JP2016512685A5 - - Google Patents
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- JP2016512685A5 JP2016512685A5 JP2016502574A JP2016502574A JP2016512685A5 JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5 JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5
- Authority
- JP
- Japan
- Prior art keywords
- air
- sequence
- polypeptide
- sequences
- region coding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 108091093088 Amplicon Proteins 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 8
- 210000004698 lymphocyte Anatomy 0.000 claims 8
- 239000002299 complementary DNA Substances 0.000 claims 4
- 238000007403 mPCR Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000010839 reverse transcription Methods 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 230000003044 adaptive effect Effects 0.000 claims 2
- 238000002474 experimental method Methods 0.000 claims 2
- 239000000833 heterodimer Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000012165 high-throughput sequencing Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789408P | 2013-03-15 | 2013-03-15 | |
| US61/789,408 | 2013-03-15 | ||
| USPCT/US2013/045994 | 2013-06-14 | ||
| PCT/US2013/045994 WO2013188831A1 (en) | 2012-06-15 | 2013-06-14 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| PCT/US2014/030859 WO2014145992A1 (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512685A JP2016512685A (ja) | 2016-05-09 |
| JP2016512685A5 true JP2016512685A5 (enExample) | 2017-04-13 |
| JP6431895B2 JP6431895B2 (ja) | 2018-12-05 |
Family
ID=51538155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502574A Active JP6431895B2 (ja) | 2013-03-15 | 2014-03-17 | 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160024493A1 (enExample) |
| EP (1) | EP2971105B1 (enExample) |
| JP (1) | JP6431895B2 (enExample) |
| KR (1) | KR20150132479A (enExample) |
| CN (1) | CN105452483B (enExample) |
| AU (2) | AU2014232314B2 (enExample) |
| CA (1) | CA2906218A1 (enExample) |
| IL (1) | IL241394B (enExample) |
| SG (2) | SG10201707394PA (enExample) |
| WO (1) | WO2014145992A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8685898B2 (en) | 2009-01-15 | 2014-04-01 | Imdaptive, Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| MX354329B (es) | 2012-05-08 | 2018-02-27 | Adaptive Biotechnologies Corp | Composiciones y metodos para medir y calibrar el error de amplificacion en reacciones de pcr multiple. |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| US10400281B2 (en) | 2014-05-22 | 2019-09-03 | The University Of British Columbia | Methods for determining lymphocyte receptor chain pairs |
| ES2784343T3 (es) | 2014-10-29 | 2020-09-24 | Adaptive Biotechnologies Corp | Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN104562215B (zh) * | 2014-12-29 | 2017-03-22 | 北京诺禾致源科技股份有限公司 | 扩增子文库的构建方法 |
| US10760120B2 (en) * | 2015-01-23 | 2020-09-01 | Qiagen Sciences, Llc | High multiplex PCR with molecular barcoding |
| US11047008B2 (en) | 2015-02-24 | 2021-06-29 | Adaptive Biotechnologies Corporation | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| EP3262193A2 (en) * | 2015-02-26 | 2018-01-03 | The Broad Institute Inc. | T cell balance gene expression, compositions of matters and methods of use thereof |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| CN107849560B (zh) * | 2015-04-27 | 2021-10-22 | 阿布维特罗有限责任公司 | 对治疗剂和疾病特异性抗原进行测序、确定、配对和验证的方法 |
| WO2017013170A1 (en) | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| GB201516276D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516274D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516265D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516275D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516269D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516270D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| WO2017079593A1 (en) * | 2015-11-04 | 2017-05-11 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| EP3414340B1 (en) * | 2016-02-12 | 2023-08-09 | CureVac SE | Method for analyzing rna |
