JP2016516068A5 - - Google Patents

Download PDF

Info

Publication number
JP2016516068A5
JP2016516068A5 JP2016503207A JP2016503207A JP2016516068A5 JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5 JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5
Authority
JP
Japan
Prior art keywords
substituted
group
unsubstituted
aryl
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016503207A
Other languages
English (en)
Japanese (ja)
Other versions
JP6572201B2 (ja
JP2016516068A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/029723 external-priority patent/WO2014145068A1/en
Publication of JP2016516068A publication Critical patent/JP2016516068A/ja
Publication of JP2016516068A5 publication Critical patent/JP2016516068A5/ja
Application granted granted Critical
Publication of JP6572201B2 publication Critical patent/JP6572201B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016503207A 2013-03-15 2014-03-14 眼疾患を処置するための組成物、製剤、および方法 Active JP6572201B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361792868P 2013-03-15 2013-03-15
US201361792679P 2013-03-15 2013-03-15
US61/792,868 2013-03-15
US61/792,679 2013-03-15
US201361882056P 2013-09-25 2013-09-25
US201361882048P 2013-09-25 2013-09-25
US61/882,048 2013-09-25
US61/882,056 2013-09-25
US201461934570P 2014-01-31 2014-01-31
US61/934,570 2014-01-31
PCT/US2014/029723 WO2014145068A1 (en) 2013-03-15 2014-03-14 Compositions, formulations and methods for treating ocular diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019147238A Division JP6865254B2 (ja) 2013-03-15 2019-08-09 眼疾患を処置するための組成物、製剤、および方法

Publications (3)

Publication Number Publication Date
JP2016516068A JP2016516068A (ja) 2016-06-02
JP2016516068A5 true JP2016516068A5 (https=) 2017-04-20
JP6572201B2 JP6572201B2 (ja) 2019-09-04

Family

ID=51529957

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016503207A Active JP6572201B2 (ja) 2013-03-15 2014-03-14 眼疾患を処置するための組成物、製剤、および方法
JP2019147238A Active JP6865254B2 (ja) 2013-03-15 2019-08-09 眼疾患を処置するための組成物、製剤、および方法
JP2021064106A Active JP7249374B2 (ja) 2013-03-15 2021-04-05 眼疾患を処置するための組成物、製剤、および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019147238A Active JP6865254B2 (ja) 2013-03-15 2019-08-09 眼疾患を処置するための組成物、製剤、および方法
JP2021064106A Active JP7249374B2 (ja) 2013-03-15 2021-04-05 眼疾患を処置するための組成物、製剤、および方法

Country Status (17)

