CN105143266B - 包含dll3结合试剂的癌症的治疗和诊断靶标 - Google Patents

包含dll3结合试剂的癌症的治疗和诊断靶标 Download PDF

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CN105143266B
CN105143266B CN201480020452.4A CN201480020452A CN105143266B CN 105143266 B CN105143266 B CN 105143266B CN 201480020452 A CN201480020452 A CN 201480020452A CN 105143266 B CN105143266 B CN 105143266B
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dll3
antibody
cancer
antibodies
protein
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CN105143266A (zh
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L·J·赫德森
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Boehringer Ingelheim International GmbH
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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CN201480020452.4A 2013-02-12 2014-02-12 包含dll3结合试剂的癌症的治疗和诊断靶标 Active CN105143266B (zh)

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Application Number Priority Date Filing Date Title
GBGB1302447.6A GB201302447D0 (en) 2013-02-12 2013-02-12 Therapeutic and diagnostic target
GB1302447.6 2013-02-12
PCT/GB2014/050407 WO2014125273A1 (en) 2013-02-12 2014-02-12 Therapeutic and diagnostic target for cancer comprising dll3 binding reagents

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CN105143266A CN105143266A (zh) 2015-12-09
CN105143266B true CN105143266B (zh) 2021-08-13

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SMT201700467T1 (it) 2012-02-24 2017-11-15 Abbvie Stemcentrx Llc Modulatori di dll3 e metodi di uso
MX377339B (es) 2013-08-28 2025-03-06 Abbvie Stemcentrx Llc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones.
CA2922544A1 (en) * 2013-08-28 2015-03-05 Stemcentrx, Inc. Engineered anti-dll3 conjugates and methods of use
EP3107576A4 (en) 2014-02-21 2017-09-06 Abbvie Stemcentrx LLC Anti-dll3 antibodies and drug conjugates for use in melanoma
MX384418B (es) * 2014-07-31 2025-03-14 Amgen Res Munich Gmbh Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido.
MX377344B (es) 2014-07-31 2025-03-07 Amgen Res Munich Gmbh Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas.
MA41613A (fr) * 2015-02-23 2018-01-02 Abbvie Stemcentrx Llc Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs
CN107849148B (zh) 2015-05-21 2023-09-19 哈普恩治疗公司 三特异性结合蛋白质及使用方法
TW202346349A (zh) * 2015-07-31 2023-12-01 德商安美基研究（慕尼黑）公司 Dll3及cd3抗體構築體
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
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