JP2016514956A5 - - Google Patents
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- JP2016514956A5 JP2016514956A5 JP2015561624A JP2015561624A JP2016514956A5 JP 2016514956 A5 JP2016514956 A5 JP 2016514956A5 JP 2015561624 A JP2015561624 A JP 2015561624A JP 2015561624 A JP2015561624 A JP 2015561624A JP 2016514956 A5 JP2016514956 A5 JP 2016514956A5
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- JP
- Japan
- Prior art keywords
- vector
- cell
- pharmaceutical composition
- binds
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013598 vector Substances 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 9
- 239000013603 viral vector Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 3
- 241000702421 Dependoparvovirus Species 0.000 claims 3
- 108010055196 EphA2 Receptor Proteins 0.000 claims 3
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 3
- 241000713666 Lentivirus Species 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 241000701161 unidentified adenovirus Species 0.000 claims 3
- 241001430294 unidentified retrovirus Species 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000000174 oncolytic effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361772803P | 2013-03-05 | 2013-03-05 | |
| US61/772,803 | 2013-03-05 | ||
| US201361775524P | 2013-03-09 | 2013-03-09 | |
| US61/775,524 | 2013-03-09 | ||
| US201461928383P | 2014-01-16 | 2014-01-16 | |
| US61/928,383 | 2014-01-16 | ||
| US201461941729P | 2014-02-19 | 2014-02-19 | |
| US61/941,729 | 2014-02-19 | ||
| PCT/US2014/020919 WO2014138306A1 (en) | 2013-03-05 | 2014-03-05 | Engager cells for immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193647A Division JP6867347B2 (ja) | 2013-03-05 | 2018-10-12 | 免疫療法のためのエンゲージャー細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016514956A JP2016514956A (ja) | 2016-05-26 |
| JP2016514956A5 true JP2016514956A5 (enExample) | 2017-03-30 |
| JP6420776B2 JP6420776B2 (ja) | 2018-11-07 |
Family
ID=51491924
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561624A Expired - Fee Related JP6420776B2 (ja) | 2013-03-05 | 2014-03-05 | 免疫療法のためのエンゲージャー細胞 |
| JP2018193647A Expired - Fee Related JP6867347B2 (ja) | 2013-03-05 | 2018-10-12 | 免疫療法のためのエンゲージャー細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193647A Expired - Fee Related JP6867347B2 (ja) | 2013-03-05 | 2018-10-12 | 免疫療法のためのエンゲージャー細胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20160015749A1 (enExample) |
| EP (2) | EP2964675B1 (enExample) |
| JP (2) | JP6420776B2 (enExample) |
| AU (1) | AU2014225788B2 (enExample) |
| CA (1) | CA2904230A1 (enExample) |
| ES (1) | ES2681948T3 (enExample) |
| WO (1) | WO2014138306A1 (enExample) |
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| LT2647707T (lt) | 2010-11-30 | 2018-11-12 | Chugai Seiyaku Kabushiki Kaisha | Citotoksiškumą indukuojantis terapinis agentas |
| WO2014138314A1 (en) * | 2013-03-05 | 2014-09-12 | Baylor College Of Medicine | Oncolytic virus |
| MX380176B (es) | 2014-04-07 | 2025-03-12 | Chugai Pharmaceutical Co Ltd | Molecula ligada a antigeno inmunoactivada. |
| US11505605B2 (en) | 2014-05-13 | 2022-11-22 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| KR20170074243A (ko) * | 2014-10-31 | 2017-06-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 변형된 t 세포의 생성 방법 및 조성물 |
| JP6779873B2 (ja) | 2014-11-12 | 2020-11-04 | メモリアル スローン ケタリング キャンサー センター | 抗コンドロイチン硫酸プロテオグリカン４抗体およびその使用 |
| US10865245B2 (en) | 2014-12-23 | 2020-12-15 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
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| KR20180029201A (ko) | 2015-05-18 | 2018-03-20 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법 |
| CN111234027A (zh) | 2015-05-21 | 2020-06-05 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| KR20240013282A (ko) * | 2015-06-10 | 2024-01-30 | 이뮤너티바이오, 인크. | 암을 치료하기 위한 변형된 nk-92 세포 |
| JP6920786B2 (ja) * | 2015-08-26 | 2021-08-18 | ドイチェス クレブスフォルシュンクスツェントルム | 免疫ウイルス療法のためのｒｎａウイルス |
| EP3340998B1 (en) * | 2015-08-28 | 2023-01-11 | The Trustees of the University of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| CA3001185A1 (en) * | 2015-10-06 | 2017-04-13 | Regents Of The University Of Minnesota | Nk engaging compounds and methods |
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| JP6931329B2 (ja) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法 |
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| SG10202104509PA (en) * | 2016-03-19 | 2021-06-29 | Exuma Biotech Corp | Methods and compositions for transducing lymphocytes and regulated expansion thereof |
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| JP6812551B2 (ja) | 2016-11-23 | 2021-01-13 | ハープーン セラピューティクス，インク． | 前立腺特異的膜抗原結合タンパク質 |
| JP7215997B2 (ja) | 2016-11-23 | 2023-01-31 | ハープーン セラピューティクス，インク． | 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法 |
| US12473343B2 (en) | 2017-01-10 | 2025-11-18 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
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| CA3063359A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
