|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
DE3668186D1
(de)
|
1985-04-01 |
1990-02-15 |
Celltech Ltd |
Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
JPS63501765A
(ja)
|
1985-11-01 |
1988-07-21 |
インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド |
抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP1541682A3
(en)
|
1988-09-02 |
2005-07-06 |
Dyax Corp. |
Generation and selection of recombinant varied binding proteins
|
|
FI903489A0
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
GB9106048D0
(en)
|
1991-03-21 |
1991-05-08 |
Smithkline Beecham Biolog |
Vaccines
|
|
DE69123848T2
(de)
|
1990-10-22 |
1997-07-10 |
Abbott Lab |
Stabile sauerstoff-freie reagenzienlösung für diagnostik
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
CA2110799A1
(en)
|
1991-06-14 |
1992-12-23 |
Arnold H. Horwitz |
Microbially-produced antibody fragments and their conjugates
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
ATE463573T1
(de)
|
1991-12-02 |
2010-04-15 |
Medimmune Ltd |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
DK0616640T3
(da)
|
1991-12-02 |
2004-12-20 |
Medical Res Council |
Fremstilling af anti-selv antistoffer fra repertoirer af antistofsegmenter og fremvist på fag
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
DE69308573T2
(de)
|
1992-08-17 |
1997-08-07 |
Genentech Inc |
Bispezifische immunoadhesine
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
DE69333969T2
(de)
|
1992-10-30 |
2006-09-14 |
The General Hospital Corp., Boston |
Wechselwirkendes Fallensystem zur Isolierung von Proteinen
|
|
US5807683A
(en)
|
1992-11-19 |
1998-09-15 |
Combichem, Inc. |
Combinatorial libraries and methods for their use
|
|
DK0698097T3
(da)
|
1993-04-29 |
2001-10-08 |
Unilever Nv |
Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
DE69531148T2
(de)
|
1994-01-31 |
2004-04-29 |
Trustees Of Boston University, Boston |
Bibliotheken aus polyklonalen antikörpern
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US5738996A
(en)
|
1994-06-15 |
1998-04-14 |
Pence, Inc. |
Combinational library composition and method
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
GB9608510D0
(en)
|
1996-04-25 |
1996-07-03 |
Medical Res Council |
Calcium dependent binding ligands
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
CA2421447C
(en)
|
2000-09-08 |
2012-05-08 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
|
CN102311986B
(zh)
|
2000-10-06 |
2015-08-19 |
协和发酵麒麟株式会社 |
产生抗体组合物的细胞
|
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
WO2002088171A2
(en)
|
2001-04-26 |
2002-11-07 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US20060223114A1
(en)
|
2001-04-26 |
2006-10-05 |
Avidia Research Institute |
Protein scaffolds and uses thereof
|
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
|
US20050089932A1
(en)
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US7129261B2
(en)
|
2001-05-31 |
2006-10-31 |
Medarex, Inc. |
Cytotoxic agents
|
|
CA2447851C
(en)
|
2001-06-28 |
2012-08-28 |
Domantis Limited |
Dual-specific ligand and its use
|
|
US20040110226A1
(en)
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
|
CN102911987B
(zh)
|
2002-04-09 |
2015-09-30 |
协和发酵麒麟株式会社 |
基因组被修饰的细胞
|
|
EP1517921B1
(en)
|
2002-06-28 |
2006-06-07 |
Domantis Limited |
Dual specific ligands with increased serum half-life
|
|
EP1558647B1
