JP2016515576A5

JP2016515576A5 -

Download PDF

Info

Publication number: JP2016515576A5
Authority: JP; Japan
Prior art keywords: less; dry powder; microns; tiotropium; dry
Prior art date: 2014-03-13
Legal status : Granted

Application number

JP2016505482A

Other languages

English (en)

Japanese (ja)

Other versions

JP6473738B2 (ja

JP2016515576A (ja

Filing date

2014-03-13

Publication date

2017-04-20

2014-03-13 Application filed filed Critical

2014-03-13 Priority claimed from PCT/US2014/025660 external-priority patent/WO2014165303A1/en

2016-05-30 Publication of JP2016515576A publication Critical patent/JP2016515576A/ja

2017-04-20 Publication of JP2016515576A5 publication Critical patent/JP2016515576A5/ja

2019-02-20 Application granted granted Critical

2019-02-20 Publication of JP6473738B2 publication Critical patent/JP6473738B2/ja

Status Active legal-status Critical Current

2034-03-13 Anticipated expiration legal-status Critical

Links

239000000843 powder Substances 0.000 claims 41
239000002245 particle Substances 0.000 claims 25
229940110309 tiotropium Drugs 0.000 claims 21
LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 21
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 16
239000003814 drug Substances 0.000 claims 14
229940124597 therapeutic agent Drugs 0.000 claims 14
229940112141 dry powder inhaler Drugs 0.000 claims 12
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 8
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 8
229960001469 fluticasone furoate Drugs 0.000 claims 8
XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 8
239000008194 pharmaceutical composition Substances 0.000 claims 8
239000011780 sodium chloride Substances 0.000 claims 8
BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 6
208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 6
239000002775 capsule Substances 0.000 claims 6
LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 4
LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 4
201000003883 Cystic fibrosis Diseases 0.000 claims 4
229960003728 ciclesonide Drugs 0.000 claims 4
239000010419 fine particle Substances 0.000 claims 4
229960002744 mometasone furoate Drugs 0.000 claims 4
WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 4
208000023504 respiratory system disease Diseases 0.000 claims 4
229960000257 tiotropium bromide Drugs 0.000 claims 4
239000003246 corticosteroid Substances 0.000 claims 3
229960001334 corticosteroids Drugs 0.000 claims 3
239000011859 microparticle Substances 0.000 claims 3
SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 claims 2
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
208000006673 asthma Diseases 0.000 claims 2
201000009267 bronchiectasis Diseases 0.000 claims 2
229960002714 fluticasone Drugs 0.000 claims 2
MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
230000009798 acute exacerbation Effects 0.000 claims 1
229940124599 anti-inflammatory drug Drugs 0.000 claims 1
229940125389 long-acting beta agonist Drugs 0.000 claims 1
229940125390 short-acting beta agonist Drugs 0.000 claims 1

JP2016505482A 2013-04-01 2014-03-13 チオトロピウム乾燥粉末 Active JP6473738B2 (ja)