JP2016512685A5 - - Google Patents

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JP2016512685A5
JP2016512685A5 JP2016502574A JP2016502574A JP2016512685A5 JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5 JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016512685 A5 JP2016512685 A5 JP 2016512685A5
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JP
Japan
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air
sequence
polypeptide
sequences
region coding
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JP2016502574A
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Japanese (ja)
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JP2016512685A (ja
JP6431895B2 (ja
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Priority claimed from PCT/US2013/045994 external-priority patent/WO2013188831A1/en
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Priority claimed from PCT/US2014/030859 external-priority patent/WO2014145992A1/en
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Publication of JP2016512685A5 publication Critical patent/JP2016512685A5/ja
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JP2016502574A 2013-03-15 2014-03-17 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 Active JP6431895B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361789408P 2013-03-15 2013-03-15
US61/789,408 2013-03-15
PCT/US2013/045994 WO2013188831A1 (en) 2012-06-15 2013-06-14 Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
USPCT/US2013/045994 2013-06-14
PCT/US2014/030859 WO2014145992A1 (en) 2013-03-15 2014-03-17 Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set

Publications (3)

Publication Number Publication Date
JP2016512685A JP2016512685A (ja) 2016-05-09
JP2016512685A5 true JP2016512685A5 (enExample) 2017-04-13
JP6431895B2 JP6431895B2 (ja) 2018-12-05

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JP2016502574A Active JP6431895B2 (ja) 2013-03-15 2014-03-17 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子

Country Status (10)

