JP2016512685A5 - - Google Patents

Download PDF

Info

Publication number
JP2016512685A5
JP2016512685A5 JP2016502574A JP2016502574A JP2016512685A5 JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5 JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5
Authority
JP
Japan
Prior art keywords
air
sequence
polypeptide
sequences
region coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016502574A
Other languages
English (en)
Japanese (ja)
Other versions
JP6431895B2 (ja
JP2016512685A (ja
Filing date
Publication date
Priority claimed from PCT/US2013/045994 external-priority patent/WO2013188831A1/en
Application filed filed Critical
Priority claimed from PCT/US2014/030859 external-priority patent/WO2014145992A1/en
Publication of JP2016512685A publication Critical patent/JP2016512685A/ja
Publication of JP2016512685A5 publication Critical patent/JP2016512685A5/ja
Application granted granted Critical
Publication of JP6431895B2 publication Critical patent/JP6431895B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016502574A 2013-03-15 2014-03-17 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 Active JP6431895B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361789408P 2013-03-15 2013-03-15
US61/789,408 2013-03-15
USPCT/US2013/045994 2013-06-14
PCT/US2013/045994 WO2013188831A1 (en) 2012-06-15 2013-06-14 Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
PCT/US2014/030859 WO2014145992A1 (en) 2013-03-15 2014-03-17 Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set

Publications (3)

Publication Number Publication Date
JP2016512685A JP2016512685A (ja) 2016-05-09
JP2016512685A5 true JP2016512685A5 (enExample) 2017-04-13
JP6431895B2 JP6431895B2 (ja) 2018-12-05

Family

ID=51538155

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016502574A Active JP6431895B2 (ja) 2013-03-15 2014-03-17 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子

Country Status (10)

Country Link
US (2) US20160024493A1 (enExample)
EP (1) EP2971105B1 (enExample)
JP (1) JP6431895B2 (enExample)
KR (1) KR20150132479A (enExample)
CN (1) CN105452483B (enExample)
AU (2) AU2014232314B2 (enExample)
CA (1) CA2906218A1 (enExample)
IL (1) IL241394B (enExample)
SG (2) SG11201506991VA (enExample)
WO (1) WO2014145992A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
HUE029424T2 (en) 2009-01-15 2017-02-28 Adaptive Biotechnologies Corp Adaptive immunity profiling and a method for producing monoclonal antibodies
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
DK2831276T3 (da) 2012-05-08 2016-08-01 Adaptive Biotechnologies Corp Sammensætninger og fremgangsmåde til at måle og kalibrere amplifikations-bias i multipleks-PCR-reaktioner
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US10202640B2 (en) * 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
CA2947320C (en) 2014-05-22 2023-03-14 The University Of British Columbia Methods for determining lymphocyte receptor chain pairs
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CN104562215B (zh) * 2014-12-29 2017-03-22 北京诺禾致源科技股份有限公司 扩增子文库的构建方法
EP3247804B1 (en) * 2015-01-23 2020-08-05 Qiagen Sciences, LLC High multiplex pcr with molecular barcoding
ES2858306T3 (es) 2015-02-24 2021-09-30 Adaptive Biotechnologies Corp Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario
EP3262193A2 (en) * 2015-02-26 2018-01-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2016176322A1 (en) * 2015-04-27 2016-11-03 Abvitro Llc Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
WO2017013170A1 (en) * 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
GB201516276D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516269D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516275D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516270D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516265D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516274D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
JP7064439B2 (ja) * 2015-11-04 2022-05-10 アトレカ インコーポレイテッド 単一細胞に関連する核酸の解析のための、核酸バーコードの組み合わせセット
WO2017137095A1 (en) * 2016-02-12 2017-08-17 Curevac Ag Method for analyzing rna
CN109196115A (zh) * 2016-03-01 2019-01-11 通用测序技术公司 跟踪核酸靶标来源以用于核酸测序的方法和试剂盒
US11920174B2 (en) 2016-03-03 2024-03-05 CureVac SE RNA analysis by total hydrolysis and quantification of released nucleosides
CA3019589A1 (en) 2016-05-02 2017-11-09 Cellular Research, Inc. Accurate molecular barcoding
WO2017210469A2 (en) * 2016-06-01 2017-12-07 F. Hoffman-La Roche Ag Immuno-pete
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN110366557B (zh) 2016-12-23 2024-04-09 威特拉公司 结合多肽及其制备方法
US20210087610A9 (en) * 2017-01-12 2021-03-25 Massachusetts Institute Of Technology Methods for analyzing t cell receptors and b cell receptors
US10920273B2 (en) 2017-01-17 2021-02-16 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
WO2018144410A1 (en) * 2017-01-31 2018-08-09 Ludwig Institute For Cancer Research Ltd. Enhanced immune cell receptor sequencing methods
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
CN109536594B (zh) * 2017-09-20 2022-11-01 深圳华大智造科技股份有限公司 一种用于Small RNA的测序方法、测序试剂和应用
JP7101419B2 (ja) * 2017-10-27 2022-07-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 内因性t細胞受容体の標的置換
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN112005115A (zh) 2018-02-12 2020-11-27 10X基因组学有限公司 表征来自单个细胞或细胞群体的多种分析物的方法
CN108374203B (zh) * 2018-03-01 2021-07-23 艾吉泰康生物科技(北京)有限公司 一种用于双向测序的扩增子文库的构建方法
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
EP3824104A1 (en) * 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
EP3841219A4 (en) * 2018-08-24 2022-05-04 Swift Biosciences, Inc. ASYMMETRIC TARGETED AMPLIFICATION METHODS
WO2020228664A1 (en) * 2019-05-10 2020-11-19 The Chinese University Of Hong Kong Primers and assays for linking regions using polymerases
US12305235B2 (en) * 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
US11149322B2 (en) * 2019-06-07 2021-10-19 Chapter Diagnostics, Inc. Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification
EP4025595A4 (en) * 2019-09-03 2023-11-29 The Regents Of The University Of California METHOD FOR SEQUENCE OF MRNA IN PARALLEL SINGLE CELLS WITH QUANTIFICATION OF INTRACELLULAR PHENOTYPE
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
EP4139486A4 (en) * 2020-04-24 2024-10-16 The Board of Trustees of the Leland Stanford Junior University Novel t-cell specificities and uses thereof
US10941453B1 (en) * 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
US20240011020A1 (en) * 2020-09-08 2024-01-11 Seqwell, Inc Sequencing oligonucleotides and methods of use thereof
US11111489B1 (en) 2021-01-06 2021-09-07 Think Therapeutics, Inc. Multiplexed testing of lymphocytes for antigen specificity
BR112023019195A2 (pt) 2021-03-24 2023-10-17 Genentech Inc Edição eficiente do gene tcr em linfócitos t
WO2022207682A1 (en) * 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing
CN114561454B (zh) * 2022-03-03 2025-11-14 中国人民解放军陆军军医大学 一种基于高通量测序对TCR β进行定量的方法
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
US12091715B2 (en) 2022-04-21 2024-09-17 Paragon Genomics, Inc. Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing
TWI867406B (zh) * 2022-10-27 2024-12-21 醫華生技股份有限公司 生物微粒分析方法
EP4603595A1 (en) * 2024-02-13 2025-08-20 ImmuneDiscover Sweden AB A method for typing the immune genes and the allelic variants thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US6031091A (en) 1987-09-21 2000-02-29 Gen-Probe Incorporated Non-nucleotide linking reagents for nucleotide probes
KR920003787B1 (ko) 1990-03-05 1992-05-14 한국과학기술 연구원 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법
AU681082B2 (en) 1992-05-06 1997-08-21 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
US5596090A (en) 1992-07-24 1997-01-21 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human VCAM-1 RNA
US5571711A (en) 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
ATE272113T1 (de) 1994-02-16 2004-08-15 Crucell Holland Bv Melanoma-assoziierte antigene, epitope davon und impstoffe gegen melanoma
US5821122A (en) 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
JPH0975090A (ja) 1995-09-13 1997-03-25 Kanegafuchi Chem Ind Co Ltd 細胞付着部材
EP3257949A1 (en) * 2005-06-15 2017-12-20 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US8911948B2 (en) 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2719774B8 (en) * 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
RU2539032C2 (ru) 2009-06-25 2015-01-10 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения искусственного иммунитета
WO2011106738A2 (en) 2010-02-25 2011-09-01 Fred Hutchinson Cancer Research Center Use of tcr clonotypes as biomarkers for disease
AU2011249041B2 (en) * 2010-05-06 2014-10-30 Adaptive Biotechnologies Corp. Monitoring health and disease status using clonotype profiles
CA2802111A1 (en) * 2010-07-23 2012-01-26 Esoterix Genetic Laboratories, Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012027503A2 (en) 2010-08-24 2012-03-01 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
WO2012083069A2 (en) * 2010-12-15 2012-06-21 The Board Of Trustees Of The Leland Stanford Junior University Measurement and monitoring of cell clonality
US20140057799A1 (en) 2010-12-16 2014-02-27 Gigagen System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells
DK2683736T3 (en) * 2011-03-09 2018-04-23 Cell Signaling Technology Inc METHODS AND REAGENTS FOR CREATING MONOCLONAL ANTIBODIES
HRP20250981T1 (hr) * 2011-05-24 2025-10-24 BioNTech SE Individualizirana cjepiva protiv raka
EP2823060B1 (en) * 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits

