JP2016507247A5 - - Google Patents
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- JP2016507247A5 JP2016507247A5 JP2015558950A JP2015558950A JP2016507247A5 JP 2016507247 A5 JP2016507247 A5 JP 2016507247A5 JP 2015558950 A JP2015558950 A JP 2015558950A JP 2015558950 A JP2015558950 A JP 2015558950A JP 2016507247 A5 JP2016507247 A5 JP 2016507247A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mhc
- nucleotide sequence
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 102
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 102
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 102
- 239000002773 nucleotide Substances 0.000 claims description 67
- 125000003729 nucleotide group Chemical group 0.000 claims description 67
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 45
- 241001465754 Metazoa Species 0.000 claims description 36
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 10
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 10
- 230000001086 cytosolic effect Effects 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 241000283984 Rodentia Species 0.000 claims description 8
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 8
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 8
- 230000006801 homologous recombination Effects 0.000 claims description 8
- 238000002744 homologous recombination Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 5
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 5
- 241000699670 Mus sp. Species 0.000 claims description 4
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims description 2
- 108010058607 HLA-B Antigens Proteins 0.000 claims description 2
- 108010052199 HLA-C Antigens Proteins 0.000 claims description 2
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 2
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 2
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 2
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims description 2
- 102000047279 human B2M Human genes 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 241001529936 Murinae Species 0.000 claims 3
- 108700043516 mouse H-2Kb Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 5
- 241000700159 Rattus Species 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767811P | 2013-02-22 | 2013-02-22 | |
| US61/767,811 | 2013-02-22 | ||
| PCT/US2014/017387 WO2014130667A1 (en) | 2013-02-22 | 2014-02-20 | Mice expressing humanized major histocompatibility complex |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101501A Division JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507247A JP2016507247A (ja) | 2016-03-10 |
| JP2016507247A5 true JP2016507247A5 (enExample) | 2017-03-23 |
| JP6444321B2 JP6444321B2 (ja) | 2018-12-26 |
Family
ID=50236326
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558950A Active JP6444321B2 (ja) | 2013-02-22 | 2014-02-20 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| JP2018101501A Active JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101501A Active JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10154658B2 (enExample) |
| EP (3) | EP2958937B1 (enExample) |
| JP (2) | JP6444321B2 (enExample) |
| KR (1) | KR102211267B1 (enExample) |
| CN (2) | CN110192541B (enExample) |
| AU (2) | AU2014218893C1 (enExample) |
| CA (1) | CA2900824A1 (enExample) |
| CY (1) | CY1121223T1 (enExample) |
| DK (1) | DK2958937T3 (enExample) |
| ES (3) | ES2697248T3 (enExample) |
| HR (1) | HRP20181866T1 (enExample) |
| HU (1) | HUE041878T2 (enExample) |
| LT (1) | LT2958937T (enExample) |
| PL (1) | PL2958937T3 (enExample) |
| PT (1) | PT2958937T (enExample) |
| RS (1) | RS57963B1 (enExample) |
| SI (1) | SI2958937T1 (enExample) |
| SM (1) | SMT201800614T1 (enExample) |
| WO (1) | WO2014130667A1 (enExample) |
Families Citing this family (44)
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|---|---|---|---|---|
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| AU2014249148B2 (en) * | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
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| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| EP3071024B1 (en) | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| EP3430898A1 (en) | 2013-11-19 | 2019-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| SMT202000332T1 (it) | 2014-04-08 | 2020-07-08 | Regeneron Pharma | Animali non umani aventi recettori fc-gamma umanizzati |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| KR20170083534A (ko) | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| ES2969389T3 (es) | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) * | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| CA3014645C (en) | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| EP3585162B1 (en) | 2017-09-29 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| SMT202500038T1 (it) | 2018-03-24 | 2025-03-12 | Regeneron Pharma | Topi o ratti geneticamente modificati per la generazione di anticorpi terapeutici contro complessi peptide-mhc, metodi di produzione e loro utilizzo |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| AU2020253532B2 (en) | 2019-04-04 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| CN113105555B (zh) * | 2020-01-10 | 2023-05-30 | 百奥赛图(北京)医药科技股份有限公司 | Mhc分子人源化的非人动物的构建方法及应用 |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| CA3258639A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharma | Multispecific molecules to modulate T lymphocyte activity, and their uses |
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| EP4590120A1 (en) | 2022-09-22 | 2025-07-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| US20250339384A1 (en) | 2023-01-27 | 2025-11-06 | Regeneron Pharmaceuticals, Inc. | Modified rhabdovirus glycoproteins and uses thereof |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| WO2025064470A1 (en) | 2023-09-19 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Viral peptides and uses thereof |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025136809A2 (en) | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
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| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| PL3720279T3 (pl) | 2017-12-05 | 2023-01-16 | Regeneron Pharmaceuticals, Inc. | Myszy posiadające zmodyfikowany sposobami inżynierii łańcuch lekki lambda immunoglobuliny oraz ich zastosowania |
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2014
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- 2014-02-20 WO PCT/US2014/017387 patent/WO2014130667A1/en not_active Ceased
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