JP2016513094A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016513094A5 JP2016513094A5 JP2015556574A JP2015556574A JP2016513094A5 JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5 JP 2015556574 A JP2015556574 A JP 2015556574A JP 2015556574 A JP2015556574 A JP 2015556574A JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5
- Authority
- JP
- Japan
- Prior art keywords
- dll3
- cancer
- fragments
- level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100036466 Delta-like protein 3 Human genes 0.000 claims 32
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 32
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000012544 monitoring process Methods 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 239000003560 cancer drug Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1302447.6 | 2013-02-12 | ||
| GBGB1302447.6A GB201302447D0 (en) | 2013-02-12 | 2013-02-12 | Therapeutic and diagnostic target |
| PCT/GB2014/050407 WO2014125273A1 (en) | 2013-02-12 | 2014-02-12 | Therapeutic and diagnostic target for cancer comprising dll3 binding reagents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513094A JP2016513094A (ja) | 2016-05-12 |
| JP2016513094A5 true JP2016513094A5 (enExample) | 2017-03-16 |
| JP6654046B2 JP6654046B2 (ja) | 2020-02-26 |
Family
ID=47998983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556574A Active JP6654046B2 (ja) | 2013-02-12 | 2014-02-12 | Ｄｌｌ３結合試薬を含む治療薬及び診断薬の癌標的 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20160032006A1 (enExample) |
| EP (2) | EP3736293A1 (enExample) |
| JP (1) | JP6654046B2 (enExample) |
| KR (1) | KR102167550B1 (enExample) |
| CN (1) | CN105143266B (enExample) |
| AU (1) | AU2014217611B2 (enExample) |
| CA (1) | CA2900134A1 (enExample) |
| CL (1) | CL2015002223A1 (enExample) |
| DK (1) | DK2956483T3 (enExample) |
| EA (1) | EA034182B1 (enExample) |
| ES (1) | ES2813360T3 (enExample) |
| GB (1) | GB201302447D0 (enExample) |
| HU (1) | HUE050828T2 (enExample) |
| IL (1) | IL239983B (enExample) |
| MX (1) | MX370597B (enExample) |
| PH (1) | PH12015501744A1 (enExample) |
| PL (1) | PL2956483T3 (enExample) |
| WO (1) | WO2014125273A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037021T2 (hu) | 2012-02-24 | 2018-08-28 | Abbvie Stemcentrx Llc | DLL3- modulátorok és eljárások alkalmazásukra |
| KR20160044042A (ko) | 2013-08-28 | 2016-04-22 | 스템센트알엑스 인코포레이티드 | 부위-특이적 항체 접합 방법 및 조성물 |
| WO2015031693A1 (en) * | 2013-08-28 | 2015-03-05 | Stem Centrx, Inc. | Engineered anti-dll3 conjugates and methods of use |
| EA201691683A1 (ru) | 2014-02-21 | 2017-04-28 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Антитела против dll3 и конъюгаты антитело-лекарственное средство для применения при меланоме |
| MX377344B (es) | 2014-07-31 | 2025-03-07 | Amgen Res Munich Gmbh | Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas. |
| EP3174903B1 (en) * | 2014-07-31 | 2024-04-10 | Amgen Research (Munich) GmbH | Bispecific single chain antibody construct with enhanced tissue distribution |
| MA41613A (fr) * | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| EA039859B1 (ru) * | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究（慕尼黑）公司 | Dll3及cd3抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| EA039325B1 (ru) * | 2016-02-03 | 2022-01-13 | Эмджен Рисерч (Мюник) Гмбх | Конструкции биспецифических антител, связывающиеся с дпб3 (dll3) и кд3 (cd3) |
| CN114716557A (zh) | 2016-02-03 | 2022-07-08 | 安进研发（慕尼黑）股份有限公司 | Psma和cd3双特异性t细胞接合抗体构建体 |
| WO2018224685A1 (en) * | 2017-06-08 | 2018-12-13 | Tusk Therapeutics Ltd | Cd38 modulating antibody |
| WO2019034752A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | CD38 MODULATOR ANTIBODY |
