CN109925312A - 用于治疗眼病的组合物、制剂和方法 - Google Patents

用于治疗眼病的组合物、制剂和方法 Download PDF

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Publication number
CN109925312A
CN109925312A CN201910221542.4A CN201910221542A CN109925312A CN 109925312 A CN109925312 A CN 109925312A CN 201910221542 A CN201910221542 A CN 201910221542A CN 109925312 A CN109925312 A CN 109925312A
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base
ethyl
thiazole
phenyl
group
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Chinese (zh)
Inventor
K·彼得斯
R·塞尔维茨
约翰·雅努什
亚历山大·史密斯
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Viewpoint Pharmaceutical Co
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Akebia Therapeutics Inc
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Publication of CN109925312A publication Critical patent/CN109925312A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
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CN201910221542.4A 2013-03-15 2014-03-14 用于治疗眼病的组合物、制剂和方法 Pending CN109925312A (zh)

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US201361792868P 2013-03-15 2013-03-15
US201361792679P 2013-03-15 2013-03-15
US61/792,679 2013-03-15
US61/792,868 2013-03-15
US201361882056P 2013-09-25 2013-09-25
US201361882048P 2013-09-25 2013-09-25
US61/882,048 2013-09-25
US61/882,056 2013-09-25
US201461934570P 2014-01-31 2014-01-31
US61/934,570 2014-01-31
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US (10) US9440963B2 (https=)
EP (3) EP2967066B1 (https=)
JP (3) JP6572201B2 (https=)
KR (1) KR20150129019A (https=)
CN (2) CN109925312A (https=)
AU (2) AU2014233363B2 (https=)
BR (1) BR112015023753A2 (https=)
CA (1) CA2903871A1 (https=)
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GB (3) GB2549865B (https=)
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