JP2016513094A5 - - Google Patents
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- JP2016513094A5 JP2016513094A5 JP2015556574A JP2015556574A JP2016513094A5 JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5 JP 2015556574 A JP2015556574 A JP 2015556574A JP 2015556574 A JP2015556574 A JP 2015556574A JP 2016513094 A5 JP2016513094 A5 JP 2016513094A5
- Authority
- JP
- Japan
- Prior art keywords
- dll3
- cancer
- fragments
- level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100036466 Delta-like protein 3 Human genes 0.000 claims 32
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 32
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000012544 monitoring process Methods 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 239000003560 cancer drug Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1302447.6A GB201302447D0 (en) | 2013-02-12 | 2013-02-12 | Therapeutic and diagnostic target |
| GB1302447.6 | 2013-02-12 | ||
| PCT/GB2014/050407 WO2014125273A1 (en) | 2013-02-12 | 2014-02-12 | Therapeutic and diagnostic target for cancer comprising dll3 binding reagents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513094A JP2016513094A (ja) | 2016-05-12 |
| JP2016513094A5 true JP2016513094A5 (enExample) | 2017-03-16 |
| JP6654046B2 JP6654046B2 (ja) | 2020-02-26 |
Family
ID=47998983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556574A Active JP6654046B2 (ja) | 2013-02-12 | 2014-02-12 | Ｄｌｌ３結合試薬を含む治療薬及び診断薬の癌標的 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20160032006A1 (enExample) |
| EP (2) | EP2956483B1 (enExample) |
| JP (1) | JP6654046B2 (enExample) |
| KR (1) | KR102167550B1 (enExample) |
| CN (1) | CN105143266B (enExample) |
| AU (1) | AU2014217611B2 (enExample) |
| CA (1) | CA2900134A1 (enExample) |
| CL (1) | CL2015002223A1 (enExample) |
| DK (1) | DK2956483T3 (enExample) |
| EA (1) | EA034182B1 (enExample) |
| ES (1) | ES2813360T3 (enExample) |
| GB (1) | GB201302447D0 (enExample) |
| HU (1) | HUE050828T2 (enExample) |
| IL (1) | IL239983B (enExample) |
| MX (1) | MX370597B (enExample) |
| PH (1) | PH12015501744A1 (enExample) |
| PL (1) | PL2956483T3 (enExample) |
| WO (1) | WO2014125273A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS56443B1 (sr) | 2012-02-24 | 2018-01-31 | Abbvie Stemcentrx Llc | Ddl3 modulatori i postupci primene |
| CN105848671B (zh) | 2013-08-28 | 2019-12-13 | 艾伯维施特姆森特克斯有限责任公司 | 位点特异性抗体缀合方法和组合物 |
| KR20160047567A (ko) * | 2013-08-28 | 2016-05-02 | 스템센트알엑스 인코포레이티드 | 조작된 항-dll3 접합체 및 사용 방법 |
| MX2016010677A (es) | 2014-02-21 | 2017-04-10 | Abbvie Stemcentrx Llc | Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma. |
| AR101400A1 (es) * | 2014-07-31 | 2016-12-14 | Amgen Res Munich Gmbh | Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido |
| AR101936A1 (es) | 2014-07-31 | 2017-01-25 | Amgen Res Munich Gmbh | Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas |
| MA41613A (fr) * | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| CA2986575A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI793062B (zh) * | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Ｄｌｌ３及ｃｄ３抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| EA039859B1 (ru) * | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
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| EA039325B1 (ru) * | 2016-02-03 | 2022-01-13 | Эмджен Рисерч (Мюник) Гмбх | Конструкции биспецифических антител, связывающиеся с дпб3 (dll3) и кд3 (cd3) |
| WO2018224685A1 (en) | 2017-06-08 | 2018-12-13 | Tusk Therapeutics Ltd | Cd38 modulating antibody |
| AU2018316521B2 (en) | 2017-08-16 | 2025-01-30 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| WO2019034753A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | ANTIBODY CD38 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| WO2019111871A1 (en) | 2017-12-05 | 2019-06-13 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding cd3 and cd137 |