Country Link
US (10) US9440963B2 (https=)
EP (3) EP2967066B1 (https=)
JP (3) JP6572201B2 (https=)
KR (1) KR20150129019A (https=)
CN (2) CN105307498B (https=)
AU (2) AU2014233363B2 (https=)
BR (1) BR112015023753A2 (https=)
CA (1) CA2903871A1 (https=)
ES (2) ES2766326T3 (https=)
GB (3) GB2540638B (https=)
HK (2) HK1206558A1 (https=)
IL (2) IL240786B (https=)
MX (1) MX371382B (https=)
MY (1) MY171945A (https=)
PH (2) PH12015502153B1 (https=)
SG (1) SG11201507131WA (https=)
WO (1) WO2014145068A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
DK3254676T3 (en) 2009-10-30 2019-03-11 Ix Biopharma Ltd QUICK-SOLVING SOLID DOSAGE FORM
US12186426B2 (en) 2009-10-30 2025-01-07 Ix Biopharma Ltd. Solid dosage form
EP3698794A1 (en) 2009-11-06 2020-08-26 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
US20180092883A1 (en) * 2010-10-07 2018-04-05 Aerpio Therapeutics, Inc. Phosphatase inhibitors for treating ocular diseases
JP5965409B2 (ja) 2010-12-08 2016-08-03 コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc 創傷滲出液を評価するための統合システム
CN103347562B (zh) 2010-12-08 2016-08-10 康沃特克科技公司 伤口分泌液系统附件
AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
EP3501536B1 (en) 2011-10-13 2025-12-24 EyePoint Pharmaceuticals, Inc. Treatment of ocular disease
SG11201502425WA (en) * 2012-10-11 2015-05-28 Ix Biopharma Ltd Solid dosage form
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
AU2014233363B2 (en) * 2013-03-15 2017-06-29 EyePoint, Inc. Compositions, formulations and methods for treating ocular diseases
JP6549140B2 (ja) 2014-02-19 2019-07-24 エアーピオ セラピューティクス インコーポレイテッド N−ベンジル−3−ヒドロキシ−4−置換ピリジン−2−(1h)−オン
EP3116503A4 (en) * 2014-03-14 2017-08-23 Aerpio Therapeutics, Inc. Hptp-beta inhibitors
WO2016022813A1 (en) 2014-08-07 2016-02-11 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of tie-2
ES2981607T3 (es) * 2015-09-23 2024-10-09 Eyepoint Pharmaceuticals Inc Activadores de Tie-2 para uso en el tratamiento de la presión intraocular
WO2017075814A1 (zh) * 2015-11-06 2017-05-11 华为技术有限公司 一种语音漫游方法,移动性管理网元及接入网网元
AU2017299581B2 (en) 2016-07-20 2024-05-23 EyePoint, Inc. Humanized monoclonal antibodies that target ve-ptp (hptp-β)
CN109996440A (zh) * 2016-10-21 2019-07-09 曼宁研究有限公司 Ve-ptp敲除
CN120058958A (zh) 2018-09-24 2025-05-30 视点制药公司 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体
CN114072205A (zh) * 2019-04-18 2022-02-18 视点制药公司 用tie-2激活剂治疗高血压的方法
EP3962482A4 (en) * 2019-04-29 2023-01-11 EyePoint Pharmaceuticals, Inc. TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL
CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
GB2589400A (en) * 2019-06-24 2021-06-02 Aerpio Pharmaceuticals Inc Formulations of tie-2 activators and methods of use thereof
US11613534B2 (en) 2019-10-29 2023-03-28 EyePoint Pharmaceuticals, Inc. Small molecule activators of Tie-2
EP4164690A1 (en) * 2020-06-16 2023-04-19 Amy Ripka Small molecule ve-ptp inhibitors
WO2022133232A1 (en) * 2020-12-18 2022-06-23 EyePoint Pharmaceuticals, Inc. Methods for manufacture of small molecule activators of tie-2
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2025128706A1 (en) * 2023-12-11 2025-06-19 Massachusetts Eye And Ear Infirmary Methods of using tie-2 activators