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| US12259379B2 (en) | 2017-06-30 | 2025-03-25 | Osaka University | Method for predicting effect of tumor immunotherapy using tumor cytotoxic activity of peripheral blood T cells as index |
| US11525004B2 (en) * | 2017-07-20 | 2022-12-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Recombinant CD123-binding antibodies |
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| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| UA129446C2 (uk) | 2017-10-13 | 2025-04-30 | Гарпун Терап'Ютікс, Інк. | Триспецифічні білки і способи їх застосування |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
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| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| AU2019297451A1 (en) | 2018-07-03 | 2021-01-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| CA3114707A1 (en) | 2018-10-19 | 2020-04-23 | Regents Of The University Of Minnesota | Nk engager molecules and methods of use thereof |
| EP3870297B1 (en) * | 2018-10-25 | 2023-08-30 | Baylor College of Medicine | Oncolytic virotherapy and immunotherapy |
| HUE068630T2 (hu) * | 2018-12-10 | 2025-01-28 | Amgen Inc | Mutáns PiggyBac transzpozáz |
| AU2019397152A1 (en) * | 2018-12-14 | 2021-06-24 | 2Seventy Bio, Inc. | Dimerizing agent regulated immunoreceptor complexes |
| CN113474458A (zh) * | 2019-01-30 | 2021-10-01 | 威斯塔解剖学和生物学研究所 | 靶向癌症抗原的dna编码的双特异性t细胞连接子以及在癌症治疗中的使用方法 |
| EP3927747A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
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| US20220184129A1 (en) * | 2019-04-12 | 2022-06-16 | The Trustees Of The University Of Pennsylvania | Compositions and Methods Comprising a High Affinity Chimeric Antigen Receptor (CAR) with Cross-Reactivity to Clinically-Relevant EGFR Mutated Proteins |
| CN111001016B (zh) * | 2019-12-20 | 2022-06-17 | 中国人民解放军陆军军医大学 | 一种vha抑制dr5在缺氧下精子生成减少的检测方法 |
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| IL295129A (en) * | 2020-01-30 | 2022-09-01 | Umoja Biopharma Inc | Bispecific transduction enhancer |
| EP3865513A1 (en) * | 2020-02-17 | 2021-08-18 | Fundación Para La Investigación Biomédica Del Hospital 12 De Octubre | Anti-cd19/anti-cd3 bispecific antibody, t cells secreting the same, method of preparation and use thereof |
| IL295448A (en) | 2020-02-21 | 2022-10-01 | Harpoon Therapeutics Inc | flt3 binding proteins and methods of use |
| CN113481165B (zh) * | 2020-07-16 | 2022-06-03 | 山东博安生物技术股份有限公司 | 分泌双特异性t细胞衔接子的car-t及治疗实体肿瘤的应用 |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
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| KR102532260B1 (ko) * | 2022-07-07 | 2023-05-16 | 주식회사 유틸렉스 | 돌연변이 EGFR 및 EphA2를 동시 타겟하는 키메라 항원 수용체 |
| WO2024010119A1 (ko) * | 2022-07-07 | 2024-01-11 | 주식회사 유틸렉스 | 돌연변이 egfr 및 epha2를 동시 타겟하는 키메라 항원 수용체 |
| WO2024040261A1 (en) * | 2022-08-19 | 2024-02-22 | The Children's Hospital Of Philadelphia | Gd2 bi-specific invariant natural killer t cell engagers and methods of use thereof |
| WO2025101551A1 (en) * | 2023-11-06 | 2025-05-15 | Regents Of The University Of Minnesota | Prostate-specific membrane antigen (psma)-binding peptides and method of use |
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| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| GB9304200D0 (en) | 1993-03-02 | 1993-04-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| FR2724320B1 (fr) * | 1994-09-13 | 1996-12-20 | Transgene Sa | Nouvel implant pour le traitement des maladies acquises |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
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| KR20080090441A (ko) * | 2005-12-21 | 2008-10-08 | 메디뮨 엘엘씨 | Ｅｐｈａ２ ｂｉｔｅ 분자 및 이의 용도 |
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| BRPI0919840B1 (pt) * | 2008-10-01 | 2023-02-28 | Amgen Research (Munich) Gmbh | Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende |
| EP2640750A1 (en) * | 2010-11-16 | 2013-09-25 | Boehringer Ingelheim International GmbH | Agents and methods for treating diseases that correlate with bcma expression |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| CN104583230A (zh) | 2012-07-13 | 2015-04-29 | 宾夕法尼亚大学董事会 | 通过共同引入双特异性抗体增强car t细胞的活性 |
-
2014
- 2014-03-05 JP JP2015561624A patent/JP6420776B2/ja not_active Expired - Fee Related
- 2014-03-05 WO PCT/US2014/020919 patent/WO2014138306A1/en not_active Ceased
- 2014-03-05 EP EP14714473.7A patent/EP2964675B1/en not_active Revoked
- 2014-03-05 ES ES14714473.7T patent/ES2681948T3/es active Active
- 2014-03-05 US US14/773,327 patent/US20160015749A1/en not_active Abandoned
- 2014-03-05 CA CA2904230A patent/CA2904230A1/en not_active Abandoned
- 2014-03-05 EP EP18171595.4A patent/EP3447072A3/en not_active Withdrawn
- 2014-03-05 AU AU2014225788A patent/AU2014225788B2/en not_active Ceased
-
2018
- 2018-08-22 US US16/109,615 patent/US20190117692A1/en not_active Abandoned
- 2018-10-12 JP JP2018193647A patent/JP6867347B2/ja not_active Expired - Fee Related
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