JP2016513094A5 - - Google Patents
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- JP2016513094A5 JP2016513094A5 JP2015556574A JP2015556574A JP2016513094A5 JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5 JP 2015556574 A JP2015556574 A JP 2015556574A JP 2015556574 A JP2015556574 A JP 2015556574A JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5
- Authority
- JP
- Japan
- Prior art keywords
- dll3
- cancer
- fragments
- level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100036466 Delta-like protein 3 Human genes 0.000 claims 32
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 32
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000012544 monitoring process Methods 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 239000003560 cancer drug Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1302447.6 | 2013-02-12 | ||
| GBGB1302447.6A GB201302447D0 (en) | 2013-02-12 | 2013-02-12 | Therapeutic and diagnostic target |
| PCT/GB2014/050407 WO2014125273A1 (en) | 2013-02-12 | 2014-02-12 | Therapeutic and diagnostic target for cancer comprising dll3 binding reagents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513094A JP2016513094A (ja) | 2016-05-12 |
| JP2016513094A5 true JP2016513094A5 (enExample) | 2017-03-16 |
| JP6654046B2 JP6654046B2 (ja) | 2020-02-26 |
Family
ID=47998983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556574A Active JP6654046B2 (ja) | 2013-02-12 | 2014-02-12 | Ｄｌｌ３結合試薬を含む治療薬及び診断薬の癌標的 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20160032006A1 (enExample) |
| EP (2) | EP2956483B1 (enExample) |
| JP (1) | JP6654046B2 (enExample) |
| KR (1) | KR102167550B1 (enExample) |
| CN (1) | CN105143266B (enExample) |
| AU (1) | AU2014217611B2 (enExample) |
| CA (1) | CA2900134A1 (enExample) |
| CL (1) | CL2015002223A1 (enExample) |
| DK (1) | DK2956483T3 (enExample) |
| EA (1) | EA034182B1 (enExample) |
| ES (1) | ES2813360T3 (enExample) |
| GB (1) | GB201302447D0 (enExample) |
| HU (1) | HUE050828T2 (enExample) |
| IL (1) | IL239983B (enExample) |
| MX (1) | MX370597B (enExample) |
| PH (1) | PH12015501744A1 (enExample) |
| PL (1) | PL2956483T3 (enExample) |
| WO (1) | WO2014125273A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104520324A (zh) | 2012-02-24 | 2015-04-15 | 施特姆森特Rx股份有限公司 | Dll3调节剂及其使用方法 |
| RU2016111137A (ru) * | 2013-08-28 | 2017-10-03 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Сконструированные конъюгаты против dll3 и способы применения |
| BR112016004242A8 (pt) | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Métodos para conjugação sítio-específica de anticorpos e composições |
| AU2015218633A1 (en) | 2014-02-21 | 2016-09-01 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
| AR101400A1 (es) * | 2014-07-31 | 2016-12-14 | Amgen Res Munich Gmbh | Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido |
| WO2016016859A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
| MA41613A (fr) * | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| WO2016187594A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI793062B (zh) * | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Ｄｌｌ３及ｃｄ３抗體構築體 |
| US10781264B2 (en) | 2016-02-03 | 2020-09-22 | Amgen Research (Munich) Gmbh | PSMA and CD3 bispecific T cell engaging antibody constructs |
| EA039325B1 (ru) * | 2016-02-03 | 2022-01-13 | Эмджен Рисерч (Мюник) Гмбх | Конструкции биспецифических антител, связывающиеся с дпб3 (dll3) и кд3 (cd3) |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| CN110997722B (zh) | 2017-06-08 | 2023-09-26 | 黑带医疗有限公司 | Cd38调节抗体 |
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| SG11202000321PA (en) | 2017-08-16 | 2020-02-27 | Black Belt Therapeutics Ltd | Cd38 modulating antibody |
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| US11667713B2 (en) | 2017-12-28 | 2023-06-06 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
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| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| CN110412179A (zh) * | 2018-04-26 | 2019-11-05 | 缪荣明 | 一种液相色谱检测颗粒酶a的方法 |
