SG10201707394PA - Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set - Google Patents
Uniquely tagged rearranged adaptive immune receptor genes in a complex gene setInfo
- Publication number
- SG10201707394PA SG10201707394PA SG10201707394PA SG10201707394PA SG10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA
- Authority
- SG
- Singapore
- Prior art keywords
- adaptive immune
- gene set
- immune receptor
- receptor genes
- complex gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/155—Modifications characterised by incorporating/generating a new priming site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789408P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/045994 WO2013188831A1 (en) | 2012-06-15 | 2013-06-14 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201707394PA true SG10201707394PA (en) | 2017-10-30 |
Family
ID=51538155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201707394PA SG10201707394PA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| SG11201506991VA SG11201506991VA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201506991VA SG11201506991VA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160024493A1 (en) |
| EP (1) | EP2971105B1 (en) |
| JP (1) | JP6431895B2 (en) |
| KR (1) | KR20150132479A (en) |
| CN (1) | CN105452483B (en) |
| AU (2) | AU2014232314B2 (en) |
| CA (1) | CA2906218A1 (en) |
| IL (1) | IL241394B (en) |
| SG (2) | SG10201707394PA (en) |
| WO (1) | WO2014145992A1 (en) |
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| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| ES2568509T3 (en) | 2009-01-15 | 2016-04-29 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for the generation of monoclonal antibodies |
| JP6302847B2 (en) | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | Determination of paired immunoreceptor chains from frequency matched subunits |
| RU2631797C2 (en) | 2012-05-08 | 2017-09-26 | Эдэптив Байотекнолоджиз Корпорейшн | Compositions and methods of measurement and calibration of systematic mistake of amplification in multiplex pcr-reactions |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| CA2941612A1 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| US10400281B2 (en) | 2014-05-22 | 2019-09-03 | The University Of British Columbia | Methods for determining lymphocyte receptor chain pairs |
| WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN104562215B (en) * | 2014-12-29 | 2017-03-22 | 北京诺禾致源科技股份有限公司 | Method for constructing amplicon library |
| US10760120B2 (en) * | 2015-01-23 | 2020-09-01 | Qiagen Sciences, Llc | High multiplex PCR with molecular barcoding |
| EP3262196B1 (en) | 2015-02-24 | 2020-12-09 | Adaptive Biotechnologies Corp. | Method for determining hla status using immune repertoire sequencing |
| EP3262193A2 (en) | 2015-02-26 | 2018-01-03 | The Broad Institute Inc. | T cell balance gene expression, compositions of matters and methods of use thereof |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| EP3289082A4 (en) * | 2015-04-27 | 2018-09-12 | AbVitro LLC | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| WO2017013170A1 (en) | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
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| GB201516270D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516274D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516276D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| CA3004310A1 (en) * | 2015-11-04 | 2017-05-11 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| EP3414340B1 (en) * | 2016-02-12 | 2023-08-09 | CureVac SE | Method for analyzing rna |
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| ES2956757T3 (en) * | 2016-05-02 | 2023-12-27 | Becton Dickinson Co | Accurate molecular barcode coding |
| US11306356B2 (en) | 2016-06-01 | 2022-04-19 | Roche Sequencing Solutions, Inc. | Immuno-PETE |
| CN106283201B (en) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | The detection of TCR diversity and library construction based on high-flux sequence |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
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| KR20190111036A (en) | 2016-12-23 | 2019-10-01 | 비스테라, 인크. | Binding Polypeptides and Methods for Making the Same |
| EP3568508A4 (en) * | 2017-01-12 | 2020-12-16 | Massachusetts Institute Of Technology | Methods for analyzing t cell receptors and b cell receptors |
| WO2018136562A2 (en) * | 2017-01-17 | 2018-07-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| US11319590B2 (en) * | 2017-01-31 | 2022-05-03 | Ludwig Institute For Cancer Research Ltd. | Enhanced immune cell receptor sequencing methods |
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| CN109536594B (en) * | 2017-09-20 | 2022-11-01 | 深圳华大智造科技股份有限公司 | Sequencing method, sequencing reagent and application for Small RNA |
| WO2019084552A1 (en) | 2017-10-27 | 2019-05-02 | The Regents Of The University Of California | Targeted replacement of endogenous t cell receptors |
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| JP2023515265A (en) * | 2020-04-24 | 2023-04-12 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Novel T-cell specificity and its use |
| US10941453B1 (en) * | 2020-05-20 | 2021-03-09 | Paragon Genomics, Inc. | High throughput detection of pathogen RNA in clinical specimens |
| CA3214486A1 (en) | 2021-03-24 | 2022-09-29 | Genentech, Inc. | Efficient tcr gene editing in t lymphocytes |
| WO2022207682A1 (en) * | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
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| US9193997B2 (en) * | 2010-12-15 | 2015-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Measuring and monitoring of cell clonality |
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| JP6211931B2 (en) * | 2011-03-09 | 2017-10-11 | セル・シグナリング・テクノロジー・インコーポレイテツド | Methods and reagents for producing monoclonal antibodies |
| SI3892295T1 (en) * | 2011-05-24 | 2023-09-29 | BioNTech SE | Individualized vaccines for cancer |
| JP6302847B2 (en) * | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | Determination of paired immunoreceptor chains from frequency matched subunits |
-
2014
- 2014-03-17 SG SG10201707394PA patent/SG10201707394PA/en unknown
- 2014-03-17 WO PCT/US2014/030859 patent/WO2014145992A1/en active Application Filing
- 2014-03-17 SG SG11201506991VA patent/SG11201506991VA/en unknown
- 2014-03-17 CN CN201480025490.9A patent/CN105452483B/en active Active
- 2014-03-17 CA CA2906218A patent/CA2906218A1/en not_active Abandoned
- 2014-03-17 EP EP14722474.5A patent/EP2971105B1/en active Active
- 2014-03-17 US US14/777,294 patent/US20160024493A1/en not_active Abandoned
- 2014-03-17 KR KR1020157029634A patent/KR20150132479A/en not_active Application Discontinuation
- 2014-03-17 JP JP2016502574A patent/JP6431895B2/en active Active
- 2014-03-17 AU AU2014232314A patent/AU2014232314B2/en active Active
-
2015
- 2015-09-09 IL IL241394A patent/IL241394B/en active IP Right Grant
-
2020
- 2020-08-06 AU AU2020213348A patent/AU2020213348B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2906218A1 (en) | 2014-09-18 |
| WO2014145992A1 (en) | 2014-09-18 |
| IL241394B (en) | 2019-12-31 |
| EP2971105B1 (en) | 2018-08-01 |
| US20160024493A1 (en) | 2016-01-28 |
| JP2016512685A (en) | 2016-05-09 |
| AU2014232314B2 (en) | 2020-05-14 |
| KR20150132479A (en) | 2015-11-25 |
| AU2020213348A1 (en) | 2020-08-27 |
| SG11201506991VA (en) | 2015-10-29 |
| AU2020213348B2 (en) | 2022-05-19 |
| EP2971105A1 (en) | 2016-01-20 |
| AU2014232314A1 (en) | 2015-09-17 |
| CN105452483B (en) | 2019-01-11 |
| JP6431895B2 (en) | 2018-12-05 |
| CN105452483A (en) | 2016-03-30 |
| IL241394A0 (en) | 2015-11-30 |
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