Similar Documents

Publication Publication Date Title
JP2016512685A5 (enExample)
US10760123B2 (en) Sequential sequencing
US20260022372A1 (en) Semi-random barcodes for nucleic acid analysis
EP2735617B1 (en) Method and kit for dna typing of hla gene
CN105861487B (zh) 用于靶向核酸序列富集和高效文库产生的组合物和方法
JP2020504709A5 (enExample)
US10604800B2 (en) Methods of increasing sequencing accuracy
JP2016526876A5 (enExample)
RU2019138698A (ru) Способы и композиции для днк-профилирования
JP2020523034A5 (enExample)
JP2017510244A5 (enExample)
JP2018509896A5 (enExample)
RU2013141237A (ru) Способы неинвазивного пренатального установления плоидности
JP2016521548A5 (enExample)
Gao et al. Forensic genetic informativeness of an SNP panel consisting of 19 multi-allelic SNPs
KR20190104611A (ko) 1 단계 프로세스를 통한 앰플리콘 라이브러리 구축 방법
KR20160138168A (ko) 카피수 보존 rna 분석 방법
JP2018518968A5 (enExample)
WO2017058810A3 (en) Polymerase compositions and kits, and methods of using and making the same
CN107541554A (zh) 用于人体个体识别和/或亲权鉴定的遗传标记及其检测方法和试剂盒
Martins et al. A new trilocus sequence-based multiplex-PCR to detect major Acinetobacter baumannii clones
CN106164287A (zh) 高分辨率hla分型
Berthenet et al. Recent “omics” advances in Helicobacter pylori
Davletshina et al. Application of ITS1 and ITS2 for population genetic studies of sturgeons (Acipenseridae)
RU2021132736A (ru) Способ получения однонуклеотидных молекулярных маркеров для определения вероятного этногеографического происхождения человека методом мультиплексной амплификации для работы с образцами деградированной ДНК