(en)
|
2002-11-08 |
2015-06-10 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP1578801A2
(en)
|
2002-12-27 |
2005-09-28 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
JP4889493B2
(ja)
|
2003-05-14 |
2012-03-07 |
ドマンティス リミテッド |
ポリペプチドレパートリーから可逆的にアンフォールドするポリペプチドを回収するための方法
|
|
CA2523716C
(en)
|
2003-05-31 |
2014-11-25 |
Micromet Ag |
Human anti-human cd3 binding molecules
|
|
SI1639011T1
(sl)
|
2003-06-30 |
2009-04-30 |
Domantis Ltd |
Pegilirana protitelesa z enojno domeno (dAb)
|
|
WO2005040229A2
(en)
|
2003-10-24 |
2005-05-06 |
Avidia, Inc. |
Ldl receptor class a and egf domain monomers and multimers
|
|
US20060008844A1
(en)
|
2004-06-17 |
2006-01-12 |
Avidia Research Institute |
c-Met kinase binding proteins
|
|
US20060234299A1
(en)
|
2004-11-16 |
2006-10-19 |
Avidia Research Institute |
Protein scaffolds and uses thereof
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
WO2007039818A2
(en)
|
2005-05-09 |
2007-04-12 |
Glycart Biotechnology Ag |
Antigen binding molecules having modified fc regions and altered binding to fc receptors
|
|
JP2009509535A
(ja)
|
2005-09-27 |
2009-03-12 |
アムニクス， インコーポレイテッド |
タンパク様薬剤およびその使用
|
|
AU2006317242A1
(en)
|
2005-11-28 |
2007-05-31 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
BRPI0620695A2
(pt)
*
|
2005-12-16 |
2011-11-22 |
Genentech, Inc |
método para tratar um tumor do tipo glioma, métodos de prognóstico e/ou diagnóstico de glioma, método de monitoramento ou diagnóstico, método para inibir o tamanho ou crescimento de um tumor do tipo glioma, métodos para tratar terapeuticamente, método para determinar o nìvel de expressão de marcadores determinantes de glioma ("gdm") de pn, prolif ou mes, método para prognosticar o tempo de sobrevida, método para diagnosticar a severidade de um tumor do tipo glioma e uso
|
|
WO2007080597A2
(en)
|
2006-01-16 |
2007-07-19 |
Compugen Ltd. |
Polynucleotide and polypeptide sequences and methods for diagnosis
|
|
US7862813B2
(en)
*
|
2006-07-29 |
2011-01-04 |
Bjork Jr Robert Lamar |
Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug
|
|
WO2008119567A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific cd3-epsilon binding domain
|
|
JP2011509079A
(ja)
|
2007-12-24 |
2011-03-24 |
オックスフォード ビオトヘラペウトイクス エルティーディー． |
エフリンａ型受容体１０タンパク質
|
|
WO2009124931A2
(en)
*
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Amino acid sequences directed against the notch pathways and uses thereof
|
|
EP2307051B1
(en)
|
2008-07-08 |
2015-02-11 |
OncoMed Pharmaceuticals, Inc. |
Notch-binding agents and antagonists and methods of use thereof
|
|
RU2012115480A
(ru)
|
2009-09-18 |
2013-10-27 |
Микромет Аг |
РЕЖИМ ДОЗИРОВАНИЯ ПРИ ВВЕДЕНИИ БИСПЕЦИФИЧЕСКОГО АНТИТЕЛА EpCAMxCD3
|
|
LT2530091T
(lt)
*
|
2010-01-29 |
2018-06-11 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-dll3 antikūnas
|
|
US9002545B2
(en)
|
2011-01-07 |
2015-04-07 |
Wabtec Holding Corp. |
Data improvement system and method
|
|
AU2012245116A1
(en)
*
|
2011-04-20 |
2013-11-07 |
Genmab A/S |
Bispecific antibodies against HER2 and CD3
|
|
CN107827985A
(zh)
|
2011-05-21 |
2018-03-23 |
宏观基因有限公司 |
能够与人和非人cd3结合的cd3结合分子
|
|
WO2013026837A1
(en)
|
2011-08-23 |
2013-02-28 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
EP3093294A1
(en)
*
|
2012-02-24 |
2016-11-16 |
Stemcentrx, Inc. |
Dll3 modulators and methods of use
|