JP2016510998A5 - - Google Patents
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- JP2016510998A5 JP2016510998A5 JP2016501146A JP2016501146A JP2016510998A5 JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5 JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- polypeptide
- human
- item
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 55
- 108090000765 processed proteins & peptides Proteins 0.000 description 55
- 102000004196 processed proteins & peptides Human genes 0.000 description 55
- 239000002773 nucleotide Substances 0.000 description 26
- 125000003729 nucleotide group Chemical group 0.000 description 26
- 102000012153 HLA-B27 Antigen Human genes 0.000 description 15
- 108010061486 HLA-B27 Antigen Proteins 0.000 description 15
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 12
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 101000937526 Mus musculus Beta-2-microglobulin Proteins 0.000 description 5
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 4
- 230000001086 cytosolic effect Effects 0.000 description 4
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 241000283984 Rodentia Species 0.000 description 3
- 108700043516 mouse H-2Kb Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 108700024394 Exon Proteins 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/793,812 | 2013-03-11 | ||
| US13/793,812 US9591835B2 (en) | 2011-10-28 | 2013-03-11 | Genetically modified major histocompatibility complex animals |
| PCT/US2014/023076 WO2014164640A1 (en) | 2013-03-11 | 2014-03-11 | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510998A JP2016510998A (ja) | 2016-04-14 |
| JP2016510998A5 true JP2016510998A5 (enExample) | 2017-04-13 |
| JP6456351B2 JP6456351B2 (ja) | 2019-01-23 |
Family
ID=50513441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501146A Active JP6456351B2 (ja) | 2013-03-11 | 2014-03-11 | キメラ主要組織適合複合体（ｍｈｃ）クラスｉ分子を発現する遺伝子導入マウス |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2967014B1 (enExample) |
| JP (1) | JP6456351B2 (enExample) |
| KR (1) | KR102313053B1 (enExample) |
| CN (1) | CN105188358B (enExample) |
| AU (2) | AU2014249150B2 (enExample) |
| CA (1) | CA2902543A1 (enExample) |
| ES (1) | ES2764829T3 (enExample) |
| WO (1) | WO2014164640A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| WO2016065245A1 (en) | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
| EP3209769B1 (en) | 2014-10-24 | 2020-08-05 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
| AU2016246698B2 (en) * | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
| JP7699749B2 (ja) * | 2019-05-27 | 2025-06-30 | 株式会社トランスジェニックグループ | エクソンヒト化マウス |
| US10841728B1 (en) | 2019-10-10 | 2020-11-17 | Boomcloud 360, Inc. | Multi-channel crosstalk processing |
| CN113105555B (zh) * | 2020-01-10 | 2023-05-30 | 百奥赛图(北京)医药科技股份有限公司 | Mhc分子人源化的非人动物的构建方法及应用 |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| EP4215042A1 (en) | 2022-01-21 | 2023-07-26 | Max-Delbrück-Centrum für Molekulare Medizin | A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489742A (en) * | 1990-10-23 | 1996-02-06 | Board Of Regents, The University Of Texas System | Transgenic rats and animal models of inflammatory disease |
| US20020151690A1 (en) * | 1997-08-12 | 2002-10-17 | Luxemburg Alain T | Purification of antigen-specific t cells |
| WO2000065058A1 (en) * | 1999-04-23 | 2000-11-02 | Pharmexa A/S | Method for down-regulating il5 activity |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JPWO2002047474A1 (ja) | 2000-12-13 | 2004-04-15 | 住友製薬株式会社 | Ｈｌａ−ａ２４発現トランスジェニック動物及びその利用 |
| FR2827302B1 (fr) * | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
| US20040052773A1 (en) * | 2002-01-18 | 2004-03-18 | Inovio As | Production of multi-chain protein from muscle |
| SE0301109D0 (sv) * | 2003-04-14 | 2003-04-14 | Mallen Huang | Nucleotide vaccine composition |
| US7663017B2 (en) * | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| EP1878342A1 (en) | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses |
| KR102295746B1 (ko) * | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
-
2014
- 2014-03-11 WO PCT/US2014/023076 patent/WO2014164640A1/en not_active Ceased
- 2014-03-11 CN CN201480025263.6A patent/CN105188358B/zh active Active
- 2014-03-11 KR KR1020157028380A patent/KR102313053B1/ko active Active
- 2014-03-11 JP JP2016501146A patent/JP6456351B2/ja active Active
- 2014-03-11 ES ES14718226T patent/ES2764829T3/es active Active
- 2014-03-11 AU AU2014249150A patent/AU2014249150B2/en active Active
- 2014-03-11 EP EP14718226.5A patent/EP2967014B1/en active Active
- 2014-03-11 CA CA2902543A patent/CA2902543A1/en active Pending
-
2020
- 2020-07-01 AU AU2020204410A patent/AU2020204410C1/en active Active
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