JP6431895B2 - 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 - Google Patents
複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 Download PDFInfo
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- JP6431895B2 JP6431895B2 JP2016502574A JP2016502574A JP6431895B2 JP 6431895 B2 JP6431895 B2 JP 6431895B2 JP 2016502574 A JP2016502574 A JP 2016502574A JP 2016502574 A JP2016502574 A JP 2016502574A JP 6431895 B2 JP6431895 B2 JP 6431895B2
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- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789408P | 2013-03-15 | 2013-03-15 | |
| US61/789,408 | 2013-03-15 | ||
| PCT/US2013/045994 WO2013188831A1 (en) | 2012-06-15 | 2013-06-14 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| USPCT/US2013/045994 | 2013-06-14 | ||
| PCT/US2014/030859 WO2014145992A1 (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512685A JP2016512685A (ja) | 2016-05-09 |
| JP2016512685A5 JP2016512685A5 (enExample) | 2017-04-13 |
| JP6431895B2 true JP6431895B2 (ja) | 2018-12-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502574A Active JP6431895B2 (ja) | 2013-03-15 | 2014-03-17 | 複合遺伝子セットにおいてユニークにタグ付けされた再構成された適応免疫受容体遺伝子 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160024493A1 (enExample) |
| EP (1) | EP2971105B1 (enExample) |
| JP (1) | JP6431895B2 (enExample) |
| KR (1) | KR20150132479A (enExample) |
| CN (1) | CN105452483B (enExample) |
| AU (2) | AU2014232314B2 (enExample) |
| CA (1) | CA2906218A1 (enExample) |
| IL (1) | IL241394B (enExample) |
| SG (2) | SG11201506991VA (enExample) |
| WO (1) | WO2014145992A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| PT2831276T (pt) | 2012-05-08 | 2016-07-26 | Adaptive Biotechnologies Corp | Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| EP3146079B1 (en) | 2014-05-22 | 2019-01-30 | The University Of British Columbia | Methods for determining lymphocyte receptor chain pairs |
| EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| US11066705B2 (en) | 2014-11-25 | 2021-07-20 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN104562215B (zh) * | 2014-12-29 | 2017-03-22 | 北京诺禾致源科技股份有限公司 | 扩增子文库的构建方法 |
| EP3763825B1 (en) * | 2015-01-23 | 2023-10-04 | Qiagen Sciences, LLC | High multiplex pcr with molecular barcoding |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016138488A2 (en) | 2015-02-26 | 2016-09-01 | The Broad Institute Inc. | T cell balance gene expression, compositions of matters and methods of use thereof |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| CN107849560B (zh) * | 2015-04-27 | 2021-10-22 | 阿布维特罗有限责任公司 | 对治疗剂和疾病特异性抗原进行测序、确定、配对和验证的方法 |
| WO2017013170A1 (en) * | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516276D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516275D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516270D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516265D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516274D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516269D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| WO2017079593A1 (en) * | 2015-11-04 | 2017-05-11 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| WO2017137095A1 (en) * | 2016-02-12 | 2017-08-17 | Curevac Ag | Method for analyzing rna |
| CN109196115A (zh) * | 2016-03-01 | 2019-01-11 | 通用测序技术公司 | 跟踪核酸靶标来源以用于核酸测序的方法和试剂盒 |
| WO2017149139A1 (en) | 2016-03-03 | 2017-09-08 | Curevac Ag | Rna analysis by total hydrolysis |
| WO2017192387A1 (en) * | 2016-05-02 | 2017-11-09 | Cellular Research, Inc. | Accurate molecular barcoding |
| WO2017210469A2 (en) * | 2016-06-01 | 2017-12-07 | F. Hoffman-La Roche Ag | Immuno-pete |
| CN106283201B (zh) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | 基于高通量测序的tcr多样性检测和文库构建 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| IL315727A (en) | 2016-12-23 | 2024-11-01 | Visterra Inc | Binding polypeptides and methods for their preparation |
| US20210087610A9 (en) * | 2017-01-12 | 2021-03-25 | Massachusetts Institute Of Technology | Methods for analyzing t cell receptors and b cell receptors |
| CN110249060A (zh) * | 2017-01-17 | 2019-09-17 | 生命技术公司 | 用于免疫组库测序的组合物和方法 |
| EP3577234B1 (en) * | 2017-01-31 | 2024-03-20 | Ludwig Institute For Cancer Research Ltd. | Enhanced immune cell receptor sequencing methods |
| EP3676399B1 (en) | 2017-09-01 | 2022-05-11 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| CN109536594B (zh) * | 2017-09-20 | 2022-11-01 | 深圳华大智造科技股份有限公司 | 一种用于Small RNA的测序方法、测序试剂和应用 |
| EP3700924A4 (en) | 2017-10-27 | 2021-11-03 | The Regents of the University of California | TARGETED REPLACEMENT OF ENDOGENOUS T-CELL RECEPTORS |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| CN108374203B (zh) * | 2018-03-01 | 2021-07-23 | 艾吉泰康生物科技(北京)有限公司 | 一种用于双向测序的扩增子文库的构建方法 |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| EP3824104A1 (en) * | 2018-07-18 | 2021-05-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| EP3824103A1 (en) | 2018-07-18 | 2021-05-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| WO2020041702A1 (en) * | 2018-08-24 | 2020-02-27 | Swift Biosciences, Inc. | Asymmetric targeted amplification methods |