| WO2019034753A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | ANTIBODY CD38 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN BINDING MOLECULE INCLUDING A VARIABLE REGION OF MODIFIED ANTIBODIES BINDING TO CD3 AND CD137 |
| TWI817974B (zh) * | 2017-12-28 | 2023-10-11 | 日商中外製藥股份有限公司 | 細胞毒性誘導治療劑 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| CN110412179A (zh) * | 2018-04-26 | 2019-11-05 | 缪荣明 | 一种液相色谱检测颗粒酶a的方法 |
| MX2020011914A (es) | 2018-05-08 | 2021-01-29 | Phanes Therapeutics Inc | Anticuerpos anti-dll3 y usos de los mismos. |
| TWI848953B (zh) * | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| IL297931B2 (en) | 2018-09-25 | 2025-03-01 | Harpoon Therapeutics Inc | DLL3 binding proteins and methods of use |
| WO2020067399A1 (en) | 2018-09-28 | 2020-04-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region |
| CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CN114026122B (zh) | 2019-02-21 | 2024-12-31 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| CN113874526A (zh) * | 2019-03-08 | 2021-12-31 | 肿瘤实验室诊断有限公司 | 癌症的诊断和预后 |
| WO2020210067A1 (en) * | 2019-04-08 | 2020-10-15 | Phanes Therapeutics, Inc. | Humanized anti-dll3 chimeric antigen receptors and uses thereof |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| BR112022014667A2 (pt) | 2020-01-29 | 2022-09-20 | Inhibrx Inc | Anticorpos de domínio único de cd28 e construtos multivalentes e multiespecíficos dos mesmos |
| US12486331B2 (en) | 2020-01-31 | 2025-12-02 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| US11976133B2 (en) * | 2020-01-31 | 2024-05-07 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| IL296803A (en) | 2020-03-31 | 2022-11-01 | Chugai Pharmaceutical Co Ltd | Multispecific antigen binding molecules targeting dll3 and their uses |
| US20240124574A1 (en) * | 2021-02-05 | 2024-04-18 | Phanes Therapeutics, Inc. | Bispecific Antibodies with Charge Pairs and Uses Thereof |
| EP4401775A4 (en) * | 2021-09-17 | 2025-12-17 | Wuxi Biologics Ireland Ltd | D3-binding molecules and uses thereof |
| CN119585300A (zh) * | 2022-05-04 | 2025-03-07 | 医尔利有限公司 | 使用表面可表达的可激活表位定位和/或治疗病变细胞的方法 |
| TW202530259A (zh) * | 2023-09-21 | 2025-08-01 | 大陸商樂普創一生物科技（上海）有限公司 | 抗ｄｌｌ３抗體及其用途 |
| WO2025190281A1 (en) * | 2024-03-11 | 2025-09-18 | Lepu Biopharma Co., Ltd. | Anti-dll3 antibodies and uses thereof |
| CN119841904A (zh) * | 2025-03-18 | 2025-04-18 | 中国科学院近代物理研究所 | 一种dll3亲和肽及其应用 |
| CN120168667A (zh) * | 2025-03-18 | 2025-06-20 | 中国科学院近代物理研究所 | 一种多肽在制备dll3过度表达的肿瘤的特异性靶向分子探针中的应用 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JP2532858B2 (ja) | 1985-04-01 | 1996-09-11 | セルテツク リミテツド | 形質転換したミエロ―マ細胞系 |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| GB9106048D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccines |
| DE69123848T2 (de) | 1990-10-22 | 1997-07-10 | Abbott Lab | Stabile sauerstoff-freie reagenzienlösung für diagnostik |
| EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| WO1992022324A1 (en) | 1991-06-14 | 1992-12-23 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| AU665221B2 (en) | 1991-12-02 | 1995-12-21 | Cambridge Antibody Technology Limited | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク，インコーポレイテッド | 二特異的免疫アドヘジン |
| US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| CA2148252C (en) | 1992-10-30 | 2007-06-12 | Roger Brent | Interaction trap system for isolating novel proteins |
| US5807683A (en) | 1992-11-19 | 1998-09-15 | Combichem, Inc. | Combinatorial libraries and methods for their use |
| ATE204325T1 (de) | 1993-04-29 | 2001-09-15 | Unilever Nv | Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae |
| WO1995015982A2 (en) | 1993-12-08 | 1995-06-15 | Genzyme Corporation | Process for generating specific antibodies |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| EP1231268B1 (en) | 1994-01-31 | 2005-07-27 | Trustees Of Boston University | Polyclonal antibody libraries |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| US5738996A (en) | 1994-06-15 | 1998-04-14 | Pence, Inc. | Combinational library composition and method |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| GB9608510D0 (en) | 1996-04-25 | 1996-07-03 | Medical Res Council | Calcium dependent binding ligands |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| ES2420835T3 (es) | 1999-04-09 | 2013-08-27 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de las moléculas inmunofuncionales |
| ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| EP3263702A1 (en) | 2000-10-06 | 2018-01-03 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| US20060223114A1 (en) | 2001-04-26 | 2006-10-05 | Avidia Research Institute | Protein scaffolds and uses thereof |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20030082630A1 (en) | 2001-04-26 | 2003-05-01 | Maxygen, Inc. | Combinatorial libraries of monomer domains |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| KR20030033007A (ko) | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
| JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| JPWO2003085107A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | ゲノムが改変された細胞 |
| BRPI0316092B8 (pt) | 2002-11-08 | 2021-05-25 | Ablynx Nv | anticorpos de domínio único direcionados contra o fator de necrose tumoral alfa e usos para os mesmos |
| AU2003290330A1 (en) | 2002-12-27 | 2004-07-22 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| JP4889493B2 (ja) | 2003-05-14 | 2012-03-07 | ドマンティス リミテッド | ポリペプチドレパートリーから可逆的にアンフォールドするポリペプチドを回収するための方法 |
| DK1629011T3 (da) | 2003-05-31 | 2010-05-03 | Micromet Ag | Humane anti-humane-DC3-bindingsmolekyler |
| ES2315664T3 (es) | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
| AU2004284090A1 (en) | 2003-10-24 | 2005-05-06 | Avidia, Inc. | LDL receptor class A and EGF domain monomers and multimers |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| US20060234299A1 (en) | 2004-11-16 | 2006-10-19 | Avidia Research Institute | Protein scaffolds and uses thereof |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| BRPI0611445A2 (pt) | 2005-05-09 | 2010-09-08 | Glycart Biotechnology Ag | molécula de ligação a antìgeno glicomanipulada, polinucleotìdeo, polipeptìdeo, vetor, célula hospedeira, método para produção, uso e composição farmacêutica |
| EP1929073A4 (en) | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
| JP5525729B2 (ja) | 2005-11-28 | 2014-06-18 | ゲンマブ エー／エス | 組換え一価抗体およびその作製方法 |
| US20070141066A1 (en) * | 2005-12-16 | 2007-06-21 | Genentech, Inc. | Method for Diagnosing, Prognosing and Treating Glioma |
| EP2216339A1 (en) | 2006-01-16 | 2010-08-11 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis |
| US7862813B2 (en) * | 2006-07-29 | 2011-01-04 | Bjork Jr Robert Lamar | Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug |
| EP2155783B2 (en) | 2007-04-03 | 2022-10-19 | Amgen Research (Munich) GmbH | Cross-species-specific cd3-epsilon binding domain |
| WO2009087462A2 (en) | 2007-12-24 | 2009-07-16 | Oxford Biotherapeutics Ltd. | Ephrin type-a receptor 10 protein |
| EP2947097A1 (en) * | 2008-04-07 | 2015-11-25 | Ablynx N.V. | Amino acid sequences directed against the Notch pathways and uses thereof |
| EP2899211A1 (en) | 2008-07-08 | 2015-07-29 | OncoMed Pharmaceuticals, Inc. | Notch1 receptor binding agents and methods of use thereof |
| EP2477653A1 (en) | 2009-09-18 | 2012-07-25 | Micromet AG | Dosage regimen for administering an epcamxcd3 bispecific antibody |
| PT2530091T (pt) | 2010-01-29 | 2018-05-17 | Chugai Pharmaceutical Co Ltd | Anticorpo anti-dll3 |
| US9002545B2 (en) | 2011-01-07 | 2015-04-07 | Wabtec Holding Corp. | Data improvement system and method |