| BR112020021280A2 (pt) | 2018-05-08 | 2021-01-26 | Phanes Therapeutics, Inc. | anticorpos anti-dll3 e usos dos mesmos |
| TWI848953B (zh) | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| CA3114038A1 (en) * | 2018-09-25 | 2020-04-02 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| SG11202102882YA (en) | 2018-09-28 | 2021-04-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule comprising altered antibody variable region |
| TW202028245A (zh) * | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CN114127111B (zh) | 2019-02-21 | 2024-09-10 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| EP3908679A1 (en) * | 2019-03-08 | 2021-11-17 | OncoLab Diagnostics GmbH | Cancer diagnosis and prognosis |
| WO2020210067A1 (en) * | 2019-04-08 | 2020-10-15 | Phanes Therapeutics, Inc. | Humanized anti-dll3 chimeric antigen receptors and uses thereof |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN115380047A (zh) | 2020-01-29 | 2022-11-22 | 印希比股份有限公司 | Cd28单结构域抗体及其多价和多特异性构建体 |
| US12486331B2 (en) | 2020-01-31 | 2025-12-02 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| US11976133B2 (en) * | 2020-01-31 | 2024-05-07 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| MX2022012091A (es) | 2020-03-31 | 2022-10-13 | Chugai Pharmaceutical Co Ltd | Moleculas de union al antigeno multiespecificas dirigidas a ligando de tipo delta 3 (dll3) y sus usos. |
| AU2022217274A1 (en) * | 2021-02-05 | 2023-07-27 | Phanes Therapeutics, Inc. | Bispecific antibodies with charge pairs and uses thereof |
| MX2024003331A (es) * | 2021-09-17 | 2024-06-19 | Wuxi Biologics Ireland Ltd | Moleculas de union a d3 y usos de estas. |
| KR20250036727A (ko) * | 2022-05-04 | 2025-03-14 | 얼리 인크. | 질환에 걸린 세포를 국재화시키고/거나 치료하기 위한 표면-발현가능한 활성화가능한 에피토프를 사용하는 방법 |
| WO2025061132A1 (en) * | 2023-09-21 | 2025-03-27 | Concept To Medicine Biotech Co., Ltd. | Anti-dll3 antibodies and uses thereof |
| WO2025163082A1 (en) * | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Dll3-specific binding constructs and their use in radiotherapy |
| WO2025190281A1 (en) * | 2024-03-11 | 2025-09-18 | Lepu Biopharma Co., Ltd. | Anti-dll3 antibodies and uses thereof |
| CN120168667A (zh) * | 2025-03-18 | 2025-06-20 | 中国科学院近代物理研究所 | 一种多肽在制备dll3过度表达的肿瘤的特异性靶向分子探针中的应用 |
| CN119841904A (zh) * | 2025-03-18 | 2025-04-18 | 中国科学院近代物理研究所 | 一种dll3亲和肽及其应用 |
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-
2013
- 2013-02-12 GB GBGB1302447.6A patent/GB201302447D0/en not_active Ceased
-
2014
- 2014-02-12 MX MX2015010372A patent/MX370597B/es active IP Right Grant
- 2014-02-12 US US14/766,992 patent/US20160032006A1/en not_active Abandoned
- 2014-02-12 AU AU2014217611A patent/AU2014217611B2/en not_active Ceased
- 2014-02-12 CN CN201480020452.4A patent/CN105143266B/zh active Active
- 2014-02-12 DK DK14705561.0T patent/DK2956483T3/da active
- 2014-02-12 KR KR1020157024805A patent/KR102167550B1/ko not_active Expired - Fee Related
- 2014-02-12 EP EP14705561.0A patent/EP2956483B1/en not_active Revoked
- 2014-02-12 JP JP2015556574A patent/JP6654046B2/ja active Active
- 2014-02-12 PL PL14705561T patent/PL2956483T3/pl unknown
- 2014-02-12 CA CA2900134A patent/CA2900134A1/en not_active Abandoned
- 2014-02-12 WO PCT/GB2014/050407 patent/WO2014125273A1/en not_active Ceased
- 2014-02-12 HU HUE14705561A patent/HUE050828T2/hu unknown
- 2014-02-12 EA EA201500835A patent/EA034182B1/ru not_active IP Right Cessation
- 2014-02-12 EP EP20175944.6A patent/EP3736293A1/en not_active Withdrawn
- 2014-02-12 ES ES14705561T patent/ES2813360T3/es active Active
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2015
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- 2015-08-07 PH PH12015501744A patent/PH12015501744A1/en unknown
- 2015-08-07 CL CL2015002223A patent/CL2015002223A1/es unknown
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2018
- 2018-03-07 US US15/914,432 patent/US20180201691A1/en not_active Abandoned
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2020
- 2020-11-20 US US16/953,459 patent/US20210079114A1/en not_active Abandoned
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