| US20190078150A1 (en) * | 2016-03-01 | 2019-03-14 | Universal Sequencing Technology Corporation | Methods and Kits for Tracking Nucleic Acid Target Origin for Nucleic Acid Sequencing |
| EP3423595A1 (en) | 2016-03-03 | 2019-01-09 | CureVac AG | Rna analysis by total hydrolysis |
| WO2017192387A1 (en) | 2016-05-02 | 2017-11-09 | Cellular Research, Inc. | Accurate molecular barcoding |
| WO2017210469A2 (en) * | 2016-06-01 | 2017-12-07 | F. Hoffman-La Roche Ag | Immuno-pete |
| CN106283201B (zh) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | 基于高通量测序的tcr多样性检测和文库构建 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| JP7360324B2 (ja) | 2016-12-23 | 2023-10-12 | ビステラ， インコーポレイテッド | 結合ポリペプチドおよびそれを作製する方法 |
| US20210087610A9 (en) * | 2017-01-12 | 2021-03-25 | Massachusetts Institute Of Technology | Methods for analyzing t cell receptors and b cell receptors |
| CN110249060A (zh) * | 2017-01-17 | 2019-09-17 | 生命技术公司 | 用于免疫组库测序的组合物和方法 |
| US11319590B2 (en) * | 2017-01-31 | 2022-05-03 | Ludwig Institute For Cancer Research Ltd. | Enhanced immune cell receptor sequencing methods |
| EP3676399B1 (en) | 2017-09-01 | 2022-05-11 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| CN109536594B (zh) * | 2017-09-20 | 2022-11-01 | 深圳华大智造科技股份有限公司 | 一种用于Small RNA的测序方法、测序试剂和应用 |
| IL305485B2 (en) * | 2017-10-27 | 2025-10-01 | Univ California | Targeted replacement of endogenous T cell receptors |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| SG11202007686VA (en) | 2018-02-12 | 2020-09-29 | 10X Genomics Inc | Methods characterizing multiple analytes from individual cells or cell populations |
| CN108374203B (zh) * | 2018-03-01 | 2021-07-23 | 艾吉泰康生物科技(北京)有限公司 | 一种用于双向测序的扩增子文库的构建方法 |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| WO2020018836A1 (en) | 2018-07-18 | 2020-01-23 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| WO2020018837A1 (en) * | 2018-07-18 | 2020-01-23 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| WO2020041702A1 (en) | 2018-08-24 | 2020-02-27 | Swift Biosciences, Inc. | Asymmetric targeted amplification methods |
| CA3139178A1 (en) * | 2019-05-10 | 2020-11-19 | The Chinese University Of Hong Kong | Primers and assays for linking regions using polymerases |
| WO2020247263A1 (en) * | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| US11149322B2 (en) * | 2019-06-07 | 2021-10-19 | Chapter Diagnostics, Inc. | Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification |
| WO2021046121A1 (en) * | 2019-09-03 | 2021-03-11 | The Regents Of The University Of California | Method to sequence mrna in single cells in parallel with quantification of intracellular phenotype |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| JP2023515265A (ja) * | 2020-04-24 | 2023-04-12 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 新規ｔ細胞特異性とその使用 |
| US10941453B1 (en) * | 2020-05-20 | 2021-03-09 | Paragon Genomics, Inc. | High throughput detection of pathogen RNA in clinical specimens |
| EP4211239A4 (en) * | 2020-09-08 | 2024-09-11 | Seqwell, Inc. | Sequencing oligonucleotides and methods of use thereof |
| US11111489B1 (en) | 2021-01-06 | 2021-09-07 | Think Therapeutics, Inc. | Multiplexed testing of lymphocytes for antigen specificity |
| KR20230160885A (ko) | 2021-03-24 | 2023-11-24 | 제넨테크, 인크. | T 림프구에서 효율적인 tcr 유전자 편집 |
| WO2022207682A1 (en) * | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
| CN114561454B (zh) * | 2022-03-03 | 2025-11-14 | 中国人民解放军陆军军医大学 | 一种基于高通量测序对TCR β进行定量的方法 |
