JP2020504709A5 - - Google Patents
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- Publication number
- JP2020504709A5 JP2020504709A5 JP2019525959A JP2019525959A JP2020504709A5 JP 2020504709 A5 JP2020504709 A5 JP 2020504709A5 JP 2019525959 A JP2019525959 A JP 2019525959A JP 2019525959 A JP2019525959 A JP 2019525959A JP 2020504709 A5 JP2020504709 A5 JP 2020504709A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide library
- polynucleotides
- percent
- genomic fragment
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091033319 polynucleotide Proteins 0.000 claims 74
- 102000040430 polynucleotide Human genes 0.000 claims 74
- 239000002157 polynucleotide Substances 0.000 claims 74
- 239000012634 fragment Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 6
- 238000012163 sequencing technique Methods 0.000 claims 5
- 238000009396 hybridization Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108700024394 Exon Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022173718A JP2023017863A (ja) | 2016-11-18 | 2022-10-28 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
| JP2024192262A JP2025028854A (ja) | 2016-11-18 | 2024-10-31 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662424302P | 2016-11-18 | 2016-11-18 | |
| US62/424,302 | 2016-11-18 | ||
| US201762548307P | 2017-08-21 | 2017-08-21 | |
| US62/548,307 | 2017-08-21 | ||
| US201762558666P | 2017-09-14 | 2017-09-14 | |
| US62/558,666 | 2017-09-14 | ||
| PCT/US2017/062391 WO2018094263A1 (en) | 2016-11-18 | 2017-11-17 | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022173718A Division JP2023017863A (ja) | 2016-11-18 | 2022-10-28 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020504709A JP2020504709A (ja) | 2020-02-13 |
| JP2020504709A5 true JP2020504709A5 (enExample) | 2020-12-24 |
Family
ID=62144787
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019525959A Pending JP2020504709A (ja) | 2016-11-18 | 2017-11-17 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
| JP2022173718A Pending JP2023017863A (ja) | 2016-11-18 | 2022-10-28 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
| JP2024192262A Pending JP2025028854A (ja) | 2016-11-18 | 2024-10-31 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022173718A Pending JP2023017863A (ja) | 2016-11-18 | 2022-10-28 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
| JP2024192262A Pending JP2025028854A (ja) | 2016-11-18 | 2024-10-31 | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180142289A1 (enExample) |
| EP (1) | EP3541973B1 (enExample) |
| JP (3) | JP2020504709A (enExample) |
| KR (1) | KR102569164B1 (enExample) |
| CN (1) | CN110382752A (enExample) |
| AU (2) | AU2017363204B2 (enExample) |
| CA (1) | CA3044057A1 (enExample) |
| GB (1) | GB2572877A (enExample) |
| IL (2) | IL266681B2 (enExample) |
| WO (1) | WO2018094263A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102160389B1 (ko) | 2013-08-05 | 2020-09-28 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| EP3384077A4 (en) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF |
| EP3452614B1 (en) | 2016-05-02 | 2023-06-28 | Becton, Dickinson and Company | Accurate molecular barcoding |
| WO2018038772A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| EP4664304A3 (en) | 2016-09-21 | 2026-01-21 | Atlas Data Storage, Inc. | Nucleic acid based data storage |
| AU2017363204B2 (en) * | 2016-11-18 | 2022-12-08 | Twist Bioscience Corporation | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| IL312616B2 (en) | 2018-01-04 | 2025-08-01 | Twist Bioscience Corp | Dna-based digital information storage |
| EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
| EP3902816A4 (en) | 2018-12-26 | 2022-09-14 | Twist Bioscience Corporation | HIGH-PRECISION DE NOVO POLYNUCLEOTIDE SYNTHESIS |
| WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| KR20210144698A (ko) | 2019-02-26 | 2021-11-30 | 트위스트 바이오사이언스 코포레이션 | 항체 최적화를 위한 변이 핵산 라이브러리 |
| CA3131689A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| CN115023440B (zh) | 2019-09-23 | 2025-09-12 | 特韦斯特生物科学公司 | 结合CD3ε的抗体 |
| EP4055159A4 (en) | 2019-11-06 | 2024-04-17 | Adaptive Biotechnologies Corporation | SYNTHETIC STRANDS FOR NUCLEIC ACID SEQUENCING AND RELATED METHODS AND SYSTEMS |
| CN110853708B (zh) * | 2019-11-13 | 2022-03-08 | 上海仁东医学检验所有限公司 | 用于hla分型的核酸捕获探针的设计方法 |
| AU2020400030B2 (en) | 2019-12-09 | 2026-05-21 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
| BR112022021780A2 (pt) | 2020-04-27 | 2023-03-07 | Twist Bioscience Corp | Bibliotecas de ácido nucléico variantes para coronavírus |
