JP2016507247A5 - - Google Patents
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- JP2016507247A5 JP2016507247A5 JP2015558950A JP2015558950A JP2016507247A5 JP 2016507247 A5 JP2016507247 A5 JP 2016507247A5 JP 2015558950 A JP2015558950 A JP 2015558950A JP 2015558950 A JP2015558950 A JP 2015558950A JP 2016507247 A5 JP2016507247 A5 JP 2016507247A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mhc
- nucleotide sequence
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 102
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 102
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 102
- 239000002773 nucleotide Substances 0.000 claims description 67
- 125000003729 nucleotide group Chemical group 0.000 claims description 67
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 45
- 241001465754 Metazoa Species 0.000 claims description 36
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 10
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 10
- 230000001086 cytosolic effect Effects 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 241000283984 Rodentia Species 0.000 claims description 8
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 8
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 8
- 230000006801 homologous recombination Effects 0.000 claims description 8
- 238000002744 homologous recombination Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 5
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 5
- 241000699670 Mus sp. Species 0.000 claims description 4
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims description 2
- 108010058607 HLA-B Antigens Proteins 0.000 claims description 2
- 108010052199 HLA-C Antigens Proteins 0.000 claims description 2
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 2
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 2
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 2
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims description 2
- 102000047279 human B2M Human genes 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 241001529936 Murinae Species 0.000 claims 3
- 108700043516 mouse H-2Kb Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 5
- 241000700159 Rattus Species 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767811P | 2013-02-22 | 2013-02-22 | |
| US61/767,811 | 2013-02-22 | ||
| PCT/US2014/017387 WO2014130667A1 (en) | 2013-02-22 | 2014-02-20 | Mice expressing humanized major histocompatibility complex |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101501A Division JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507247A JP2016507247A (ja) | 2016-03-10 |
| JP2016507247A5 true JP2016507247A5 (enExample) | 2017-03-23 |
| JP6444321B2 JP6444321B2 (ja) | 2018-12-26 |
Family
ID=50236326
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558950A Active JP6444321B2 (ja) | 2013-02-22 | 2014-02-20 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| JP2018101501A Active JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101501A Active JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10154658B2 (enExample) |
| EP (3) | EP3699190B9 (enExample) |
| JP (2) | JP6444321B2 (enExample) |
| KR (1) | KR102211267B1 (enExample) |
| CN (2) | CN110192541B (enExample) |
| AU (2) | AU2014218893C1 (enExample) |
| CA (1) | CA2900824A1 (enExample) |
| CY (1) | CY1121223T1 (enExample) |
| DK (1) | DK2958937T3 (enExample) |
| ES (3) | ES2949029T3 (enExample) |
| HR (1) | HRP20181866T1 (enExample) |
| HU (1) | HUE041878T2 (enExample) |
| LT (1) | LT2958937T (enExample) |
| PL (1) | PL2958937T3 (enExample) |
| PT (1) | PT2958937T (enExample) |
| RS (1) | RS57963B1 (enExample) |
| SI (1) | SI2958937T1 (enExample) |
| SM (1) | SMT201800614T1 (enExample) |
| WO (1) | WO2014130667A1 (enExample) |
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| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
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| AU2014249148B2 (en) * | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| HRP20231121T1 (hr) | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| JP6492095B2 (ja) | 2013-10-15 | 2019-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｉｌ−１５動物 |
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| RS60398B1 (sr) | 2014-04-08 | 2020-07-31 | Regeneron Pharma | Ne-humane životinje sa humanizovanim fc-gama receptorima |
| MX2016014504A (es) | 2014-05-05 | 2017-05-23 | Regeneron Pharma | Animales c5 y c3 humanizados. |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
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| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
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| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| EP4534560A3 (en) | 2018-03-24 | 2025-06-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
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| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
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| KR20260074976A (ko) | 2023-09-19 | 2026-05-27 | 리제너론 파마슈티칼스 인코포레이티드 | 바이러스 펩티드 및 이의 용도 |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
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| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
| AU2014249148B2 (en) | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| CA2902543A1 (en) | 2013-03-11 | 2014-10-09 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
| WO2014195159A1 (en) | 2013-06-03 | 2014-12-11 | Theravectys | Lentiviral vectors containing an mhc class i, mhc class ii, or beta-2 microglobulin upstream promoter sequence |
| US10278373B2 (en) | 2013-10-18 | 2019-05-07 | Taiho Pharmaceutical Co., Ltd. | HLA class I-expressing non-human animal |
| MX2017012829A (es) | 2015-04-06 | 2018-02-23 | Regeneron Pharma | Respuestas inmunitarias mediadas por células t humanizadas en animales no humanos. |
| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| WO2019113065A1 (en) | 2017-12-05 | 2019-06-13 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof |
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2014
- 2014-02-20 SI SI201430965T patent/SI2958937T1/sl unknown
- 2014-02-20 US US14/185,316 patent/US10154658B2/en active Active
- 2014-02-20 KR KR1020157026032A patent/KR102211267B1/ko active Active
- 2014-02-20 HU HUE14708429A patent/HUE041878T2/hu unknown
- 2014-02-20 PL PL14708429T patent/PL2958937T3/pl unknown
- 2014-02-20 ES ES20163735T patent/ES2949029T3/es active Active
- 2014-02-20 ES ES14708429T patent/ES2697248T3/es active Active
- 2014-02-20 DK DK14708429.7T patent/DK2958937T3/en active
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- 2014-02-20 CN CN201910379017.5A patent/CN110192541B/zh active Active
- 2014-02-20 SM SM20180614T patent/SMT201800614T1/it unknown
- 2014-02-20 EP EP20163735.2A patent/EP3699190B9/en active Active
- 2014-02-20 PT PT14708429T patent/PT2958937T/pt unknown
- 2014-02-20 HR HRP20181866TT patent/HRP20181866T1/hr unknown
- 2014-02-20 ES ES18182319T patent/ES2798751T3/es active Active
- 2014-02-20 EP EP14708429.7A patent/EP2958937B1/en active Active
- 2014-02-20 RS RS20181333A patent/RS57963B1/sr unknown
- 2014-02-20 AU AU2014218893A patent/AU2014218893C1/en active Active
- 2014-02-20 CA CA2900824A patent/CA2900824A1/en active Pending
- 2014-02-20 CN CN201480022254.1A patent/CN105164154B/zh active Active
- 2014-02-20 LT LTEP14708429.7T patent/LT2958937T/lt unknown
- 2014-02-20 WO PCT/US2014/017387 patent/WO2014130667A1/en not_active Ceased
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2018
- 2018-05-28 JP JP2018101501A patent/JP6681939B2/ja active Active
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2021
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