| AU2012245116A1 (en) * | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| NZ703939A (en) | 2011-05-21 | 2016-01-29 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| WO2013026837A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| HUE037021T2 (hu) * | 2012-02-24 | 2018-08-28 | Abbvie Stemcentrx Llc | DLL3- modulátorok és eljárások alkalmazásukra |
-
2013
- 2013-02-12 GB GBGB1302447.6A patent/GB201302447D0/en not_active Ceased
-
2014
- 2014-02-12 KR KR1020157024805A patent/KR102167550B1/ko not_active Expired - Fee Related
- 2014-02-12 EP EP20175944.6A patent/EP3736293A1/en not_active Withdrawn
- 2014-02-12 PL PL14705561T patent/PL2956483T3/pl unknown
- 2014-02-12 US US14/766,992 patent/US20160032006A1/en not_active Abandoned
- 2014-02-12 DK DK14705561.0T patent/DK2956483T3/da active
- 2014-02-12 HU HUE14705561A patent/HUE050828T2/hu unknown
- 2014-02-12 CA CA2900134A patent/CA2900134A1/en not_active Abandoned
- 2014-02-12 WO PCT/GB2014/050407 patent/WO2014125273A1/en not_active Ceased
- 2014-02-12 JP JP2015556574A patent/JP6654046B2/ja active Active
- 2014-02-12 EP EP14705561.0A patent/EP2956483B1/en not_active Revoked
- 2014-02-12 AU AU2014217611A patent/AU2014217611B2/en not_active Ceased
- 2014-02-12 CN CN201480020452.4A patent/CN105143266B/zh active Active
- 2014-02-12 MX MX2015010372A patent/MX370597B/es active IP Right Grant
- 2014-02-12 ES ES14705561T patent/ES2813360T3/es active Active
- 2014-02-12 EA EA201500835A patent/EA034182B1/ru not_active IP Right Cessation
-
2015
- 2015-07-16 IL IL239983A patent/IL239983B/en active IP Right Grant
- 2015-08-07 CL CL2015002223A patent/CL2015002223A1/es unknown
- 2015-08-07 PH PH12015501744A patent/PH12015501744A1/en unknown
-
2018
- 2018-03-07 US US15/914,432 patent/US20180201691A1/en not_active Abandoned
-
2020
- 2020-11-20 US US16/953,459 patent/US20210079114A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016513094A5 (enExample) | ||
| Ameling et al. | Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study | |
| JP2016500110A5 (enExample) | ||
| EP4282405A3 (en) | Detection of cancer biomarkers using nanoparticles | |
| CY1122871T1 (el) | Μεθοδος ποσοτικου προσδιορισμου για την εκφραση της pd-l1 | |
| EA201070738A1 (ru) | Композиции и способы детекции tiab | |
| Kofla-Dłubacz et al. | Metalloproteinase-3 and-9 as novel markers in the evaluation of ulcerative colitis activity in children | |
| BR112015023120A2 (pt) | método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado | |
| WO2009090553A3 (en) | Compositions and methods of detecting post-stop peptides | |
| WO2013068374A3 (en) | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment | |
| WO2017025617A8 (en) | Method for the quantification of faecalibacterium prausnitzii phylogroup i and/or phylogroup ii members and the use thereof as biomarkers | |
| WO2018183817A3 (en) | Tumor burden as measured by cell free dna | |
| EP3208617A3 (en) | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment | |
| JP2016536012A5 (enExample) | ||
| WO2014036495A3 (en) | Diagnostic assays and kits for detection of folate receptor 1 | |
| JP2012500389A5 (enExample) | ||
| RU2015102194A (ru) | Способы лечения связанных с fgfr3 состояний | |
| JP2014521089A5 (enExample) | ||
| JP2015210268A5 (enExample) | ||
| Bahadır et al. | Biosensor technologies for analyses of food contaminants | |
| JP2013178260A5 (enExample) | ||
| JP2017505897A5 (enExample) | ||
| Zhang et al. | Prognostic significance of combining VEGFA, FLT1 and KDR mRNA expression in lung cancer | |
| WO2008089135A3 (en) | Identification of biomarkers predictive of dasatinib effects in cancer cells | |
| Schlaeger et al. | Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? |