| WO2021231324A1 (en) * | 2020-05-11 | 2021-11-18 | Personal Genome Diagnostics Inc. | Selective capture of target dna sequences |
| WO2021242668A1 (en) * | 2020-05-28 | 2021-12-02 | Illumina, Inc. | Comparing copies of polynucleotides with different features |
| CA3190667A1 (en) | 2020-08-26 | 2022-03-03 | Aaron Sato | Methods and compositions relating to glp1r variants |
| US12534494B2 (en) | 2020-08-28 | 2026-01-27 | Twist Bioscience Corporation | Devices and methods for synthesis |
| EP4229210A4 (en) | 2020-10-19 | 2025-01-08 | Twist Bioscience Corporation | METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES |
| WO2022159620A1 (en) | 2021-01-21 | 2022-07-28 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
| BE1029144B1 (fr) * | 2021-02-25 | 2022-09-20 | Oncodna | Méthode de caracterisation d'une tumeur à l'aide d'un séquençage ciblé |
| US12258406B2 (en) | 2021-03-24 | 2025-03-25 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| WO2022235584A1 (en) | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
| WO2022271884A2 (en) | 2021-06-22 | 2022-12-29 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| WO2023023285A2 (en) | 2021-08-19 | 2023-02-23 | Twist Bioscience Corporation | Methods and compositions relating to covalently closed nucleic acids |
| US12697597B2 (en) | 2021-11-01 | 2026-08-04 | Twist Bioscience Corporation | Methods for polynucleotide synthesis |
| EP4433085A2 (en) | 2021-11-18 | 2024-09-25 | Twist Bioscience Corporation | Dickkopf-1 variant antibodies and methods of use |
| US12325739B2 (en) | 2022-01-03 | 2025-06-10 | Twist Bioscience Corporation | Bispecific SARS-CoV-2 antibodies and methods of use |
| EP4490318A4 (en) | 2022-03-07 | 2026-06-10 | Twist Bioscience Corp | METHYLATION-MEDIATED ADAPTER ELIMINATION ON NUCLEIC ACID SEQUENCES |
| CN116417071B (zh) * | 2023-04-07 | 2026-04-03 | 祥符实验室 | 一种dna数据存储的选择性访问方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US7655791B2 (en) * | 2001-11-13 | 2010-02-02 | Rubicon Genomics, Inc. | DNA amplification and sequencing using DNA molecules generated by random fragmentation |
| US9598737B2 (en) | 2012-05-09 | 2017-03-21 | Longhorn Vaccines And Diagnostics, Llc | Next generation genomic sequencing methods |
| WO2010030683A1 (en) * | 2008-09-09 | 2010-03-18 | Rosetta Inpharmatics Llc | Methods of generating gene specific libraries |
| US8828688B2 (en) * | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| JP6017458B2 (ja) * | 2011-02-02 | 2016-11-02 | ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション | 大量並列連続性マッピング |
| CA2871505C (en) * | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| EP2880182B1 (en) * | 2012-08-02 | 2017-07-26 | Qiagen GmbH | Recombinase mediated targeted dna enrichment for next generation sequencing |
| US20160032396A1 (en) * | 2013-03-15 | 2016-02-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and Use of Circulating Nucleic Acid Tumor Markers |
| KR102160389B1 (ko) * | 2013-08-05 | 2020-09-28 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| GB2534067B (en) * | 2013-08-30 | 2021-07-21 | Personalis Inc | Methods and systems for genomic analysis |
| CA2929108A1 (en) * | 2013-10-29 | 2015-05-07 | Longhorn Vaccines And Diagnostics, Llc | Next generation genomic sequencing methods |
| AU2017363204B2 (en) * | 2016-11-18 | 2022-12-08 | Twist Bioscience Corporation | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
-
2017
- 2017-11-17 AU AU2017363204A patent/AU2017363204B2/en not_active Ceased
- 2017-11-17 EP EP17872347.4A patent/EP3541973B1/en active Active
- 2017-11-17 WO PCT/US2017/062391 patent/WO2018094263A1/en not_active Ceased
- 2017-11-17 US US15/816,995 patent/US20180142289A1/en not_active Abandoned
- 2017-11-17 IL IL266681A patent/IL266681B2/en unknown
- 2017-11-17 CA CA3044057A patent/CA3044057A1/en active Pending
- 2017-11-17 JP JP2019525959A patent/JP2020504709A/ja active Pending
- 2017-11-17 CN CN201780084031.1A patent/CN110382752A/zh active Pending
- 2017-11-17 IL IL314890A patent/IL314890A/en unknown
- 2017-11-17 GB GB1908719.6A patent/GB2572877A/en not_active Withdrawn
- 2017-11-17 KR KR1020197017281A patent/KR102569164B1/ko active Active
-
2021
- 2021-06-17 US US17/350,750 patent/US20210348220A1/en not_active Abandoned
-
2022
- 2022-10-28 JP JP2022173718A patent/JP2023017863A/ja active Pending
-
2023
- 2023-02-15 AU AU2023200850A patent/AU2023200850A1/en not_active Abandoned
-
2024
- 2024-10-31 JP JP2024192262A patent/JP2025028854A/ja active Pending
-
2025
- 2025-08-13 US US19/298,873 patent/US20260132447A1/en active Pending
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