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US (2) US20160024493A1 (enExample)
EP (1) EP2971105B1 (enExample)
JP (1) JP6431895B2 (enExample)
KR (1) KR20150132479A (enExample)
CN (1) CN105452483B (enExample)
AU (2) AU2014232314B2 (enExample)
CA (1) CA2906218A1 (enExample)
IL (1) IL241394B (enExample)
SG (2) SG11201506991VA (enExample)
WO (1) WO2014145992A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
DK3059337T3 (da) 2009-01-15 2019-07-22 Adaptive Biotechnologies Corp Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
EP3091089B1 (en) 2012-05-08 2019-01-23 Adaptive Biotechnologies Corporation Method for measuring and calibrating amplification bias in multiplexed pcr reactions
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US10202640B2 (en) * 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
WO2015176162A1 (en) 2014-05-22 2015-11-26 The University Of British Columbia Methods for determining lymphocyte receptor chain pairs
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3224384A4 (en) 2014-11-25 2018-04-18 Adaptive Biotechnologies Corp. Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CN104562215B (zh) * 2014-12-29 2017-03-22 北京诺禾致源科技股份有限公司 扩增子文库的构建方法
EP3247804B1 (en) * 2015-01-23 2020-08-05 Qiagen Sciences, LLC High multiplex pcr with molecular barcoding
US11047008B2 (en) 2015-02-24 2021-06-29 Adaptive Biotechnologies Corporation Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
WO2016138488A2 (en) * 2015-02-26 2016-09-01 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
HK1252248A1 (zh) * 2015-04-27 2019-05-24 Abvitro Llc 对治疗剂和疾病特异性抗原进行测序、确定、配对和验证的方法
WO2017013170A1 (en) 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
GB201516269D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516276D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516265D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516275D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516274D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516270D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
AU2016348439B2 (en) * 2015-11-04 2023-03-09 Atreca, Inc. Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells
EP4289965A3 (en) * 2016-02-12 2024-02-21 CureVac SE Method for analyzing rna
EP3423598B1 (en) * 2016-03-01 2024-05-01 Universal Sequencing Technology Corporation Methods and kits for tracking nucleic acid target origin for nucleic acid sequencing
US11920174B2 (en) 2016-03-03 2024-03-05 CureVac SE RNA analysis by total hydrolysis and quantification of released nucleosides
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
ES2898088T3 (es) 2016-06-01 2022-03-03 Hoffmann La Roche Inmuno-PETE
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
RU2019123063A (ru) 2016-12-23 2021-01-26 Вистерра, Инк. Связывающие полипептиды и способы их получения
WO2018132635A1 (en) * 2017-01-12 2018-07-19 Massachusetts Institute Of Technology Methods for analyzing t cell receptors and b cell receptors
US10920273B2 (en) 2017-01-17 2021-02-16 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
WO2018144410A1 (en) * 2017-01-31 2018-08-09 Ludwig Institute For Cancer Research Ltd. Enhanced immune cell receptor sequencing methods
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
CN109536594B (zh) * 2017-09-20 2022-11-01 深圳华大智造科技股份有限公司 一种用于Small RNA的测序方法、测序试剂和应用
WO2019084552A1 (en) 2017-10-27 2019-05-02 The Regents Of The University Of California TARGETED REPLACEMENT OF ENDOGENIC T CELL RECEPTORS
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
CN108374203B (zh) * 2018-03-01 2021-07-23 艾吉泰康生物科技(北京)有限公司 一种用于双向测序的扩增子文库的构建方法
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
US20220002802A1 (en) * 2018-07-18 2022-01-06 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
EP3841219A4 (en) 2018-08-24 2022-05-04 Swift Biosciences, Inc. ASYMMETRIC TARGETED AMPLIFICATION METHODS
EP3966345A4 (en) * 2019-05-10 2023-06-28 The Chinese University of Hong Kong Primers and assays for linking regions using polymerases
EP3980559A1 (en) * 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US11149322B2 (en) * 2019-06-07 2021-10-19 Chapter Diagnostics, Inc. Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification
US20220308061A1 (en) * 2019-09-03 2022-09-29 The Regents Of The University Of California Method to sequence mrna in single cells in parallel with quantification of intracellular phenotype
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
EP4139486A4 (en) * 2020-04-24 2024-10-16 The Board of Trustees of the Leland Stanford Junior University Novel t-cell specificities and uses thereof
US10941453B1 (en) * 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
US20240011020A1 (en) * 2020-09-08 2024-01-11 Seqwell, Inc Sequencing oligonucleotides and methods of use thereof
US11111489B1 (en) 2021-01-06 2021-09-07 Think Therapeutics, Inc. Multiplexed testing of lymphocytes for antigen specificity
CA3214486A1 (en) 2021-03-24 2022-09-29 Genentech, Inc. Efficient tcr gene editing in t lymphocytes
EP4314337A1 (en) * 2021-04-01 2024-02-07 F. Hoffmann-La Roche AG Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing
CN114561454B (zh) * 2022-03-03 2025-11-14 中国人民解放军陆军军医大学 一种基于高通量测序对TCR β进行定量的方法
US12091715B2 (en) 2022-04-21 2024-09-17 Paragon Genomics, Inc. Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
TWI867406B (zh) * 2022-10-27 2024-12-21 醫華生技股份有限公司 生物微粒分析方法
EP4603595A1 (en) * 2024-02-13 2025-08-20 ImmuneDiscover Sweden AB A method for typing the immune genes and the allelic variants thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US6031091A (en) 1987-09-21 2000-02-29 Gen-Probe Incorporated Non-nucleotide linking reagents for nucleotide probes
KR920003787B1 (ko) 1990-03-05 1992-05-14 한국과학기술 연구원 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법
CA2135073C (en) 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5596090A (en) 1992-07-24 1997-01-21 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human VCAM-1 RNA
US5571711A (en) 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
DE69533295T3 (de) 1994-02-16 2009-07-16 The Government Of The United States Of America, As Represented By The Secretary, The Department Of Health And Human Services Melanoma-assoziierte Antigene, Epitope davon und Impstoffe gegen Melanoma
US5821122A (en) 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
JPH0975090A (ja) 1995-09-13 1997-03-25 Kanegafuchi Chem Ind Co Ltd 細胞付着部材
AU2006259565B2 (en) * 2005-06-15 2011-01-06 Complete Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US8911948B2 (en) 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2364368B1 (en) * 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
RU2014144463A (ru) 2009-06-25 2015-06-20 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения адаптивного иммунитета
US20120058902A1 (en) 2009-06-25 2012-03-08 Livingston Robert J Method of measuring adaptive immunity
WO2011106738A2 (en) 2010-02-25 2011-09-01 Fred Hutchinson Cancer Research Center Use of tcr clonotypes as biomarkers for disease
WO2011139372A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Sequence analysis of complex amplicons
CN103069006A (zh) * 2010-07-23 2013-04-24 艾索特里克斯遗传实验室有限责任公司 区别表达的胚胎或母源基因组区的鉴定及其用途
US9193997B2 (en) * 2010-12-15 2015-11-24 The Board Of Trustees Of The Leland Stanford Junior University Measuring and monitoring of cell clonality
ES2615733T3 (es) 2010-12-16 2017-06-08 Gigagen, Inc. Métodos para el análisis masivo paralelo de ácidos nucleicos en células individuales
CN108220297A (zh) * 2011-03-09 2018-06-29 细胞信号科技公司 用于生成单克隆抗体的方法和试剂
PL3892295T3 (pl) * 2011-05-24 2023-07-24 BioNTech SE Zindywidualizowane szczepionki przeciwnowotworowe
DK2823060T3 (en) * 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits

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