| AU2020276518B2 (en) * | 2019-05-10 | 2025-03-20 | The Chinese University Of Hong Kong | Primers and assays for linking regions using polymerases |
| EP3980559A1 (en) * | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| US11149322B2 (en) * | 2019-06-07 | 2021-10-19 | Chapter Diagnostics, Inc. | Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification |
| US20220308061A1 (en) * | 2019-09-03 | 2022-09-29 | The Regents Of The University Of California | Method to sequence mrna in single cells in parallel with quantification of intracellular phenotype |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| JP2023515265A (ja) * | 2020-04-24 | 2023-04-12 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 新規t細胞特異性とその使用 |
| US10941453B1 (en) * | 2020-05-20 | 2021-03-09 | Paragon Genomics, Inc. | High throughput detection of pathogen RNA in clinical specimens |
| WO2022055969A1 (en) * | 2020-09-08 | 2022-03-17 | Seqwell, Inc. | Sequencing oligonucleotides and methods of use thereof |
| US11111489B1 (en) | 2021-01-06 | 2021-09-07 | Think Therapeutics, Inc. | Multiplexed testing of lymphocytes for antigen specificity |
| BR112023019195A2 (pt) | 2021-03-24 | 2023-10-17 | Genentech Inc | Edição eficiente do gene tcr em linfócitos t |
| WO2022207682A1 (en) * | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
| CN114561454B (zh) * | 2022-03-03 | 2025-11-14 | 中国人民解放军陆军军医大学 | 一种基于高通量测序对TCR β进行定量的方法 |
| US12091715B2 (en) | 2022-04-21 | 2024-09-17 | Paragon Genomics, Inc. | Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing |
| US11680293B1 (en) | 2022-04-21 | 2023-06-20 | Paragon Genomics, Inc. | Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules |
| TWM645911U (zh) * | 2022-10-27 | 2023-09-11 | 醫華生技股份有限公司 | 生物微粒富集設備及其微滴產生器 |
| EP4603595A1 (en) * | 2024-02-13 | 2025-08-20 | ImmuneDiscover Sweden AB | A method for typing the immune genes and the allelic variants thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US6031091A (en) | 1987-09-21 | 2000-02-29 | Gen-Probe Incorporated | Non-nucleotide linking reagents for nucleotide probes |
| KR920003787B1 (ko) | 1990-03-05 | 1992-05-14 | 한국과학기술 연구원 | 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법 |
| WO1993022461A1 (en) | 1992-05-06 | 1993-11-11 | Gen-Probe Incorporated | Nucleic acid sequence amplification method, composition and kit |
| US5596090A (en) | 1992-07-24 | 1997-01-21 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human VCAM-1 RNA |
| US5571711A (en) | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
| EP0668350B2 (en) | 1994-02-16 | 2008-12-03 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Melanoma associated antigenic polypeptide, epitopes thereof and vaccines against melanoma |
| US5821122A (en) | 1995-06-07 | 1998-10-13 | Inserm (Institute Nat'l De La Sante Et De La Recherche . .) | Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof |
| JPH0975090A (ja) | 1995-09-13 | 1997-03-25 | Kanegafuchi Chem Ind Co Ltd | 細胞付着部材 |
| DK2620510T4 (da) * | 2005-06-15 | 2020-03-30 | Complete Genomics Inc | Enkeltmolekyle-arrays til genetisk og kemisk analyse |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| EP3699296A1 (en) * | 2008-11-07 | 2020-08-26 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
| RU2014144463A (ru) | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
| US20120058902A1 (en) * | 2009-06-25 | 2012-03-08 | Livingston Robert J | Method of measuring adaptive immunity |
| WO2011106738A2 (en) | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
| JP6158080B2 (ja) * | 2010-05-06 | 2017-07-05 | アダプティヴ バイオテクノロジーズ コーポレーション | クロノタイププロファイルを用いた健康状態および疾患状態のモニタリング |
| WO2012012703A2 (en) * | 2010-07-23 | 2012-01-26 | Esoterix Genetic Laboratories, Llc | Identification of differentially represented fetal or maternal genomic regions and uses thereof |
| WO2012083069A2 (en) * | 2010-12-15 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and monitoring of cell clonality |
| US20140057799A1 (en) | 2010-12-16 | 2014-02-27 | Gigagen | System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells |
| KR101938343B1 (ko) * | 2011-03-09 | 2019-01-14 | 셀 시그널링 테크놀러지, 인크. | 모노클로날 항체를 생성하는 방법 및 시약 |
| ES2746233T3 (es) * | 2011-05-24 | 2020-03-05 | Biontech Rna Pharmaceuticals Gmbh | Vacunas individualizadas para el cáncer |
| ES2662128T3 (es) * | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
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| US20250043272A1 (en) | 2025-02-06 |
| CN105452483A (zh) | 2016-03-30 |
| AU2014232314B2 (en) | 2020-05-14 |
| AU2020213348A1 (en) | 2020-08-27 |
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| CN105452483B (zh) | 2019-01-11 |
| IL241394B (en) | 2019-12-31 |
| SG11201506991VA (en) | 2015-10-29 |
| AU2020213348B2 (en) | 2022-05-19 |
| US20160024493A1 (en) | 2016-01-28 |
| JP2016512685A (ja) | 2016-05-09 |
| EP2971105B1 (en) | 2018-08-01 |
| SG10201707394PA (en) | 2017-10-30 |
| KR20150132479A (ko) | 2015-11-25 |
| CA2906218A1 (en) | 2014-09-18 |
| WO2014145992A1 (en) | 2014-09-18 |
| EP2971105A1 (en) | 2016-01-20 |
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