| US11680293B1 (en) | 2022-04-21 | 2023-06-20 | Paragon Genomics, Inc. | Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules |
| US12091715B2 (en) | 2022-04-21 | 2024-09-17 | Paragon Genomics, Inc. | Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing |
| TWI867406B (zh) * | 2022-10-27 | 2024-12-21 | 醫華生技股份有限公司 | 生物微粒分析方法 |
| EP4603595A1 (en) * | 2024-02-13 | 2025-08-20 | ImmuneDiscover Sweden AB | A method for typing the immune genes and the allelic variants thereof |
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| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US6031091A (en) | 1987-09-21 | 2000-02-29 | Gen-Probe Incorporated | Non-nucleotide linking reagents for nucleotide probes |
| KR920003787B1 (ko) | 1990-03-05 | 1992-05-14 | 한국과학기술 연구원 | 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법 |
| CA2135073C (en) | 1992-05-06 | 2002-11-19 | Daniel L. Kacian | Nucleic acid sequence amplification method, composition and kit |
| US5596090A (en) | 1992-07-24 | 1997-01-21 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human VCAM-1 RNA |
| US5571711A (en) | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
| ATE272113T1 (de) | 1994-02-16 | 2004-08-15 | Crucell Holland Bv | Melanoma-assoziierte antigene, epitope davon und impstoffe gegen melanoma |
| US5821122A (en) | 1995-06-07 | 1998-10-13 | Inserm (Institute Nat'l De La Sante Et De La Recherche . .) | Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof |
| JPH0975090A (ja) | 1995-09-13 | 1997-03-25 | Kanegafuchi Chem Ind Co Ltd | 細胞付着部材 |
| DK1907571T3 (en) * | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
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| US8236503B2 (en) * | 2008-11-07 | 2012-08-07 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
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| WO2011106738A2 (en) | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
| ES2593614T3 (es) * | 2010-05-06 | 2016-12-12 | Adaptive Biotechnologies Corporation | Monitorización de estados de salud y enfermedad usando perfiles de clonotipos |
| US20120021919A1 (en) * | 2010-07-23 | 2012-01-26 | Thomas Scholl | Identification of Differentially Represented Fetal or Maternal Genomic Regions and Uses Thereof |
| WO2012083069A2 (en) * | 2010-12-15 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and monitoring of cell clonality |
| DK2652155T3 (en) | 2010-12-16 | 2017-02-13 | Gigagen Inc | Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells |
| EP3345922A1 (en) * | 2011-03-09 | 2018-07-11 | Cell Signaling Technology, Inc. | Methods and reagents for creating monoclonal antibodies |
| HRP20230443T1 (hr) * | 2011-05-24 | 2023-09-15 | BioNTech SE | Individualizirana cjepiva protiv raka |
| US10077478B2 (en) * | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
-
2014
- 2014-03-17 SG SG10201707394PA patent/SG10201707394PA/en unknown
- 2014-03-17 KR KR1020157029634A patent/KR20150132479A/ko not_active Withdrawn
- 2014-03-17 JP JP2016502574A patent/JP6431895B2/ja active Active
- 2014-03-17 CN CN201480025490.9A patent/CN105452483B/zh active Active
- 2014-03-17 WO PCT/US2014/030859 patent/WO2014145992A1/en not_active Ceased
- 2014-03-17 SG SG11201506991VA patent/SG11201506991VA/en unknown
- 2014-03-17 EP EP14722474.5A patent/EP2971105B1/en active Active
- 2014-03-17 US US14/777,294 patent/US20160024493A1/en not_active Abandoned
- 2014-03-17 AU AU2014232314A patent/AU2014232314B2/en active Active
- 2014-03-17 CA CA2906218A patent/CA2906218A1/en not_active Abandoned
-
2015
- 2015-09-09 IL IL241394A patent/IL241394B/en active IP Right Grant
-
2020
- 2020-08-06 AU AU2020213348A patent/AU2020213348B2/en active Active
-
2024
- 2024-04-25 US US18/646,564 patent/US20250043272A1/en active Pending
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