정상화 또는 안정화제 및 주름 방지·개선제 |
| ES2637346T3 (es) | 2008-05-20 | 2017-10-11 | Shl Group Ab | Dispositivo de administración de medicamentos con un amortiguador |
| WO2009150071A1 (en) | 2008-06-11 | 2009-12-17 | Shl Group Ab | Medicament delivery device |
| CN102813689B (zh) * | 2008-06-18 | 2016-08-10 | 株式会社资生堂 | 淋巴管的稳定剂 |
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| CN102246349A (zh) | 2008-12-22 | 2011-11-16 | 株式会社藤仓 | 薄膜天线及其制造方法 |
| SG10201702247SA (en) * | 2009-01-12 | 2017-04-27 | Aerpio Therapeutics Inc | Methods for treating vascular leak syndrome |
| US9096555B2 (en) | 2009-01-12 | 2015-08-04 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome |
| MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| US8883832B2 (en) | 2009-07-06 | 2014-11-11 | Aerpio Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| TWI393578B (zh) | 2009-07-07 | 2013-04-21 | Shl Group Ab | 注射裝置 |
| TW201105363A (en) * | 2009-07-14 | 2011-02-16 | Univ Yamagata | Eye drop for macular edema treatment |
| EP3698794A1 (en) | 2009-11-06 | 2020-08-26 | Aerpio Therapeutics, Inc. | Compositions and methods for treating colitis |
| JP2011201811A (ja) * | 2010-03-25 | 2011-10-13 | Shiseido Co Ltd | Tie2活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤 |
| US20110319455A1 (en) | 2010-04-19 | 2011-12-29 | Bruce Steven Klein | Antifungal Treatment |
| US9186390B2 (en) * | 2010-04-28 | 2015-11-17 | Sunnybrook Health Sciences Center | Methods and uses of TIE2 binding and/or activating agents |
| US20180092883A1 (en) | 2010-10-07 | 2018-04-05 | Aerpio Therapeutics, Inc. | Phosphatase inhibitors for treating ocular diseases |
| US20120129847A1 (en) | 2010-10-07 | 2012-05-24 | Kevin Gene Peters | Compositions and methods for treating ocular edema, neovascularization and related diseases |
| CN103249422A (zh) * | 2010-12-02 | 2013-08-14 | 丸善制药株式会社 | Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物 |
| CN102532042A (zh) * | 2010-12-30 | 2012-07-04 | 上海医药工业研究院 | 一种芳基脲类化合物、其中间体及其应用 |
| CN103402582A (zh) * | 2011-02-11 | 2013-11-20 | 普西维达公司 | 使用抗水肿疗法治疗黄斑水肿的方法 |
| EP3501536B1 (en) | 2011-10-13 | 2025-12-24 | EyePoint Pharmaceuticals, Inc. | Treatment of ocular disease |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| AU2014233363B2 (en) | 2013-03-15 | 2017-06-29 | EyePoint, Inc. | Compositions, formulations and methods for treating ocular diseases |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US20160151410A1 (en) | 2013-07-02 | 2016-06-02 | The Trustees Of Columbia University In The City Of New York | Clearance of bioactive lipids from membrane structures by cyclodextrins |
| JP6549140B2 (ja) | 2014-02-19 | 2019-07-24 | エアーピオ セラピューティクス インコーポレイテッド | N−ベンジル−3−ヒドロキシ−4−置換ピリジン−2−(1h)−オン |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| US9719135B2 (en) * | 2014-07-03 | 2017-08-01 | Mannin Research Inc. | Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system |
-
2014
- 2014-03-14 AU AU2014233363A patent/AU2014233363B2/en active Active
- 2014-03-14 KR KR1020157029411A patent/KR20150129019A/ko not_active Ceased
- 2014-03-14 CN CN201480028572.9A patent/CN105307498B/zh active Active
- 2014-03-14 GB GB1520656.8A patent/GB2540638B/en active Active
- 2014-03-14 EP EP14762974.5A patent/EP2967066B1/en active Active
- 2014-03-14 ES ES14762974T patent/ES2766326T3/es active Active
- 2014-03-14 ES ES19174479T patent/ES2928162T3/es active Active
- 2014-03-14 EP EP22171032.0A patent/EP4101297A1/en active Pending
- 2014-03-14 US US13/999,670 patent/US9440963B2/en active Active
- 2014-03-14 GB GB1411935.8A patent/GB2516561B/en active Active
- 2014-03-14 BR BR112015023753A patent/BR112015023753A2/pt not_active Application Discontinuation
- 2014-03-14 MX MX2015011131A patent/MX371382B/es active IP Right Grant
- 2014-03-14 HK HK15107185.3A patent/HK1206558A1/xx unknown
- 2014-03-14 GB GB1709419.4A patent/GB2549865B/en active Active
- 2014-03-14 WO PCT/US2014/029723 patent/WO2014145068A1/en not_active Ceased
- 2014-03-14 JP JP2016503207A patent/JP6572201B2/ja active Active
- 2014-03-14 CN CN201910221542.4A patent/CN109925312A/zh active Pending
- 2014-03-14 HK HK16108038.9A patent/HK1219836A1/zh unknown
- 2014-03-14 SG SG11201507131WA patent/SG11201507131WA/en unknown
- 2014-03-14 CA CA2903871A patent/CA2903871A1/en not_active Abandoned
- 2014-03-14 EP EP19174479.6A patent/EP3607821B1/en active Active
- 2014-03-14 MY MYPI2015002288A patent/MY171945A/en unknown
-
2015
- 2015-08-24 IL IL240786A patent/IL240786B/en active IP Right Grant
- 2015-09-15 PH PH12015502153A patent/PH12015502153B1/en unknown
-
2016
- 2016-04-14 US US15/098,955 patent/US20160220540A1/en not_active Abandoned
- 2016-04-14 US US15/099,161 patent/US20160220541A1/en not_active Abandoned
-
2017
- 2017-02-27 US US15/443,622 patent/US20180022741A1/en not_active Abandoned
- 2017-09-28 AU AU2017235953A patent/AU2017235953B2/en not_active Expired - Fee Related
-
2018
- 2018-04-20 US US15/958,346 patent/US20180237429A1/en not_active Abandoned
- 2018-04-20 US US15/958,355 patent/US20180237430A1/en not_active Abandoned
- 2018-04-20 US US15/958,358 patent/US20180237431A1/en not_active Abandoned
- 2018-05-02 US US15/969,109 patent/US20180251457A1/en not_active Abandoned
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2019
- 2019-07-11 IL IL267997A patent/IL267997A/en unknown
- 2019-08-09 JP JP2019147238A patent/JP6865254B2/ja active Active
- 2019-09-04 PH PH12019502018A patent/PH12019502018A1/en unknown
-
2020
- 2020-05-29 US US16/888,247 patent/US20200361926A1/en not_active Abandoned
-
2021
- 2021-04-05 JP JP2021064106A patent/JP7249374B2/ja active Active
-
2022
- 2022-03-03 US US17/685,802 patent/US12152023B2/en active Active
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