JP2019511497A5 - - Google Patents

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Publication number
JP2019511497A5
JP2019511497A5 JP2018548652A JP2018548652A JP2019511497A5 JP 2019511497 A5 JP2019511497 A5 JP 2019511497A5 JP 2018548652 A JP2018548652 A JP 2018548652A JP 2018548652 A JP2018548652 A JP 2018548652A JP 2019511497 A5 JP2019511497 A5 JP 2019511497A5
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JP
Japan
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optionally substituted
alkyl
aryl
heteroaryl
heteroarylalkyl
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JP2018548652A
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English (en)
Japanese (ja)
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JP7017248B2 (ja
JP2019511497A (ja
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Priority claimed from PCT/US2017/022791 external-priority patent/WO2017161174A1/en
Publication of JP2019511497A publication Critical patent/JP2019511497A/ja
Publication of JP2019511497A5 publication Critical patent/JP2019511497A5/ja
Application granted granted Critical
Publication of JP7017248B2 publication Critical patent/JP7017248B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018548652A 2016-03-16 2017-03-16 エキセナチド類似体の持続放出コンジュゲート Expired - Fee Related JP7017248B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662309330P 2016-03-16 2016-03-16
US62/309,330 2016-03-16
US201662416058P 2016-11-01 2016-11-01
US62/416,058 2016-11-01
PCT/US2017/022791 WO2017161174A1 (en) 2016-03-16 2017-03-16 Extended release conjugates of exenatide analogs

Publications (3)

Publication Number Publication Date
JP2019511497A JP2019511497A (ja) 2019-04-25
JP2019511497A5 true JP2019511497A5 (https=) 2020-04-30
JP7017248B2 JP7017248B2 (ja) 2022-02-08

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ID=59852218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018548652A Expired - Fee Related JP7017248B2 (ja) 2016-03-16 2017-03-16 エキセナチド類似体の持続放出コンジュゲート

Country Status (13)

Country Link
US (1) US20200164083A1 (https=)
EP (2) EP3922269A1 (https=)
JP (1) JP7017248B2 (https=)
KR (1) KR20180129825A (https=)
CN (1) CN109414469A (https=)
AU (2) AU2017234680A1 (https=)
BR (1) BR112018068639A2 (https=)
CA (1) CA3016814A1 (https=)
MX (1) MX2018011149A (https=)
RU (1) RU2764547C2 (https=)
SG (1) SG11201807832VA (https=)
WO (1) WO2017161174A1 (https=)
ZA (2) ZA201805953B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10745456B2 (en) * 2015-04-01 2020-08-18 The Scripps Research Institute Methods and compositions related to GPCR agonist polypeptides
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
WO2020206358A1 (en) 2019-04-05 2020-10-08 Prolynx Llc Improved conjugation linkers
EP4010041A4 (en) * 2019-08-07 2024-12-11 Prolynx LLC Steam sterilization of hydrogels crosslinked by beta-eliminative linkers
WO2022115563A1 (en) * 2020-11-25 2022-06-02 Prolynx Llc Extended release hydrogel conjugates of c-natriuretic peptides
US12576400B2 (en) 2021-01-08 2026-03-17 Cellanome, Inc. Methods for incubating and analyzing a cell in a compartment of a fluidic device
JP2024502618A (ja) 2021-01-08 2024-01-22 セラノーム， インコーポレイテッド 生体試料を分析するためのデバイスおよび方法
WO2025128916A1 (en) * 2023-12-13 2025-06-19 Cellanome, Inc. Devices and methods for analyzing biological samples
KR102716759B1 (ko) 2023-12-20 2024-10-15 (주)인벤티지랩 엑세나타이드를 포함하는 서방형 주사제 조성물 및 이의 제조 방법
WO2026020143A1 (en) * 2024-07-19 2026-01-22 Prolynx Llc Extended-release conjugates of lipidated peptides, and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1143989T3 (da) * 1999-01-14 2007-04-16 Amylin Pharmaceuticals Inc Exendiner til glucagonundertrykkelse
JP2006501820A (ja) * 2002-09-06 2006-01-19 バイエル・フアーマシユーチカルズ・コーポレーシヨン 修飾ｇｌｐ−１受容体アゴニストおよびそれらの薬理学的使用法
AU2003268621B2 (en) 2002-10-02 2009-01-15 Zealand Pharma A/S Stabilized exendin-4 compounds
CA2603630C (en) * 2005-01-14 2015-06-09 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exendins and uses thereof
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
CN101125207B (zh) * 2006-11-14 2012-09-05 上海华谊生物技术有限公司 带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途
WO2008116294A1 (en) 2007-03-23 2008-10-02 Matregen Corp. Exendin analogs
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
WO2010017215A2 (en) * 2008-08-04 2010-02-11 The Regents Of The University Of California Biodegradable microspheres and methods of use thereof
NZ599847A (en) * 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
EP2566334B1 (en) * 2010-05-05 2018-04-18 Prolynx, LLC Controlled drug release from solid supports
EP2566335B1 (en) * 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates
US8703907B2 (en) 2010-05-05 2014-04-22 Prolynx Llc Controlled drug release from dendrimers
WO2011156407A2 (en) * 2010-06-09 2011-12-15 Amylin Pharmaceuticals, Inc. Glp-1 receptor agonists to treat pancre-atitis
KR102109067B1 (ko) 2011-09-07 2020-05-13 프로린크스 엘엘시 생분해성 교차결합을 가지는 하이드로젤
US20140256626A1 (en) * 2011-10-18 2014-09-11 Prolynx Llc Peg conjugates of exenatide

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