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078486A (en) 1989-10-13 1992-01-07 Evans David W Self-calibrating vision test apparatus
US5688781A (en) 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
WO1996031598A1 (en) 1995-04-06 1996-10-10 Regeneron Pharmaceuticals, Inc. Tie-2 ligands, methods of making and uses thereof
US20030040463A1 (en) 1996-04-05 2003-02-27 Wiegand Stanley J. TIE-2 ligands, methods of making and uses thereof
US6455031B1 (en) * 1997-06-18 2002-09-24 David G Davies Methods and compositions for controlling biofilm development
US5980929A (en) 1998-03-13 1999-11-09 Johns Hopkins University, School Of Medicine Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
US5919813C1 (en) 1998-03-13 2002-01-29 Univ Johns Hopkins Med Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
PT1165115E (pt) 1999-03-26 2003-10-31 Univ California Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2
US6455035B1 (en) * 1999-03-26 2002-09-24 Regeneron Pharmaceuticals, Inc. Angiopoietins and methods of use thereof
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
NZ536196A (en) 2000-06-23 2006-12-22 Schering Ag Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use (II)
CA2431319A1 (en) * 2000-12-11 2002-06-20 Hiroto Bando Pharmaceutical composition having an improved water solubility
SE518981C2 (sv) 2000-12-14 2002-12-17 Shl Medical Ab Autoinjektor
US7166435B2 (en) * 2001-08-06 2007-01-23 The Quigley Corporation Compositions and methods for reducing the transmissivity of illnesses
US20030158199A1 (en) * 2002-01-25 2003-08-21 Kylix, B.V. Novel compounds for inhibition of Tie-2
WO2003090686A2 (en) 2002-04-25 2003-11-06 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
US7226755B1 (en) 2002-09-25 2007-06-05 The Procter & Gamble Company HPTPbeta as a target in treatment of angiogenesis mediated disorders
US7507568B2 (en) 2002-09-25 2009-03-24 The Proctor & Gamble Company Three dimensional coordinates of HPTPbeta
AU2003279911A1 (en) * 2002-10-09 2004-05-04 Kosan Biosciences, Inc. Therapeutic formulations
US6946479B2 (en) 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
WO2004060373A1 (ja) * 2002-12-27 2004-07-22 Santen Pharmaceutical Co., Ltd. 滲出型加齢黄斑変性治療剤
WO2004091480A2 (en) 2003-04-09 2004-10-28 Exelixis, Inc. Tie-2 modulators and methods of use
MXPA05012723A (es) * 2003-05-30 2006-02-08 Genentech Inc Tratamiento con anticuerpos anti-vgf.
US20050059639A1 (en) 2003-09-11 2005-03-17 Wei Edward T. Ophthalmic compositions and method for treating eye discomfort and pain
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
JP2008509085A (ja) * 2004-06-02 2008-03-27 バルティオン テクニリーネン トゥトキムスケスクス T細胞タンパク質チロシンホスファターゼの活性化方法およびそれに基づく治療方法
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
HRP20100559T1 (hr) 2005-11-29 2010-11-30 Glaxosmithkline Llc Liječenje neovaskularnih poremećaja oka, poput makularne degeneracije, angioidnih strija, uveitisa i edema makule
CA2633211A1 (en) 2005-12-15 2007-06-21 Astrazeneca Ab Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
JP5133071B2 (ja) * 2006-02-09 2013-01-30 第一三共株式会社 抗癌医薬組成物
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US7795444B2 (en) 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
US8846685B2 (en) * 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7589212B2 (en) 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US20130023542A1 (en) 2006-06-27 2013-01-24 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
CN101583357B (zh) * 2006-08-29 2013-03-20 新加坡国立癌症中心 Mtor拮抗剂和血管生成抑制剂用于制备治疗癌症的药物的用途
PT2076290T (pt) 2006-10-27 2017-01-17 Sunnybrook Health Sciences Center Agonistas de tie 2 multiméricos e utilizações dos mesmos na estimulação da angiogénese
ES2365931T3 (es) 2006-12-13 2011-10-13 Shl Group Ab Inyector automático.
CN101678170B (zh) 2007-03-23 2012-05-30 Shl集团有限责任公司 自动注射器
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US11078262B2 (en) 2007-04-30 2021-08-03 Allergan, Inc. High viscosity macromolecular compositions for treating ocular conditions
DK2162170T3 (da) 2007-07-06 2011-06-14 Shl Group Ab Enkeltskudsinjektionssprøjte med dobbeltfjedre
JP4934841B2 (ja) 2007-09-18 2012-05-23 エス・ホー・エル・グループ・アクチボラゲット 針挿入を伴う自動注射装置
KR101710727B1 (ko) * 2008-03-31 2017-02-27 가부시키가이샤 시세이도 혈관의 성숙화, 정상화 또는 안정화제 및 주름 방지·개선제
ES2637346T3 (es) 2008-05-20 2017-10-11 Shl Group Ab Dispositivo de administración de medicamentos con un amortiguador
WO2009150071A1 (en) 2008-06-11 2009-12-17 Shl Group Ab Medicament delivery device
CN102813689B (zh) * 2008-06-18 2016-08-10 株式会社资生堂 淋巴管的稳定剂
WO2010010689A1 (ja) * 2008-07-22 2010-01-28 株式会社メニコン コンタクトレンズ用液剤
CN102246349A (zh) 2008-12-22 2011-11-16 株式会社藤仓 薄膜天线及其制造方法
SG10201702247SA (en) * 2009-01-12 2017-04-27 Aerpio Therapeutics Inc Methods for treating vascular leak syndrome
US9096555B2 (en) 2009-01-12 2015-08-04 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
US8883832B2 (en) 2009-07-06 2014-11-11 Aerpio Therapeutics Inc. Compounds, compositions, and methods for preventing metastasis of cancer cells
TWI393578B (zh) 2009-07-07 2013-04-21 Shl Group Ab 注射裝置
TW201105363A (en) * 2009-07-14 2011-02-16 Univ Yamagata Eye drop for macular edema treatment
EP3698794A1 (en) 2009-11-06 2020-08-26 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
JP2011201811A (ja) * 2010-03-25 2011-10-13 Shiseido Co Ltd Tie2活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤
US20110319455A1 (en) 2010-04-19 2011-12-29 Bruce Steven Klein Antifungal Treatment
US9186390B2 (en) * 2010-04-28 2015-11-17 Sunnybrook Health Sciences Center Methods and uses of TIE2 binding and/or activating agents
US20180092883A1 (en) 2010-10-07 2018-04-05 Aerpio Therapeutics, Inc. Phosphatase inhibitors for treating ocular diseases
US20120129847A1 (en) 2010-10-07 2012-05-24 Kevin Gene Peters Compositions and methods for treating ocular edema, neovascularization and related diseases
CN103249422A (zh) * 2010-12-02 2013-08-14 丸善制药株式会社 Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物
CN102532042A (zh) * 2010-12-30 2012-07-04 上海医药工业研究院 一种芳基脲类化合物、其中间体及其应用
CN103402582A (zh) * 2011-02-11 2013-11-20 普西维达公司 使用抗水肿疗法治疗黄斑水肿的方法
EP3501536B1 (en) 2011-10-13 2025-12-24 EyePoint Pharmaceuticals, Inc. Treatment of ocular disease
AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
AU2014233363B2 (en) 2013-03-15 2017-06-29 EyePoint, Inc. Compositions, formulations and methods for treating ocular diseases
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
US20160151410A1 (en) 2013-07-02 2016-06-02 The Trustees Of Columbia University In The City Of New York Clearance of bioactive lipids from membrane structures by cyclodextrins
JP6549140B2 (ja) 2014-02-19 2019-07-24 エアーピオ セラピューティクス インコーポレイテッド N−ベンジル−3−ヒドロキシ−4−置換ピリジン−2−(1h)−オン
EP3116503A4 (en) 2014-03-14 2017-08-23 Aerpio Therapeutics, Inc. Hptp-beta inhibitors
US9719135B2 (en) * 2014-07-03 2017-08-01 Mannin Research Inc. Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system

