JP2016510998A5 - - Google Patents

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Publication number
JP2016510998A5
JP2016510998A5 JP2016501146A JP2016501146A JP2016510998A5 JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5 JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5
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JP
Japan
Prior art keywords
mouse
polypeptide
human
item
nucleotide sequence
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JP2016501146A
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English (en)
Japanese (ja)
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JP2016510998A (ja
JP6456351B2 (ja
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Priority claimed from US13/793,812 external-priority patent/US9591835B2/en
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Priority claimed from PCT/US2014/023076 external-priority patent/WO2014164640A1/en
Publication of JP2016510998A publication Critical patent/JP2016510998A/ja
Publication of JP2016510998A5 publication Critical patent/JP2016510998A5/ja
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Publication of JP6456351B2 publication Critical patent/JP6456351B2/ja
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JP2016501146A 2013-03-11 2014-03-11 キメラ主要組織適合複合体（ｍｈｃ）クラスｉ分子を発現する遺伝子導入マウス Active JP6456351B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/793,812 US9591835B2 (en) 2011-10-28 2013-03-11 Genetically modified major histocompatibility complex animals
US13/793,812 2013-03-11
PCT/US2014/023076 WO2014164640A1 (en) 2013-03-11 2014-03-11 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Publications (3)

Publication Number Publication Date
JP2016510998A JP2016510998A (ja) 2016-04-14
JP2016510998A5 true JP2016510998A5 (enExample) 2017-04-13
JP6456351B2 JP6456351B2 (ja) 2019-01-23

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ID=50513441

Family Applications (1)

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JP2016501146A Active JP6456351B2 (ja) 2013-03-11 2014-03-11 キメラ主要組織適合複合体（ｍｈｃ）クラスｉ分子を発現する遺伝子導入マウス

Country Status (8)

Country Link
EP (1) EP2967014B1 (enExample)
JP (1) JP6456351B2 (enExample)
KR (1) KR102313053B1 (enExample)
CN (1) CN105188358B (enExample)
AU (2) AU2014249150B2 (enExample)
CA (1) CA2902543A1 (enExample)
ES (1) ES2764829T3 (enExample)
WO (1) WO2014164640A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
KR20240147707A (ko) 2013-02-20 2024-10-08 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
CN110192541B (zh) 2013-02-22 2022-02-18 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
EP3209769B1 (en) * 2014-10-24 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
KR20240132525A (ko) * 2015-04-06 2024-09-03 리제너론 파아마슈티컬스, 인크. 비인간 동물에서의 인간화 t 세포 매개 면역반응
CN109456942A (zh) * 2017-09-06 2019-03-12 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
JP7699749B2 (ja) * 2019-05-27 2025-06-30 株式会社トランスジェニックグループ エクソンヒト化マウス
US10841728B1 (en) 2019-10-10 2020-11-17 Boomcloud 360, Inc. Multi-channel crosstalk processing
KR20220125797A (ko) * 2020-01-10 2022-09-14 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 인간 또는 키메라 mhc 단백질 복합체를 갖는, 유전자 변형된 비-인간 동물
AU2022249328A1 (en) 2021-03-31 2023-09-21 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire
EP4215042A1 (en) * 2022-01-21 2023-07-26 Max-Delbrück-Centrum für Molekulare Medizin A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof
WO2025212991A1 (en) 2024-04-05 2025-10-09 Regeneron Pharmaceuticals, Inc. Rodent models of disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489742A (en) * 1990-10-23 1996-02-06 Board Of Regents, The University Of Texas System Transgenic rats and animal models of inflammatory disease
US20020151690A1 (en) * 1997-08-12 2002-10-17 Luxemburg Alain T Purification of antigen-specific t cells
US7285273B1 (en) * 1999-04-23 2007-10-23 Pharmexa A/S Method for down-regulating IL5 activity
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2002222610A1 (en) 2000-12-13 2002-06-24 Sumitomo Pharmaceuticals Company, Limited Transgenic animal expressing hla-a24 and utilization thereof
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
CA2474002A1 (en) * 2002-01-18 2003-07-24 Bjarne Bogen Bispecific antibody dna constructs for intramuscular administration
SE0301109D0 (sv) * 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
US7663017B2 (en) * 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
RS56656B1 (sr) * 2011-10-28 2018-03-30 Regeneron Pharma Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti

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