| TWI817974B (zh) * | 2017-12-28 | 2023-10-11 | 日商中外製藥股份有限公司 | 細胞毒性誘導治療劑 |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| WO2019200022A1 (en) | 2018-04-11 | 2019-10-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| CN110412179A (zh) * | 2018-04-26 | 2019-11-05 | 缪荣明 | 一种液相色谱检测颗粒酶a的方法 |
| US12037391B2 (en) | 2018-05-08 | 2024-07-16 | Phanes Therapeutics, Inc. | Anti-DLL3 antibodies and uses thereof |
| TWI848953B (zh) * | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| US12195533B2 (en) | 2018-07-24 | 2025-01-14 | Inhibrx Biosciences, Inc. | Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| EP3856771A4 (en) * | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| WO2020076977A2 (en) * | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| WO2020182517A1 (en) * | 2019-03-08 | 2020-09-17 | Oncolab Diagnostics Gmbh | Cancer diagnosis and prognosis |
| CN113795262A (zh) * | 2019-04-08 | 2021-12-14 | 东莞凡恩世生物医药有限公司 | 人源化抗dll3嵌合抗原受体及其用途 |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| EP4084823A4 (en) | 2020-01-03 | 2024-05-15 | Marengo Therapeutics, Inc. | ANTI-TCR ANTIBODY MOLECULES AND THEIR USES |
| US11976133B2 (en) * | 2020-01-31 | 2024-05-07 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| US12486331B2 (en) | 2020-01-31 | 2025-12-02 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| CR20220541A (es) | 2020-03-31 | 2022-11-28 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos |
| EP4401775A4 (en) * | 2021-09-17 | 2025-12-17 | Wuxi Biologics Ireland Ltd | D3-binding molecules and uses thereof |
| JP2025515134A (ja) * | 2022-05-04 | 2025-05-13 | アーリ インコーポレイテッド | 疾患細胞の位置を決定するおよび／または疾患細胞を処置するために表面発現可能な活性化可能エピトープを使用する方法 |
| TW202530259A (zh) * | 2023-09-21 | 2025-08-01 | 大陸商樂普創一生物科技（上海）有限公司 | 抗ｄｌｌ３抗體及其用途 |
| WO2025190281A1 (en) * | 2024-03-11 | 2025-09-18 | Lepu Biopharma Co., Ltd. | Anti-dll3 antibodies and uses thereof |
| CN119841904A (zh) * | 2025-03-18 | 2025-04-18 | 中国科学院近代物理研究所 | 一种dll3亲和肽及其应用 |
| CN120168667A (zh) * | 2025-03-18 | 2025-06-20 | 中国科学院近代物理研究所 | 一种多肽在制备dll3过度表达的肿瘤的特异性靶向分子探针中的应用 |
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-
2013
- 2013-02-12 GB GBGB1302447.6A patent/GB201302447D0/en not_active Ceased
-
2014
- 2014-02-12 EP EP14705561.0A patent/EP2956483B1/en not_active Revoked
- 2014-02-12 KR KR1020157024805A patent/KR102167550B1/ko not_active Expired - Fee Related
- 2014-02-12 AU AU2014217611A patent/AU2014217611B2/en not_active Ceased
- 2014-02-12 JP JP2015556574A patent/JP6654046B2/ja active Active
- 2014-02-12 HU HUE14705561A patent/HUE050828T2/hu unknown
- 2014-02-12 CN CN201480020452.4A patent/CN105143266B/zh active Active
- 2014-02-12 MX MX2015010372A patent/MX370597B/es active IP Right Grant
- 2014-02-12 WO PCT/GB2014/050407 patent/WO2014125273A1/en not_active Ceased
- 2014-02-12 EP EP20175944.6A patent/EP3736293A1/en not_active Withdrawn
- 2014-02-12 ES ES14705561T patent/ES2813360T3/es active Active
- 2014-02-12 DK DK14705561.0T patent/DK2956483T3/da active
- 2014-02-12 US US14/766,992 patent/US20160032006A1/en not_active Abandoned
- 2014-02-12 PL PL14705561T patent/PL2956483T3/pl unknown
- 2014-02-12 EA EA201500835A patent/EA034182B1/ru not_active IP Right Cessation
- 2014-02-12 CA CA2900134A patent/CA2900134A1/en not_active Abandoned
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2015
- 2015-07-16 IL IL239983A patent/IL239983B/en active IP Right Grant
- 2015-08-07 PH PH12015501744A patent/PH12015501744A1/en unknown
- 2015-08-07 CL CL2015002223A patent/CL2015002223A1/es unknown
-
2018
- 2018-03-07 US US15/914,432 patent/US20180201691A1/en not_active Abandoned
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2020
- 2020-11-20 US US16/953,459 patent/US20210079114A1/en not_active Abandoned
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