Similar Documents

Publication Publication Date Title
JP2016516068A5 (https=)
JP2018528273A5 (https=)
Fernandez et al. N-Succinyl-(β-alanyl-l-leucyl-l-alanyl-l-leucyl) doxorubicin: an extracellularly tumor-activated prodrug devoid of intravenous acute toxicity
US20050085446A1 (en) Fluoroquinolone formulations and methods of making and using the same
JP6968921B2 (ja) 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション
JP2018518537A5 (https=)
JP2015503635A (ja) フマギリン誘導体phf複合体の医薬品配合物
AU2014273983A1 (en) Cyclodextrin-based polymers for the therapeutic delivery
JP2010524963A5 (https=)
JP2015071624A (ja) 治療的送達のためのシクロデキストリンに基づく重合体
RU2015143898A (ru) Офтальмологические составы для доставки лекарственных средств к заднему сегменту глаза
US20190142957A1 (en) Stable compositions of pegylated carfilzomib compounds
JP2019511497A5 (https=)
US20220226444A1 (en) Formulations of fosaprepitant and aprepitant
JP2017506640A5 (https=)
JP2024112842A (ja) Mcl1タンパク質を阻害する化合物を投与するための製剤及び投与量
JP2020526497A (ja) 合成バイオコンジュゲート
CN110876259A (zh) 注射用组合物
US10660906B2 (en) Hyaluronan conjugates with pharmaceutically active substances, methods and compositions
US20070049552A1 (en) Fluoroquinolone formulations and methods of making and using the same
JP2013532664A5 (https=)
JP2018536650A5 (https=)
US20130196946A1 (en) Cyclodextrin-based polymers for therapeutic delivery
ES2749053T3 (es) Polimixinas de baja sustitución y sus composiciones
US20210228577A1 (en) Substituted cyclodextrin-metal complexes and uses thereof