JP2016507569A - ラミブジン結晶塩 - Google Patents

ラミブジン結晶塩 Download PDF

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Publication number
JP2016507569A
JP2016507569A JP2015557055A JP2015557055A JP2016507569A JP 2016507569 A JP2016507569 A JP 2016507569A JP 2015557055 A JP2015557055 A JP 2015557055A JP 2015557055 A JP2015557055 A JP 2015557055A JP 2016507569 A JP2016507569 A JP 2016507569A
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JP
Japan
Prior art keywords
lamivudine
crystalline
hydrochloride
sulfate
peaks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2015557055A
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English (en)
Japanese (ja)
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JP2016507569A5 (enExample
Inventor
ショーン マーク ダルジール，
ショーン マーク ダルジール，
マーク マイケル メニング，
マーク マイケル メニング，
Original Assignee
トビラ セラピューティクス， インコーポレイテッド
トビラ セラピューティクス， インコーポレイテッド
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Application filed by トビラ セラピューティクス， インコーポレイテッド, トビラ セラピューティクス， インコーポレイテッド filed Critical トビラ セラピューティクス， インコーポレイテッド
Publication of JP2016507569A publication Critical patent/JP2016507569A/ja
Publication of JP2016507569A5 publication Critical patent/JP2016507569A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015557055A 2013-02-07 2014-02-06 ラミブジン結晶塩 Pending JP2016507569A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361762018P 2013-02-07 2013-02-07
US61/762,018 2013-02-07
PCT/US2014/015024 WO2014124092A2 (en) 2013-02-07 2014-02-06 Lamivudine salts

Publications (2)

Publication Number Publication Date
JP2016507569A true JP2016507569A (ja) 2016-03-10
JP2016507569A5 JP2016507569A5 (enExample) 2017-01-19

Family

ID=50151399

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015557055A Pending JP2016507569A (ja) 2013-02-07 2014-02-06 ラミブジン結晶塩

Country Status (5)

Country Link
US (1) US9688666B2 (enExample)
EP (1) EP2953945A2 (enExample)
JP (1) JP2016507569A (enExample)
CA (1) CA2898092A1 (enExample)
WO (1) WO2014124092A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2898092A1 (en) * 2013-02-07 2014-08-14 Tobira Therapeutics, Inc. Lamivudine salts

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225069A (zh) * 2011-04-29 2011-10-26 陶珍珠 一种耐药性显著降低的药物组合物及其制备方法和其应用

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US6288033B1 (en) * 1998-09-25 2001-09-11 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis B infection with thymosin alpha 1 in combination with lamivudine or in combination with lamivudine and famciclovir
IL151188A0 (en) * 2000-02-28 2003-04-10 Bayer Ag Medicament for viral diseases
CA2351049C (en) 2001-06-18 2007-03-13 Brantford Chemicals Inc. Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
BR0314259A (pt) * 2002-09-13 2005-07-26 Idenix Cayman Ltd ß-l-2'-desoxinucleosìdeos para o tratamento de cepas de hbv resistentes e terapias combinadas
US20050053916A1 (en) * 2002-10-01 2005-03-10 Korba Brent E. Diagnostic for long term response of HBV carrier to 3TC therapy
CN1517347A (zh) * 2003-01-16 2004-08-04 北京昭衍新药研究中心 抗病毒核苷衍生物
TWI332402B (en) * 2003-12-19 2010-11-01 Ind Tech Res Inst An extract for treating hepatitis
DE602007009957D1 (de) * 2006-04-18 2010-12-02 Lupin Ltd Neue kristalline form von lamivudin
KR20080086687A (ko) * 2007-03-23 2008-09-26 주식회사 파나진 라미부딘 내성 ｂ형 간염바이러스 검출을 위한 ρνα프로브, 키트 및 방법
WO2009031026A2 (en) * 2007-09-06 2009-03-12 Combino Pharm, S.L. Novel pharmaceutical compositions
US20100190982A1 (en) * 2007-09-17 2010-07-29 Janardhana Rao Vascuri Process for the preparation of lamivudine form i
BRPI0820222A2 (pt) * 2007-11-29 2015-06-16 Ranbaxy Lab Ltd Forma i cristalina estável de lamivudina e processo de preparação
US8536151B2 (en) * 2008-09-01 2013-09-17 Hetero Research Foundation Process for preparing lamivudine polymorph form
WO2010082128A1 (en) * 2009-01-19 2010-07-22 Aurobindo Pharma Limited Process for the preparation of cis-nucleoside derivative
EP2435052B1 (en) * 2009-05-27 2015-07-15 Hetero Research Foundation Solid oral dosage forms of lamivudine with isomalt
BRPI0903664B8 (pt) * 2009-09-22 2021-05-25 Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp método de obtenção de nova forma cristalina de lamivudina, seu sal cloridrato monoidratado, formulações farmacêuticas e seus usos
US8816074B2 (en) * 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
MX2012005601A (es) * 2009-11-16 2012-08-01 Univ Georgia Nucleosidos carboxiclicos de 2'-fluoro-6'-metileno y metodos para tratar infecciones virales.
US9700560B2 (en) * 2009-11-16 2017-07-11 University Of Georgia Research Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
AU2011215878A1 (en) * 2010-02-12 2012-08-09 Merck Sharp & Dohme Corp. Preparation of lamivudine Form I
CN102167696B (zh) * 2010-02-25 2013-09-18 南京正大天晴制药有限公司 拉米夫定草酸盐及其制备方法
CN103282369A (zh) * 2011-04-08 2013-09-04 劳乐斯实验室私营有限公司 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物
US20140193491A1 (en) * 2011-05-30 2014-07-10 Cipla Limited Pharmaceutical antiretroviral composition
CA2866133A1 (en) * 2012-03-05 2013-09-12 Cipla Limited Pharmaceutical antiretroviral combinations comprising lamivudine, festinavir and nevirapine
CA2898092A1 (en) * 2013-02-07 2014-08-14 Tobira Therapeutics, Inc. Lamivudine salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225069A (zh) * 2011-04-29 2011-10-26 陶珍珠 一种耐药性显著降低的药物组合物及其制备方法和其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ELLENA JAVIER, CRYSTENGCOMM, vol. V14 N7, JPN5016002056, 2012, pages 2373 - 2376, ISSN: 0003791321 *
TATSUO MARUYAMA ET AL.: "Sequence-selective extraction of single-stranded DNA using DNA-functionalized reverse micelles", CHEMICAL COMMUNICATIONS, vol. 43, JPN7016002055, 21 November 2007 (2007-11-21), pages 4450 - 4452, ISSN: 0003791320 *
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0003791322 *

Also Published As

Publication number Publication date
US20150368232A1 (en) 2015-12-24
US9688666B2 (en) 2017-06-27
EP2953945A2 (en) 2015-12-16
WO2014124092A2 (en) 2014-08-14
CA2898092A1 (en) 2014-08-14
WO2014124092A3 (en) 2014-10-23

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